Circulation is a digital health company that coordinates non-emergency medical transportation (NEMT) for patients through partnerships with transportation companies like Uber and Lyft. By streamlining NEMT, Circulation has helped reduce no-show rates for medical appointments from 20-25% industry average to only 8% for partner hospitals. Circulation also saves those hospitals up to 70% on transportation costs and ensures 95% of patients arrive on time for their appointments. The company works with over 1000 health facilities across 44 US states.
HealthXL: How Artificial Intelligence (AI) Can Improve Research & Care Models...Maeve Lyons
Artificial Intelligence in Pharma and Care Delivery Delivering on the Promise.
Earlier this week we published a blog about the state of AI in pharma and care delivery, and we also mentioned we’d be launching an accompanying report. We’re happy share our initial report presentation as part of HealthXL’s Big Data & AI Working Group above.
In the future, HealthXL’s Working Group will go deeper into use cases and discuss other relevant industry topics such as best practices for acquiring quality data, regulatory guidelines for AI solutions, leading academic centers, and much more!
https://healthxl.co/report-artificial-intelligence-pharma-care-delivery-delivering-promise/
There is increasing awareness that seniors represent a diverse group ranging in age, ability, and needs. As a result, senior care solutions are not “one size fits all” – an important lesson as innovators aim to scale solutions. Solutions geared towards seniors must be easy-to-use and solve a specific problem. This helps ensure technology actually improves quality of life and wellbeing, and does not become a nuisance. Ideally, developing senior care solutions should involve various stakeholders including clinicians, designers, and seniors themselves. Mass market products aimed at improving convenience and livability (e.g., Blue Apron, Amazon’s Alexa) have the opportunity to enable independent living. However, large companies need to better market their products to seniors and their caregivers. Venture capitalists are realizing that seniors represent a significant opportunity, but usually tend to invest in solutions that have a broader impact across any one single population or disease state (with some exception).
Rock Report: Personalization in Consumer Health by @Rock_HealthRock Health
Overview of personalization in healthcare, including opportunities, barriers and case studies related to a market estimated to reach $450B+ by 2015. Purchase the report here: https://gumroad.com/l/XxcA
Q3 2012 Digital Health Funding Report by @Rock_HealthRock Health
Highlights:
- The number of digital health deals has increased 82% from this time last year
- The total amount of investment has increased 70% from this time last year
10% of digital health investors this year are new to healthcare
Digital Health Funding 2013 Year in Review by @Rock_HealthRock Health
A summary of the companies, investors and themes that drove digital health funding to a record $1.97B in 2013. Includes details on crowdfunding, exits, and digital health in the public markets. Purchase this report here: https://gumroad.com/l/tZYVH
2013 Midyear Digital Health Funding by @Rock_HealthRock Health
A review of venture capital funding of digital health companies in 2013, totaling $849M through June (Q2). This report covers the major companies, investors and trends in digital health that are emerging in 2013. Purchase this report here: https://gumroad.com/l/TgefY
A look at the key trends and challenges in applying Big Data to transform healthcare by supporting research, self care, providers and building ecosystems. Purchase the report here: https://gumroad.com/l/PlXP
HealthXL: How Artificial Intelligence (AI) Can Improve Research & Care Models...Maeve Lyons
Artificial Intelligence in Pharma and Care Delivery Delivering on the Promise.
Earlier this week we published a blog about the state of AI in pharma and care delivery, and we also mentioned we’d be launching an accompanying report. We’re happy share our initial report presentation as part of HealthXL’s Big Data & AI Working Group above.
In the future, HealthXL’s Working Group will go deeper into use cases and discuss other relevant industry topics such as best practices for acquiring quality data, regulatory guidelines for AI solutions, leading academic centers, and much more!
https://healthxl.co/report-artificial-intelligence-pharma-care-delivery-delivering-promise/
There is increasing awareness that seniors represent a diverse group ranging in age, ability, and needs. As a result, senior care solutions are not “one size fits all” – an important lesson as innovators aim to scale solutions. Solutions geared towards seniors must be easy-to-use and solve a specific problem. This helps ensure technology actually improves quality of life and wellbeing, and does not become a nuisance. Ideally, developing senior care solutions should involve various stakeholders including clinicians, designers, and seniors themselves. Mass market products aimed at improving convenience and livability (e.g., Blue Apron, Amazon’s Alexa) have the opportunity to enable independent living. However, large companies need to better market their products to seniors and their caregivers. Venture capitalists are realizing that seniors represent a significant opportunity, but usually tend to invest in solutions that have a broader impact across any one single population or disease state (with some exception).
