icometrix offers imaging biomarkers for anatomical MRI or CT images as well as for functional, diffusion and perfusion MR images. Medical imaging serves as an endpoint in an increasing number of clinical trials for neurological disorders to evaluate the effectiveness of novel therapeutic options and to better understand the pathophysiology. It is critical to obtain objective imaging measurements.Therefore, the use of high-quality MRI data and quantitative MRI biomarkers is also recommended in the latest guidelines of the European Medicine Agency on clinical investigation of medicinal products for treatment of dementia, multiple sclerosis and other neurological disorders.

1. Clinical trials
with icometrix!

2. Quantitative MRI biomarkers for you ?
About icometrix
Experience
Future
The use of high quality MRI data and quantitative MRI
biomarkers is recommended in the latest guidelines of
the European Medicine Agency (EMA) on clinical
investigation of medicinal products for treatment of
dementia, multiple sclerosis and other neurological
disorders.
www.ema.europa.eu
!!

3. HISTORY MEASURING BLOOD GLUCOSE
Clarke et al. 2012
Sight, touch, smell &
taste
Copper reagent
tablet
First glucose meter
for quantification
Standardized
glucose measures
Reduced observer-dependency & measurement error!
Better patient monitoring & treatment decisions!
Improved outcome for patients!
Standardization!

4. HISTORY OF MRI MEASUREMENTS
“EYE-BALLING”
à STANDARDIZED
MEASUREMENTS
Reduced observer-dependency & measurement error!
Better patient monitoring & treatment decisions!
Improved outcome for patients!
Standardization!

5. BRAIN IMAGING BIOMARKERS
Alzheimer’s Disease
Parkinson’s Disease
Huntington’s Disease
Amyotrophic lateral sclerosis
Stroke
Traumatic brain injury
Epilepsy
Migraine
Autism
Anxiety Disorders
Multiple Sclerosis
Sleep Disorders
Major Depressive Disorder
Bipolar Disorders
Schizophrenia
* Definition by icometrix!
Brain imaging biomarkers are features that can be detected on a
medical brain scan (visually or by computerized analyses).
For patients with a neurological disorder, imaging biomarkers provide
neurologists & radiologists with key information on how the
disease is progressing in their brain. Imaging biomarkers can give an
indication of how well treatment is working. *

6. MRI & CT!
Imaging biomarkers for anatomical MRI or
CT images as well as for functional, diffusion
and perfusion MR images.
Guidance for imaging protocol!
Imaging data management
Quality control!
Close collaboration for result reporting &
statistics!
icometrix quantitative MRI biomarkers

7. To measure is to know
Automated quantification of imaging biomarkers
provides fast and objective answers.
From one to many!
Biomarkers for clinical practice:
• low measurement error
• high accuracy
Trial: maximize the power!
Advanced image analysis!
• Anatomical
• Functional
• Diffusion
• Perfusion
• Spectroscopy
icometrix quantitative MRI biomarkers

8. Quantitative MRI biomarkers for you?
About icometrix
Experience
Future
!!

9. Leuven Belgium!
Boston USA!
Dirk Loeckx & Wim Van Hecke !
Quantitative image analysis !
for clinical practice & clinical trials!
Founded in 2011 by

10. Active in!
ISO9001,
ISO13485 (Medical Devices) &
ISO27001 (Information Security)
> 30 countries
> 300 centers!
Leuven Belgium!
Boston USA!
HIPAA compliant!
Grown to an established organization

11. MSmetrix Ÿ icobrain!
CE approved Ÿ FDA cleared
Reliably track brain
v o l u m e l o s s!
Closely monitor new
& enlarging FLAIR
w h i t e m a t t e r
h y p e r i n t e n s i t i e s!
Brain MRI biomarkers made easy
to monitor neurological disorders !
Time
V O L U M E L O S S!
B R A I N
Time
I N F L A M M A T I O N!

12. MSmetrix Ÿ icobrain!
CE approved Ÿ FDA cleared
Brain MRI biomarkers made easy
to monitor neurological disorders !

13. Quantitative MRI biomarkers
About icometrix
Experience
Future
!!Dr. Max Wintermark, M.D., Professor of Radiology & Chief of
Neuroradiology at the Stanford University Medical Center.
MRI biomarkers are becoming of vital importance in the clinical
care path for various pathologies including neurological disorders
such as multiple sclerosis, traumatic brain injury and stroke. It is of
paramount importance that the biomarker measurements are
extremely reproducible & sensitive enough to detect relevant
clinical changes.

14. Collaborations Imaging
Research institutes
& hospitals
worldwide
Clinical trials
Phase I, II, III, IV
Multiple Sclerosis,
Trauma, stroke,
Epilepsy,
Parkinson’s disease,
Alzheimer’s disease
Cloud service
Fast & secure
processing of
large datasets
Registries
Segmentation
multi-modal
registration,
diffusion analysis,
population studies
& stratification, MR
spectroscopy, etc.
EXPERIENCE in clinical trials & clinical practice
Easy data transfer
& data
management
Top pharma

15. Retrospective clinical trial data!
More significant results & better patient selection
MS clinical trials!
Cost-effective, lower sample size needed & better
patient selection
More CNS trials!
Cost-effective, lower sample size needed & better
patient selection

16. Quantitative MRI biomarkers
About icometrix
Experience
Future
To measure is to know. If you
cannot measure it, you cannot
improve it. !
Lord Kelvin
Scots-Irish mathematical physicist
& engineer (1824 – 1907)
!!

17. IMPACT FOR
P A T I E N T S
Monitoring therapy response and disease progression
Patient selection for optimal treatment and
treatment change
Patient selection for clinical trials
Improved outcomes of clinical trials
New era of personalized medicine
New era of digital health
New era of patient empowerment
Increased need for objective biomarkers
Increased costs to bring drugs on the market
HEALTHCARE
(R)EVOLUTION
Non-invasive
Automated (thus cost-effective)
Reliable markers of disease progression
Reduce sample size of clinical trials
I M A G I N G
BIOMARKERS

18. icometrix!
Real world data
Neurological disorders!
Therapy & monitoring go hand in hand
Help patients!
Incorporate imaging biomarkers
Shift to digital health
Improve cost-efficiency of clinical trials
Next step in Radiology
Right drug / medical device!
Right patient!
Right time! You?!

19. icometrix!
info@icometrix.com
or
www.icometrix.com