Solid pseudopapillary neoplasm of the pancreas is a distinctive pancreatic neoplasm with low metastatic potential. This study examines clinical differences and prognosis between male and female patients.
http://www.drmarcel.com.br
This document discusses neoplasms of the pancreas. It covers the epidemiology, risk factors, molecular genetics, pathology, staging, clinical features, diagnosis, management including surgical and non-surgical options, and postoperative results of pancreatic cancer. Some key points include that pancreatic cancer is the 4th leading cause of cancer death, risk factors include age, smoking, diet, and certain genetic syndromes. The most common type is ductal adenocarcinoma. Surgical resection if possible offers the only chance for cure, but postoperative mortality rates have decreased in recent decades.
This document provides information on pancreatic neoplasms. It begins with the anatomy of the pancreas and its blood supply. It then discusses the different types of pancreatic neoplasms, including cystic neoplasms and ductal adenocarcinoma. Risk factors for ductal adenocarcinoma are outlined. The pathogenesis and molecular progression of pancreatic cancer from pancreatic intraepithelial neoplasia to invasive cancer is described. Clinical presentation, diagnostic imaging modalities, staging, treatment options including surgery and adjuvant therapy, palliative care, and recent advances are summarized. Finally, cystic neoplasms of the pancreas including mucinous cystic neoplasms are briefly covered.
This document provides information on pancreatic adenocarcinoma, including its anatomy, physiology, clinical presentation, investigations, staging, treatment and prognosis. It discusses the exocrine and endocrine functions of the pancreas. It also covers cystic lesions of the pancreas and pancreatic endocrine tumours. The staging and survival rates for pancreatic cancer are presented. Complications of pancreatic surgery and mortality rates at high volume centers are summarized.
1) The document discusses pancreatic neoplasms, including classification into exocrine and endocrine tumors.
2) It highlights adenocarcinoma of the pancreas, noting risk factors like smoking, chronic pancreatitis, genetics, and more.
3) Diagnosis involves imaging like CT/MRI, blood tests, and pathology examination of biopsies showing malignant cells and fibrosis.
1. The document discusses carcinoma of the head of the pancreas, including its epidemiology, risk factors, pathology, clinical features, imaging, staging, and surgical management via the Whipple procedure.
2. It provides details of the Whipple procedure, including exposing and dissecting key structures like the superior mesenteric vein, Kocher maneuver, dividing vessels like the gastroduodenal artery, and transecting the stomach and jejunum.
3. The Whipple procedure involves a pancreaticoduodenectomy to resect the pancreatic head tumors while preserving stomach, duodenum, common bile duct, and pancreas.
Pancreatic Biliary Cancer by Dr Mahipal reddyguest407122
The document discusses pathology, risk factors, clinical presentation, diagnosis, staging, and treatment options for pancreatic cancer and cholangiocarcinoma. For pancreatic cancer, the most common type is infiltrating ductal adenocarcinoma. Risk factors include age, smoking, diabetes, and diet. Symptoms include abdominal pain and weight loss. Diagnosis involves imaging like CT/MRI and biopsy. Treatment involves surgical resection if possible or chemotherapy with gemcitabine if unresectable. For cholangiocarcinoma, risk factors include inflammation and parasites. Symptoms are usually painless jaundice. Diagnosis involves imaging and ERCP. Surgery is the main treatment if resectable but prognosis is unclear
Determining resectability in pancreatic cancer harish Ys
The document discusses determining resectability in pancreatic cancer. It begins with an introduction to pancreatic cancer rates, stages, and classifications. It then discusses the National Comprehensive Cancer Network guidelines for classifying pancreatic cancers as resectable, borderline resectable, or unresectable based on tumor involvement of arteries and veins. The document outlines surgical procedures for pancreatic cancer and discusses how venous and arterial resection can increase resectability rates when performed by specialized surgeons, though they may increase morbidity.
This document discusses neoplasms of the pancreas. It covers the epidemiology, risk factors, molecular genetics, pathology, staging, clinical features, diagnosis, management including surgical and non-surgical options, and postoperative results of pancreatic cancer. Some key points include that pancreatic cancer is the 4th leading cause of cancer death, risk factors include age, smoking, diet, and certain genetic syndromes. The most common type is ductal adenocarcinoma. Surgical resection if possible offers the only chance for cure, but postoperative mortality rates have decreased in recent decades.
This document provides information on pancreatic neoplasms. It begins with the anatomy of the pancreas and its blood supply. It then discusses the different types of pancreatic neoplasms, including cystic neoplasms and ductal adenocarcinoma. Risk factors for ductal adenocarcinoma are outlined. The pathogenesis and molecular progression of pancreatic cancer from pancreatic intraepithelial neoplasia to invasive cancer is described. Clinical presentation, diagnostic imaging modalities, staging, treatment options including surgery and adjuvant therapy, palliative care, and recent advances are summarized. Finally, cystic neoplasms of the pancreas including mucinous cystic neoplasms are briefly covered.
This document provides information on pancreatic adenocarcinoma, including its anatomy, physiology, clinical presentation, investigations, staging, treatment and prognosis. It discusses the exocrine and endocrine functions of the pancreas. It also covers cystic lesions of the pancreas and pancreatic endocrine tumours. The staging and survival rates for pancreatic cancer are presented. Complications of pancreatic surgery and mortality rates at high volume centers are summarized.
1) The document discusses pancreatic neoplasms, including classification into exocrine and endocrine tumors.
2) It highlights adenocarcinoma of the pancreas, noting risk factors like smoking, chronic pancreatitis, genetics, and more.
3) Diagnosis involves imaging like CT/MRI, blood tests, and pathology examination of biopsies showing malignant cells and fibrosis.
1. The document discusses carcinoma of the head of the pancreas, including its epidemiology, risk factors, pathology, clinical features, imaging, staging, and surgical management via the Whipple procedure.
2. It provides details of the Whipple procedure, including exposing and dissecting key structures like the superior mesenteric vein, Kocher maneuver, dividing vessels like the gastroduodenal artery, and transecting the stomach and jejunum.
3. The Whipple procedure involves a pancreaticoduodenectomy to resect the pancreatic head tumors while preserving stomach, duodenum, common bile duct, and pancreas.
Pancreatic Biliary Cancer by Dr Mahipal reddyguest407122
The document discusses pathology, risk factors, clinical presentation, diagnosis, staging, and treatment options for pancreatic cancer and cholangiocarcinoma. For pancreatic cancer, the most common type is infiltrating ductal adenocarcinoma. Risk factors include age, smoking, diabetes, and diet. Symptoms include abdominal pain and weight loss. Diagnosis involves imaging like CT/MRI and biopsy. Treatment involves surgical resection if possible or chemotherapy with gemcitabine if unresectable. For cholangiocarcinoma, risk factors include inflammation and parasites. Symptoms are usually painless jaundice. Diagnosis involves imaging and ERCP. Surgery is the main treatment if resectable but prognosis is unclear
Determining resectability in pancreatic cancer harish Ys
The document discusses determining resectability in pancreatic cancer. It begins with an introduction to pancreatic cancer rates, stages, and classifications. It then discusses the National Comprehensive Cancer Network guidelines for classifying pancreatic cancers as resectable, borderline resectable, or unresectable based on tumor involvement of arteries and veins. The document outlines surgical procedures for pancreatic cancer and discusses how venous and arterial resection can increase resectability rates when performed by specialized surgeons, though they may increase morbidity.
Pancreatic carcinoma is a relatively common and deadly form of cancer. The majority of pancreatic cancers are adenocarcinoma originating from the ductal cells. Risk factors include tobacco use, older age, genetic conditions, and chronic pancreatitis. Symptoms can include jaundice, abdominal pain, weight loss, and new-onset diabetes. Diagnosis involves blood tests for markers like CA19-9, imaging with CT, MRI, or EUS to identify tumors, and tissue sampling when needed. Surgical resection offers the only chance of cure but many tumors are inoperable at diagnosis due to late presentation and aggressive nature.