Rock Report: Personalization in Consumer Health by @Rock_HealthRock Health
Overview of personalization in healthcare, including opportunities, barriers and case studies related to a market estimated to reach $450B+ by 2015. Purchase the report here: https://gumroad.com/l/XxcA
Q3 2012 Digital Health Funding Report by @Rock_HealthRock Health
Highlights:
- The number of digital health deals has increased 82% from this time last year
- The total amount of investment has increased 70% from this time last year
10% of digital health investors this year are new to healthcare
Digital Health Funding 2013 Year in Review by @Rock_HealthRock Health
A summary of the companies, investors and themes that drove digital health funding to a record $1.97B in 2013. Includes details on crowdfunding, exits, and digital health in the public markets. Purchase this report here: https://gumroad.com/l/tZYVH
2013 Midyear Digital Health Funding by @Rock_HealthRock Health
A review of venture capital funding of digital health companies in 2013, totaling $849M through June (Q2). This report covers the major companies, investors and trends in digital health that are emerging in 2013. Purchase this report here: https://gumroad.com/l/TgefY
A look at the key trends and challenges in applying Big Data to transform healthcare by supporting research, self care, providers and building ecosystems. Purchase the report here: https://gumroad.com/l/PlXP
9 Actionable Healthcare Tweets from HIMSS 2015Buddy Scalera
9 tweets and action items for healthcare marketers and content strategists, as developed by Marilyn Cox @MarilynECox (Oracle) and Buddy Scalera @MarketingBuddy.
Be sure to visit: http://www.slideshare.net/americanregistry
In a new report, SVB Analytics examines the challenges facing stakeholders in the U.S. healthcare system, the solutions made possible by technology advancements and opportunities for entrepreneurs and investors.
Learn more here: http://www.svb.com/Blogs/Alex_Lee/Digital_Health__Mapping_Digital_Health_Solutions/
New AI innovations bring the healthcare sector to a CAGR of 54.5% by 2025 Bella Harris
The healthcare sector explores AI with innovations focusing on improved treatments. With this, AI in the healthcare industry is anticipated to grow with a healthy CAGR of more than 54.5% by 2025.
Rock Report: Fitness Technology for Athletes by @Rock_HealthRock Health
Point of view on how apps and sensors are transforming fitness and athletics, from the perspective of experts, including Olympians, coaches and entrepreneurs. Purchase the report here: https://gumroad.com/l/BTnV
This presentation offers an overview of the Digital Health space, including thematic investment areas, business models, metrics for evaluation, and adoption models for digital health interventions.
The Entrepreneur's Guide to Hospital Partnerships by @Rock_HealthRock Health
A living document and initial guide for entrepreneurs as they navigate partnering with health providers, initially compiled after 22 interviews with entrepreneurs, hospital administrators, investors, lawyers, clinicians and researchers. Purchase the report here: https://gumroad.com/l/qgUT
- HealthTech innovation is disrupting healthcare and its established players
- Technology is driving a new paradigm to create better health care
- Developing markets can leapfrog their healthcare infrastructure limitations
- New opportunities are opening to shape the new paradigm
How Big Data, Smart Devices and Wearables Will Save Lives: Revealing the Emer...Enspektos, LLC
Big Data, mobile, sensors and human experts are being combined to develop next-generation wellness solutions that may help us win the war against diseases like heart disease that are caused by poor health habits. Read this introduction to the emerging TechnoWellness revolution and how it could save lives.
