This document discusses considerations for performing total hip arthroplasty in patients with sickle cell disease. Key points include that these patients are at high risk for infection, osteonecrosis of the femoral head, and marrow hyperplasia leading to thin cortices and enlarged medullary canals. The surgery requires special attention to bleeding risks, bone quality issues, and prevention of post-operative sickle cell crises or infections. While THA can relieve pain, these patients remain at risk for long-term complications.