Knowing how to increase dopamine naturally is challenging and sometimes easier for most people.
In today’s time, we all are trapped or engaged in certain activities such as shopping offers, social media apps, video games, smartphones, porn videos, YouTube, Netflix, eating junk foods, etc.
But this kind of way to increase dopamine may give a harmful effect on your body. It could be a mental problem, stress, obesity, insomnia, etc.
If you increase your dopamine in natural ways. In that case, you become happier, smarter, more productive, more creative, more focused, and more social. Therefore, we should have a sufficient amount of dopamine in our brains.
In this article, we will discover how to increase dopamine levels naturally.
Dopamine is considered a happy neuro-hormone because it releases in the happiest or most pleasurable moment. It acts as a chemical messenger or neurotransmitter that helps to pass information from one nerve cell to another.
The main function of the dopamine neurotransmitter is movement, motivation memory and emotional responses.
If you think you have a low level of dopamine, you may have struggled in enthusiasm, movement, and motivation.
There are a lot of reasons that cause low dopamine in our brains. It could indicate a neurological disease such as –
-Parkinson disease
-Depression
-Restless leg syndrome
-ADHD (Attention Deficit Hyperkinetic Disorder)
If you’re wondering how to increase dopamine naturally, I have mentioned the 9 best ways to increase dopamine levels naturally –
1. Avoid junk foods
2. Healthy foods that increase dopamine
3. Exercise releases dopamine
4. Get good sleep
5. Supplements that increase dopamine
6. Drugs that increase dopamine
7. Music release dopamine
8. Reduce stress from your life
9. Engage in good pleasurable activities
Happiness is just a neurochemical spurt.
Four different brain chemicals create happy feelings, and you need all of them to feel good.
You miss out when you rely on one or two old familiar ways of triggering your happy chemicals.
You can enjoy a balanced happy chemical diet if you know the distinct kind of happiness each brain chemical evolved for
Happiness is just a neurochemical spurt.
Four different brain chemicals create happy feelings, and you need all of them to feel good.
You miss out when you rely on one or two old familiar ways of triggering your happy chemicals.
You can enjoy a balanced happy chemical diet if you know the distinct kind of happiness each brain chemical evolved for
The most successful storytellers often focus listeners’ minds on a single important idea and they take no longer than a 30-second to forge an emotional connection.
Story telling can be effective if and only if both teller and listeners are in happy mood
Happiness is just a neurochemical spurt of four different brain chemicals
WE need all of them to feel good.
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Unlimited Counseling CEUs for $59 https://www.allceus.com/
Specialty Certificate tracks starting at $89 https://www.allceus.com/certificate-tracks/
Live Webinars $5/hour https://www.allceus.com/live-interactive-webinars/
CEs can be earned for this presentation at https://www.allceus.com/member/cart/index/search?q=pharmacology+of+recovery
Pinterest: drsnipes
Nurses, addiction and mental health counselors, social workers and marriage and family therapists can earn CEUs for this and other presentations at AllCEUs.com
Learn how to add certain foods and make little changes to your lifestyle to improve your mood and support recovery from physical illness, mood disorders and addictions.
Dopamine effect on different hormones. PdfArubSultan
In summary, grasping the impact of dopamine on other hormones is paramount for
maintaining overall health. Dopamine’s multifaceted role extends beyond its well-known
function as a neurotransmitter, influencing a range of hormonal systems. It regulates
prolactin, growth hormone, and plays a part in the stress response, thyroid hormone
regulation, and sex hormone balance. Disorders arising from dopamine imbalances, such as
hyperprolactinemia and hypercortisolism, underscore its clinical importance. Additionally,
the use of medications targeting dopamine receptors, like antipsychotics and dopamine
agonists, provides effective treatment options for various conditions. Balanced dopamine
activity is essential to ensure hormonal equilibrium, emphasizing the intricate harmony
between neural and endocrine systems in maintaining holistic well-being. Understanding
these interactions enhances the capacity to diagnose, manage, and treat hormonal imbalances,
ultimately contributing to improved healthcare and informed patient choices.
Hormonal regulation of blood glucose level_pdf.pdfSumit Sharma
Insulin and Glucagon are two key hormones that maintaining blood glucose level (or glucose homeostasis) in your body.
If there is a problem with your Insulin or Glucagon, you may have an imbalance blood glucose level. It may be either a high blood glucose level or a low blood glucose level.
This post will describe the hormonal regulation of blood glucose levels. Moreover, we will see how Insulin and Glucagon work together to maintain homeostatic glucose levels.
When glucose enters your systemic circulation, it goes to tissues, but glucose cannot enter your cells without Insulin.
Insulin helps in glucose uptake into cells. This means that Insulin increases the entry of glucose into your cells.
When you have a meal, incretins (GIP, GLP, etc.) release from your gut and go to your Pancreas. It stimulates Pancreas and releases Insulin.
Eventually, Incretins help to release Insulin. Due to this, Incretins are considered a natural anti-diabetic hormone.
After releasing Insulin from Pancreas, it goes to your blood circulation. It acts on the Tyrosine Kinase receptor that is present on the cell surface.
As soon as Insulin binds to the Tyrosine Kinase receptor, it facilitates the entry of glucose into cells.
Glucose also binds on the cell surface but acts on GLUT receptors or transporter like GLUT 1, GLUT 2, GLUT 3 and GLUT 4.
This is a normal process that occurs in the human body.
But our blood glucose level does not remain the same for an entire day; it fluctuates. Sometimes it gets high or low blood glucose levels.
To maintain this fluctuation, our Pancreas releases two crucial hormones – Insulin and Glucagon.
What is the Difference Between Conjugated and Unconjugated Bilirubin?Sumit Sharma
Bilirubin is a biochemical parameter of your liver function test. Your doctor uses this tool to diagnose liver disease.
In the human body, bilirubin is a waste product of your hemoglobin produced during the red blood cells breakdown in the spleen.
Although bilirubin does not have a specific function, it is generally a component of bile juice. It is also called a bile pigment, which is yellow in color.
There are two forms of bilirubin in our blood.
One is unconjugated bilirubin, which forms during the breakdown of red blood cells, and the other is conjugated, which starts during metabolism in the liver.
The unconjugated bilirubin is a catabolic product of red blood cells. This non-conjugated compound is also known as indirect bilirubin.
