Galectin-3 and HBME-1 are highly sensitive and specific molecular markers for diagnosing thyroid cancer. Galectin-3 has a sensitivity of 93.7% and specificity of 83% for differentiating benign from malignant thyroid tumors, while HBME-1 has a sensitivity of 81% and specificity of 84.7% for diagnosing thyroid cancer. Using a panel of multiple molecular markers together can provide nearly 100% accuracy in diagnosing thyroid cancer, as individual markers may not be expressed in all tumors.
Lab Diagnosis of Chronic lymphoproliferative disorders (CLPD);Flowcytometric...Dr Siddartha
Lab Diagnosis of Chronic lymphoproliferative disorders (CLPD);Flowcytometric Evaluation
Basavatarakam Indo-American Cancer Hospital and Research Institute
Lab Diagnosis of Chronic lymphoproliferative disorders (CLPD);Flowcytometric...Dr Siddartha
Lab Diagnosis of Chronic lymphoproliferative disorders (CLPD);Flowcytometric Evaluation
Basavatarakam Indo-American Cancer Hospital and Research Institute
Canine oncoprotein targets for Melanoma, Breast Cancer, OsteosarcomaSnehal Salunkhe
We can acquire the basic knowledge about canine oncoprotein targets specifically for Melanoma, Osteosarcoma and Breast cancer. I haven't mentioned all the proteins and their targets involved, but just a general overview of these targets with the drugs involved in their treatment/clinical trials.
In the recent years, knowledge about cancer biomarkers has increased tremendously
providing great opportunities for improving the management of cancer patients by
enhancing the efficiency of detection and efficacy of treatment.
• Recent technological advancement has enabled the examination of many
potential biomarkers and renewed interest in developing new biomarkers.
• Biomarkers of cancer could include a broad range of biochemical entities, such as nucleic
acids, proteins, sugars, lipids, and small metabolites, cytogenetic and cytokinetic
parameters as well as whole tumour cells found in the body
fluid. A COMPREHENSIVE UNDERSTANDING OF THE RELEVANCE
OF EACH BIOMARKER WILL BE VERY IMPORTANT NOT
ONLY FOR DIAGNOSING THE DISEASE RELIABLY, BUT ALSO
HELP IN THE CHOICE OF MULTIPLE THERAPEUTIC
ALTERNATIVES CURRENTLY AVAILABLE THAT IS LIKELY TO
BENEFIT THE PATIENTS.• Measure or evaluate the normal biological process, pathogenic processes, or
pharmacological response to a therapeutic interventions.
• Includes ~ diagnostic test and imaging technology
• “ Cancer is clusters disease involving alterations in status and expression of
multiple genes that confer a survival advantage & diminished proliferative
potential to somatic or germinal cells"
Specific to tumor
• Level change in response to tumor size
• No fluctuations in level
• Low level in healthy individual
• Predict recurrence
• Test should be cost effective
DNA methylation
2. Alteration pattern of histone modification
3. Alterations in chromatin condensation
National Vector Borne Control Disease Control Programme (NVBDCP) is a division of National Health Mission (NHM) in the Department of Health & Family Welfare. NVBDCP division covers 6 Vector Borne Diseases namely Malaria, Dengue, Chikungunya, Japanese Encephalistis, Kala Azar and Lymphatic Filariasis.
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
3. INTRODUCTION
• A biomarker, or biological marker, generally refers to a measurable
indicator of some biological state or condition.
• Immunohistochemistry (IHC) refers to the process of selectively
imaging antigens (e.g. proteins) in cells of a tissue section by
exploiting the principle of antibodies binding specifically to
antigens in biological tissues.
• A molecular marker is a molecule contained within a sample taken
from an organism (biological markers) or other matter. It can be used
to reveal certain characteristics about the respective source. DNA, for
example, is a molecular marker containing information about genetic
disorders, genealogy and the evolutionary history of life.
4.
5. IMMUNOHISTOCHEMISTRY IN THYROID CANCER
• Diagnosis of thyroid cancer being commonly done by histology,
immunohistochemistry and imaging modalities like X-ray,
Ultrasonography and Computed tomography(CT).
• Though histology is considered as the standard diagnostic method
for thyroid cancer but it shows some limitations where the
morphological features are ambiguous.
6. Several molecular markers have been detected in thyroid cancer
actively involved in cancer development and metastasis:
• Papillary- GAL-3,HBME-1,CK-19,TPO,VEGFR, EGFR,CITED-1,HGF
• Follicular- TPO,GAL-3,VEGFR,EGFR
• Medullary- Calcitonin, VEGFR, EGFR, Chromogranin
• Anaplastic- EGFR,VEGFR,
7. GALECTIN 3
• Galectin-3 (GAL-3) is a member of β-galactosil binding lectin family and
expressed in both nucleus and cytoplasm which interacts with
carbohydrate and protein ligand to form pentamers therefore helping
initiation and regulation of cell growth, cell differentiation and malignant
transformation.
• It is highly sensitive in differentiating benign from malignant thyroid
tumor . After analyzing the recent IHC data, on thyroid cancer , the average
sensitivity and specificity of GAL-3 is found to be 93.7% and 83%
respectively .
8. HECTOR BATTIFORA MESOTHELIAL-1(HBME-1)
• Hector Battifora Mesothelial-1(HBME-1) is an antimesothelial monoclonal
antibody reacts against unknown antigen on mesothelial cell surface,
commonly used in differential diagnosis of mesothelioma and
adenocarcinoma.
• HBME-1 is highly expressed in both PTC and FTC with little expression in
MTC and ATC, stimulates cancer cell proliferation and migration.
• HBME-1 is the most specific marker for thyroid cancer and may be useful in
differentiating malignant thyroid cancer from benign tumor.
• the average sensitivity and specificity of HBME-1 was found to be 81% and
84.7% respectively, showing HBME-1 is most specific in diagnosing thyroid
9. CYTOKERATIN-19
• Cytokeratin-19 (CK-19) is the smallest of 20 member keratin family (48-60
KDa, IpH 4.9-7.8) expressed in the periderm, the transiently superficial layer
that envelops the developing epidermis.
• CK-19 expression pattern is often used for distinction of different types of
epithelial malignancies , which is also expressed in endometrial cancer,
bladder cancer and breast cancers, showing marked sensitivity, but poor
specificity.
• Wide expression of CK-19 occurs in thyroid cancer, but most commonly
noticed in 80% of PTC than other thyroid tumors. Its high reactivity may
help in diagnosis of different thyroid tumors in IHC study.
10. GENE MUTATION AND REARRANGEMENT
• RET/PTC rearrangement, BRAF, PAX-8/PPARγ, RAS and LOH of 3p-3q are
important genes involved in thyroid cancer.
• BRAF mutation is the most sensitive papillary thyroid cancer marker,
followed by RET/ PTC rearrangement.
• Gene mutation and activation have greater importance in the thyroid cancer
diagnosis, prognosis and targeted therapy. However, these are time
consuming and expensive and only suitable for research and evaluation of
prolonged treatment and cancer recurrence.
11. COMBINED MARKER STUDY
• Combined marker study may improve the accuracy of thyroid cancer
diagnosis.
• Individual study of biomarker shows that some markers are more specific and
some are more sensitive and of course, all these markers may not be expressed
in a single tumor.
• The diagnosis of thyroid cancer by using a panel of markers may enhance the
accuracy of diagnosis.
• Nearly 100% sensitivity and specificity can be reached by combining a panel
of markers for diagnosis of thyroid cancer.