HVP Country Node: Malaysia - Zilfalil bin Alwi
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The document summarizes information about the Malaysian Node of the Human Variome Project (MyHVP). It provides details such as: - MyHVP was established in 2010 and is funded by Universiti Sains Malaysia. - It is linked to several national human genetics societies and has an ethical framework for privacy and consent approved by Universiti Sains Malaysia. The document also outlines MyHVP's technical aspects including its national data repository, data sharing policies, and plans to increase engagement and publications over the next 12 months. It notes that continued funding is one challenge faced.
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![Malaysia: a snapshot
• Genetic testing & genetic healthcare services:
[How are they funded?]
i. Funding from Government under Ministry of Health (MOH)
ii. University/Institution funded
iii. Private laboratory
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Clinical Lab Clinical Geneticist Paediatricians Genetic
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Clinical Genetics in Malaysia
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The rate of variant discovery continues to surpass the rate of clinicalgrade interpretation. This is a challenge for precision medicine, because fast, reliable access to variant interpretations is necessary to provide well-informed and timely interpretations of test results to patients. ClinVar is a public repository for interpretations of clinical significance and functional effects of variants in any gene and for any disease. Interpretations are submitted by many sources, including clinical testing laboratories, research laboratories, locus-specific databases, expert panels, practice guidelines, as well as OMIM® and GeneReviews™. Collecting variant interpretations in ClinVar depends on integrating data from these different sources, which has several benefits. First, data integration requires standardizing the data from each source. This improves the quality of the data in ClinVar as well as in each of the individual datasets. ClinVar staff validate HGVS expressions as a routine part of ClinVar submission processing. Submitters are encouraged to use standard terms in MedGen for diseases and phenotypes. Standard terms for clinical significance are used in ClinVar when available; for example, ClinVar uses the terms recommended by ACMG to classify variants for Mendelian diseases. Secondly, ClinVar aggregates all data for a variant defined by its genomic location. Therefore, HGVS descriptions on different transcripts or on different genomic sequences can be recognized as the same variant. Thirdly, integrating data from multiple submitters allows the evidence from all sources to be pooled together. This larger collection of evidence aids the re-evaluation of variant classifications, and is especially valuable for rare variants and novel gene-disease relationships. Fourthly, data integration means that variant interpretations from different sources can be viewed together and compared. Thus a ClinVar user has access to interpretations outside any internal system and knows when there is consensus in the interpretation or not. Submitting laboratories use reports of conflicting interpretations in ClinVar to prioritize variants that they should re-evaluate. ClinVar receives data from many data providers, and therefore provides clear attribution to each contributing group, including links to records in LSDBs. Each source may update their submission to ClinVar at any time. For example, a record may be updated when a variant is re-classified or when additional evidence is available to support the interpretation. Submitters may consider providing regular updates to ClinVar to prevent their interpretations from becoming out of date. Submissions to ClinVar describe variants that range in complexity from simple alleles with explicit sequence locations through copy number changes and cytogenetic rearrangements with fuzzy boundaries.
The BRCA Share(TM) Consortium - Christophe Beroud
The BRCA ShareTM Consortium is a public-private partnership that promotes sharing of BRCA genetic data. It has over 35,000 BRCA test results from US and French clinical labs. The goal is to accelerate BRCA research. It is a open user group co-founded by Inserm and Quest Diagnostics. BRCA ShareTM is well adopted internationally. In June 2016, it incorporated new data from private partners, increasing the number of known BRCA mutations. The consortium of French experts helps curate and reclassify variants of unknown significance based on multiple lines of evidence. This benefits all partners through improved annotation of shared variants.
Establishing validity, reproducibility, and utility of highly scalable geneti...
Establishing validity, reproducibility, and utility of highly scalable geneti...Human Variome Project
Background: New technologies and increased competition have, and will continue to improve the cost-effectiveness of genetic testing, making genetic analysis more accessible to medical practices worldwide. However, challenges remain to establishing the validity of such tests. Moreover many patients harbor rare or novel variants and classification is likely to remain a bottleneck in broader deployment of genetic medicine.The PhenX Toolkit: Standard Measures for Collaborative Research - Wayne Huggins
The PhenX Toolkit: Standard Measures for Collaborative Research - Wayne HugginsHuman Variome Project
Introduction and Background: The Web-based PhenX Toolkit (consensus measures for Phenotypes and eXposures, https://www. phenxtoolkit.org/) is a catalog of standard measures designed to facilitate collaborative biomedical research. PhenX measures help ensure that phenotypes from different studies are collected and represented in a consistent format. This consistency can enable data comparability across sites in large cohorts (e.g., Precision Medicine Initiative) and facilitates combining data to validate clinically actionable variants, increase statistical power (e.g., studies of rare genetic conditions or gene-enviroment interactions), or compare treatments and outcomes between patients.Legal and regulatory challenges to data sharing for clinical genetics and ge...
