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Strategic Pricing & Market Access,
Health Economics & Outcomes Research
               consulting in life sciences
Our company


              Do you want your
              research investment
              to produce great returns?

                    Creative answers to your challenges
      Creativ-Ceutical is an international consulting
                                                                                Market Access is a passage obligé
      firm dedicated to supporting the life science
      industry and health authorities in strategic
      decision making. We provide pricing, market
                                                                          “     to commercial success. Not integrating
                                                                                market access early in development
      access, health economics and outcomes                                     can seriously jeopardize your return
      research services that combine strong technical                           on investment.
      know-how with real strategic expertise.

      We have broad experience in the areas of
                                                                                                    ”
                                                                                Mondher Toumi, MD - PhD
                                                                                Founder & President
      central nervous system, oncology, vaccines
      and rare diseases. These are complex and
      developing fields, where treatment paradigms               Key Strengths to Serve Your Needs
      are in constant evolution and where clinical
      and economic issues require rigorous analysis     Multidisciplinary skills drawn from industry, academia and agencies
      to determine the best choices. With this
                                                        Strong understanding of the European healthcare environment,
      understanding, we can anticipate issues that      with direct access to top-level experts and decision-makers
      will arise in other therapeutic domains, and
                                                        Growing local presence for deep country insight. Offices in
      address even the most difficult challenges.       Luxembourg, France, UK, Denmark, Tunisia.

      The youth and size of our company gives us
      flexibility and encourage innovative thinking,
      while our collective experience gives us the                A Dedicated and Passionate Team
      maturity and perspective to anticipate and
      address the real needs of our customers.          40 employees with top qualifications in statistics,
                                                        health economics, public health, medicine, econometrics
                                                        Published experts, with leading-edge methodology knowledge
                                                        A wealth of experience, gained at major pharmaceutical
                                                        companies and prestigious European institutions
Our services


                How can your new product
                successfully
                access the market?

        Pricing, Reimbursement & Market Access Strategy
      Market access, the “fourth hurdle” in drug
      development, is an inescapable reality for
      pharmaceutical, medical device and biotech
      companies. No company can expect to succeed
                                                                                     “      Early-stage product profiling from a payer
                                                                                            perspective is a key step towards value creation.
                                                                                            It is not enough to show that your product works;
      without designing a pricing and reimbursement                                         payers want to know how well, relative to what
      strategy early in the development process.                                            alternative and all this needs projecting 3-5 years
                                                                                            into the future in a dynamic marketplace.
      To maximize the value of your product, rely on
      our insight and advice from planning to
      execution. We work closely with clients to define                              Adam Plich, MSc
                                                                                                                                               ”
      a clear path to achieve the best market access                                 PMA Director Associate

      conditions, and then deliver the strategic and
      technical services to:

               Perform pricing research among payers                                          Define market entry strategies to optimise
               and stakeholders, including conjoint and                                       reference pricing.
               discrete-choice analysis.                                                      Build the value story for the core value
               Prepare and manage payer discussions at                                        dossier and prepare for HTA.
               national and regional levels.


                                                                Market Access Value Chain©


               Our Market Access Value Chain© identifies the key levers to optimize pricing, reimbursement and access conditions for your product, and
               organizes activities into a coherent, integrated plan.
Our services


               How to best determine
               the value of your drug
               or device in the real world?

                  Health Economics & Outcomes Research
      Health economics addresses issues related
                                                                   It is vital to go beyond discussions of technique, to
      to scarcity in the allocation healthcare resources.
      With limited means, payers must make hard
      choices among multiple, different interventions
                                                             “     consider the true consequences of our research on
                                                                   our clients, on patients and on society in general.
      to make the best use of available funding. In this           Our work definitely has a social dimension.
      context, proving value for money is crucial,
      but the challenges are many. What is the appro-
                                                             Samuel Aballéa, MSc
                                                                                                                              ”
      priate comparator? Across what time-frame?             Health Economics & Outcomes Research Director
      From which perspective? These are just a few
      of the questions we help our clients to address.