Pancreatic cancer is the 10th most common cancer and the 4th leading cause of cancer death. 80% are adenocarcinomas from the exocrine pancreas. Risk factors include smoking, low fruit/vegetable intake, obesity, and family history. Symptoms are nonspecific but include jaundice, weight loss, and pain. Imaging like CT scans and endoscopic ultrasound are used to determine if tumors are resectable in 15-20% of patients. The Whipple procedure removes the pancreas head while distal pancreatectomy removes the body/tail. Adjuvant chemo may be given but 70-80% of patients still recur due to the pancreas' rich blood supply
This document outlines a seminar plan on carcinoma of the pancreas presented by Dr. Jyotindra Singh. The seminar will cover topics such as the anatomy and surgical anatomy of the pancreas, pancreatic tumors, modes of presentation, pre-operative workup, various surgeries and surgical videos, recent updates, studies and trials, and a take home message. The seminar introduction discusses that carcinoma of the exocrine pancreas accounts for over 90% of pancreatic tumors and remains an oncologic challenge with a 5-year survival rate of 3%.
This document summarizes recent advances in pancreatic cancer. It covers molecular genetics and tumor biology, methods for early detection of precursor lesions, investigation modalities like imaging tests and tumor markers, surgical management approaches including criteria for resectability, and adjuvant treatment modalities like chemotherapy and radiation. Newer chemotherapy regimens have improved survival rates and some targeted therapies show promise. Multidisciplinary treatment at high-volume centers results in better outcomes. While improvements have been made, pancreatic cancer remains difficult to treat and more research is still needed.
Pancreatic neoplasms can be classified based on their function as exocrine tumors, endocrine tumors, or mesenchymal tumors. The most common pancreatic neoplasm is pancreatic ductal adenocarcinoma, which arises from the exocrine pancreatic ductal cells. Endocrine tumors arise from the islet cells and include functional tumors like insulinomas and non-functional tumors. Rare pancreatic mesenchymal neoplasms originate from the pancreatic structural elements and include both benign and malignant subtypes.
Pancreatic cancer develops from DNA damage to cells in the pancreas that causes uncontrolled growth. Most cases are ductal adenocarcinoma. Risk factors include smoking, obesity, family history, and chronic pancreatitis. Symptoms include jaundice, abdominal pain, weight loss, and fatigue. Diagnosis involves imaging like CT, MRI, and endoscopic ultrasound. Only 20% of cases are surgically resectable; the remainder receive chemotherapy, radiation, or supportive care. Prognosis is generally poor with a median survival of 4-6 months for metastatic disease.
The document discusses carcinoma of the pancreas. It covers the anatomy, epidemiology, risk factors, genetics, screening, staging, pathologic conditions, clinical presentation, evaluation, management approaches for resectable, borderline resectable, and unresectable disease, surgical procedures including Whipple procedure and distal pancreatectomy, complications, adjuvant therapy approaches studied in trials such as ESPAC-1, and the role of chemoradiation following gemcitabine chemotherapy.
This document provides an outline and overview of pancreatic cancer. It begins with discussing the anatomy and functions of the pancreas. It then covers the epidemiology, types, pathophysiology, risk factors, signs and symptoms, diagnosis, and staging of pancreatic cancer. Imaging studies that can be used include CT, MRI, ERCP, and PET scans. Laboratory findings may include elevated bilirubin and tumor markers like CA19-9. Staging uses the TNM and stage models, with stage 1 being localized cancer and stage 4 being distant metastasis.
This document discusses the management of periampullary cancers. It covers the role of fine needle aspiration in diagnosis and pre-operative biliary decompression. Staging laparoscopy and clinicopathological staging are discussed. The document outlines curative surgeries like pancreaticoduodenectomy and distal pancreatectomy. It also discusses operative and non-operative palliative options. Adjuvant therapies including chemo-radiation are mentioned. Emerging novel agents for treatment are noted.
Pancreatic neoplasms can be either solid tumors like adenocarcinomas or cystic neoplasms. Pancreatic adenocarcinoma has an extremely low 5-year survival rate of only 6% and is usually diagnosed at an advanced stage. Risk factors include smoking, chronic pancreatitis, diabetes and family history. Imaging tests like CT, MRI and EUS are used to stage the cancer and determine resectability. Surgical resection through a pancreatoduodenectomy or distal pancreatectomy offers the only chance for cure if the cancer is localized.
This document discusses ampullary carcinomas, including their epidemiology, clinical manifestations, diagnosis, staging, treatment, and prognosis. It provides details on: the average age of diagnosis being 60-70 years old; the most common histologic subtype being intestinal (47%); obstructive jaundice being the most common presenting symptom (80%); diagnostic tests including ERCP, CT, and tumor markers; the TNM staging system; pancreaticoduodenectomy being the standard treatment for localized disease; and adjuvant therapy options including chemotherapy and chemoradiotherapy for stage IB or higher cancers.
This document summarizes various types of pancreatic tumours. It describes pancreatic ductal adenocarcinoma as the most common exocrine pancreatic cancer, accounting for 85% of cases. Risk factors and clinical features are provided. Other exocrine tumours discussed include acinar cell carcinoma, cystic pancreatic neoplasms such as microcystic cystadenoma and mucinous cystadenoma. Neuroendocrine tumours such as insulinomas are also summarized. Rare tumour types like anaplastic carcinoma, giant cell tumour and intraductal papillary mucinous neoplasms are described.
This document discusses pancreatic adenocarcinoma and assessing resectability with CT imaging. It provides background on pancreatic cancer and details CT findings that indicate:
1) The tumor is locally advanced and surrounds blood vessels, making it unresectable.
2) Distant metastases are present, such as small liver lesions typical of metastases or enlarged lymph nodes, also making the tumor unresectable.
3) Complete surgical resection, which offers the only chance of cure, requires that the tumor can be safely removed without involvement of nearby structures.
- Gastrointestinal carcinoid tumors most commonly occur in the small bowel and appendix. They arise from enterochromaffin cells and can produce symptoms if they secrete excess serotonin.
- Diagnosis is usually achieved through complementary imaging techniques such as somatostatin receptor scintigraphy, CT, MRI, and ultrasound. Somatostatin receptor scintigraphy is particularly useful for detecting primary tumors and metastases.
- Imaging findings include well-defined bowel masses that can invade the mesentery, associated lymphadenopathy, and liver metastases appearing as hypoechoic lesions that enhance with contrast.
This document discusses neuroendocrine tumors (NETs), which arise from neuroendocrine cells derived from neural crest cells. NETs were previously called APUDomas and carcinoids but are now classified as neuroendocrine gastroenteropancreatic tumors. Specific NETs discussed include insulinomas, glucagonomas, gastrinomas, vipomas, and somatostatinomas. Diagnosis and treatment options are described for each tumor type. The document also covers carcinoid syndrome, typical and atypical carcinoid tumors, and treatment approaches for NETs such as surgery, medical therapy, peptide receptor radionuclide therapy, and hepatic artery embolization.
Role of MSCT in evaluation of pancreatic tumors and its resectability with pr...Waleed Alrayis
MDCT is the most commonly used and accurate imaging modality for detecting and staging pancreatic tumors. It allows for assessment of the tumor as well as surrounding blood vessels. Studies show CT has a sensitivity of 77-85% and specificity of 81-82% for diagnosing vascular invasion which is important for determining resectability. Carefully timed contrast enhanced MDCT allows for comprehensive preoperative staging and assessment of local resectability of pancreatic carcinoma.
The document discusses pancreatic cancer and liver tumors. Regarding pancreatic cancer, it notes that it is one of the leading causes of cancer mortality, with 28,000 new cases per year in the US. Risk factors include smoking, high fat/protein diets, and genetics. Symptoms are vague and include abdominal pain, weight loss, and jaundice. Diagnosis involves blood tests, CT/ultrasound, and biopsy. Treatment options include chemotherapy, radiation, surgery such as the Whipple procedure, and palliative care.