Legal and regulatory challenges to data sharing for clinical genetics and ge...Human Variome Project
There are many factors that impede genomic variant sharing in the UK, despite it becoming a necessary part of clinical care. These include the lack of a designated infrastructure or mechanism aggravated by the complexity of laws that apply, and fragmented and variable advice from local ‘Caldicott guardians’ who guide NHS trusts on their responsibilities concerning data protection and confidentiality. Since the legitimacy of data sharing in the UK is framed in terms of ‘personal data’ being shared for ‘direct care’ (subject to legal exceptions), the blurred boundaries between clinical care and research, and the spectrum of identifiability of data also lead to differing interpretations resulting in inconsistent practices.
In a multidisciplinary collaboration, the PHG Foundation and the UK’s Association for Clinical Genetic Science co-hosted a workshop to examine the clinical necessity for sharing variant data and associated phenotypic information, the technical feasibility and the legal and regulatory impediments to such sharing. Delegates included clinicians, laboratory scientists, and key policy makers, including the National Data Guardian for Health and Care and representatives from the 100,000 Genomes Project, a pioneering research project which promises to build a legacy for future genomics services in the UK. The key finding from our work was that current arrangements for sharing genomic variants within the NHS are unsatisfactory and inconsistent practices are compromising safety and quality. Our workshop report [1] highlights the urgent need for (i) national agreement to optimise sharing within the NHS and develop consensus on the legitimacy of data sharing, (ii) standardised operational processes, including a designated sustainable database or mechanism for sharing, and (iii) strong leadership by the multiple relevant health organisations to demonstrate the benefits and risks associated with sharing and not sharing data.
Since publication of the workshop report, the NHS Consortium (operating within the DECIPHER database) has reported a 120% increase in the number of cases shared, the 100,000 Genomes Project and associated data embassy have got underway and the EU Data Protection Regulation has been finalised. However research highlights continuing public reservations about some aspects of data sharing including commercial access and misgivings around secondary uses of data. Publication of the National Data Guardian’s long-awaited review of consent and security provisions to provide guidance on a new consent and opt-out model for sharing patient information in the NHS, has been delayed pending the results of the EU referendum being known. Against this backdrop, the imperative to develop robust, proportionate policies for genomic data sharing becomes increasingly acute.
Funding from the PHG Foundation and the Association for Clinical Genetic Science.Report from the International Confederation of Countries Advisory Council - M...
Report from the International Confederation of Countries Advisory Council - M...Human Variome Project
This document summarizes discussions from Session V of the Human Variome Project on Thursday June 2nd.
It provides information on 3 country nodes - Austria, Democratic Republic of Congo, and an interim node. For Austria, it outlines the genetic testing landscape, notes progress establishing a national genetic database, and plans for selecting database software in the next year. It also briefly mentions the Democratic Republic of Congo and an interim country node. The document discusses challenges around data sharing, quality, and submission across national databases.Human variome project quality assessment criteria for variation databases - M...
Human variome project quality assessment criteria for variation databases - M...Human Variome Project
This document discusses quality assessment criteria for variation databases that are developed by the Human Variome Project working group. It outlines two key components of quality - the contents, update frequency, and quality of numerous available variation databases. It also describes work done by the working group to produce guidelines for defining variation database quality, which includes evaluating databases based on criteria and providing feedback and an electronic seal to indicate quality. The document concludes by outlining next steps, which include beta testing the quality evaluation scheme with real databases, performing independent evaluations of databases, and refining the quality criteria over time through voluntary participation.HVP Country Node: Venezuela - Aida Falcon de Vargas
The Venezuelan Country Node was established in 2012 and is organized through a Steering Committee and Advisory Groups. It currently has 35 clinical laboratories, 60 clinicians, and genetic counseling is performed by clinicians. Genetic healthcare services are provided partially through the national health system and private sector, though the national system has insufficient budgeting. The Country Node is working to establish a national data repository and develop data collection, access, and ownership policies, though it currently lacks funding and only has data available within individual institutions. Its plans for the next year include continuing collaboration efforts and workshops to build databases and train professionals to develop the national genomic infrastructure.
