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Health Outcomes Liaisons:
: The New Information Conduits for Showing Value
                    to Payers




             Best Practices, LLC
        Webinar Presentation Highlights
About Our Guest Speaker
 Cameron Tew serves as executive director of research for Best Practices, LLC. He has
 led numerous projects in Medical Affairs, and specifically surrounding MSLs. He
 currently is completing a new project examining how to optimize the management of Key
 Opinion Leaders.

                                                              Client Sectors

                                                                    PHARMA



                                                    MEDICAL
                                                    DEVICES                     BIOTECH


                                                                    GROUP
                                                                   PROBLEM
                                                                   SOLVING


                                                  HOSPITALS                      PAYERS


                                                                   COMMERCIAL
                                                                      & R&D
      E-mail: ctew@best-in-class.com
           Phone 919-767-9246

Copyright © Best Practices, LLC          2
Companies Participating in Study

                                           Benchmark Participants

                                                                                                      Represented
                                                                                                       Industries


                                                                                                      4% 4%




                                                                                                        92%
                                                                                           (n = 23)


                                                                                                      Bio-pharmaceutical
                                                                                                      Medical Device
                                                                                                      Diagnostic




    Amgen, Becton Dickinson, Boehringer Ingelheim, Cubist, Daiichi-Sankyo, Endo Pharmaceuticals, Fresenius, Genentech,
    GlaxoSmithKline, Janssen, Medivation, Merck & Co., Merck Serono, Pacira, Peloton, Sanofi, Sanofi Pasteur, Shire, Teva


Copyright © Best Practices, LLC                              3
Health Outcome Liaisons: Key Recommendations

                                      High-performing HOLs have clinical backgrounds, advanced degrees,
                                       experience in the payer industry, analytics skills and an ability to build and
      Recruit & Retain
                                       maintain lasting customer relationships. Because recruiting and hiring for
       Talented HOLs
                                       this unique skillset is difficult, savvy companies invest in developing and
                                       retaining HOL staff after they are brought on board.

                                      Interviewed executives favor a generalist model, with HOLs typically
                                       covering all major products for an assigned region.
     Adopt a Generalist
        HOL Model
                                      The preference for generalization over specialization by product or
                                       therapeutic area is customer driven, with customers favoring “one stop
                                       shopping” and a single point of contact.

                                      Differentiation falls along the line of emerging value-based decision makers,
                                       though some companies are building hybrid groups
     Differentiate HOLs               Strong business acumen to go with scientific knowledge sets HOLs apart from
                                       other liaisons
                                      HOLs can have greater access to clients at some levels than sales reps or
                                       MSLs because of regulatory concerns
                                      As the field becomes more sophisticated, the pathway toward a highly
                                       developed model based on patient outcomes continues to emerge.
                                       Stakeholders must move along the organizational maturity curve from simple
      Advance Along
                                       cost analysis of one drug vs. another to looking holistically at treatment,
      Maturity Curve
                                       including cost of avoidance, cost of medical vs. surgical approaches, and
                                       patient outcomes.

Copyright © Best Practices, LLC                             4                                 BEST PRACTICES,     ®
                                                                                                                        LLC
HOL Role Impacts Pharma Product & Healthcare System Quality

                                                    HOL Collaboration

                                                  Deliver Outcomes Data

                                        Collect                                 Inform                  Customer/
             Pharma
                                                              HOL                                        Thought
            Company
                                         Inform                               Define Need                 Leader

                                             Deliver Customer Feedback



      Better Products                                                            Better Healthcare Management


  “We provide a translation component—explain why the information matters—when we talk with customers to put actionable
  information into their hands. You have to get this information out there to get feedback on how it resonates and what’s
  important to the customers so that you can improve. Once we get more individuals in these positions and look at it as a
  two-way equation, it’s going to be better for everyone. Because of the value of the information that we bring back, HOLs
  are being given increasing responsibility and internal credibility. As a result, they are involving us more in the decision making
  or strategic planning around products.”                                 -- Interviewed Director


Copyright © Best Practices, LLC                                  5
Presenting Data & Delivering Speeches Are Top HOL Activities

          Q. Please indicate the level of an HOL's time dedicated to each of the following activities.

                                                   Primary HOL Activities
         Activity not performed    Little time spent         Some time spent      Much time spent      Activity is a central
         by HOLs                   on activity               on activity          on activity          focus of HOLs

                                                                                                                               n=
         Presenting                                                                                                            16
                          5% 13%                         13%        13%                       56%
    pharmacoeconomic data
           Delivering                                                                                                          16
                                       6%              25%             19%                       50%
     presentations/speeches
      Identifying and building                                                                                                 16
                                                       38%                     24%                  38%
         KOL relationships
        Advocating for higher
                                                             53%                       21%          13%         13%            15
        reimbursement rates
         Developing scientific
                               5%                            44%                           38%                  13%            16
         collateral/documents