For liver tumors, common benign tumors include hemangiomas, focal nodular hyperplasia, and cysts. Hepatocellular carcinoma is the most common malignant primary liver tumor
Pancreatic Carcinoma Classification and Preoperative evaluation in Whipple's ...Dr.Bhavin Vadodariya
The document discusses pancreatic tumor classification and preoperative evaluation for Whipple's procedure. It summarizes the main types of pancreatic tumors including pancreatic ductal adenocarcinoma, cystic neoplasms like serous cystic neoplasm and mucinous cystic neoplasm, and pancreatic neuroendocrine tumors. For preoperative evaluation, CT scan is useful for assessing resectability while ERCP may help with biliary decompression. Tissue biopsy is not always needed but can provide confirmation when the diagnosis is uncertain.
Pancreatic cancer has a poor prognosis, with only 15-20% of patients eligible for potentially curative surgery. Recent data shows survival may be improving, especially for those who receive adjuvant chemoradiation therapy after surgery. Diagnosis involves imaging like CT scans and endoscopic ultrasound to stage the cancer and determine if it can be surgically removed. Endoscopic ultrasound is particularly useful for assessing local tumor spread and blood vessel involvement. A tissue biopsy may also be taken during endoscopic ultrasound to identify the type of cancer.
Appleby operation for pancreatic cancer. Cancer de pancreas - tratamentoMarcel Autran Machado
We described a modified Appleby operation for locally advanced distal pancreatic cancer with compromised hepatic collateral flow that needed hepatic arterial revascularization, successfully accomplished by left external iliac-hepatic arterial bypass with Dacron prosthesis.
This document describes a technique for resection and reconstruction of the retrohepatic vena cava without the need for a venous graft during major hepatectomies. The technique involves transecting the liver parenchyma to expose the vena cava. The vena cava is then clamped and resected with the tumor-invaded portion of liver. For reconstruction, a transverse anastomosis of the vena cava is performed using running sutures on the posterior and anterior walls. This technique was successfully used in 8 patients and avoided the need for a graft while minimizing ischemic damage to the remnant liver.
Pancreatic carcinoma is a relatively common and deadly form of cancer. The majority of pancreatic cancers are adenocarcinoma originating from the ductal cells. Risk factors include tobacco use, older age, genetic conditions, and chronic pancreatitis. Symptoms can include jaundice, abdominal pain, weight loss, and new-onset diabetes. Diagnosis involves blood tests for markers like CA19-9, imaging with CT, MRI, or EUS to identify tumors, and tissue sampling when needed. Surgical resection offers the only chance of cure but many tumors are inoperable at diagnosis due to late presentation and aggressive nature.
Pancreatic cancer is the 10th most common cancer and the 4th leading cause of cancer death. 80% are adenocarcinomas from the exocrine pancreas. Risk factors include smoking, low fruit/vegetable intake, obesity, and family history. Symptoms are nonspecific but include jaundice, weight loss, and pain. Imaging like CT scans and endoscopic ultrasound are used to determine if tumors are resectable in 15-20% of patients. The Whipple procedure removes the pancreas head while distal pancreatectomy removes the body/tail. Adjuvant chemo may be given but 70-80% of patients still recur due to the pancreas' rich blood supply
This document outlines a seminar plan on carcinoma of the pancreas presented by Dr. Jyotindra Singh. The seminar will cover topics such as the anatomy and surgical anatomy of the pancreas, pancreatic tumors, modes of presentation, pre-operative workup, various surgeries and surgical videos, recent updates, studies and trials, and a take home message. The seminar introduction discusses that carcinoma of the exocrine pancreas accounts for over 90% of pancreatic tumors and remains an oncologic challenge with a 5-year survival rate of 3%.
This document summarizes recent advances in pancreatic cancer. It covers molecular genetics and tumor biology, methods for early detection of precursor lesions, investigation modalities like imaging tests and tumor markers, surgical management approaches including criteria for resectability, and adjuvant treatment modalities like chemotherapy and radiation. Newer chemotherapy regimens have improved survival rates and some targeted therapies show promise. Multidisciplinary treatment at high-volume centers results in better outcomes. While improvements have been made, pancreatic cancer remains difficult to treat and more research is still needed.
Pancreatic neoplasms can be classified based on their function as exocrine tumors, endocrine tumors, or mesenchymal tumors. The most common pancreatic neoplasm is pancreatic ductal adenocarcinoma, which arises from the exocrine pancreatic ductal cells. Endocrine tumors arise from the islet cells and include functional tumors like insulinomas and non-functional tumors. Rare pancreatic mesenchymal neoplasms originate from the pancreatic structural elements and include both benign and malignant subtypes.
Pancreatic cancer develops from DNA damage to cells in the pancreas that causes uncontrolled growth. Most cases are ductal adenocarcinoma. Risk factors include smoking, obesity, family history, and chronic pancreatitis. Symptoms include jaundice, abdominal pain, weight loss, and fatigue. Diagnosis involves imaging like CT, MRI, and endoscopic ultrasound. Only 20% of cases are surgically resectable; the remainder receive chemotherapy, radiation, or supportive care. Prognosis is generally poor with a median survival of 4-6 months for metastatic disease.
The document discusses carcinoma of the pancreas. It covers the anatomy, epidemiology, risk factors, genetics, screening, staging, pathologic conditions, clinical presentation, evaluation, management approaches for resectable, borderline resectable, and unresectable disease, surgical procedures including Whipple procedure and distal pancreatectomy, complications, adjuvant therapy approaches studied in trials such as ESPAC-1, and the role of chemoradiation following gemcitabine chemotherapy.
This document provides an outline and overview of pancreatic cancer. It begins with discussing the anatomy and functions of the pancreas. It then covers the epidemiology, types, pathophysiology, risk factors, signs and symptoms, diagnosis, and staging of pancreatic cancer. Imaging studies that can be used include CT, MRI, ERCP, and PET scans. Laboratory findings may include elevated bilirubin and tumor markers like CA19-9. Staging uses the TNM and stage models, with stage 1 being localized cancer and stage 4 being distant metastasis.
This document discusses the management of periampullary cancers. It covers the role of fine needle aspiration in diagnosis and pre-operative biliary decompression. Staging laparoscopy and clinicopathological staging are discussed. The document outlines curative surgeries like pancreaticoduodenectomy and distal pancreatectomy. It also discusses operative and non-operative palliative options. Adjuvant therapies including chemo-radiation are mentioned. Emerging novel agents for treatment are noted.
Pancreatic neoplasms can be either solid tumors like adenocarcinomas or cystic neoplasms. Pancreatic adenocarcinoma has an extremely low 5-year survival rate of only 6% and is usually diagnosed at an advanced stage. Risk factors include smoking, chronic pancreatitis, diabetes and family history. Imaging tests like CT, MRI and EUS are used to stage the cancer and determine resectability. Surgical resection through a pancreatoduodenectomy or distal pancreatectomy offers the only chance for cure if the cancer is localized.
This document discusses ampullary carcinomas, including their epidemiology, clinical manifestations, diagnosis, staging, treatment, and prognosis. It provides details on: the average age of diagnosis being 60-70 years old; the most common histologic subtype being intestinal (47%); obstructive jaundice being the most common presenting symptom (80%); diagnostic tests including ERCP, CT, and tumor markers; the TNM staging system; pancreaticoduodenectomy being the standard treatment for localized disease; and adjuvant therapy options including chemotherapy and chemoradiotherapy for stage IB or higher cancers.
