Hepatoma disease, also known as liver cancer, affects rainbow trout. It is caused by the deposition of aflatoxin in the liver from the fungus Aspergillus flavus. Trout fed commercial feeds containing oil or aflatoxin-contaminated cottonseed meal are more susceptible. Symptoms do not usually appear until the disease is advanced, with liver discoloration and nodules. Control measures include using aflatoxin-free fish feed stored in dry, ventilated conditions and destroying contaminated stocks.