Human Genetics of Infectious Diseases - Laurent Abel
This document discusses human genetics research into infectious diseases. It summarizes that:
1) Genetic factors contribute to variability in individual responses to infection exposure and clinical outcomes. Rare single gene mutations can cause highly selective predispositions to specific pathogens like Herpes simplex virus-1 or mycobacteria.
2) Research has identified genetic causes of severe infectious diseases like Herpes simplex encephalitis and Mendelian susceptibility to mycobacterial disease. Defects in the TLR3 and IL-12/IFN-γ pathways increase risk.
3) Genome-wide studies of common infections like tuberculosis have found limited roles for common variants but suggest searching for rare variants using deep sequencing. Gen
GENETIC HETEROGENEITY OF MITOCHONDRIAL DISORDERS - Agnès Rötig
1. Genetic heterogeneity of mitochondrial disorders is high, with mutations in over 250 nuclear genes and 13 mitochondrial genes known to cause primary mitochondrial disorders. 2. Complex I deficiency is a common presentation and has high genetic and clinical heterogeneity, with mutations in over 30 nuclear genes associated. 3. Mitochondrial translation deficiency is another common presentation, with mutations in over 30 genes encoding mitochondrial aminoacyl-tRNA synthetases and other translation factors associated.
The BRCA Challenge & Exchange: Progress and Plans - Gunnar Rätsch
The BRCA Challenge aims to improve care for patients at risk of breast and ovarian cancer through global data sharing and collaboration on BRCA1 and BRCA2 variants. It plans to:
1) Share BRCA variants publicly via the BRCA Exchange portal, displaying a curated list of variants interpreted through expert consensus.
2) Address challenges of global data sharing through its organization structure and subcommittees.
3) Create a model for data sharing and analysis for all disease genes.
Richard GH Cotton: He may have been a bit before his time - Michael Watson
A tribute to Dick Cotton from Michael Watson. Part 2 of the inaugural Richard Cotton Memorial lecture.
HVP Country Node: Canada - Matthew Lebo
The document summarizes information about the Canadian Open Genetics Repository (COGR), which serves as the HVP Country Node for Canada. It provides details on clinical genetics resources in Canada, the structure and funding of COGR, its data sharing policies and technical capabilities. COGR's data holdings have doubled in the past year and it plans to strengthen genomic data sharing by publishing findings and seeking additional funding. The primary challenges are obtaining funding and data from all sites.
Use of open, curated variant databases: ethics? Liability? - Bartha Knoppers
Translation of genomics into medicine and drug development requires comprehensive, high-quality, genomic variant databases. To support translation, there is a movement towards sharing clinical annotations of variants (e.g., benign, unknown, pathogenic) internationally via open access. Despite the growing popularity of variant databases, ethical issues and liability risks have received scant attention. Ethical priorities for variant databases include 1) competence – ensuring that data is responsibly managed, curated, and used; 2) confidentiality – ensuring appropriate safeguards for patient data; 3) communication – clearly describing the purpose, quality standards, and data handling practices to contributing patients and potential users; and 4) continuous oversight to adapt database governance in a rapidly evolving environment. How can database managers fulfill these obligations when these responsibilities are increasingly distributed along the clinical pipeline? Legal issues include medical liability based on potential harm to patients; liability based on third-party intellectual property or privacy rights in the data; and regulatory risks as variant data is integrated into genetic tests or devices. Can these risks can be managed through appropriate governance structures – including adequate consents, access processes, contributor agreements, and disclaimers – while still facilitating sharing and clinical use?
HVP6: Final Thoughts - John Burn & Raj Ramesar
This document summarizes discussions from a workshop on developing capacity for gene variant data sharing in low and middle income countries. It outlines sessions on understanding the challenges, the current situations in different global regions, ELSI issues, funding and partnerships. Key outcomes include practical steps to develop LOVD databases, recommendations on hemoglobinopathies, and plans to facilitate networks through WHO collaborating centers and a future meeting in sub-Saharan Africa. The overall goal is to strengthen global collaboration and data sharing for conditions like sickle cell disease and thalassemias.
