This document provides a guide on how corporations can effectively collaborate with startups to promote innovation. It outlines 10 steps for kickstarting startup-driven innovation, including defining goals, finding the right innovation projects, securing internal buy-in, starting small with hackathons or workshops, going bigger with accelerators or open innovation programs, issuing open calls, defining startup offerings, selecting the best-fit startups, and embarking on successful collaborations with guidance from advisors. The advisory firm Pioneers Discover can help corporations at every step of working with startups.