Future of patient data global summary - 29 may 2018Future Agenda
We are witnessing a growing revolution around the provision of healthcare. Much is being driven by the proliferation of medical data and the technology that supports this. As the pressures on healthcare providers continue to escalate, the better collection, management and use of more patient-specific information provides a significant opportunity for innovation and change. The Future Agenda team made this, the Future of Patient Data, the focus of our major Open Foresight project for 2017/18 – 12 discussions across 11 countries, gathering views from over 300 experts.
This report shares the findings from the Future of Patient Data research project. It highlights several important emerging issues that are the source of major differences of opinion around the world. These include how to best accommodate rising data sovereignty concerns, the privatisation of health information and the growing value of health data. Some of the challenges and opportunities are technical in nature, but many are concerned with different ethical, philosophical and cultural approaches to health and how we treat the sick in society.
To access the full report please see https://www.futureofpatientdata.org
How do we see the healthcare's digital future and its impact on our lives?Jane Vita
"Healthcare is undergoing major changes spurred on by, but not limited to, technology.
Digitalisation is changing the way we think about health, what taking care of it really entails, our personal role in healthcare systems and the way we interact with technology in the context of health.
In many ways, we are entering a post-institutional age of increased personal responsibility, which presents healthcare service providers and other players in the field with major opportunities and great risks. Technology has the potential to empower people and help them become more active in the management of their and their families’ health. This will change the relationship of the patient and the caregiver in profound ways." Mirkka Länsisalo
A co-creation with Mirkka Läansisalo and Sala Heinänen, at Futurice.
'The Digital Healthcare Leap' highlights insights into how digital health could be an answer to the emerging markets’ challenge to achieve sustainable growth; and leapfrog the developed nations to provide quality, affordable, universal and patient-centric care.
With increased internet and smartphone penetration, and the arrival of new affordable technological solutions in the market, digital healthcare will eventually become a fundamental business imperative. The challenge to healthcare providers for the future, is to adapt and set strategies that leverage new technology while putting patients at the heart of everything they do.
Rock Report: Smart Seating - Opportunities at the intersection of automotive ...Rock Health
This report explores existing and potential opportunities that can improve health by utilizing new advances in automotive technologies, including incorporation of biosensors. Purchase the report here: https://gumroad.com/l/YEXX
The 10 most innovative companies bringing ai to healthcare optimizeinsightscare
In this issue of “The 10 Most Innovative Companies Bringing AI to Healthcare”, we have highlighted some of the renowned organizations from all over the globe
Insights Success is The Best Business Magazine in the world for enterprises.It is being a best platform, to growing healthcare solutions provider companies in 2017.
Digital Health Success Stories Report - Part 1Tom Parsons
Part 1 of HealthXL’s ‘Digital Health Success Stories’ report is now available and delves into some of the recent successes in healthcare technology and asks the experts what it all means.
TechTalks | Digital Transformation in Healthcare: Opportunities and Trendsrmcsoft
Of all the industries out there, healthcare has perhaps the most to gain from digital transformation. Technology can decrease wait times, reduce medical errors and increase collaboration across providers — all of which helps people find their way to better health and healthcare businesses achieve a better bottom line.
The problem is, healthcare has struggled more than pretty much any other industry out there to keep up with the times. Why is that? How do we buck the trend and begin to embrace the tremendous opportunity of digital transformation in healthcare? And who out there is already doing it really, really well?
RMCSoft and Advent Coworking brought together a panel of experts to dig into all of that at their TechTalks event on Tuesday, Jan. 22.
This fascinating conversation highlighted not only the challenges facing health care in the digital age, but also ideas and vision for a path forward.
About TechTalks: TechTalks series is a chance for you to improve your knowledge regarding new technology and technology-related issues. Brought by RMCSoft and Advent Coworking, TechTalks target tech startups as well as all other companies utilizing software & digital products in their day-to-day operations.
We cover a wide variety of tech-related topics, offer valuable insights on the best practices, discuss the most common issues, review the tech trends and provide plenty of opportunities to enhance your tech knowledge.
For more information, please write back to us at info@rmcsoft.com
Our analysis regarding the evolution of what we believe is the development of the Healthcare Cloud. We discuss the siloed nature of HCIT in terms of legacy and cloud and discuss how we believe entities need to shift from point to platform solutions over time. We also lay out the fundamental underpinnings of what makes a compelling digital healthcare investment.