Report from the International Scientific Advisory Committee - John Burn
The document summarizes a report from the International Scientific Advisory Committee meeting of the Human Variome Project held from June 11-15, 2012 in Paris. It lists the voting and non-voting members of the committee and provides information on their accountabilities, remit, and domains. These include providing strategic scientific direction, approving publications, authorizing new initiatives, and making recommendations on behalf of the Human Variome Project Consortium. It also mentions functional classification of SNPs identified and goals of establishing standards, facilitating research, and strengthening capacity for sharing genomic data equitably and sustainably.
HVP Country Node: Italy - Domenico Coviello
The document summarizes Italy's HVP Country Node activities. It provides an overview of genetic services and resources in Italy, including 198 genetic diagnostic laboratories and approximately 200 clinicians. The HVP Country Node was established in 2014 and is endorsed by the national genetics society SIGU. However, it currently lacks formal policies and infrastructure for data sharing. Plans over the next 12 months include establishing a consortium to formalize collaboration for building a national website and installing LOVD software for a national database. The main challenges are a lack of financial and administrative support.
Rare and common variants contribute to the complex inheritance of Hirschsprun...
Rare and common variants contribute to the complex inheritance of Hirschsprun...Human Variome Project
1) The document discusses the genetic factors that contribute to Hirschsprung disease (HSCR), a congenital disorder caused by the lack of enteric nervous system in parts of the intestine.
2) It finds that both rare and common genetic variants contribute to the complex inheritance of HSCR. Common variants were identified in RET, NRG1 and SEMA3C-3D genes, with ethnic differences in frequencies.
3) Rare coding variants were also found to influence risk, suggesting HSCR has a complex genetic architecture involving both regulatory and coding changes across several loci. Understanding how these various genetic factors interact remains an area of ongoing research.Report from the Gene & Disease Specific Database Advisory Council - Peter Ta...
Report from the Gene & Disease Specific Database Advisory Council - Peter Ta...Human Variome Project
A report from the Chair of the Human Variome Project Gene & Disease Specific Database Advisory CouncilChecking the experts: compliance with author instructions regarding HGVS nome...
Checking the experts: compliance with author instructions regarding HGVS nome...Human Variome Project
We have investigated compliance with guidelines regarding HGVS nomenclature and/or submission of variants to public databases in the author instructions of several genetics and genomics journals. For this, we used a list of genetics and genomics journals created by the Human Variome Project (HVP) office (See http://www.humanvariomeproject.org/resources/genetics-and-genomics-journals.html). The HVP aims to work towards open and free sharing of high quality information on genetic variation and its effect on human health. The HVP Gene and Disease-specific Database Council has created example instructions for authors for genetics and genomic journals containing guidelines regarding HGVS nomenclature and submission of variants to public databases. The HVP office has sent this document to journal editors asking them to include similar requirements in their instructions for authors. The rationale is that better instructions will help improving the quality of variant descriptions in manuscripts and access to variant information in databases.
We have used this list to select journals including both requirements. We have investigated the January 2016 issue of several of them. A group of students has checked the publications first for the basic requirements: mentions of the reference sequence used to describe variants and the presence of the variants in public databases. The next step was to check variant and phenotype descriptions with specific attention for predicted protein effects. Our preliminary results suggest that predicted protein effects in publications cannot be verified in case of altered splice sites without supporting RNA-level evidence or in case of insertions of unspecified nucleotides. Although the underlying variants are likely to have disease-causing effects, lack of supporting evidence disqualifies this information for diagnostic use. In several cases, the RNA-level information was specified in the gene variant database submission, indicating that submission of variants to databases prior to manuscript acceptance might improve the quality of publications. We have observed that authors include statements suggesting variants have been submitted to databases, but the variants were not found. Reviewers and journal editors could help improving manuscript quality by insisting on compliance and enforcing the existing guidelines.More from Human Variome Project (20)
ClinVar: Aggregating Data to Improve Variant Interpretation - Melissa Landrum
ClinVar: Aggregating Data to Improve Variant Interpretation - Melissa Landrum
Establishing validity, reproducibility, and utility of highly scalable geneti...
Establishing validity, reproducibility, and utility of highly scalable geneti...