      Outcomes research studies the end results of
                                                                                        Our HEOR solutions
      healthcare interventions. With payers looking
      beyond efficacy to real-world effectiveness,
      demonstrating end results is of increasing               Our experts can help you to define and execute health
                                                               economic and outcomes research projects in the following areas:
      importance to our clients.
                                                                   Modelling of cost-effectiveness and budgetary impact analysis
      To demonstrate to payers that your drug or
                                                                   Piggyback analysis alongside clinical trials
      device improves clinical outcomes enough to
                                                                   Patient database analyses, e.g. real-life efficacy, compliance, safety
      justify funding, we align our technical services
      with your strategic needs to ensure that results are         Preference elicitation studies
      of value to your business.                                   Patient-reported outcome studies
                                                                   Epidemiological studies
                                                                   Burden of illness studies
                                                                   Literature reviews
Our services


               How to select the most appropriate
               methods and develop real insight
               that can effectively guide your decisions?

                 Business Intelligence & Market Research
      A product launch plan requires relevant and           Creativ-Ceutical is experienced with these and
      precise information that feeds each strategic         other approaches, and can provide expert
      decision. In today's complex life sciences markets,   guidance for your development and launch
      development decisions require more than simply        plans. Our methods apply to:
      facts and data. Projections using probabilistic
      techniques, simulations, scenario planning and             Forecasting and modelling
      trade-off analysis are all approaches that can             Market value driver identification
      improve decision-making. But how to select the
                                                                 Positioning and messaging research
      most appropriate methods and develop real
      insight that can effectively guide your choices?           Segmentation studies



                        Portfolio Management & Licensing
      Creativ-Ceutical has created a proprietary            separately based on this multidimensional
      portfolio management tool box to address              approach and put in the context of the overall
      this challenge using the most suitable analytic       portfolio and the company strategy. These
      approaches for the decision at hand. We help          instruments are based on a Bayesian stochastic
      our clients identify the right choices at the right   methodology and multi-trait analysis.
      time during the development cycle of a drug.
                                                            Creativ-Ceutical also provides advisory support
      Our portfolio tool enables clients to compute a       in the development of licensing strategies, and
      risk-revenue curve based on a detailed product        can act as a facilitator or as an assessor during
      attribute analysis. Any project can be analysed       due diligence for acquisitions or divestitures.
Luxembourg
                                                        33, boulevard du Prince Henri
                                                                   1724 Luxembourg

                                                                               France
                                                   215, rue du Faubourg Saint-Honoré
                                                                        75008 Paris

                                                                     United Kingdom
                                                               29/30 Windmill Street
                                                                    London W1T 2JL

                                                                              Tunisia
                                                                    Rue du lac Huron
                                                                     Résidence Farah
                                                              1053 Les Berges Du Lac

                                                                          Denmark
                                                                     Fruebjergvej 3
                                                                 2100 København Ø
©2011 Creativ-Ceutical S.A. All Rights Reserved.

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Creativ-Ceutical Corporate Brochure