The 10 Leading Patient Engagement Solution Providers in 2018insightscare
There are a few contributors in the industry aiding to take this concept further and to help the care givers to adopt and apply it. To acknowledge the good work of these business giants, we bring to you our special edition of “The 10 Leading Patient Engagement Solution Providers in 2018”.
9 Actionable Healthcare Tweets from HIMSS 2015Buddy Scalera
9 tweets and action items for healthcare marketers and content strategists, as developed by Marilyn Cox @MarilynECox (Oracle) and Buddy Scalera @MarketingBuddy.
Be sure to visit: http://www.slideshare.net/americanregistry
In a new report, SVB Analytics examines the challenges facing stakeholders in the U.S. healthcare system, the solutions made possible by technology advancements and opportunities for entrepreneurs and investors.
Learn more here: http://www.svb.com/Blogs/Alex_Lee/Digital_Health__Mapping_Digital_Health_Solutions/
New AI innovations bring the healthcare sector to a CAGR of 54.5% by 2025 Bella Harris
The healthcare sector explores AI with innovations focusing on improved treatments. With this, AI in the healthcare industry is anticipated to grow with a healthy CAGR of more than 54.5% by 2025.
Rock Report: Fitness Technology for Athletes by @Rock_HealthRock Health
Point of view on how apps and sensors are transforming fitness and athletics, from the perspective of experts, including Olympians, coaches and entrepreneurs. Purchase the report here: https://gumroad.com/l/BTnV
This presentation offers an overview of the Digital Health space, including thematic investment areas, business models, metrics for evaluation, and adoption models for digital health interventions.
The Entrepreneur's Guide to Hospital Partnerships by @Rock_HealthRock Health
A living document and initial guide for entrepreneurs as they navigate partnering with health providers, initially compiled after 22 interviews with entrepreneurs, hospital administrators, investors, lawyers, clinicians and researchers. Purchase the report here: https://gumroad.com/l/qgUT
- HealthTech innovation is disrupting healthcare and its established players
- Technology is driving a new paradigm to create better health care
- Developing markets can leapfrog their healthcare infrastructure limitations
- New opportunities are opening to shape the new paradigm
How Big Data, Smart Devices and Wearables Will Save Lives: Revealing the Emer...Enspektos, LLC
Big Data, mobile, sensors and human experts are being combined to develop next-generation wellness solutions that may help us win the war against diseases like heart disease that are caused by poor health habits. Read this introduction to the emerging TechnoWellness revolution and how it could save lives.
Future of patient data global summary - 29 may 2018Future Agenda
We are witnessing a growing revolution around the provision of healthcare. Much is being driven by the proliferation of medical data and the technology that supports this. As the pressures on healthcare providers continue to escalate, the better collection, management and use of more patient-specific information provides a significant opportunity for innovation and change. The Future Agenda team made this, the Future of Patient Data, the focus of our major Open Foresight project for 2017/18 – 12 discussions across 11 countries, gathering views from over 300 experts.
This report shares the findings from the Future of Patient Data research project. It highlights several important emerging issues that are the source of major differences of opinion around the world. These include how to best accommodate rising data sovereignty concerns, the privatisation of health information and the growing value of health data. Some of the challenges and opportunities are technical in nature, but many are concerned with different ethical, philosophical and cultural approaches to health and how we treat the sick in society.
To access the full report please see https://www.futureofpatientdata.org
How do we see the healthcare's digital future and its impact on our lives?Jane Vita
"Healthcare is undergoing major changes spurred on by, but not limited to, technology.
Digitalisation is changing the way we think about health, what taking care of it really entails, our personal role in healthcare systems and the way we interact with technology in the context of health.
In many ways, we are entering a post-institutional age of increased personal responsibility, which presents healthcare service providers and other players in the field with major opportunities and great risks. Technology has the potential to empower people and help them become more active in the management of their and their families’ health. This will change the relationship of the patient and the caregiver in profound ways." Mirkka Länsisalo
A co-creation with Mirkka Läansisalo and Sala Heinänen, at Futurice.