This document summarizes various types of pancreatic tumours. It describes pancreatic ductal adenocarcinoma as the most common exocrine pancreatic cancer, accounting for 85% of cases. Risk factors and clinical features are provided. Other exocrine tumours discussed include acinar cell carcinoma, cystic pancreatic neoplasms such as microcystic cystadenoma and mucinous cystadenoma. Neuroendocrine tumours such as insulinomas are also summarized. Rare tumour types like anaplastic carcinoma, giant cell tumour and intraductal papillary mucinous neoplasms are described.
This document discusses pancreatic adenocarcinoma and assessing resectability with CT imaging. It provides background on pancreatic cancer and details CT findings that indicate:
1) The tumor is locally advanced and surrounds blood vessels, making it unresectable.
2) Distant metastases are present, such as small liver lesions typical of metastases or enlarged lymph nodes, also making the tumor unresectable.
3) Complete surgical resection, which offers the only chance of cure, requires that the tumor can be safely removed without involvement of nearby structures.
- Gastrointestinal carcinoid tumors most commonly occur in the small bowel and appendix. They arise from enterochromaffin cells and can produce symptoms if they secrete excess serotonin.
- Diagnosis is usually achieved through complementary imaging techniques such as somatostatin receptor scintigraphy, CT, MRI, and ultrasound. Somatostatin receptor scintigraphy is particularly useful for detecting primary tumors and metastases.
- Imaging findings include well-defined bowel masses that can invade the mesentery, associated lymphadenopathy, and liver metastases appearing as hypoechoic lesions that enhance with contrast.
This document discusses neuroendocrine tumors (NETs), which arise from neuroendocrine cells derived from neural crest cells. NETs were previously called APUDomas and carcinoids but are now classified as neuroendocrine gastroenteropancreatic tumors. Specific NETs discussed include insulinomas, glucagonomas, gastrinomas, vipomas, and somatostatinomas. Diagnosis and treatment options are described for each tumor type. The document also covers carcinoid syndrome, typical and atypical carcinoid tumors, and treatment approaches for NETs such as surgery, medical therapy, peptide receptor radionuclide therapy, and hepatic artery embolization.
Role of MSCT in evaluation of pancreatic tumors and its resectability with pr...Waleed Alrayis
MDCT is the most commonly used and accurate imaging modality for detecting and staging pancreatic tumors. It allows for assessment of the tumor as well as surrounding blood vessels. Studies show CT has a sensitivity of 77-85% and specificity of 81-82% for diagnosing vascular invasion which is important for determining resectability. Carefully timed contrast enhanced MDCT allows for comprehensive preoperative staging and assessment of local resectability of pancreatic carcinoma.
The document discusses pancreatic cancer and liver tumors. Regarding pancreatic cancer, it notes that it is one of the leading causes of cancer mortality, with 28,000 new cases per year in the US. Risk factors include smoking, high fat/protein diets, and genetics. Symptoms are vague and include abdominal pain, weight loss, and jaundice. Diagnosis involves blood tests, CT/ultrasound, and biopsy. Treatment options include chemotherapy, radiation, surgery such as the Whipple procedure, and palliative care.
For liver tumors, common benign tumors include hemangiomas, focal nodular hyperplasia, and cysts. Hepatocellular carcinoma is the most common malignant primary liver tumor
Pancreatic Carcinoma Classification and Preoperative evaluation in Whipple's ...Dr.Bhavin Vadodariya
The document discusses pancreatic tumor classification and preoperative evaluation for Whipple's procedure. It summarizes the main types of pancreatic tumors including pancreatic ductal adenocarcinoma, cystic neoplasms like serous cystic neoplasm and mucinous cystic neoplasm, and pancreatic neuroendocrine tumors. For preoperative evaluation, CT scan is useful for assessing resectability while ERCP may help with biliary decompression. Tissue biopsy is not always needed but can provide confirmation when the diagnosis is uncertain.
Pancreatic cancer has a poor prognosis, with only 15-20% of patients eligible for potentially curative surgery. Recent data shows survival may be improving, especially for those who receive adjuvant chemoradiation therapy after surgery. Diagnosis involves imaging like CT scans and endoscopic ultrasound to stage the cancer and determine if it can be surgically removed. Endoscopic ultrasound is particularly useful for assessing local tumor spread and blood vessel involvement. A tissue biopsy may also be taken during endoscopic ultrasound to identify the type of cancer.
Appleby operation for pancreatic cancer. Cancer de pancreas - tratamentoMarcel Autran Machado
We described a modified Appleby operation for locally advanced distal pancreatic cancer with compromised hepatic collateral flow that needed hepatic arterial revascularization, successfully accomplished by left external iliac-hepatic arterial bypass with Dacron prosthesis.
This document describes a technique for resection and reconstruction of the retrohepatic vena cava without the need for a venous graft during major hepatectomies. The technique involves transecting the liver parenchyma to expose the vena cava. The vena cava is then clamped and resected with the tumor-invaded portion of liver. For reconstruction, a transverse anastomosis of the vena cava is performed using running sutures on the posterior and anterior walls. This technique was successfully used in 8 patients and avoided the need for a graft while minimizing ischemic damage to the remnant liver.
The subtotal laparoscopic pancreatic resection can safely be performed. The da Vinci robotic system allowed for technical refinements of laparoscopic pancreatic resection. Robotic assistance improved the dissection and control of major blood vessels due to three-dimensional visualization of the operative field and instruments with wrist-type end-effectors.
Laparoscopic intrahepatic Glissonian technique for liver surgery. Hepatectomi...Marcel Autran Machado
The main advantage of the intrahepatic Glissonian procedure over other techniques is the possibility of gaining a rapid and precise access to the left Glissonian sheaths facilitating left hemihepatectomy, bisegmentectomy 2-3, and individual resections of segments 2, 3, and 4. The authors believe that the intrahepatic Glissonian technique facilitates laparoscopic liver resection and may increase the development of segment-based laparoscopic liver resection.
1) Mastectomy is the surgical removal of breast tissue, either partially or completely. It is commonly performed to treat breast cancer.
2) There are several types of mastectomy procedures including simple/total mastectomy, modified radical mastectomy, and breast conserving surgery.
3) Factors such as tumor size, lymph node involvement, and patient preferences help determine which mastectomy procedure is most suitable. Post-operative care and follow up is also important after mastectomy.
Bridge therapy in hepatocellular carcinoma before liver transplantationRicardo Yanez
This study reviewed the experience of two Chilean centers with bridge therapy prior to liver transplantation for hepatocellular carcinoma (HCC). Among 29 patients who received liver transplants for HCC between 1993-2009, 88% underwent bridge therapy during the mean 12 month wait for transplantation. The most common bridge therapies were chemoembolization (48%), alcohol ablation (30%), and radiofrequency ablation (13%). Patients who received bridge therapy had a slightly lower 5-year survival rate of 73% compared to 86% for all patients transplanted for HCC, likely because the bridge therapy group had more advanced disease. Only 33% of explanted livers in the bridge therapy group met the Milan criteria.
The study found that a cell cycle progression (CCP) gene expression signature can differentiate indolent from aggressive prostate cancer and provide prognostic information beyond standard clinical parameters. Specifically:
1) Higher CCP scores, indicating more actively dividing cells, were associated with increased risk of biochemical recurrence after prostatectomy and death from prostate cancer in a conservatively managed cohort.
2) The CCP score was a strong univariate predictor of outcome and added significant prognostic information when combined with clinical factors like PSA and Gleason score in multivariate analyses.
3) The CCP score was robust across different patient populations and clinical settings and may help physicians select optimal treatment strategies at diagnosis.
