Presentation given by Vincent-Henri Peuch, Head of the Copernicus Atmosphere Monitoring Service at the Copernicus COP21 Briefing Event, London, UK, 10 November 2015.
Improving scientific graphics of climate (change) dataZachary Labe
Creating visuals of data is a critical part of our jobs as scientists. We use figures for journal publications, presentations, posters, and science communication. This week we'll discuss a framework for making better figures, particularly in the climate sciences. I will also give examples of what not to do, and how we can improve these figures moving forward. e
Improving science (communication) through data visualizationZachary Labe
Creating visuals of data is an important part of our jobs as scientists. We use figures for journal publications, presentations, posters, lab group meetings, science communication, and more. In this workshop, we'll use examples from climate science to discuss a framework and network of resources available for making accessible figures. I will also share examples of what not to do and how to improve these figures moving forward.
Improving scientific graphics of climate (change) dataZachary Labe
Creating visuals of data is a critical part of our jobs as scientists. We use figures for journal publications, presentations, posters, and science communication. This week we'll discuss a framework for making better figures, particularly in the climate sciences. I will also give examples of what not to do, and how we can improve these figures moving forward. e
Improving science (communication) through data visualizationZachary Labe
Creating visuals of data is an important part of our jobs as scientists. We use figures for journal publications, presentations, posters, lab group meetings, science communication, and more. In this workshop, we'll use examples from climate science to discuss a framework and network of resources available for making accessible figures. I will also share examples of what not to do and how to improve these figures moving forward.
The case for addressing climate change with machineHiteshPandharkar
The presentation intends to explain global warming, where our understanding of the problem is not enough, and how machine learning can help us tackle the problem.
Presentation given by Darius Bazazi, GeoPlace, as part of the EDINA Geoforum 2014 event on Thursday 19th June 2014 at the Informatics Forum, University of Edinburgh.
Gokhan Danabasoglu, Senior Scientist and Community Earth System Model Chief Scientist, National Center for Atmospheric Research (NCAR)
UCAR Congressional Briefing - April 2018
Slides from a presentation about modeling past and future climate as part of the "School of Ice" workshop for educators at Oregon State University on Aug. 2, 2021.
Record Setting: The Origins of Extreme Hail on 19 March 2018 during VORTEX-SEDeanMeyer14
Authors Dean Meyer and Ryan Wade. UAH Department of Atmospheric Science. Completed as Dean Meyer's student research as part of the UAH RCEU program at SWIRLL.
The case for addressing climate change with machineHiteshPandharkar
The presentation intends to explain global warming, where our understanding of the problem is not enough, and how machine learning can help us tackle the problem.
Presentation given by Darius Bazazi, GeoPlace, as part of the EDINA Geoforum 2014 event on Thursday 19th June 2014 at the Informatics Forum, University of Edinburgh.
Gokhan Danabasoglu, Senior Scientist and Community Earth System Model Chief Scientist, National Center for Atmospheric Research (NCAR)
UCAR Congressional Briefing - April 2018
Slides from a presentation about modeling past and future climate as part of the "School of Ice" workshop for educators at Oregon State University on Aug. 2, 2021.
Record Setting: The Origins of Extreme Hail on 19 March 2018 during VORTEX-SEDeanMeyer14
Authors Dean Meyer and Ryan Wade. UAH Department of Atmospheric Science. Completed as Dean Meyer's student research as part of the UAH RCEU program at SWIRLL.
Intervento del Dott. Antonio Navarra Presidente del Centro Euro-Mediterraneo per i Cambiamenti Climatici durante il convegno del 9 ottobre tenutosi a Roma presso la Prfotomoteca del Campidoglio
Presentation by ICOS DG Werner Kutsch at the UNFCCC Earth Information Day in UN COP22 on Tue 8 November 2016.