'The Digital Healthcare Leap' highlights insights into how digital health could be an answer to the emerging markets’ challenge to achieve sustainable growth; and leapfrog the developed nations to provide quality, affordable, universal and patient-centric care.
With increased internet and smartphone penetration, and the arrival of new affordable technological solutions in the market, digital healthcare will eventually become a fundamental business imperative. The challenge to healthcare providers for the future, is to adapt and set strategies that leverage new technology while putting patients at the heart of everything they do.
Rock Report: Smart Seating - Opportunities at the intersection of automotive ...Rock Health
This report explores existing and potential opportunities that can improve health by utilizing new advances in automotive technologies, including incorporation of biosensors. Purchase the report here: https://gumroad.com/l/YEXX
The 10 most innovative companies bringing ai to healthcare optimizeinsightscare
In this issue of “The 10 Most Innovative Companies Bringing AI to Healthcare”, we have highlighted some of the renowned organizations from all over the globe
Insights Success is The Best Business Magazine in the world for enterprises.It is being a best platform, to growing healthcare solutions provider companies in 2017.
Digital Health Success Stories Report - Part 1Tom Parsons
Part 1 of HealthXL’s ‘Digital Health Success Stories’ report is now available and delves into some of the recent successes in healthcare technology and asks the experts what it all means.
TechTalks | Digital Transformation in Healthcare: Opportunities and Trendsrmcsoft
Of all the industries out there, healthcare has perhaps the most to gain from digital transformation. Technology can decrease wait times, reduce medical errors and increase collaboration across providers — all of which helps people find their way to better health and healthcare businesses achieve a better bottom line.
The problem is, healthcare has struggled more than pretty much any other industry out there to keep up with the times. Why is that? How do we buck the trend and begin to embrace the tremendous opportunity of digital transformation in healthcare? And who out there is already doing it really, really well?
RMCSoft and Advent Coworking brought together a panel of experts to dig into all of that at their TechTalks event on Tuesday, Jan. 22.
This fascinating conversation highlighted not only the challenges facing health care in the digital age, but also ideas and vision for a path forward.
About TechTalks: TechTalks series is a chance for you to improve your knowledge regarding new technology and technology-related issues. Brought by RMCSoft and Advent Coworking, TechTalks target tech startups as well as all other companies utilizing software & digital products in their day-to-day operations.
We cover a wide variety of tech-related topics, offer valuable insights on the best practices, discuss the most common issues, review the tech trends and provide plenty of opportunities to enhance your tech knowledge.
For more information, please write back to us at info@rmcsoft.com
Our analysis regarding the evolution of what we believe is the development of the Healthcare Cloud. We discuss the siloed nature of HCIT in terms of legacy and cloud and discuss how we believe entities need to shift from point to platform solutions over time. We also lay out the fundamental underpinnings of what makes a compelling digital healthcare investment.
The 10 Leading Patient Engagement Solution Providers in 2018insightscare
There are a few contributors in the industry aiding to take this concept further and to help the care givers to adopt and apply it. To acknowledge the good work of these business giants, we bring to you our special edition of “The 10 Leading Patient Engagement Solution Providers in 2018”.
The 20 most disruptive healthcare solution providers 2018insightscare
With an idea to acknowledge the fast-growing companies, contributing extraordinarily to the revolution of disruption in healthcare, we bring to you the special edition of “The 20 Most Disruptive Healthcare Solution Providers 2018”.
Innovating for health mObile Health perspectiveRuchi Dass
In the face of the enormous challenges of managing chronic diseases, delivery innovations appear to have the most impact when multiple parties (e.g., physicians, nurses, payors) interact seamlessly to provide the best possible patient care over an extended period of time. Such integrated models have the potential to reduce costs dramatically, while increasing patient satisfaction and clinical quality
Startup Health creert een eigen categorie business incubators. In 10 jaar tijd wil zij 1.000 startup wereldwijd verbinden aan de uitdaging om de gezondheidszorg dramatisch te vernieuwen. Een waar 'Global Entrepreneurship' aanpak, die het ambitieniveau van Amerikaanse ondernemers weergeeft.