            Training new HOLs          6%              25%                      44%                    19%          6%         16

           Developing product
                                            19%                25%                   31%               19%          6%
                profiles                                                                                                       16

                                                                    % Responses

Copyright © Best Practices, LLC                                   6                                   BEST PRACTICES,          ®
                                                                                                                                    LLC
HOLs Maximize Value by Focusing on Payer Relationships

                   Value Added Proposition: Differentiating By Function and Activity


                  Medical Science Liaisons                    Health Outcome Liaisons
                                                                                                         Lower
          Scientific Value Critical:                  Minor Opportunity for Value:                       HOL
          • Provide medical or clinical information   • Provide health outcomes data to sales reps       Value
                                                                                                         Added
 KOLs




            to physicians                               to share with physicians to inform decisions
          • Help companies understand where           • Ensure delivery of scientifically credible and
            therapeutic guidelines and practices        consistent key value messages to public and
            are headed                                  private segments

          Minor Opportunity for Value                 Greatest Value Proposition for HOLs:
          Proposition:                                • Have most influence with managed care
           • Field based teams charged with             organizations and outcomes-focused KOLs
                                                      • Payers are more in need of clinical
 Payers




             calling on payers to discuss health
             economic potential of company’s            data to inform decisions                         Greater
                                                                                                         HOL
             brands                                   • Develop specific payer communication plans       Value
                                                        for delivering evidence based HEOR               Added




Copyright © Best Practices, LLC                          7                                BEST PRACTICES,    ®
                                                                                                                   LLC
On Average, Face-to-Face Visits Last 30-60 Minutes

  Q. On average, how long does each face-to-face           Q. On average, how long does each face-to-face
          visit with a thought leader last?                  visit with a payer group/representative last?

     Length of Visits with Thought Leaders                      Length of Visits with Payer Group

        Less than                                             Less than
                                   6%                                         0%
        15 minutes                                            15 minutes

              15-30                                                  15-30
                                        18%                                        18%
             minutes                                                minutes

        30 minutes                                            30 minutes
                                                 59%                                         47%
        to an hour                                            to an hour

          More than                                            More than
                                        18%                                              35%
           an hour                                              an hour


                 Other        0%                                      Other   0%


                                   % Responses                                 % Responses

 (n=17)                                                    (n=17)

Copyright © Best Practices, LLC                       8                             BEST PRACTICES,   ®
                                                                                                           LLC
About Best Practices, LLC
  Best Practices, LLC is a research and consulting firm that conducts work based on the
  simple yet profound principle that organizations can chart a course to superior economic
  performance by studying the best business practices, operating tactics, and winning
  strategies of world-class companies.


                                   Best Practices, LLC
                                      6350 Quadrangle Drive, Suite 200,
                                            Chapel Hill, NC 27517
                                           www.best-in-class.com
                                          Telephone: 919-403-0251
                                          best@best-in-class.com




Copyright © Best Practices, LLC                      9
                                                                          BEST PRACTICES,   ®
                                                                                                LLC