Some possible reasons or diseases associated with unconjugated hyperbilirubinemia –
1. Hemolytic anemia
2. Neonatal Jaundice
3. Genetic factors
4. Drug induced unconjugated hyperbilirubinemia
On the other hands, Conjugated bilirubin is generally formed after the glucuronidation of the unconjugated bilirubin.
The conjugation process occurs in your liver and converts your unconjugated bilirubin into conjugated bilirubin. This type of glucuronidation compound is also known as direct bilirubin.
In simple words, direct bilirubin means conjugated bilirubin.
The elevated conjugated bilirubin indicates Conjugated hyperbilirubinemia.
This condition is most commonly seen in cholestatic liver disease.
Cholestatic is a medical condition where the flow of bile juice gets reduced or stopped. You may have this cholestatic liver disease in two forms – Intrahepatic and extrahepatic obstruction.
In this article, we will discuss bilirubin, metabolism of bilirubin, normal range of bilirubin, and its clinical relevance. Further, we will also know the difference between conjugated and unconjugated bilirubin.
Happiness is just a neurochemical spurt.
Four different brain chemicals create happy feelings, and you need all of them to feel good.
You miss out when you rely on one or two old familiar ways of triggering your happy chemicals.
You can enjoy a balanced happy chemical diet if you know the distinct kind of happiness each brain chemical evolved for
Happiness is just a neurochemical spurt.
Four different brain chemicals create happy feelings, and you need all of them to feel good.
You miss out when you rely on one or two old familiar ways of triggering your happy chemicals.
You can enjoy a balanced happy chemical diet if you know the distinct kind of happiness each brain chemical evolved for
The most successful storytellers often focus listeners’ minds on a single important idea and they take no longer than a 30-second to forge an emotional connection.
Story telling can be effective if and only if both teller and listeners are in happy mood
Happiness is just a neurochemical spurt of four different brain chemicals
WE need all of them to feel good.
The video for this presentation is available on our Youtube channel:
https://youtube.com/allceuseducation A continuing education course for this presentation can be found at https://www.allceus.com/member/cart/index/index?c=
Unlimited Counseling CEUs for $59 https://www.allceus.com/
Specialty Certificate tracks starting at $89 https://www.allceus.com/certificate-tracks/
Live Webinars $5/hour https://www.allceus.com/live-interactive-webinars/
CEs can be earned for this presentation at https://www.allceus.com/member/cart/index/search?q=pharmacology+of+recovery
Pinterest: drsnipes
Nurses, addiction and mental health counselors, social workers and marriage and family therapists can earn CEUs for this and other presentations at AllCEUs.com
Learn how to add certain foods and make little changes to your lifestyle to improve your mood and support recovery from physical illness, mood disorders and addictions.
Dopamine effect on different hormones. PdfArubSultan
In summary, grasping the impact of dopamine on other hormones is paramount for
maintaining overall health. Dopamine’s multifaceted role extends beyond its well-known
function as a neurotransmitter, influencing a range of hormonal systems. It regulates
prolactin, growth hormone, and plays a part in the stress response, thyroid hormone
regulation, and sex hormone balance. Disorders arising from dopamine imbalances, such as
hyperprolactinemia and hypercortisolism, underscore its clinical importance. Additionally,
the use of medications targeting dopamine receptors, like antipsychotics and dopamine
agonists, provides effective treatment options for various conditions. Balanced dopamine
activity is essential to ensure hormonal equilibrium, emphasizing the intricate harmony
between neural and endocrine systems in maintaining holistic well-being. Understanding
these interactions enhances the capacity to diagnose, manage, and treat hormonal imbalances,
ultimately contributing to improved healthcare and informed patient choices.
Hormonal regulation of blood glucose level_pdf.pdfSumit Sharma
Insulin and Glucagon are two key hormones that maintaining blood glucose level (or glucose homeostasis) in your body.
If there is a problem with your Insulin or Glucagon, you may have an imbalance blood glucose level. It may be either a high blood glucose level or a low blood glucose level.
This post will describe the hormonal regulation of blood glucose levels. Moreover, we will see how Insulin and Glucagon work together to maintain homeostatic glucose levels.
When glucose enters your systemic circulation, it goes to tissues, but glucose cannot enter your cells without Insulin.
Insulin helps in glucose uptake into cells. This means that Insulin increases the entry of glucose into your cells.
When you have a meal, incretins (GIP, GLP, etc.) release from your gut and go to your Pancreas. It stimulates Pancreas and releases Insulin.
Eventually, Incretins help to release Insulin. Due to this, Incretins are considered a natural anti-diabetic hormone.
After releasing Insulin from Pancreas, it goes to your blood circulation. It acts on the Tyrosine Kinase receptor that is present on the cell surface.
As soon as Insulin binds to the Tyrosine Kinase receptor, it facilitates the entry of glucose into cells.
Glucose also binds on the cell surface but acts on GLUT receptors or transporter like GLUT 1, GLUT 2, GLUT 3 and GLUT 4.
This is a normal process that occurs in the human body.
But our blood glucose level does not remain the same for an entire day; it fluctuates. Sometimes it gets high or low blood glucose levels.
To maintain this fluctuation, our Pancreas releases two crucial hormones – Insulin and Glucagon.
What is the Difference Between Conjugated and Unconjugated Bilirubin?Sumit Sharma
Bilirubin is a biochemical parameter of your liver function test. Your doctor uses this tool to diagnose liver disease.
In the human body, bilirubin is a waste product of your hemoglobin produced during the red blood cells breakdown in the spleen.
Although bilirubin does not have a specific function, it is generally a component of bile juice. It is also called a bile pigment, which is yellow in color.
There are two forms of bilirubin in our blood.
One is unconjugated bilirubin, which forms during the breakdown of red blood cells, and the other is conjugated, which starts during metabolism in the liver.
The unconjugated bilirubin is a catabolic product of red blood cells. This non-conjugated compound is also known as indirect bilirubin.
Some possible reasons or diseases associated with unconjugated hyperbilirubinemia –
1. Hemolytic anemia
2. Neonatal Jaundice
3. Genetic factors
4. Drug induced unconjugated hyperbilirubinemia
On the other hands, Conjugated bilirubin is generally formed after the glucuronidation of the unconjugated bilirubin.
The conjugation process occurs in your liver and converts your unconjugated bilirubin into conjugated bilirubin. This type of glucuronidation compound is also known as direct bilirubin.
In simple words, direct bilirubin means conjugated bilirubin.
