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Design of implementation measures are extremely
important to increase the participation rates and success of
a population-based screening program




                                Eunate Arana-Arria, Begoña Zuberoa, Isabel Portillob,
                                              Isabel Idigorasb, José Ignacio Pijoana
                           Clinical Epidemiology Unit, Cruces University Hospital, Basque Health Service
                            a

                        Center Program Coordinator Colorectal Cancer Screening, Basque Health Service
                        b
CLORECTAL CANCER (CCR)
 •   Worldwide:
       – Third most common cancer
       – Fourth most common cause of cancer deaths
       – 1.2 million estimated cases and 609,000 estimated deaths in 2008
 •   European Union (EU)
       – Second most common newly-diagnosed cancer
       – Second most common cause of cancer death
 •   Basque Country
       – First cause of mortality
       – Second cancer after:
            Breast
            Lung
 •   Mortality rates for the Basque Country (2006)
       – 32.2/100,000 in men and 13.1/100,000 in women
             (Rates adjusted to European Standard Population)


25/06/2012                                                                  2
COLORECTAL CANCER SCREENING
  •    European Code Against Cancer
                 “men and women aged 50 years or over
             should participate in colorectal cancer screening”




25/06/2012                                                        3
PREVENTION / SCREENING

        The aim of colorectal cancer screening is to
       improve prognosis by the detection of cancer
                     at its early stages


 • PREVENTION:
       –     no smoking
       –     avoiding obesity
       –     doing regular physical exercise
       –     increasing the daily intake of fruits and vegetables
       –     limiting the consumption of foods containing animal fats




25/06/2012                                                              4
CRC SCREENING PROGRAM
                  OF THE BASQUE COUNTRY

 •   Target population:
       50-69 years (EU 2003 50 to 74)
 •   Fecal Occult Blood Test (FOBT):
       – Every two years
       –     Cut-off 100 ng/ml
       –     Home delivery test
       –     Pick up at the health center
       –     Reference laboratory analysis
 •   FOBT POSITIVE:
              Complete colonoscopy with deep sedation/anesthesia
 •   Coordinated Program
 •   Engaging Primary Care and Specialty Care
 •   Information System



25/06/2012                                                         5
CCR SCREENING PROGRAM: 2009-2010




25/06/2012                         6
PARTICIPATION RATES / POSITIVES
             N= 28,300
             N= 28,300   N= 11,266
                         N= 11,266   N= 116,980
                                     N= 116,980




25/06/2012                                        7
Population-based
                   43%




25/06/2012                  8
PARTICIPATION AND POSITIVE RATES
               By age group: males




25/06/2012                               9
PARTICIPATION AND POSITIVE RATES
               By age group: females




25/06/2012                               10
Diagnostic confirmation: 4,492 colonoscopies

              INDICATORS                         Results

   Complete Colonoscopy Rate             90.8% (95% CI 90.0-91.6)

   Low Grade Adenoma Detection Rate     9.9 x 1,000 (95% CI 9.2-10.6)

   High Grade Adenoma Detection Rate   26.6 x 1,000 (95% CI 25.4-27.8)

   Invasive Cancer Detection Rate       3.9 x 1,000 (95% CI 3.5-4.4)




25/06/2012                                                               11
Diagnostic confirmation: result of colonoscopies




                                             48%




                                             %




 25/06/2012                                    12
Complications of colonoscopies


             INDICATORS                     Results

   Complications rate                1.09% (95% IC 0.8-1.4)

   Complications rate in the first
                                     1.02% (95% IC 0.7-1.4)
   colonoscopy




25/06/2012                                                    13
COSTS


  • Cancer detected:
  7,324.38
  • Premalignant and/or malignant lesion:
  941.75
  • Screened person:
  28.71




25/06/2012                                  14
CONCLUSIONS
 • REASONS FOR HIGH PARTICIPATION
   RATES:

       – Involvement of primary care physicians and nurses
       – Submission of the kits to patients homes
       – Delivery of the kits at the primary care settings with
         open schedule
       – Analysis of the sample in the reference hospital without
         any frills or papers
       – Results to primary care physicians and patients homes
       – Public and universal health care system