  • 1. Strategic Pricing & Market Access, Health Economics & Outcomes Research consulting in life sciences
  • 2. Our company Do you want your research investment to produce great returns? Creative answers to your challenges Creativ-Ceutical is an international consulting Market Access is a passage obligé firm dedicated to supporting the life science industry and health authorities in strategic decision making. We provide pricing, market “ to commercial success. Not integrating market access early in development access, health economics and outcomes can seriously jeopardize your return research services that combine strong technical on investment. know-how with real strategic expertise. We have broad experience in the areas of ” Mondher Toumi, MD - PhD Founder & President central nervous system, oncology, vaccines and rare diseases. These are complex and developing fields, where treatment paradigms Key Strengths to Serve Your Needs are in constant evolution and where clinical and economic issues require rigorous analysis Multidisciplinary skills drawn from industry, academia and agencies to determine the best choices. With this Strong understanding of the European healthcare environment, understanding, we can anticipate issues that with direct access to top-level experts and decision-makers will arise in other therapeutic domains, and Growing local presence for deep country insight. Offices in address even the most difficult challenges. Luxembourg, France, UK, Denmark, Tunisia. The youth and size of our company gives us flexibility and encourage innovative thinking, while our collective experience gives us the A Dedicated and Passionate Team maturity and perspective to anticipate and address the real needs of our customers. 40 employees with top qualifications in statistics, health economics, public health, medicine, econometrics Published experts, with leading-edge methodology knowledge A wealth of experience, gained at major pharmaceutical companies and prestigious European institutions
  • 3. Our services How can your new product successfully access the market? Pricing, Reimbursement & Market Access Strategy Market access, the “fourth hurdle” in drug development, is an inescapable reality for pharmaceutical, medical device and biotech companies. No company can expect to succeed “ Early-stage product profiling from a payer perspective is a key step towards value creation. It is not enough to show that your product works; without designing a pricing and reimbursement payers want to know how well, relative to what strategy early in the development process. alternative and all this needs projecting 3-5 years into the future in a dynamic marketplace. To maximize the value of your product, rely on our insight and advice from planning to execution. We work closely with clients to define Adam Plich, MSc ” a clear path to achieve the best market access PMA Director Associate conditions, and then deliver the strategic and technical services to: Perform pricing research among payers Define market entry strategies to optimise and stakeholders, including conjoint and reference pricing. discrete-choice analysis. Build the value story for the core value Prepare and manage payer discussions at dossier and prepare for HTA. national and regional levels. Market Access Value Chain© Our Market Access Value Chain© identifies the key levers to optimize pricing, reimbursement and access conditions for your product, and organizes activities into a coherent, integrated plan.
  • 4. Our services How to best determine the value of your drug or device in the real world? Health Economics & Outcomes Research Health economics addresses issues related It is vital to go beyond discussions of technique, to to scarcity in the allocation healthcare resources. With limited means, payers must make hard choices among multiple, different interventions “ consider the true consequences of our research on our clients, on patients and on society in general. to make the best use of available funding. In this Our work definitely has a social dimension. context, proving value for money is crucial, but the challenges are many. What is the appro- Samuel Aballéa, MSc ” priate comparator? Across what time-frame? Health Economics & Outcomes Research Director From which perspective? These are just a few of the questions we help our clients to address. Outcomes research studies the end results of Our HEOR solutions healthcare interventions. With payers looking beyond efficacy to real-world effectiveness, demonstrating end results is of increasing Our experts can help you to define and execute health economic and outcomes research projects in the following areas: importance to our clients. Modelling of cost-effectiveness and budgetary impact analysis To demonstrate to payers that your drug or Piggyback analysis alongside clinical trials device improves clinical outcomes enough to Patient database analyses, e.g. real-life efficacy, compliance, safety justify funding, we align our technical services with your strategic needs to ensure that results are Preference elicitation studies of value to your business. Patient-reported outcome studies Epidemiological studies Burden of illness studies Literature reviews
  • 5. Our services How to select the most appropriate methods and develop real insight that can effectively guide your decisions? Business Intelligence & Market Research A product launch plan requires relevant and Creativ-Ceutical is experienced with these and precise information that feeds each strategic other approaches, and can provide expert decision. In today's complex life sciences markets, guidance for your development and launch development decisions require more than simply plans. Our methods apply to: facts and data. Projections using probabilistic techniques, simulations, scenario planning and Forecasting and modelling trade-off analysis are all approaches that can Market value driver identification improve decision-making. But how to select the Positioning and messaging research most appropriate methods and develop real insight that can effectively guide your choices? Segmentation studies Portfolio Management & Licensing Creativ-Ceutical has created a proprietary separately based on this multidimensional portfolio management tool box to address approach and put in the context of the overall this challenge using the most suitable analytic portfolio and the company strategy. These approaches for the decision at hand. We help instruments are based on a Bayesian stochastic our clients identify the right choices at the right methodology and multi-trait analysis. time during the development cycle of a drug. Creativ-Ceutical also provides advisory support Our portfolio tool enables clients to compute a in the development of licensing strategies, and risk-revenue curve based on a detailed product can act as a facilitator or as an assessor during attribute analysis. Any project can be analysed due diligence for acquisitions or divestitures.
  • 6. Luxembourg 33, boulevard du Prince Henri 1724 Luxembourg France 215, rue du Faubourg Saint-Honoré 75008 Paris United Kingdom 29/30 Windmill Street London W1T 2JL Tunisia Rue du lac Huron Résidence Farah 1053 Les Berges Du Lac Denmark Fruebjergvej 3 2100 København Ø ©2011 Creativ-Ceutical S.A. All Rights Reserved.