The elevated conjugated bilirubin indicates Conjugated hyperbilirubinemia.
This condition is most commonly seen in cholestatic liver disease.
Cholestatic is a medical condition where the flow of bile juice gets reduced or stopped. You may have this cholestatic liver disease in two forms – Intrahepatic and extrahepatic obstruction.
In this article, we will discuss bilirubin, metabolism of bilirubin, normal range of bilirubin, and its clinical relevance. Further, we will also know the difference between conjugated and unconjugated bilirubin.
Like diabetes, Fatty liver disease is also considered a Silent Killer disease because people don’t feel any symptoms in the initial stage of fatty liver disease.
It slowly comes into your body and causes chronic liver disease.
The severity of the fatty liver disease depends on fatty liver grades. Your liver condition will become more vulnerable if fatty liver grades get increase.
Fatty liver disease is a metabolic disease where fat gets stored in your hepatocytes or liver cells that, cause inflammation.
There are two main types of fatty liver disease – alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD).
Fatty liver disease is generally graded based on the amount of fat stored and the degree of liver damage. This is called Fatty Liver Grades.
Simply, this fatty liver grade represents stages of fatty liver. There are four grades of fatty liver – Grade 1, Grade 2, Grade 3 and Grade 4.
Fatty liver disease is a silent disease; it comes with no signs or symptoms.
NAFLD (non-inflammatory or Grade 1 fatty liver) is asymptomatic, meaning you don’t feel any symptoms.
Still, you may have fatigue, thirst, anxiety, upper abdominal pain, bloating or discomfort, etc. These are the most common symptoms of NAFLD.
As the disease progresses, symptoms start appearing, usually in advance grading of fatty liver disease such as NASH (inflammatory fatty liver)
If left untreated, you may have a more severe liver condition that gets more complicated.
Although the exact cause of fatty liver is still unclear, but there are certain possible reasons to cause fatty liver.
A bad lifestyle is the most significant risk factor for developing NAFLD (Non-alcoholic fatty liver disease).
The good news is that you can reverse your fatty liver disease and even cure it.
If you get diagnosed early, it can be treated because some fatty liver grades are reversible, such as grade 1, grade 2 and grade 3.
But if you get liver cirrhosis or grade 4 fatty liver, that is irreversible. At this stage, your liver cells cannot reduce fat and can’t return to a healthy liver.
This post will discuss fatty liver grades, types, causes, pathology, symptoms, complications, diagnostic tests and treatment.
Dopamine injection is an inotropic agent that contracts your heart muscles effectively.
This injection is one of the primary emergency drugs in emergency hospital areas to treat life-threatening medical conditions.
So, the primary use of dopamine injection is to save patient life. That’s why it is also called Life Saving Drug.
This post will describe dopamine injection uses, side effects, action, route and dose.
Dopamine belongs to a category of sympathomimetic drug or adrenergic drug. This drug contains a catechol ring, that’s why it comes in the catecholamine category.
Dopamine is a potent agonist on dopaminergic receptors (D1 and D2 receptors).
It also works on adrenergic receptors (Alpha 1 and Beta 1 receptors) that mimic the effect of the sympathomimetic nervous system.
The significant therapeutic action of dopamine injection is
-Vasoconstrictor means to increase the blood flow due to stimulation of alpha 1 adrenergic receptor
-Cardiac stimulant means to increase the heart pumping due to stimulation of beta 1 adrenergic receptor
-Nephroprotective means increasing the renal blood flow due to stimulation of the D1 receptor.
Dopamine injection is always injected into a vein through an intravenous (i.v.) route of administration. This injection must be diluted in a sterile parenteral preparation such as 5% dextrose, normal saline etc.
If you receive dopamine injections, your vital organs will be closely monitored, such as your breathing, heart rate, blood pressure, blood sugar level, oxygen levels, kidney function, etc.
Dopamine injection has the potential to cause unwanted effects or side effects.
Dopamine injection is only prescribed by an expert doctor.
You may have been given dopamine injections in emergencies such as congestive heart failure, septic shock, and cardiogenic shock with oliguria.
You will be shocked to know that there are 500 functions of the liver in our body.
Well! The liver plays a versatile role in the human body.
Your liver has a lot of functions, such as digestion, metabolism, detoxification, filtration of blood, producing essential proteins etc.
But do you know the primary function of the liver?
The primary function of the liver is the production and secretion of bile.
In this post, you will learn about numerous functions of the liver, anatomy, histology, and physiology.
e liver is the heaviest organ and largest gland of your body which is around 1.5 kg weight.
Your liver is covered by Glisson’s capsule, made of white fibrous connective tissue.
Basically, the liver is an intraperitoneal organ that presents within the peritoneal cavity. You can’t feel the liver because most of the portion is covered with the ribcage.
Your liver cells or hepatocytes are responsible for many functions of the liver.
It is believed that the liver performs more than 500 different functions, usually in conjunction with other body systems.
Here, we will discuss only the major functions of the liver.
1. Function of the liver in the digestive system
2. Function of the liver in bilirubin metabolism
3. Role of the liver in deamination and urea production
4. Function of the liver in glucose metabolism
5. Function of the liver in lipid metabolism
6. Role of the liver in drug metabolism
7. Role of the liver in production of essential blood proteins
8. Function of the liver in detoxification
9. Function of the liver in modification of Vitamin-D
10. Some other functions of the liver in the human body
Best pain killer tablet for body pain_pdf.pdfSumit Sharma
Painkillers are the most commonly used medicines that help reduce pain sensation and inflammatory response. These medicines are also known as analgesics or anti-inflammatory drugs.
Analgesic medicines also improve the quality of life in long-lasting pain and help to relieve different pain conditions like generalized body pain, headaches, joint pain, muscle pain, etc.
They are broadly classified into three groups –
1. Paracetamol (Antipyretic)
2. NSAIDs (Non-Steroidal Anti-inflammatory Drugs)
3. Opioids (Narcotics)
Paracetamol has two important properties – antipyretic and analgesic. In other words, it can treat fever and mild to moderate body pain by inhibiting prostaglandin synthesis in the brain region.
However, it does not have anti-inflammatory properties. So, it would not work in swelling and severe pain.
As far as the concern of NSAIDs, these medicines have three important properties – antipyretic, analgesic, and anti-inflammatory.
NSAIDs generally decrease prostaglandin production by blocking cyclooxygenase enzymes (COX-1 and COX-2) or only COX-2.