Journal of the Formosan Medical Association (2011) 110, 695e70.docxcroysierkathey
Journal of the Formosan Medical Association (2011) 110, 695e700
Available online at www.sciencedirect.com
journal homepage: www.jfma-online.com
ORIGINAL ARTICLE
A multivariable logistic regression equation to
evaluate prostate cancer
Jhih-Cheng Wang a, Steven K. Huan a, Jinn-Rung Kuo b, Chin-Li Lu c,
Hung Lin a, Kun-Hung Shen a,*
a Division of Urology, Departments of Surgery, Chi-Mei Medical Center, Tainan, Taiwan
b Division of Neurosurgery, Department of Surgery, Chi-Mei Medical Center, Tainan, Taiwan
c Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan
Received 29 January 2010; received in revised form 14 May 2010; accepted 9 August 2010
KEYWORDS
Logistic regression;
men’s health;
probability;
prostate cancer;
risk factor;
score
* Corresponding author. Division of U
Taiwan 710.
E-mail address: [email protected]
0929-6646/$ - see front matter Copyr
doi:10.1016/j.jfma.2011.09.005
Background/Purpose: A possible means of decreasing prostate cancer mortality is through
improved early detection. We attempted to create an equation to predict the likelihood of
having prostate cancer.
Methods: Between January 2005 and May 2008, patients who received prostate biopsies were
retrospective evaluated. The relationship between the possibility of prostate cancer and the
following variables were evaluated: age; serum prostate specific antigen (PSA) level, prostate
volume, numbers of prostatic biopsies, digital rectal examination (DRE) findings, and the pres-
ence of hypoechoic nodule under transrectal ultrasonography.
Results: A multivariate regression model was created to predict the possibility of having pros-
tate cancer, and a receiver-operating characteristic (ROC) curve was drawn based on the
predictive scoring equation. Using a predictive equation, P Z 1/(1 � e�x), where X Z
�4.88, þ 1.11 (if DRE positive), þ 0.75 (if hypoechoic nodule of prostate present), þ 1.27
(when 7 < PSA � 10), þ 2.02 (when 10 < PSA � 24), þ 2.28 (when 24 < PSA � 50), þ 3.93 (when
50 < PSA), þ 1.23 (when 65 < age � 75), þ 1.66 (when 75 < age), followed by ROC curve
analysis, we showed that the sensitivity was 88.5% and specificity was 79.1% in predicting
the possibility of prostate cancer.
Conclusion: Clinicians can tailor each patient’s follow-up according to the nomogram based on
this equation to increase the efficacy of evaluating for prostate cancer.
Copyright ª 2011, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
rology, Department of Surgery, Chi-Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan,
il.com (K.-H. Shen).
ight ª 2011, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
mailto:[email protected]
http://dx.doi.org/10.1016/j.jfma.2011.09.005
www.sciencedirect.com/science/journal/09296646
http://www.jfma-online.com
http://dx.doi.org/10.1016/j.jfma.2011.09.005
http://dx.doi.org/10.1016/j.jfma.2011.09.005
696 J.-C. Wang et al.
Prostate cancer is the most common solid malignancy ...
This study aimed to compare the overall and disease specific survivals of patients who underwent laparoscopic and open resection of colorectal cancer in a high volume tertiary center.
Causes of surgical failure for prostate cancerGil Lederman
1) Radical prostatectomy is often considered the gold standard treatment for prostate cancer but surgical failure still occurs in many patients. 2) A recent study found that during radical prostatectomy, malignant cells are often spread to both the operative field and blood circulating away from the site, which may be a cause of treatment failure despite removing the entire prostate gland. 3) The study detected tumor cells in the operative field of 20 out of 22 patients and in the peripheral blood of 10 patients after surgery, despite only 6 patients testing positive before surgery.
New research studies presented at the 2011 Annual Meeting of the American Urological Association examine promising biomarkers and genetic tests for bladder and prostate cancers. Certain genetic variants on chromosomes 8q24 and 19q13 were found to be associated with higher rates of prostate cancer aggressiveness. Combining measurements of the PCA3 and TMPRSS2:ERG tests improved the sensitivity and accuracy of prostate cancer diagnosis compared to the PCA3 test alone. Additionally, a urine assay measuring TMPRSS2:ERG gene fusion levels correlated with higher pathologic stage, Gleason score, and Gleason upgrading in prostate cancer patients. The studies suggest newer diagnostic tests may help distinguish between indolent and aggressive forms of prostate and bladder cancers.
New research studies presented at the 2011 Annual Meeting of the American Urological Association examine promising biomarkers and genetic tests for bladder and prostate cancers. Certain genetic variants on chromosomes 8q24 and 19q13 were found to be associated with higher rates of prostate cancer aggressiveness. Combining measurements of the PCA3 and TMPRSS2:ERG tests improved the sensitivity and accuracy of prostate cancer diagnosis compared to the PCA3 test alone. Additionally, a urine assay measuring TMPRSS2:ERG gene fusion levels correlated with higher pathologic stage, Gleason score, and Gleason upgrading in prostate cancer patients. The studies suggest newer diagnostic tests may help distinguish between indolent and aggressive forms of prostate and bladder cancers.
This document discusses several studies on urological injuries and conditions:
1. A study of 25 female patients with urethral and bladder neck injuries from pelvic fractures, finding many required surgical repair and long-term urinary and sexual dysfunction for some.
2. A study of 8 girls with pelvic fracture urethral strictures, finding 1-stage repair and substitution urethroplasty had 100% success rates and advocating early cystostomy drainage and deferred reconstruction when needed.
3. An editorial comment on female urethral injuries from pelvic fractures, noting they require high suspicion to diagnose and advocating early repair of urethral and vaginal injuries to
This document discusses management strategies for localized prostate cancer, including active surveillance and radical prostatectomy. It notes that active surveillance involves delayed treatment if cancer progresses, allowing patients to avoid or delay unnecessary treatment. However, criteria for patient selection and treatment triggers require further definition and validation. Radical prostatectomy remains the gold standard for treating localized prostate cancer as it offers the possibility of cure while minimizing damage to surrounding tissues when performed skillfully. Innovations have led to improved preservation of urinary continence and erectile function with this procedure.
- The Personalized OncoGenomics (POG) program at the British Columbia Cancer Agency conducted whole-genome analysis on tumors from 100 patients with advanced or incurable cancers to inform treatment decisions.
- Fresh tumor and blood samples were obtained from patients and underwent whole-genome and RNA sequencing. Computational analysis identified potential driver mutations, genes and pathways.
- A multidisciplinary team discussed genomic findings weekly and established guidelines for interpreting and communicating results to integrate them into patient care. Genomic findings were considered actionable in 55 of 78 cases that underwent whole-genome analysis, and motivated treatment changes in 23 cases.
- The experience demonstrated that a multidisciplinary team can implement an approach where whole-genome
The document summarizes a study that aimed to predict clinical failure in patients with metastatic prostate cancer by identifying genes related to prostate cancer. Researchers analyzed gene expression levels of androgen receptor, estrogen receptor, and stem cell markers in cancer and stromal cells collected via laser capture microdissection from biopsy samples of 76 patients. Logistic regression analysis showed that expression of Sox2, Her2, and CRP in cancer cells and AR and ER in stromal cells highly predicted prostate-specific antigen recurrence. Ten factors were identified as prognostic for cancer-specific survival, including expression of Oct1, TRIM36, Sox2, c-Myc, AR, Klf4, ER, and clinical parameters. Patients were divided into risk
The document summarizes a study that aimed to predict clinical failure in patients with metastatic prostate cancer by identifying genes related to prostate cancer. Researchers analyzed gene expression levels of androgen receptor, estrogen receptor, and stem cell markers in cancer and stromal cells collected via laser capture microdissection from biopsy samples of 76 patients. Logistic regression analysis showed that expression of Sox2, Her2, and CRP in cancer cells and AR and ER in stromal cells highly predicted prostate-specific antigen recurrence. Ten factors were identified as prognostic for cancer-specific survival, including expression of Oct1, TRIM36, Sox2, c-Myc, AR, Klf4, ER, as well as PSA, Gleason score
recent advances in hepatobiliary and GI surgeryhr77
1. Advances in surgical techniques, devices, and perioperative management have led to reduced operative times, blood loss, morbidity, and mortality associated with hepatic resection.