The 10 leading patient engagement solution providers in 2018insightscare
There are a few contributors in the industry aiding to take this concept further and to help the care givers to adopt and apply it. To acknowledge the good work of these business giants, we bring to you our special edition of “The 10 Leading Patient Engagement Solution Providers in 2018”.
The 20 most disruptive healthcare solution providers 2018 convertedinsightscare
With an idea to acknowledge the fast-growing companies, contributing extraordinarily to the revolution of disruption in healthcare, we bring to you the special edition of “The 20 Most Disruptive Healthcare Solution Providers 2018”.
In the latest issue of HealthCare Everything, ‘10 Best Companies in Digital Therapeutics Market 2023,’ We explore Best Companies in the Digital Therapeutics Market.
The 10 companies booming in healthcare sector smallinsightscare
Development is a continuous process in any sector. It brings in more comfort, more precision, and more enhanced way of living.Acknowledging the remarkable contribution of the leading companies in the care sector, we bring to you the special issue of “The 10 Companies Booming in Healthcare Sector”.
Healthcare Everything’s latest edition “10 Most Trusted Healthcare Consulting Firms” have shortlisted a few healthcare consulting firms that are pivotal in driving positive change and innovation within the healthcare industry.
mHealth Israel_GEARING COMMUNICATIONS TO RAISE CAPITAL AND ATTRACT CUSTOMERS_...Levi Shapiro
Presentation by Gil Bashe, Managing Director, Healthcare Practice, Finn Partners: "GEARING COMMUNICATIONS TO RAISE CAPITAL AND ATTRACT CUSTOMERS- FROM PLAN TO PARTNERS TO PATIENTS". Includes tips to avoid failure by embracing complexity, description of the Health Ecosystem Landscape, developing a plan to impact care, cost and outcomes, overview of the US Payer market, and top digital health influencers.
The 10 Best Revenue Cycle Management Solution Providers 2018insightscare
In a pursuit to acknowledge the revolution some of these companies are bringing to the existing revenue cycle segment in healthcare, we bring to you the special edition, titled “The 10 Best Revenue Cycle Management Solution Providers 2018”. It highlights the pioneers in this industry as well as their contribution to augment the existing workflow.
10 Best Healthcare Solution Companies in 2022.pdfinsightscare
Enabling a plethora of such exemplary traits and combining them with innovative solutions, Insights Care features the “10 Best Healthcare Solution Companies in 2022” that are transforming the healthcare niche and reshaping the future of healthcare delivery with a novel approach.
Insighs Success has curated a list of The 10 Most Innovative Healthcare Solution Providers 2018 which are reforming the benchmarks of Healthcare with their ground-breaking innovation and real-time assistance.
The 10 Companies Booming in Healthcare Sectorinsightscare
Acknowledging the remarkable contribution of the leading companies in the care sector, we bring to you the special issue of “The 10 Companies Booming in Healthcare Sector”. This edition portrays the inspiring stories of the listed pre-eminent organizations that are shaping the future of healthcare through innovation and dedication.
Top 5 Emerging Patient Monitoring Solution Providers in Healthcare.pdfinsightscare
In this edition of Insights Care, Top 5 Emerging Patient Monitoring Solution Providers in Healthcare, you will discover 5 Emerging Patient Monitoring Solution Providers in Healthcare
In this edition of Insights Care, Top 5 Emerging Patient Monitoring Solution Providers in Healthcare, you will discover 5 Emerging Patient Monitoring Solution Providers in Healthcare
Similar to HealthXL Digital Health Success Stories Report Part One (20)
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
HealthXL Digital Health Success Stories Report Part One
1. Connecting The Dots To Promote Health Innovation
HealthXL | December 2017
1
Digital Health Success
Stories (and Failures)
2. About HealthXL:
The Leading
Platform For
Collaboration
The HealthXL Community brings together
key market stakeholders in digital health
and empowers them to collaborate and
learn from each other.
(see list of some of our members on the
right).
2
3. CONTENTS
3
Navigating the Space
Success Stories
Fail Better
Expert Perspectives
What Next?