If we talk about Opioids, it has only one property – analgesic. It does not work in inflammation. It blocks pain transmission by interfering with opioid receptors.
NSAIDs are usually preferred; if there is inflammation and pain.
In contrast, opioids are the strongest painkiller. These medicines are usually preferred if there is only visceral pain (or pain in internal organs like the heart, kidney, intestine, etc.), after surgery, burn, and cancer pain.
This post has discussed the best pain killer tablet names for various conditions.
Here, I have reviewed the best painkiller medicine for fever, acute pain, toothache, stomach pain, joint pain, muscle pain, and other body pain.
Moreover, I have explored the safest pain killer in children, pregnancy, asthma conditions, peptic ulcers, and heart disease conditions.
Best Cough Syrup in India for Kids, Adults, & Pregnancy.pdfSumit Sharma
Selecting the ideal cough syrup is always challenging for everyone.
Anyone has a cough, and it is very common to have a cough and cold as the weather changes.
Although, all the coughs are not the same. So, it is evident that even cough syrups are not the same.
This post will review the best cough syrup for kids, adults, & pregnancy.
As we know, cough is a common symptom of lung infection. You need to understand the cause of the cough.
If your cough is persisting more than 8 weeks, you should not treat the cough yourself. It may be a lung infection or chronic lung disease. You must consult your doctor.
Your doctor may assess your cough based on intensity, severity, frequency, and sensitivity.
Suppose your cough is bothering you in daily routine activity or if it is an acute cough. In that case, you can take symptomatic relief or over-the-counter (OTC) cough and cold medications.
There are two types of cough syrups in the market –
-Expectorant, and
-Antitussives
These kinds of cough syrups are usually available in a combination of antihistaminic drugs, nasal decongestants, or bronchodilators like –
-Expectorant + bronchodilator
-Expectorant + antihistaminic drug
-Antitussives + antihistaminic drug
-Antitussives + antihistaminic drug + nasal decongestant
You need to understand – which type of cough do you have? We usually need clarification while selecting the best cough syrup.
If you have a productive cough, you should choose expectorant cough syrup, while for dry cough, you need to take antitussive cough syrup.
Choosing the best cough syrup for kids is also challenging because there are safety concerns.
As per FDA, if your child has a cough due to a cold or upper respiratory cough infection, it does not need treatment.
Still, if you want to give cough syrup to your children, then you may go with OTC medicines but don’t give any cough syrup to children under 2 years.
Here, I am reviewing the safest and best cough syrup for kids.
Diphenhydramine and dexchlorpheniramine are the safest and best cough relief medicine for pregnant women.
It would be best to consult your doctor before taking any cough syrup, especially in kids and pregnancy.
Albendazole mechanism of action_pdf.pdfSumit Sharma
We take albendazole medicine for deworming, get relief and forget. Many people have a curiosity to know the fate of the drug.
Albendazole is a miracle drug because it uniquely kills parasitic worms.
Albendazole medicine is basically used for deworming, and it comes on the essential drugs list of WHO (World Health Organisation).
Here, I have made an easy guide to understanding albendazole mechanism of action (moa) and pharmacokinetics.
After reading this post, you will know how albendazole works and how the body reacts in response to albendazole.
The principal mechanism of action of albendazole is inhibiting polymerization and the cell division process of helminths. But it also depends on the types of parasitic worms –
Albendazole mechanism of action for intestinal worms :
When you take albendazole, it goes to your small intestine and is directly active against intestinal worms.
Albendazole strongly binds to the β-tubulin site of worm parasites. As a result, it inhibits the polymerization process that destroys the assembly of the worm’s microtubules.
You don’t need albendazole in your blood circulation for intestinal helminths (such as hookworm, pinworm, roundworm).
In this condition, you have to take albendazole on an empty stomach so that it can stay for a longer time in your intestine. Albendazole does not absorb on an empty stomach but is rapidly absorbed with a fatty meal.
Albendazole mechanism of action for tissue worms:
Sometimes, parasitic worms penetrate your blood circulation and tissues via intestine to blood or skin to blood. In this condition, Albendazole act as a prodrug.
Suppose you have a neurocysticercosis problem (worms in your brain) and take albendazole with a fatty meal.
Firstly, it goes to your stomach and then the small intestine. From the small intestine, albendazole is rapidly absorbed into your hepatic portal circulation via the inferior mesenteric vein.
As soon as albendazole reaches the liver, it converts into albendazole sulfoxide by First Pass Metabolism. Here, albendazole sulfoxide is a real anthelmintic for systemic worm infections.
After reaching blood circulation, it easily crosses your blood-brain barrier (BBB) and enters cerebrospinal fluid (CSF) because albendazole is a highly lipid-soluble drug.
In your brain, albendazole get accumulates in higher concentrations. It effectively kills Taenia solium worms that cause neurocysticercosis.
Here, albendazole binds on the β-tubulin site of Taenia solium worms, inhibiting polymerization and cell division.
Albendazole medicine effectively works in intestinal and tissue helminths by binding on the β-tubulin site of worm parasites.
It is the safest anthelmintic with minimal side effects.
We should especially focus on the administration of albendazole – with food (for tissue parasites) or without food (intraluminal parasites). It is always best to take albendazole under proper medical supervision.
Rabeprazole sodium and domperidone capsules.pdf.pdfSumit Sharma
Here, we will discuss rabeprazole sodium and domperidone capsule’s uses, dosage, mechanism, side effects, warnings or precautions.
Rabeprazole is an anti-ulcer drug, whereas domperidone comes in the anti-emetic (or prokinetic) category. This combination of rabeprazole and domperidone medicines reliefs in stomach related problems like acidity, ulcer & gas.
Rabeprazole belongs to the proton pump inhibitors (PPIs) class. This medicine suppresses the excess acid in your stomach by inhibiting the proton pump.
Rabeprazole is a newer proton pump inhibitor drug that strongly stops gastric acid secretion. This medicine is a potent and fastest acid suppression than other PPIs. It starts to work within 5 minutes.
The combination of rabeprazole and domperidone is commonly used for treating ulcers and gastroesophageal reflux disease (GERD).
Rabeprazole is usually preferred for an empty stomach. Because it is more effective if you take an empty stomach once daily in the morning.
When you take a Rabeprazole sodium tablet or capsule on an empty stomach, it goes into your bloodstream. And it gets converted into the active form of sulphenamide (sulfenamide).