25/06/2012                                                          15
‫תודה‬




                                  धनयवाद
             спасибо   Eskerrik
                       Asko




25/06/2012                                 16

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Ht ai2012 ccrDesign of implementation measures are extremely important to increase the participation rates and success of a population-based screening program

  • 1. Design of implementation measures are extremely important to increase the participation rates and success of a population-based screening program Eunate Arana-Arria, Begoña Zuberoa, Isabel Portillob, Isabel Idigorasb, José Ignacio Pijoana Clinical Epidemiology Unit, Cruces University Hospital, Basque Health Service a Center Program Coordinator Colorectal Cancer Screening, Basque Health Service b
  • 2. CLORECTAL CANCER (CCR) • Worldwide: – Third most common cancer – Fourth most common cause of cancer deaths – 1.2 million estimated cases and 609,000 estimated deaths in 2008 • European Union (EU) – Second most common newly-diagnosed cancer – Second most common cause of cancer death • Basque Country – First cause of mortality – Second cancer after:  Breast  Lung • Mortality rates for the Basque Country (2006) – 32.2/100,000 in men and 13.1/100,000 in women (Rates adjusted to European Standard Population) 25/06/2012 2
  • 3. COLORECTAL CANCER SCREENING • European Code Against Cancer “men and women aged 50 years or over should participate in colorectal cancer screening” 25/06/2012 3
  • 4. PREVENTION / SCREENING The aim of colorectal cancer screening is to improve prognosis by the detection of cancer at its early stages • PREVENTION: – no smoking – avoiding obesity – doing regular physical exercise – increasing the daily intake of fruits and vegetables – limiting the consumption of foods containing animal fats 25/06/2012 4
  • 5. CRC SCREENING PROGRAM OF THE BASQUE COUNTRY • Target population: 50-69 years (EU 2003 50 to 74) • Fecal Occult Blood Test (FOBT): – Every two years – Cut-off 100 ng/ml – Home delivery test – Pick up at the health center – Reference laboratory analysis • FOBT POSITIVE: Complete colonoscopy with deep sedation/anesthesia • Coordinated Program • Engaging Primary Care and Specialty Care • Information System 25/06/2012 5
  • 6. CCR SCREENING PROGRAM: 2009-2010 25/06/2012 6
  • 7. PARTICIPATION RATES / POSITIVES N= 28,300 N= 28,300 N= 11,266 N= 11,266 N= 116,980 N= 116,980 25/06/2012 7
  • 8. Population-based 43% 25/06/2012 8
  • 9. PARTICIPATION AND POSITIVE RATES By age group: males 25/06/2012 9
  • 10. PARTICIPATION AND POSITIVE RATES By age group: females 25/06/2012 10
  • 11. Diagnostic confirmation: 4,492 colonoscopies INDICATORS Results Complete Colonoscopy Rate 90.8% (95% CI 90.0-91.6) Low Grade Adenoma Detection Rate 9.9 x 1,000 (95% CI 9.2-10.6) High Grade Adenoma Detection Rate 26.6 x 1,000 (95% CI 25.4-27.8) Invasive Cancer Detection Rate 3.9 x 1,000 (95% CI 3.5-4.4) 25/06/2012 11
  • 12. Diagnostic confirmation: result of colonoscopies 48% % 25/06/2012 12
  • 13. Complications of colonoscopies INDICATORS Results Complications rate 1.09% (95% IC 0.8-1.4) Complications rate in the first 1.02% (95% IC 0.7-1.4) colonoscopy 25/06/2012 13
  • 14. COSTS • Cancer detected: 7,324.38 • Premalignant and/or malignant lesion: 941.75 • Screened person: 28.71 25/06/2012 14
  • 15. CONCLUSIONS • REASONS FOR HIGH PARTICIPATION RATES: – Involvement of primary care physicians and nurses – Submission of the kits to patients homes – Delivery of the kits at the primary care settings with open schedule – Analysis of the sample in the reference hospital without any frills or papers – Results to primary care physicians and patients homes – Public and universal health care system 25/06/2012 15
  • 16. ‫תודה‬ धनयवाद спасибо Eskerrik Asko 25/06/2012 16