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IBM
- 1. INCLUSION BODY MYOSITIS Med Term 2 IRP Demi Hall
- 2. IBM Inclusion Body Myositis- inflammatory muscle disease, characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs
- 3. IBM s-IBM genetic susceptibility is thought to be an influence (not fully understood yet) i-IBM genetically inherited autosomal recessive dominant variants
- 4. Signs frequent falling struggling to climb stairs trouble standing from the setting position feet dropping while walking, causing tripping weak gripping in the hand hard time swallowing
- 5. A before and after photo of a gentlemen with IBM. The picture to the left is after and you can see the way the his muscles are no longer apparent compared to the before photo to the right.
- 6. Feet and Hands They become deformed looking and like the patient has arthritis. weakness of flexion in wrist and fingers weakness of flexion in the ankle and toes
- 7. Symptoms weakness and shrinking in the quadriceps, causing falling weakness and shrinking in the forearm muscles weakness of muscles below the knees, causing the foot to drop and toes to catch when walking weakness of the flexor muscles of the fingers used for gripping weakness of the throat muscles, causing trouble swallowing and possibly choking pain and discomfort as muscles weaken inflammatory infiltrate cytoplasmic vacuolation
- 8. Symptoms cont.…… tubo-filamentous inclusions within the cytoplasm and nuclei of the muscle cells inflammatory infiltrate cytoplasmic vacuolation
- 9. Prognosis incurable very slow progression older people tend to progress faster dysphagia is mainly associated with poorer quality of life
- 10. Facts most age related muscle disease in elderly underdiagnosed misdiagnosed as polymyositis wrongly treated with steroids found more in men then women many different forms some cases more rare then others
- 11. Standard Studies FBC calcium and phosphate creatine kinase ESR fasting glucose TFTs
- 12. Specialized Studies nerve conduction test (should come back normal) electromyography muscle biopsy of a muscle effected but not to far rendered
- 13. Management no effective treatment not many high-quality trails speech therapy for dysphagia dieatary support physiotherapy occupational therapy
- 14. This picture high lights the main muscles that IBM affects.
- 15. Why I chose IBM, you may ask? Meet Dan.
- 16. Dan’s Story About 6 years ago Dan began having troubles with his back, falling a lot from his knees just giving out on him. He became weak and unable to do the normal daily things he loved. Dan was diagnosed 3 years ago with IBM, at the young age of 45. He worked at Green Acres putting in guard rail for over 20 years, he was a very hard worker and still is today with is disability. While at work he stayed out of town a lot. This is to be said the reason Dan has IBM. His whole life he’s had an immune deficiency that has made him susceptible. Well he became unlucky and contracted IBM. His specialist in Pittsburgh says it was from staying in a hotel room, while working out of town, that most likely a foreigner who had come to the states had stayed in and this person may not have had IBM but was carrying it.
- 17. Who is Dan? He is my hero. He has sat through horse shows, doctor appointments, school plays, rode horses with me on the trails by my house almost religiously, and has always been there for me. Daniel William Hall is my father.