This active form inhibits the proton pump H+K+ ATPase enzyme. In this way, it helps in acid suppression.
The use of rabeprazole sodium is not recommended in pregnancy and breastfeeding. It should be used if clearly needed. On the other hand, domperidone has shown teratogenicity in pregnant animals. So, the use of domperidone should be avoided during pregnancy.
Although, all proton pump inhibitor (PPI) drugs have almost similar efficacy and safety profile. But clinically, rabeprazole has shown better results than other PPIs.
Rabeprazole sodium is a well-tolerated, effective and safe proton pump inhibitor.
Based on clinical experience and few clinical trials, rabeprazole is considered stronger and more powerful than other PPIs.
In addition to providing satisfying relief of symptoms of GERD, rabeprazole sodium and domperidone capsules are also well tolerated.
The use of rabeprazole sodium and domperidones capsules are not recommended in children, the elderly, liver disease, heart disease, pregnancy, and breastfeeding.
Since it is a prescription-based medicine, so you don’t take self-medication. You must consult your doctor before taking a rabeprazole sodium and domperidone capsules.
Introduction
Have you ever thought about how does medicine move throughout your body? In this post, we will learn about the process of ADME in pharmacokinetics.
Suppose you have a headache and you take Disprin (Aspirin) tablet. But do you know how Dispirin knows where to go in your body or where the problem is?
Here, we will understand the entire journey of medicine in the human body. This post will be fascinating and informative for medical students, physicians, pharmacists, nurses, and general people.
So, keep reading to learn about ADME in pharmacokinetics –
What is meant by ADME in pharmacokinetics?
Pharmacokinetics is the branch of pharmacology (study of medicine) that deals with how drugs move through the body.
If we split the term pharmacokinetics. In Greek, “Pharmakon” means drug (or medicine), and “kinetics” implies movement.
In other words, pharmacokinetics is simply a movement of medicine in the body.
All medicines are indeed drugs, but not all drugs are medicines. So, medicine is considered a drug.
The pharmacokinetics would be basically an ADME study. The ADME in pharmacokinetics refers to absorption, distribution, metabolism, and excretion.
Every medicine must follow the ADME process (absorption, distribution, metabolism, and excretion). Here, ADME in pharmacokinetics -
A represents absorption – medicine gets into the bloodstream.
D represents distribution – medicine moves from the bloodstream to tissue (or site of action)
M represents metabolism – biotransformation of medicine (drug change from one form to another form)
E represents excretion – medicine eliminate from the body via urine/stool
What are the 4 steps of pharmacokinetics?
For a good pharmacokinetic profile, a medicine must complete 4 steps of pharmacokinetics in the human body, i.e., ADME.
Step 1 Absorption, Bioavailability & Prodrug
Step 2 Distribution
Step 3 Metabolism
Step 4 Excretion
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
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Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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1. How To Increase Dopamine Naturally? Best 9
Ways to Boost Dopamine
Posted By SUMIT SHARMA
Contents
● Introduction
● What is dopamine? And, where is dopamine produced in the brain?
● What is the main function of the dopamine neurotransmitter in the brain?
● How does the dopamine synthesis pathway occur in your brain?
❖ 1. Mesolimbic Dopamine Pathways
❖ 2. Mesocortical Dopamine Pathways
❖ 3. Nigrostriatal Dopamine Pathways
❖ 4. Tuberoinfundibular Dopamine Pathways
● What activities trigger dopamine? Why is dopamine addictive?
2. ● What happens when dopamine levels are high?
● What causes low dopamine?
● What happens if dopamine levels are too low? What are the symptoms of low dopamine?
● How to Increase Dopamine Naturally?
❖ 1. Avoid junk foods
❖ 2. Healthy foods that increase dopamine
❖ 3. Exercise releases dopamine
❖ 4. Get good sleep
❖ 5. Supplements that increase dopamine
❖ 6. Drugs that increase dopamine
❖ 7. Music release dopamine
❖ 8. Reduce stress from your life
❖ 9. Engage in good pleasurable activities
● Conclusion
● FAQ
❖ Q 1. Which hormone is responsible for addiction?
❖ Q 2. Is dopamine happy hormone?
❖ Q 3. Is dopamine released during sex?
❖ Q 4. How to increase dopamine while studying
3. Introduction
Did you know that dopamine is known as a “Happy Hormone”? You must have felt
a lack of motivation, lack of energy, lack of interest, hopelessness, and fatigue in
your life. It is because of low dopamine. Here, you will learn how to increase
dopamine naturally.
Knowing how to increase dopamine naturally is challenging and sometimes easier
for most people.
Because some dopamine-boosting activities provide you attention but most of the
activities give you addiction.
You need to understand the activities that differentiate attention and addiction.
In today’s time, we all are trapped or engaged in certain activities such as shopping
offers, social media apps, video games, smartphones, porn videos, YouTube,
Netflix, eating junk foods, etc.
Suppose you visit a shopping mall and you see that various offers are running on
products like –
BUY 2 GET 1 FREE…
4. Buy only Rs. 99/-
These exclusive offers and deals force your mind to buy products.
Because these things make us happy, feel relaxed and give us a pleasurable feeling.
These types of activities (such as shopping, social media apps, video games. etc.)
strongly trigger dopamine in your brain. Due to the influence of dopamine, you
feel happy and pleasurable.
But this kind of way to increase dopamine may give a harmful effect on your body.
It could be a mental problem, stress, obesity, insomnia, etc.
You may also have been exposed to dopamine addiction due to a high surge of
dopamine.
We spend most of our time on these activities instead of giving more attention to
exercise, health, diet, working on goals, and reading books.
If you increase your dopamine in natural ways. In that case, you become happier,
smarter, more productive, more creative, more focused, and more social. Therefore,
we should have a sufficient amount of dopamine in our brains.
In this article, we will discover how to increase dopamine levels naturally. But
before that, we will know about –
● dopamine hormone, its function and dopamine synthesis pathway
● high dopamine symptoms and dopamine addiction
● low dopamine symptoms and dopamine deficiency
So, Let’s start topic –
5. What is dopamine? And, where is dopamine produced in
the brain?
Your body makes several chemicals. Dopamine is an important one among them.
Dopamine is considered a happy neuro-hormone because it releases in the happiest
or most pleasurable moment. It acts as a chemical messenger or neurotransmitter
that helps to pass information from one nerve cell to another.