2. Liver functional reserve assessment and meticulous planning are important for safe hepatic resection. Surgical portal decompression is more effective than TIPS for variceal bleeding in low-risk patients.
3. RFA has limitations for HCC treatment and is not an independent therapy; transplantation or resection are preferred when possible. Bioartificial liver devices show promise for bridging patients to transplantation or regeneration.
Treatment and early outcome of 11 children with hepatoblastoma.Dr./ Ihab Samy
Fouad A. Fouad saleep MD., Ihab samy Fayek MD.
Department of Surgical Oncology – National Cancer Institute – Cairo University - Egypt.
Kasr el-aini medical journal Volume 18, No.4, October 2012.
Ntc dr muthusamy bridge to surgery talk final 6 18MUCINGroup
This document discusses endoscopic evaluation and staging of pancreatic cancer. It begins by outlining the algorithm for evaluating suspected pancreatic cancer with CT/MRI and EUS. Key questions after detecting a pancreatic mass include determining resectability and predicting tumor stage. Stages are defined as resectable, borderline, locally advanced, and metastatic based on criteria such as vascular involvement. Examples of EUS images illustrating resectable, locally advanced, and borderline resectable cancers are provided. The document concludes that neoadjuvant therapy is increasingly used for borderline resectable pancreatic cancer and requires durable biliary drainage during treatment.
Current evidence for laparoscopic surgery in colorectal cancersApollo Hospitals
This article reviews the current evidence for laparoscopic surgery in treating colorectal cancers. It discusses several large randomized controlled trials that compared short-term and long-term outcomes of laparoscopic versus open surgery. The trials found no significant differences in cancer recurrence rates, survival rates, or number of lymph nodes retrieved between the two surgical methods. Meta-analyses of the trials validated that laparoscopic surgery is as safe and effective as open surgery for treating colorectal cancer. While the laparoscopic approach has benefits like less blood loss and shorter hospital stays, long-term oncologic outcomes are comparable to open surgery.
This document provides guidelines for follow-up surveillance after nephrectomy for renal cell carcinoma (RCC) based on the current literature. It recommends risk-stratified surveillance based on pathological tumor stage, with more frequent monitoring for higher risk groups. For stage pT1 tumors, annual clinical exams, blood tests and chest x-rays are recommended, plus abdominal CT scans at 2 and 5 years. For pT2-3 tumors, tests are more frequent initially then tapering, with abdominal CT also recommended at 1, 3, 5, 7 and 10 years for pT2 and more frequently for pT3. Patients with lymph node involvement require intensive monitoring, especially in the first 3 years. The guidelines aim to detect recurrence early to facilitate
This document summarizes a study on the clinico-demographic characteristics of colorectal carcinoma in Bangladeshi patients. The study found that the mean age was 47 years, with most patients between 50-59 years of age. Males were slightly more affected than females. The most common presenting symptoms were per rectal bleeding, abdominal pain, and altered bowel habits. Histological examination found that 88% of cases were adenocarcinoma. The study concludes that middle-aged males in Bangladesh are most at risk for colorectal carcinoma, which commonly presents with bleeding, pain, or changes in bowel habits.
1. Incidental cystic lesions of the pancreas are being discovered more frequently, occurring in approximately 1% of abdominal imaging studies.
2. Differentiating benign from premalignant or malignant cystic lesions is challenging but important, as it determines appropriate management and surveillance approaches.
3. Current guidelines recommend surgical resection for mucinous pancreatic cystic lesions showing worrisome features such as cyst size over 3 cm, mural nodules, or involvement of the main pancreatic duct, due to their elevated risk of harboring cancer.
Similar to Solid pseudopapillary neoplasm of the pancreas (20)
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
2. 30 Machado et al Surgery
January 2008
hormone-dependent neoplasm. For this reason, study was heat-induced-epitope retrieval and anti-
the expression of sex hormone receptors is contro- gen retrieval. The samples were then exposed to
versial. Progesterone receptors have been reported the following antibodies: cytokeratin 7,8,14,19,20;
as positive in more than 80% of these patients, cytokeratin high molecular weight 68,58,56,56.5,50
whereas estrogen receptors were usually negative.12 Kd; cytokeratin AE!, CA19-9, Chromogranin A and
A recent report from Geers et al13 documented alfa amylase.
positive estrogen receptor using a refined tech- Statistical analysis. Summary data are formatted
nique in exploring the beta subtype of estrogen as mean standard deviation (SD) or number of
receptors. patients (percentage of population). Statistical
Interestingly, we have noticed a high incidence analysis was performed using chi-square or Fisher
among male patients in our series. This finding exact tests for categorical variables. For continuous
allowed us to perform a detailed analysis of clinical variables, Student t test was used. All tests were
characteristics and prognosis of female and male 2-sided with P .05 considered significant. Calcu-
patients. To our knowledge, this is the first study to lations and statistical analyses were completed us-
analyze clinical differences and prognosis between ing Prism 4 software (Graph Pad, San Diego, Ca).
male and female patients.
RESULTS
PATIENTS AND METHODS There were 27 women (79%) and seven men
Thirty-four consecutive patients with solid pseu- (21%) with a median age of 23 years (range, 10-72
dopapillary neoplasms of the pancreas between years). The oldest patient in this series was a man
1990 and December 2005 were studied. All speci- receiving hormonal therapy for prostate cancer.
mens were reviewed by a senior pathologist, and Twenty-six (84%) were Caucasian. The neoplasm
only patients with a final diagnosis of solid pseudo- was single in all patients, and the most common
papillary neoplasm were included. In this process, localization was the body or tail (61%). Mean di-
two patients with initial diagnosis of solid pseudo- ameter of the tumor was 7 cm (1.5–15 cm).
papillary neoplasm were excluded from the present The main clinical findings were abdominal pain
analysis. The database included sex, location, size, (73%), nausea and vomiting (32%), and weight
portal vein invasion, metastasis, operative data, loss (18%). Seven patients (21%) were asymptom-
postoperative complications, and late results. atic with the diagnosis made by an incidental find-
Whenever feasible, an organ-preserving opera- ing on routine examination.
tion was performed. For small tumors distant from Radiologic findings. Computed tomography (CT)
the main pancreatic duct, enucleation was elected. and/or magnetic resonance imaging (MRI) showed
For tumors located in the neck of the pancreas, the typical features of solid pseudopapillary neo-
central pancreatectomy with distal pancreatojeju- plasm in 79% of the patients. Usually, the tumor
nostomy was performed. For tumors located in the appeared as well-circumscribed lesions with a
body or tail of the pancreas, a spleen-preserving mixed cystic and solid component but was almost
distal pancreatectomy was the procedure of choice. entirely solid or else cystic with thick walls (Fig 1).
Genetic study. It was possible to perform genetic Surgical treatment. Conservative resection was
analysis in 8 patients from this series. Genomic possible in 11 patients, including a spleen-preserv-
DNA was extracted from paraffin-embedded archi- ing distal pancreatectomy in 3, a central pancrea-
val specimens and evaluated for both K-ras onco- tectomy in 5, and enucleation in 3 patients. Distal
gene and p53 tumor-supressor gene. The method pancreatectomy was performed in 12 patients and
of Polymerase chain reaction-restriction fragment pancreaticoduodenectomy in 11. Five patients had
length polymorphism analysis was used for K-ras spleno-mesenteric portal axis involvement and un-
analysis and polymerase chain reaction-single derwent venous resection and reconstruction.
stranded conformational polymorphism for p53 Median hospital stay was 11 days (range, 7-18
(exons 5 to 8). PCR products were eletrophoresed days). There was no operative mortality. Surgical
and analyzed by a photodocumentation system. Tis- margins were free in all patients. Twenty-one pa-
sue sections were stained by the Feulgen method tients developed at least 1 complication with oper-
and assessed by image analysis using the WING ative morbidity rate of 62%. According to the
software for the nuclear DNA-ploidy grade (version International Study Group on Pancreatic Fistula,14
1.1, Mcom Informátia, São Paulo). 17 patients developed postoperative pancreatic fis-
Immunohistochemical study. Immunohistio- tula grade A, one patient grade B, and one patient
chemical analysis was performed in 16 patients in grade C. Infectious complications occurred in 3
the present series. The technique used for this patients and intestinal obstruction in 2. Reopera-
3. Surgery Machado et al 31
Volume 143, Number 1
Fig 1. CT and MRI findings of a solid pseudopapillary neoplasm of the pancreas. (A) A well-circumscribed neoplasm
with a mixed cystic and solid component. (B) A large neoplasm with predominant cystic component with thick wall. (C)
MRI shows an almost entirely solid neoplasm. (D) MRI shows venous involvement by the neoplasm.