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Hol webinar summary

  • 1. Health Outcomes Liaisons: : The New Information Conduits for Showing Value to Payers Best Practices, LLC Webinar Presentation Highlights
  • 2. About Our Guest Speaker Cameron Tew serves as executive director of research for Best Practices, LLC. He has led numerous projects in Medical Affairs, and specifically surrounding MSLs. He currently is completing a new project examining how to optimize the management of Key Opinion Leaders. Client Sectors PHARMA MEDICAL DEVICES BIOTECH GROUP PROBLEM SOLVING HOSPITALS PAYERS COMMERCIAL & R&D E-mail: ctew@best-in-class.com Phone 919-767-9246 Copyright © Best Practices, LLC 2
  • 3. Companies Participating in Study Benchmark Participants Represented Industries 4% 4% 92% (n = 23) Bio-pharmaceutical Medical Device Diagnostic Amgen, Becton Dickinson, Boehringer Ingelheim, Cubist, Daiichi-Sankyo, Endo Pharmaceuticals, Fresenius, Genentech, GlaxoSmithKline, Janssen, Medivation, Merck & Co., Merck Serono, Pacira, Peloton, Sanofi, Sanofi Pasteur, Shire, Teva Copyright © Best Practices, LLC 3
  • 4. Health Outcome Liaisons: Key Recommendations  High-performing HOLs have clinical backgrounds, advanced degrees, experience in the payer industry, analytics skills and an ability to build and Recruit & Retain maintain lasting customer relationships. Because recruiting and hiring for Talented HOLs this unique skillset is difficult, savvy companies invest in developing and retaining HOL staff after they are brought on board.  Interviewed executives favor a generalist model, with HOLs typically covering all major products for an assigned region. Adopt a Generalist HOL Model  The preference for generalization over specialization by product or therapeutic area is customer driven, with customers favoring “one stop shopping” and a single point of contact.  Differentiation falls along the line of emerging value-based decision makers, though some companies are building hybrid groups Differentiate HOLs  Strong business acumen to go with scientific knowledge sets HOLs apart from other liaisons  HOLs can have greater access to clients at some levels than sales reps or MSLs because of regulatory concerns  As the field becomes more sophisticated, the pathway toward a highly developed model based on patient outcomes continues to emerge. Stakeholders must move along the organizational maturity curve from simple Advance Along cost analysis of one drug vs. another to looking holistically at treatment, Maturity Curve including cost of avoidance, cost of medical vs. surgical approaches, and patient outcomes. Copyright © Best Practices, LLC 4 BEST PRACTICES, ® LLC
  • 5. HOL Role Impacts Pharma Product & Healthcare System Quality HOL Collaboration Deliver Outcomes Data Collect Inform Customer/ Pharma HOL Thought Company Inform Define Need Leader Deliver Customer Feedback Better Products Better Healthcare Management “We provide a translation component—explain why the information matters—when we talk with customers to put actionable information into their hands. You have to get this information out there to get feedback on how it resonates and what’s important to the customers so that you can improve. Once we get more individuals in these positions and look at it as a two-way equation, it’s going to be better for everyone. Because of the value of the information that we bring back, HOLs are being given increasing responsibility and internal credibility. As a result, they are involving us more in the decision making or strategic planning around products.” -- Interviewed Director Copyright © Best Practices, LLC 5
  • 6. Presenting Data & Delivering Speeches Are Top HOL Activities Q. Please indicate the level of an HOL's time dedicated to each of the following activities. Primary HOL Activities Activity not performed Little time spent Some time spent Much time spent Activity is a central by HOLs on activity on activity on activity focus of HOLs n= Presenting 16 5% 13% 13% 13% 56% pharmacoeconomic data Delivering 16 6% 25% 19% 50% presentations/speeches Identifying and building 16 38% 24% 38% KOL relationships Advocating for higher 53% 21% 13% 13% 15 reimbursement rates Developing scientific 5% 44% 38% 13% 16 collateral/documents Training new HOLs 6% 25% 44% 19% 6% 16 Developing product 19% 25% 31% 19% 6% profiles 16 % Responses Copyright © Best Practices, LLC 6 BEST PRACTICES, ® LLC
  • 7. HOLs Maximize Value by Focusing on Payer Relationships Value Added Proposition: Differentiating By Function and Activity Medical Science Liaisons Health Outcome Liaisons Lower Scientific Value Critical: Minor Opportunity for Value: HOL • Provide medical or clinical information • Provide health outcomes data to sales reps Value Added KOLs to physicians to share with physicians to inform decisions • Help companies understand where • Ensure delivery of scientifically credible and therapeutic guidelines and practices consistent key value messages to public and are headed private segments Minor Opportunity for Value Greatest Value Proposition for HOLs: Proposition: • Have most influence with managed care • Field based teams charged with organizations and outcomes-focused KOLs • Payers are more in need of clinical Payers calling on payers to discuss health economic potential of company’s data to inform decisions Greater HOL brands • Develop specific payer communication plans Value for delivering evidence based HEOR Added Copyright © Best Practices, LLC 7 BEST PRACTICES, ® LLC
  • 8. On Average, Face-to-Face Visits Last 30-60 Minutes Q. On average, how long does each face-to-face Q. On average, how long does each face-to-face visit with a thought leader last? visit with a payer group/representative last? Length of Visits with Thought Leaders Length of Visits with Payer Group Less than Less than 6% 0% 15 minutes 15 minutes 15-30 15-30 18% 18% minutes minutes 30 minutes 30 minutes 59% 47% to an hour to an hour More than More than 18% 35% an hour an hour Other 0% Other 0% % Responses % Responses (n=17) (n=17) Copyright © Best Practices, LLC 8 BEST PRACTICES, ® LLC
  • 9. About Best Practices, LLC Best Practices, LLC is a research and consulting firm that conducts work based on the simple yet profound principle that organizations can chart a course to superior economic performance by studying the best business practices, operating tactics, and winning strategies of world-class companies. Best Practices, LLC 6350 Quadrangle Drive, Suite 200, Chapel Hill, NC 27517 www.best-in-class.com Telephone: 919-403-0251 best@best-in-class.com Copyright © Best Practices, LLC 9 BEST PRACTICES, ® LLC