This dopamine neuro-hormone is a catecholamine that contains a catechol ring and
an amine group ring.
The first step in dopamine synthesis is from tyrosine amino acid.
In the nerves ending, when tyrosine enters the synaptic knob and it gets converted
into DOPA in presence of tyrosine hydroxylase enzyme.
Eventually, it forms dopamine with help of the DOPA decarboxylase enzyme.
Tyrosine
↓T. Hydroxylase
DOPA (Dihydroxyphenylalanine)
↓ D. Decarboxylase
Dopamine
This dopamine gets stored in presynaptic vesicles of neurons.
The highest concentration of dopamine is present in the subcortical structures of
the brain.
6. Dopamine is generally produced from the specific nucleus that is present in the
midbrain. This area is called VTA (ventral tegmental nucleus or area) and
substantia nigra.
These areas are called dopamine-rich nuclei and are also known as Dopamine
factories.
What is the main function of the dopamine
neurotransmitter in the brain?
The main function of the dopamine neurotransmitter is movement, motivation
memory and emotional responses.
Let’s see how?
When dopamine is released from the VTA nucleus, it goes to its target sites such as
the basal ganglia (nuclei) and limbic system.
7. Basal ganglia are a group of nuclei that are present in the centre of your brain.
They are mainly responsible to control your body’s movement and regulate muscle
tone.
If there is a slight elevation of dopamine in the basal ganglia region, you may have
full of excitement and interest in following motor skill activities such as
● Sports – cricket, football, etc.
● Increase physical performance in athletes
● Increase motivation
● Increase memory
While, Limbic system is comprised of four main structures – the hypothalamus,
amygdala, thalamus, and hippocampus. This system helps to control our
behavioural and emotional responses.
Your limbic system gets quickly influenced by dopamine in certain situations. For
example-
● If someone gives you a gift suddenly
● If you get an unexpected reward
● If there is a huge hike in your salary
● If you are getting pleasure from sex, video games, using smartphones,
gambling, etc.
8. How does the dopamine synthesis pathway occur in
your brain?
When the action potential generates, exocytosis of synaptic vesicles takes place.
After releasing dopamine, it binds to dopamine GPCR (G-protein coupled
receptor) receptor-like D1 (most specific), D2, D3, D4, and D5.
Before binding on dopamine receptors, dopamine travel in a particular area of the
brain. That area is known as the Dopaminergic pathway.
It has four significant pathways that help to convey important information. Every
path has its own function and responsibility.
1. Mesolimbic Dopamine Pathways
9. If we break the term “mesolimbic”.
“Meso” means a mid-area of the brain that refers to the VTA nucleus and “limbic”
means involvement of the subcortical structure of a limbic system that is also
present in the midbrain.
This pathway covers the midbrain area. Dopamine transmits from VTA (ventral
tegmental area) to the ventral striatum area.
This area is strongly associated with pleasure, reward, and addiction. Whenever
you encounter activities like an unexpected reward, pleasure, motivation, etc. In
that case, your dopamine influence and kick this area.
It is also called the “Reward Pathway”.
2. Mesocortical Dopamine Pathways
Similarly, if we split the mesocortical term.
“Meso” means a mid-area of the brain that refers to the VTA nucleus and “cortical”
means a cortex of the brain that is more specific to the prefrontal cortex.
This pathway also begins from a mid-area of the brain at VTA, and their action
potential generates till the prefrontal cortex.
When dopamine reaches the prefrontal cortex that helps in coordinating executive
functions like – attention, planning, skills, learning, reasoning, problem-solving,
etc.
If there is any dysfunction in this area, you will develop a lack of concentration,
depression, and an inability to decide.
3. Nigrostriatal Dopamine Pathways
10. This pathway connects the midbrain to the forebrain area to facilitate dopamine
flow.
In this pathway, dopamine travels in the basal ganglia region from the substantia
nigra (basal ganglia structure of midbrain) to the dorsal striatum (basal ganglia
structure of forebrain).
It is also a dopamine-rich area that contains 80% dopamine in the brain.
It is an important area that controls motor functions like walking, running, sitting,
jumping, etc.
If there is less dopamine supply in this area, it may lead to Parkinson’s disorder,
tardive dyskinesia, tremors, etc.
4. Tuberoinfundibular Dopamine Pathways
This pathway transmits dopamine from the hypothalamus to the pituitary gland. In
this area, dopamine regulates the secretion of the prolactin hormone.
A high dopamine level inhibits prolactin release whereas a low dopamine level
increases the secretion of prolactin.
If there is an increased prolactin level, it can affect menstrual cycles, galactorrhea,
sexual desire, fertility, etc.
What activities trigger dopamine? Why is dopamine
addictive?
Suppose your favourite food is pizza, and you are extremely craving that food.
When you visit pizza hut and get a smoky smell of Pizza. In that case, your brain
starts to increase dopamine.
11. Generally, your dopamine is released when you do any pleasurable or
dopamine-booting activities like –
● Craving for a tasty meal
● Winning a prize
● Having sex
● Gossip with friends
● Playing video games
● Watching YouTube, Netflix, etc.
12. It makes you feel better, euphoric, and happy. It also releases in non-pleasurable
activities but less amount. So, the level of pleasure feeling depends on your
day-to-day activities.
Your dopamine usually fluctuates between high and low dopamine levels
throughout the day.
● Low dopamine activity – less likely to work, study, exercise, eat a healthy
diet or any uncomfortable situation. Here, you will be more alert, motivated,
concentrated and aware.
● Moderate dopamine level activity – unexpected rewards like promotions,
salary hikes, surprise gifts, etc.
● High dopamine level activity – shopping, video games, social media,
gambling, sex, eating junk foods (like a burger, pizza, or cold drinks). You
will have craving, dependency and habituation.
● Extreme high dopamine level activity – uncertain substances like cocaine,
heroin, alcohol, nicotine, etc.
High dopamine-boosting activities may cause dopamine addiction. Suppose you
play fantasy games (such as Dream 11) or trade in the stock market, it gives you a
reward after winning and you feel very happy.
This reward stimulates your dopamine and kicks you to repeat this activity because
you get pleasure.
13. What happens when dopamine levels are high?
Dopamine levels are usually high in those activities where you feel pleasure and
happiness.
Although, many activities influence your dopamine level. For example, if you are
playing a video game like PUBG and you are quite engaging. Even if you are
skipping the meal. You don’t know the end result of this activity.