The PhenX Toolkit: Standard Measures for Collaborative Research - Wayne Huggins
The PhenX Toolkit: Standard Measures for Collaborative Research - Wayne Huggins
Legal and regulatory challenges to data sharing for clinical genetics and ge...
Legal and regulatory challenges to data sharing for clinical genetics and ge...
Report from the International Confederation of Countries Advisory Council - M...
Report from the International Confederation of Countries Advisory Council - M...
Human variome project quality assessment criteria for variation databases - M...
Human variome project quality assessment criteria for variation databases - M...
HVP Country Node: Venezuela - Aida Falcon de Vargas
HVP Country Node: Venezuela - Aida Falcon de Vargas
Human Genetics of Infectious Diseases - Laurent Abel
Human Genetics of Infectious Diseases - Laurent Abel
GENETIC HETEROGENEITY OF MITOCHONDRIAL DISORDERS - Agnès Rötig
GENETIC HETEROGENEITY OF MITOCHONDRIAL DISORDERS - Agnès Rötig
The BRCA Challenge & Exchange: Progress and Plans - Gunnar Rätsch
The BRCA Challenge & Exchange: Progress and Plans - Gunnar Rätsch
Richard GH Cotton: He may have been a bit before his time - Michael Watson
Richard GH Cotton: He may have been a bit before his time - Michael Watson
Use of open, curated variant databases: ethics? Liability? - Bartha Knoppers
Use of open, curated variant databases: ethics? Liability? - Bartha Knoppers
Report from the International Scientific Advisory Committee - John Burn
Report from the International Scientific Advisory Committee - John Burn
Rare and common variants contribute to the complex inheritance of Hirschsprun...
Rare and common variants contribute to the complex inheritance of Hirschsprun...
Report from the Gene & Disease Specific Database Advisory Council - Peter Ta...
Report from the Gene & Disease Specific Database Advisory Council - Peter Ta...
Checking the experts: compliance with author instructions regarding HGVS nome...
Checking the experts: compliance with author instructions regarding HGVS nome...
Recently uploaded
The cost of acquiring information by natural selection
This is a short talk that I gave at the Banff International Research Station workshop on Modeling and Theory in Population Biology. The idea is to try to understand how the burden of natural selection relates to the amount of information that selection puts into the genome.
It's based on the first part of this research paper:
The cost of information acquisition by natural selection
Ryan Seamus McGee, Olivia Kosterlitz, Artem Kaznatcheev, Benjamin Kerr, Carl T. Bergstrom
bioRxiv 2022.07.02.498577; doi: https://doi.org/10.1101/2022.07.02.498577
Farming systems analysis: what have we learnt?.pptx
Presentation given at the official farewell of Prof Ken Gillet at Wageningen on 13 June 2024
Pests of Storage_Identification_Dr.UPR.pdf
InIndia-post-harvestlosses-unscientificstorage,insects,rodents,micro-organismsetc.,accountforabout10percentoftotalfoodgrains
Graininfestation
Directdamage
Indirectly
•theexuviae,skin,deadinsects
•theirexcretawhichmakefoodunfitforhumanconsumption
About600speciesofinsectshavebeenassociatedwithstoredgrainproducts
100speciesofinsectpestsofstoredproductscauseeconomiclosses
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Gadgets for management of stored product pests_Dr.UPR.pdf
Insectsplayamajorroleinthedeteriorationoffoodgrainscausingbothquantitativeandqualitativelosses
Wellprovedthatnogranariescanbefilledwithgrainswithoutinsectsastheharvestedproducecontainegg(or)larvae(or)pupae(or)adultinsectinthembecauseoffieldcarryoverinfestationwhichcannotbeavoidedindevelopingcountrieslikeIndia
Simpletechnologiesfortimelydetectionofinsectsinthestoredproduceandtherebyplantimelycontrolmeasures
快速办理(UAM毕业证书)马德里自治大学毕业证学位证一模一样
学校原件一模一样【微信：741003700 】《(UAM毕业证书)马德里自治大学毕业证学位证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
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Micronuclei test.M.sc.zoology.fisheries.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
11.1 Role of physical biological in deterioration of grains.pdf
Storagedeteriorationisanyformoflossinquantityandqualityofbio-materials.
