The study assessed the effects of ethanolic extract of Sida acuta leaf on the kidney morphology of Wistar rats. Rats were divided into groups that received either 100mg/kg or 200mg/kg of the extract daily for 14 days or served as the control. Histological analysis found compressed renal corpuscles, increased Bowman's space, and constricted collecting tubules in treated rats, which may negatively impact renal function. The extract also significantly decreased body weight in treated rats compared to controls. This suggests that chronic doses of the Sida acuta extract adversely affected the kidney morphology of rats and may impair renal function. Further studies on physiological and biochemical parameters are needed to corroborate these morphological findings.