However, this video game is giving you intense pleasure because of the high
dopamine level surge. The high level of dopamine makes you feel good, and this
good feeling provokes you to repeat those activities.
Some drug substances (like cocaine, heroin, amphetamine, nicotine, alcohol, etc.)
kick your dopamine at a high level
It makes you feel at the top of the world.
But too much level of dopamine may be a big problem for you. It may lead to
mania, schizophrenia, delusion, hallucination, addiction, etc.
Despite knowing the fact that it gives a harmful effect, high (substance user)
people use it repeatedly because they are habitual of it. Eventually, they get an
addiction.
Too much dopamine stimulation is not good and hampers your quality of life. You
may have high dopamine symptoms such as –
● Anxiety
● Insomnia (difficulty sleeping)
● Hyperkinetic activity (increased energy)
● Mania
14. ● Stress
Sometimes, these mental disorders (schizophrenia, mania, etc.) generally happen,
when there is a disturbance in brain physiology (changes in the structure of the
VTA nucleus, basal ganglia or limbic system). This may cause overstimulation of
dopamine levels.
What causes low dopamine?
The low level of dopamine is also not good for us.
There are a lot of reasons that cause low dopamine in our brains. It could indicate a
neurological disease such as –
● Parkinson disease
● Depression
● Restless leg syndrome
● ADHD (Attention Deficit Hyperkinetic Disorder)
Normally, when we get older, then our body starts to decrease dopamine
neurotransmitters from the VTA nucleus. Eventually, we get dopamine deficiency.
You may also have low dopamine if someone has faced a bad situation or a big loss
in his life, e.g., the death of a person in family member, failure in exams or
financial loss. This may cause a drastic decrease in dopamine levels.
15. If there are any structural changes in parts of the brain especially the VTA nucleus,
basal ganglia, limbic system or any traumatic brain injury. In that case, it could
also be a cause of dopamine deficiency.
What happens if dopamine levels are too low? What are
the symptoms of low dopamine?
If you think you have a low level of dopamine, you may have struggled in
enthusiasm, movement, and motivation.
As we discussed earlier, dopamine is generally released from the VTA nucleus of
the brain, eventually, it binds to the basal ganglia and limbic system.
Basal ganglia are mainly responsible for movement whereas the limbic system has
the main role in managing all emotional activities like pleasure, reward,
motivation, etc.
Whenever you have low dopamine levels in these areas (such as basal ganglia and
limbic system), you may have experienced low dopamine symptoms, such as –
Low dopamine symptoms
Dopamine deficiency in basal ganglia Dopamine deficiency in limbic system
· Fatigue or tired · Lack of interest in many activities
· Loss of normal movement · Lack of energy
16. · Increase muscle stiffness · Lack of motivation
· Resting tremor · Low sex drive
· Impaired posture and balance · Lack of attention or concentration
· Sleep disturbance (insomnia)
How to Increase Dopamine Naturally?
If you’re wondering how to increase dopamine naturally, I have mentioned the 9
best ways to increase dopamine levels naturally –
17. 1. Avoid junk foods
Although, eating junk foods (such as burgers, chips, cold drinks etc.) can increase
dopamine levels rapidly for short time. You will feel short-term enjoyment and
pleasure.
But over time, long-term eating junk foods can disturb the function of your brain.
Eventually, it leads to dopamine deficiency.
This type of junk food produces a stronger craving sensation that causes food
addiction. It also increases obesity which brings many other medical conditions.
As per a study, high saturated fat (or High-fat diets) foods can decrease the
dopamine level in your brain. These foods are strongly linked to obesity, diabetes,
and cardiovascular diseases.
18. 2. Healthy foods that increase dopamine
You would be thinking that how to increase dopamine with food. Here, you need to
add tyrosine-rich foods because tyrosine is a building block of dopamine
production.
As we know dopamine is synthesized from tyrosine amino acid. Basically, tyrosine
is a non-essential amino acid that is produced in our body itself. We don’t need to
take tyrosine from food.
Sometimes, our body does not produce enough tyrosine which causes dopamine
deficiency. In that case, you need to take tyrosine-rich foods.
If you have dopamine deficiency, you need to take a high-protein diet that contains
tyrosine amino acids.
Certain foods help to increase the dopamine level in your brain. It includes –
● Animal foods such as eggs, chicken, fish, pork, beef, and lamb,
● Dairy products such as cheese, yoghurt etc.
● Fruits such as avocados, bananas and watermelon
● leafy green vegetables
● Nuts – peanuts, pumpkin seeds, sesame seeds
● Soybeans
19. 3. Exercise releases dopamine
Physical exercise is an important way to increase mood boosting monoamine
hormones such as dopamine, serotonin, endorphin and noradrenaline level in your
brain.
Regular physical workouts can decrease stress levels, anxiety, panic attacks and
mental illness like depression.
While, it improves mental health, mood, and memory. As per a study, exercise is
strongly associated with increased mood and cognitive function.
Therefore, you should give at least 30 mins exercise, running or yoga in your daily
life.
4. Get good sleep
Two main hormones control the sleep-wake cycle. These are melatonin and orexin
(or hypocretin).
A sleep cycle is mainly controlled by the pineal gland. It secretes a “melatonin
hormone.”
This melatonin helps to maintain the circadian rhythm (or sleep-wake cycle).
Whereas, the orexin hormone promotes wakefulness that releases from the
hypothalamus.
Dopamine imbalance alters the melatonin and orexin hormones which leads to
sleep deprivation.
Sleep-wake disturbances can be seen commonly in Parkinson’s disease, depression
and narcolepsy (excessive daytime sleep) patients.
In these neurological conditions, dopamine deficiency can be seen.
20. Normally, dopamine is associated with wakefulness but you should have a good
time of sleep to reset your dopamine level.
Therefore, a person should sleep at least 7 to 9 hours for healthy brain functioning.
5. Supplements that increase dopamine
Most people wonder how to increase dopamine with supplements. A low
dopamine problem could be a deficiency of vitamins and minerals.
Some important supplements increase the dopamine level in your brain. These
include –
● Tyrosine supplement
Since tyrosine is a precursor of dopamine synthesis, you can add a tyrosine
supplement to your diet.
According to a study, tyrosine is a useful supplement that enhances your cognitive
function and increase dopamine level.