See the Earth Information Day programme: http://unfccc.int/science/workstreams/items/9949.php
UK Spectrum Policy Forum – Richard Peckham, UK Space - The Case for SpacetechUK
UK Spectrum Policy Forum
Cluster 3 Meeting – 17 September 2014
Richard Peckham, UK Space
The Case for Space: The commercial, societal and macro-economic case for satellite spectrum
More information at: http://www.techuk.org/about/uk-spectrum-policy-forum
All rights reserved
Editorial – October 2011 – Three of the MyOcean long time series reanalysis products
Greengs all,
This month’s newsleer is devoted to three of the MyOcean long me series Reanalysis products: the In Situ temperature and salinity CORA reanalysis
(1990 to 2010), the reanalysis of the North Atlanc ocean biogeochemistry (1998-2007) and the Arcc Ocean sea-ice dri/ reanalysis (1992-
2010).
The first product described here is the In Situ temperature and salinity CORA reanalysis (1990 to 2010). A new version of the comprehensive and
qualified ocean in-situ dataset (the Coriolis dataset for Re-Analysis - CORA) is released for the period 1990 to 2010. This in-situ dataset of temperature
and salinity profiles, from different data types (Argo, GTS data, VOS ships, NODC historical data...) on the global scale, is meant to be used for
general oceanographic research purposes, for ocean model validaon, and also for inializaon or assimilaon of ocean models. This product is
available from the MyOcean web portal (hp://www.myocean.eu/).
The second product is the reanalysis of the North Atlanc ocean biogeochemistry (1998-2007). A system assimilang Ocean Colour SeaWiFS data
during the period 1998-2007 has been designed to construct a reanalysis of the North Atlanc ocean biogeochemistry based on a coupled physicalbiogeochemical
model at eddy-admi:ng resoluon. The aim of this study is, on the one hand to develop the skeleton of a pre-operaonal coupled
physical-biogeochemical system with real-me assimilave/forecasng capability, and on the other hand to operate this prototype system for producing
a biogeochemical reanalysis covering the 1998-2007 period. This product is not available from the MyOcean web portal yet.
The third reanalysis product is the 1992-2010 winter Arcc Ocean sea ice dri/ me series made at Ifremer/CERSAT from satellite measurements
which consists of several products: the Level 3 products from single sensors and the L4 products from the combinaon of sensors. They are available
at 3, 6 and 30 day-lag with a 62.5 km-grid size during winter. This dataset is available for oceanic and climate modelling as well as various scienfic
studies in the Arcc. The me series is ongoing and will connue for Arcc long term monitoring using the next MetOp/ASCAT operaonal
scaerometers, planned to be operated for the next 10 years. This product is available from the MyOcean web portal (hp://www.myocean.eu/).
The next January 2012 issue will be dedicated to various applicaons using the Mercator Ocean products.
We wish you a pleasant reading!
From our climate panel in Grand Junction on August 4:
Our Forest, Our Water, Our Land: Local Impacts on Climate Change. Sponsored by Conservation Colorado, Mesa County Library, Math & Science Center
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
3. Implemented by
EU’s efforts on climate change stretch beyond
ambitious carbon reduction commitments
is harnessing world
leading science and
technology to equip
society to understand and
adapt to our changing
environment
The “Sentinels”
4. Implemented by
Different
Needs
Oil Spill TrackingFarming Flood
Land Marine Atmosphere Emergency
OBSERVATIONS
Space
Infrastructure
In Situ
Infrastructure&
Air Quality
Policy Makers Public& Private,
Commercial
&
Sustainable
observation
capabilities
Surveillance
Security
Arctic change
Examples of
areas covered
6 Information
ServicesClimate
USERS
6. Implemented by
One example of Copernicus data: the next reanalysis covering the last 40 years…
This dataset alone has a volume of 6 PB = 6,000,000,000,000,000 bytes
If this dataset was stored on
CDs, the CD pile would be
about 11 km high, up to the top
of the clouds.
If this dataset was printed, there
would be enough books to reach
the moon.
7. Implemented by
drive changes in the
composition of the
atmosphere and in the
Earth system
Copernicus monitors how emissions
9. Implemented by
OMM
Facilitating access to climate big
data in order to underpin the growth
in the associated economy.
Innovators and investors are
welcome.