Table I. Patterns among male and female
tion was necessary in two patients due to pancreatic
patients
abscess and intestinal obstruction, respectively.
One patient developed a persistent pancreatic Clinicopathologic Female Male Total P
fistula that required operative intervention dur- features (n 27) (n 7) (n 34) value
ing late follow-up. Mean follow-up time was 84 Age (mean 25 2.1 37 7.4 28 13 .05
months (range, 3-170 months). Two patients de- SD)
veloped recurrent disease. One patient devel- Tumor size 7.3 0.7 6.7 1.7 7.2 0.6 NS
oped an unresectable, local recurrence after (mean
duodenopancreatectomy and received systemic SD)
chemotherapy with combination of 5-FU and cis- Head tumor 11 3 14 NS
platin, and was still alive 39 months after initial Incidental 5 2 7 NS
operation. The second patient, who had under- finding
Portal vein 3 3 6 .05
gone subtotal pancreatectomy and resection of
invasion
the portal vein, developed disseminated liver me-
Conservative 11 0 11 .05
tastases and died of the disease 24 months after surgery
the initial procedure. Tumor 1 1 2 NS
Overall late morbidity rate was 12%, with 2 pa- recurrence
tients developing peptic ulcer, 1 insulin-dependent
diabetes, and 1 with disease recurrence who had 1
episode of upper gastrointestinal hemorrhage.
Looking further into our results, we found that incidence of portal vein involvement and/or devel-
21% of our patients were males. At the time of opment of metastases) in male patients; therefore,
diagnosis, mean age was older among male patients conservative surgery was less likely to be performed
(37 vs 26; P .05). In spite of this fact, the tumor in the male patients. There was no correlation
size did not differ between sexes. There were no between tumor aggressiveness, defined by portal
statistical difference among male and female pa- vein involvement and/or neoplasm recurrence,
tients regarding preoperative symptoms, radiologic and age or size of tumor.
findings, or tumor location (Table I). The neo- Tumor size tended to be smaller at the time of
plasm was an incidental finding in 5 women and 2 diagnosis in patients treated after the year 2000
men. The neoplasms were more aggressive (greater (Table II). Other patient characteristics such as
4. 32 Machado et al Surgery
January 2008
Table II. Correlation between date of surgery
and clinicopathologic features of patients
Clinicopathologic Before 2000 After 2000
features (n 16) (n 18) P value
Age 24 2.1 31 3.9 NS
(mean SD)
Tumor Size 9.2 0.9 5.5 0.7 .005
(mean SD)
Male Gender 2 5 NS
Conservative 5 6 NS
Surgery
age, sex, and possibility of conservative surgery did
not differ before and after 2000.
Fig 2. Macroscopic features of solid pseudopapillary
PATHOLOGIC FINDINGS neoplasm of the pancreas. (A) Well-circumscribed neo-
plasm with predominant cystic (gelatinous content) and
Macroscopic appearance. Grossly, most neo- minimal solid component. (B) Well-circumscribed neo-
plasms were well-circumscribed tumors with both plasm with predominance of solid component and cystic
cystic and solid components. The neoplasm cavity with clear liquid. (C) Well-defined neoplasm en-
ranged from entirely solid to entirely cystic. The tirely cystic (gelatinous content). D, Invasive neoplasm
cystic component had gelatinous or clear liquid with entirely solid component.
content (Fig 2).
Microscopic appearance. Histologically, solid
pseudopapillary neoplasm of the pancreas pre- tial, and resection remains the main therapeutic
sented as small and uniform tumor cells with round option.1,6 The overall mortality of the disease has
nuclei with both solid and cystic growth patterns. been estimated to be about 2%.1,13 Recurrence rate
Typical features included a pseudopapillary pattern is estimated in 10-15% of patients after resection.13
with fibrovascular stalks (Fig 3). Perineural inva- Advances in imaging modalities have led to
sion was present in 5 patients, vascular invasion in more accuracy in the diagnosis of this neoplasm.3,15
7, and extension into peripancreatic tissue in 1. No Indeed, the neoplasms detected after the year 2000
lymphatic invasion was present and no lymph were smaller (P .005) than those diagnosed be-
nodes metastases were found. In 2 patients with fore 2000. This finding is related clearly to the
recurrence, microscopic vascular invasion was dem- improvement in the imaging modalities and wide-
onstrated. One patient with extension into peripan- spread use of CT and MRI in our department after
creatic tissue developed local recurrence. 2000. Moreover, almost 80% of our patients had
Genetic study. We detected a mutation in K-ras typical features on CT.
oncogene in only 1 patient (a male). There were Solid pseudopapillary neoplasms have character-
no mutations in exon 5, 6, 7, and 8 of p53 gene. All istic pathologic features. On gross analysis, they
analyses had normal DNA content (diploid). There have a typical gelatinous content mixed with a solid
was no correlation between K-ras mutation and component. Sometimes the neoplasm can be en-
development of metastasis. tirely cystic or solid. Histopathologically, these neo-
Immunohistochemical study. Neoplastic cells plasms are composed of small and uniform tumor
displayed a wide spectrum of immunohistochem- cells with round nuclei and eosinophilic cytoplasm,
ical markers. In most patients, acinar markers and may have a typical pseudopapillary pattern
(ie, CK8 and amylase) were intermingled with with fibrovascular stalks. When entirely solid, it may
markers, such as CA19-9, CK7, CK14, and CK19. be difficult to distinguish from acinar adenocarci-
CK 20 was found in 7 patients (44%), most often noma and islet cell neoplasm. Immunohistochem-
displayed by a small amount of cells. Chromo- istry and a mutation in beta catenin gene have been
granin A was found in only 3 patients and, even used for differential diagnosis.11,16
then, restricted to scarce cells. After publication of the first cases in Brazil17 in
1993, most gastroenterologists, radiologists, and pa-
DISCUSSION thologists became aware of this relatively rare neo-
Solid pseudopapillary neoplasms of pancreas are plasm; and our department, a tertiary referral
uncommon neoplasms with a low malignant poten- center, received several new patients for evaluation
5. Surgery Machado et al 33
Volume 143, Number 1
Fig 3. Microscopic features of solid pseudopapillary neoplasm of the pancreas. (A) Small and uniform tumor cells with
predominant cystic pattern. (B) Small and uniform tumor cells with round nuclei and eosinophilic cytoplasm demon-
strating a solid growth pattern (HE). (C) Tumor cells have a pseudopapillary pattern with fibrovascular stalks (HE). (D)
Immunohistochemical staining for alpha-1-antitrypsin of the pancreatic tumor. Almost all tumor cells are stained
positively, and the reaction is strong in the cytoplasm.