● Vitamin D3 supplement
Vitamin D3 (25-hydroxycholecalciferol) also helps in the dopamine synthesis
pathway.
Vitamin D3 supplements should be used if someone has ADHD (Attention Deficit
Hyperkinetic Disease), especially in school-aged children.
● Riboflavin (B2) and Pyridoxine (B6)
21. An animal study published in BMC Neuroscience, 2018 stated that riboflavin and
pyridoxine are the most specific vitamins for neurodegenerative diseases such as
Parkinson’s disease.
These B2 and B6 vitamins are useful supplements in restoring dopamine and
decreasing oxidative stress.
● Plant extract-rich flavonoids
As per a study, polymethoxylated flavones, procyanidins and isoflavones are the
most common flavonoids that present in plants.
In this study, these flavonoids were found effective and helpful in the rat model of
Parkinson’s disease.
● Fish oil capsules
Manystudies suggest that fish oil supplements increase the dopamine level in the
brain.
Fish oil contains omega-3 fatty acids that boost your dopamine level and the
functioning of the brain.
You must add a fish oil supplements if you have a dopamine deficiency.
6. Drugs that increase dopamine
Knowing how to increase dopamine with drugs can be beneficial for those people,
who are suffering from neurological problems.
But some illegal narcotic drugs are also used to increase dopamine.
22. You must have seen some young adults do night parties, nightclubs or DJ dance
music. MDMA is a very common drug used by these parties.
MDMA is also known as “Ecstasy drug”, “Party drug” or “Rave drug”. It contains
methamphetamine.
This ecstasy drug rapidly speeds up your dopamine, noradrenaline and serotonin
level. Although, it is a dangerous drug even at low doses.
A low dose of Ecstasy drug stimulates your brain, increases wakefulness, increases
memory and increases pleasure.
But at high doses, it may cause addiction and psychosis (hallucination).
Some other illegal drugs produce a much larger surge of dopamine releases such as
heroin, cocaine, marijuana, and LSD.
It gives intense euphoria or pleasure.
When someone takes this substance, he may get habitual which causes strong
dopamine addiction.
This addiction may develop into mental problems like schizophrenia, hallucination,
anxiety, mania or other psychosis.
But if you have dopamine deficiency problems or neurological problems. In that
case, you may have been prescribed certain prescription dopamine-boosting drugs
such as –
Prescription drugs that boosting dopamine level
Medical
conditions
Category Drug names
23. Parkinson’s
disease
Antiparkinsonian
drugs
Ropinirole, levodopa,
carbidopa etc.
Depression Antidepressants Fluoxetine, amitriptyline,
sertraline
ADHD CNS stimulants Methylphenidate,
Amphetamine
Restless legs
syndrome
Dopamine agonist Pramipexole
7. Music release dopamine
Listening to your favourite music is the easiest and most effective way to increase
dopamine.
Whenever you feel unmotivated, sad and lack energy. In that condition, if you
listen to your favourite music, you find pleasure, energetic and motivated because
it boosts your dopamine due to musical rhythm and synchronising beats.
It directly acts on the dopamine nucleus at the caudate-putamen and nucleus
accumbens areas of the brain.
In a 2018 study, researchers found raised dopamine and serotonin level in an
experimental study of rats after providing a musical environment to rats.
24. 8. Reduce stress from your life
Every person is living with a busy and tight schedule, they must have had some
problems or stressful situations. It could be physical stress, financial stress,
academic stress, psychological stress or traumatic stress.
According to a study, any type of stress in our life can reduce the dopamine density
in the brain. Due to this, we get unenthusiastic, unmotivated, and lack energy.
Generally, stress stimulates the sympathetic nervous system, it increases the
noradrenaline and adrenaline level.
These things trigger the stress hormone called Cortisol. You cannot be happy in
stressful conditions and eventually, it decreases dopamine production.
It is difficult to avoid these stressful conditions but we should reduce the stress in
our life.
You can do meditation. It is one of the best ways to reduce stress and improve
mental health.
It not only increases dopamine but also improves the memory and cognitive
function of our brain.
You can also engage in other activities that reduce stress such as exercising and
playing sports or get counselling from a psychiatrist.
9. Engage in good pleasurable activities
Pleasurable activities can give you a classical boost in dopamine production.
These activities can be video games, masturbation, thinking about sex, gambling
etc. Although, this can induce dopamine, but it can also give your dopamine
addiction.
So, you should give your time to good pleasurable activities such as
25. ● Planning your career
● Talking about goals
● Spend time outside
● Spending time with family or friends
● Learning a new language
● Watching movies
● Listen to music
● Having sex sometimes
Conclusion
Whatever you enjoy or do any pleasurable activities in your life because of the
dopamine neurotransmitter.
Whenever we think about how to increase dopamine levels. You may have
dopamine fluctuation. For example –
● You would be more attentive if there is a slight surge of dopamine
● You would be addicted if there is a high surge of dopamine
● You would be in depression if there is a low level of dopamine
26. Overall, the homeostasis of the dopamine hormone is very important in our life. It
should be neither high nor low.
Therefore, you should boost your dopamine naturally through exercise, a protein
diet, meditation, a healthy diet, etc.
You must consult your doctor if there is a dopamine deficiency.
I hope that you have learned something new from today’s article. If you found this
post to be informative, share it on social media.
FAQ
Q 1. Which hormone is responsible for addiction?
The dopamine hormone is mainly responsible for addiction such as gaming,
gambling, sex, too much craving for junk food, illegal drug addiction etc.
Q 2. Is dopamine happy hormone?
Dopamine is generally considered a “Happy Hormone” or “Pleasure Hormone”
because it makes you feel good and pleasure.
Q 3. Is dopamine released during sex?
Doing sex is also a kind of pleasurable activity and it releases mood-boosting
hormone i.e., dopamine. Whenever dopamine is released, it decreases depression
and anxiety-like problems. These dopamine hormones help to activate sexual
stimulation and we really do feel pleasure.
27. Q 4. How to increase dopamine while studying
Dopamine has a big role in attention, concentration and the conscious mind. Most
students get bored when they do study. But if they study with interest, practical or
experiments, basic understanding and concept. In this condition, dopamine gets
increases. It makes you more attentive.
References –
1. https://pubmed.ncbi.nlm.nih.gov/30031088/
2. https://www.hindawi.com/journals/omcl/2016/9730467/
3. https://www.ncbi.nlm.nih.gov/books/NBK535451/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684895/
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