Themajorcausesofdeteriorationinstorage
•Physical
•Biological
•Mechanical
•Chemical
Storageonlypreservesquality.Itneverimprovesquality.
Itisadvisabletostartstoragewithqualityfoodproduct.Productwithinitialpoorqualityquicklydepreciates
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
By harnessing the power of High Flux Vacuum Membrane Distillation, Travis Hills from MN envisions a future where clean and safe drinking water is accessible to all, regardless of geographical location or economic status.
Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
Recently uploaded (20)
The cost of acquiring information by natural selection
The cost of acquiring information by natural selection
Farming systems analysis: what have we learnt?.pptx
Farming systems analysis: what have we learnt?.pptx
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
Gadgets for management of stored product pests_Dr.UPR.pdf
Gadgets for management of stored product pests_Dr.UPR.pdf
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
GBSN - Biochemistry (Unit 6) Chemistry of Proteins
11.1 Role of physical biological in deterioration of grains.pdf
11.1 Role of physical biological in deterioration of grains.pdf
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
Authoring a personal GPT for your research and practice: How we created the Q...
Authoring a personal GPT for your research and practice: How we created the Q...
HVP Country Node: Malaysia - Zilfalil bin Alwi
- 1. SESSION VI HVP Country Nodes Thursday 2nd June Malaysian Node of the Human Variome Project (MyHVP) Prof. Zilflail Alwi Head, Malaysia Node of the Human Variome Project
- 2. Malaysia: a snapshot • Genetic testing & genetic healthcare services: [How are they funded?] i. Funding from Government under Ministry of Health (MOH) ii. University/Institution funded iii. Private laboratory 30 10 >1000 15 0 50 100 150 200 250 300 350 400 Clinical Lab Clinical Geneticist Paediatricians Genetic Counselors Clinical Genetics in Malaysia Clinical in Malaysia
- 3. 3
- 4. 4
- 5. National Human Genetics Society • National Human Genetics Society: [Name, President, Next Meeting] i. Malaysian Society of Human Genetics (MSHG) ii. President: Prof. Zilfalil Alwi iii. Next meeting: i. Annual General Meeting: Feb 2017 ii. Exco Meeting 1: July 2016 iii. Exco Meeting 2: Dec 2016 5@variomeproj #HVP6
- 6. HVP Country Node: MyHVP Organization • Year established: 2010 • Funding: funded by Universiti Sains Malaysia • Links with NHGS: Supported by Professional bodies; i. Malaysian Genetic Society (PGM) ii. Malaysian Society of Human Genetics (MSHG) iii. Medical Genetic Society of Malaysia (MGSOM) • Ethical framework, privacy, consent: – Ethical framework: in progress. Cooperate with Institute of Islamic Understanding (IKIM) – Privacy: Database accessibility is for local Researchers only. – Consent: Ethical approval for sampling was approved by Universiti Sains Malaysia Structure of MyHVP
- 7. HVP Country Node: Technical • National data repository: http://hvpmalaysia.kk.usm.my/mhgvc/index.php • Data available nationally: Polymorphism & Mutation database • Data available internationally: Data is not ready for the International applicants. • Available: – Data Collection Policy: Based on Ethic committee approval not available online. – Collection Agreement: Based on Ethic committee approval not available online. – Data Access Policy: was created in 2013. – Data Ownership Policy: Not available
- 8. Database Access Policy for MyHVP 8@variomeproj #HVP6
- 9. Progress, Plans and Problems • Progress in the past 12 months: i. Conference, seminar and Meeting i. (co-organiser: HUGO's HGM 2015), BioGrid Workshop 2015, Seminar on Human Genetics (co-organiser with MSHG), Second Meeting of HVP SEA Node). ii. Knowledge transfer program i. (send students to HVP SEA regional node for training in cutting edge bioinformatics analysis; Bangkok) iii. Public Engagements & Educational Activities i. (EduVariome program) iv. Networking & linkage i. ( MoA with private Company , Sengenics Sdn. Bhd - a smart partnership). v. Publication i. (MyHVP Newsletter & Research Publications) • Plan for the next 12 months: i. Public Engagements & Educational Activities i. (EduVariome Program) ii. Networking & linkage i. (Assist LIC contries to apply nternational grant) iii. Publication i. ( MyHVP newsletter & research publication s). • Problems/barriers we face: – Funding for continuing the MyHVP’s activities.