and confirmation of the diagnosis. In this setting, tended resections. Although 1 patient of the
almost 80% of patients had typical features on CT present series received systemic chemotherapy
and/or MRI. Preoperative diagnosis was especially with 5FU and cisplatin, there are no reliable data
difficult in small tumors and in those without cystic on adjuvant or neoadjuvant therapy for this low-
component. This diagnosis should always be sus- grade malignancy.11,19
pected in young women with a solid and/or cystic This neoplasm shows clear female predilection
pancreatic mass.11 with very few reported cases in male patients. In
Despite the large tumor size or vascular involve- our series, we found a greater proportion of male
ment at the time of diagnosis, operative resection is patients when compared to other reports.6,20,21
usually possible and curative. Therefore, complete This fact allowed us to compare tumor characteris-
aggressive resection is the treatment of choice for tics such as size and aggressiveness with the sex of
these neoplasms even in the presence of metasta- the patient. The mean age of the male patients was
ses. Resection of distant metastases should be per- greater than the female patients, but tumor size was
formed at the time of primary resection or even for similar. This observation suggests that the onset,
recurrences. These neoplasms are usually large but not the diagnosis, occurs later in time among male
rarely have local extrapancreatic invasion into ad- patients. Tumor aggressiveness was more marked
jacent organs, as occurred in only 1 patient of the among the male sex and portal vein invasion was
present series. In this situation, the surgeon should more frequent in those patients. When we compare
always aim for complete, en bloc resection includ- age and aggressiveness, we did not find any corre-
ing adjacent structures, preferably with microscop- lation even when we stratified the patients under
ically clear margins. Extensive lymphadenectomy and over 30 years old.8 Conservative, organ-preserv-
is not necessary because none of the patients in ing surgery was possible in 32% of patients; none of
this series had lymph node metastases. The rarity them in male patients. Recurrence occurred in
of nodal metastases is consistent with other re- only 2 patients and does not allow us to draw any
ports.18 In our series of 34 patients, 6 underwent conclusions.
portal vein resection to obtain free margins. This These differences in incidence among males
aggressive approach is supported by the present and females stimulated studies of sex hormones
5, 12, 21
series because all but 2 patients were alive and receptors. Because of conflicting results of ste-
disease-free at long-term follow-up even after ex- roid receptor analysis, it seems that sex hormones
6. 34 Machado et al Surgery
January 2008
may play an important role; however, it is not clear carcinoma and a comparative clinicopathologic analysis of
whether they influence growth of the neoplasm or 34 conventional cases. Am J Surg Pathol 2005;29:512-9.
8. Garatea R, Targarona J, Barreda L, Warshaw A, Fernandez
its pathogenesis.5 Interestingly, the oldest patient
del Castillo C. Solid pseudopapillary neoplasm of the pan-
of this series was a man who received hormonal creas: report of 31 resected cases and description of a par-
therapy for prostate cancer. adoxical inverse relation between age and tumor size
In collective reviews, solid pseudopapillary neo- [abstract]. Pancreas 2006;33:463.
plasms of the pancreas arising in older patients and 9. Sclafani LM, Reuter VE, Coit DG, Brennan MF. The malig-
in males are more likely to behave aggressively.20 nant nature of papillary and cystic neoplasm of the pan-
creas. Cancer 1991;68:153-8.
Our report is the first large enough single center
10. Nishihara K, Tsuneyoshi M, Ohshima A, Yamaguchi K. Pap-
study to be able to demonstrate that solid pseudo- illary cystic tumor of the pancreas. Is it a hormone-depen-
papillary neoplasms in male patients have distinct dent neoplasm? Pathol Res Pract 1993;189:521-6.
patterns of onset and aggressiveness when com- 11. Tipton SG, Smyrk TC, Sarr MG, Thompson GB. Malignant
pared with female patients. The reasons for more potential of solid pseudopapillary neoplasm of the pan-
aggressive behavior in male patients are not clear. creas. Br J Surg 2006;93:733-7.
12. Kosmahl M, Seada LS, Janig U, Harms D, Kloppel G. Solid-
The only difference is that male patients are older
pseudopapillary tumor of the pancreas: its origin revisited.
than females, but the clinical presentation (tumor Virchows Arch 2000;436:473-80.
location, incidental finding, and symptoms) were 13. Geers C, Moulin P, Gigot JF, Weynand B, Deprez P, Rahier
the same; the reason is not due to late presentation J, Sempoux C Solid and pseudopapillary tumor of the
or delayed diagnosis because tumor size was equiv- pancreas–review and new insights into pathogenesis. Am J
alent or even smaller in male patients. Surg Pathol 2006;30:1243-9.
14. Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki
Although valid prognostic criteria are still lack- J, et al. Postoperative pancreatic fistula: an international
ing and the number of patients is not enough to study group (ISGPF) definition. Surgery 2005;138:8-13.
draw any definitive conclusion, male patients with 15. Buetow PC, Buck JL, Pantongrag-Brown L, Beck KG, Ros
solid pseudopapillary neoplasms of pancreas may PR, Adair CF. Solid and papillary epithelial neoplasm of the
be best treated by a more radical resection, and pancreas: imaging-pathologic correlation on 56 cases. Radi-
should be observed closely during follow-up. ology 1996;199:707-11.
16. Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K,
Brennan M, et al. Solid-pseudopapillary tumors of the pan-
REFERENCES
creas are genetically distinct from pancreatic ductal adeno-
1. Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary
carcinomas and almost always harbor beta-catenin
tumor of the pancreas: a typically cystic carcinoma of low
mutations. Am J Pathol 2002;160:1361-9.
malignant potential. Semin Diagn Pathol 2000;17:66-80.
17. Machado MC, da Cunha JE, Bacchella T, Jukemura J,
2. Crawford BE II. Solid and papillary epithelial neoplasm of
Penteado S, Zerbini MC, et al. Frantz’s tumor (papillary
the pancreas, diagnosis by cytology. South Med J. 1998;
epithelial and cystic neoplasms of the pancreas): report of 3
91:973-7.
cases. Rev Hosp Clin Fac Med Sao Paulo 1993;48:29-34.
3. Nadler EP, Novikov A, Landzberg BR, Pochapin MB, Cen-
18. Goh BK, Tan YM, Cheow PC, Alexander Chung YF, Chow
teno B, Fahey TJ, et al. The use of endoscopic ultrasound in
the diagnosis of solid pseudopapillary tumors of the pan- PK, Wong WK, et al. Solid pseudopapillary neoplasms of the
creas in children. J Pediatr Surg 2002;37:1370-3. pancreas: An updated experience. J Surg Oncol 2007;
4. Casanova M, Collini P, Ferrari A, Cecchetto G, Dall’Igna P, 95:640-4.
Mazzaferro V. Solid-pseudopapillary tumor of the pancreas 19. Maffuz A, Bustamante Fde T, Silva JA, Torres-Vargas S.
(Frantz tumor) in children. Med Pediatr Oncol 2003; Preoperative gemcitabine for unresectable, solid pseudo-
41:74-6. papillary tumour of the pancreas. Lancet Oncol 2005;
5. Rebhandl W, Felberbauer FX, Puig S, Paya K, Hochschorner 6:185-6.
S, Barlan M, et al. Solid-pseudopapillary tumor of the pan- 20. Lam KY, Lo CY, Fan ST. Pancreatic solid-cystic-papillary
creas (Frantz tumor) in children: report of four cases and tumor: clinicopathologic features in eight patients from
review of the literature. J Surg Oncol 2001;76:289-96. Hong Kong and review of the literature. World J Surg
6. Papavramidis T, Papavramidis S. Solid pseudopapillary tu- 1999;23:1045-50.
mors of the pancreas: review of 718 patients reported in 21. Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR,
English literature. J Am Coll Surg 2005;200:965-72. Howard JM. Papillary cystic and solid tumors of the pan-
7. Tang LH, Aydin H, Brennan MF, Klimstra DS. Clinically creas: a pancreatic embryonic tumor? Studies of three cases
aggressive solid pseudopapillary tumors of the pancreas: a and cumulative review of the world’s literature. Surgery
report of two cases with components of undifferentiated 1995;118:821-8.