Section 1:
Section 2:
Section 3:
Section 4:
Section 5:
Hanna Phelan
Head of Clinical Engagement
Dr Chandana Fitzgerald
Medical Lead
Michael Garrow
Head of Innovator Relations
6. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
MANAGING DIRECTOR
GE VENTURES
Lisa Suennen
Lisa Suennen is Managing Director
at GE Ventures focused on early-late
stage healthcare investments
across health IT, health services and
medical devices. Lisa also leads
Venture Valkyrie LLC, a publishing
and business advisory firm and is a
founder of CSweetener, a not-for-
profit company focused on
matching women in and nearing
the healthcare C-Suite with mentors
who have been there and wish to
give back. Lisa is a member of the
faculty at the UC Berkeley Haas
School of Business, where she
teaches classes on venture capital
and the changing healthcare
economy.
6
“Digital health success cannot be defined by investment statistics. It
must be measured by the impact of these products and services on people –
the patients and providers and scientists using them to make material
changes in the healthcare system.
We must see evidence of efficacy, both clinical and financial, in order to
declare a company a possible success. And in the end, these companies will
have to produce material returns for their investors - given the amount of
money that has poured into the sector, we have yet to see more than
handful of superior financial outcomes.
It’s still early in the marketplace, but aspiring healthcare players need to
play the healthcare game, meaning evidence to justify adoption,
reimbursement and sustainable long-term business success.
We will know we have succeeded when we stop talking about “digital”
health and start talking about solutions that payers, providers, and
patients can’t live without. Digital should not be a novelty, but a feature of
a solution, as it has become in other industries.”
EXPERT PERSPECTIVE
7. Overview
DIFFERING VISIONS OF SUCCESS
The ‘digital health’ arena has
brought together a multitude of
stakeholders, from healthcare
systems to pharmaceutical
companies and start-ups. It’s no
secret that success looks very
different to each of these
players.
This report provides a bird's-eye view
of key digital health successes to
date, along with a selection of case
studies, companies and thought-
leaders who have been involved in
moving the needle so far - closely
considering reference points from
the availability of scientific backing
to engagement in commercial and
research partnerships, investment
and adoption.
THERE IS NO SILVER BULLET
If you’re looking for a quick fix look
away now. There is no one silver
bullet or success story that is
replicable but it is possible to identify
multiple common threads that will
help the community deliver the
improved health outcomes and
reduced costs that the digital
healthcare revolution has the
potential to deliver.
7
NAVIGATING KEY INDICATORS
8. ● 2001 Proteus Digital Health Solutions Founded
● 2002 Kaiser Selects EPIC for HealthConnect
● 2002 Cygnus launches the GlucoWatch and
continuous, non-invasive digital glucose
monitoring becomes commercially available
● 2004 First eHealth action plan launched by
the EU Member States
● 2004 Khosla Ventures founded. Joins NEA,
Sequoia Capital, Venrock and others as active
in the digital healthcare space
● 2005 WellDoc founded
● 2005 PatientsLikeMe Founded
● 2006 Outcome Health Founded
● 2006 23andMe Founded
● 2007 Fitbit Founded
● 2009 US adopts the HITECH (Health
Information Technology for Economic
and Clinical Health) Act
● 2010 HistoRx launches the first
commercial automated quantitative
tissue pathology analysis software
algorithm for cancer assessment
● 2014 Venture capital investments in
digital health start-ups exceed $3
billion
● 2014 The UK publishes Personalized
Health and Care 2020 outlining a new
national health data strategy
● 2015 IBM Watson Health Cloud
Launched
● 2015 37 acquisitions including
Fossil Group acquisition of Misfit
for $260 million and IBM buys
Explory’s and Merge
● 2016 HoloLens, Microsoft’s
augmented reality (AR) viewer
went on sale for developers
● 2016 Theranos Scandal
● 2016 Foundation Medicine First
FDA-Approved Companion
Diagnostic
Digital Health Activity Timeline Highlights: 2001-2016
9. And then there was 2017 and its Milestones
OCTOBER 2017MARCH 2017 NOVEMBER 2017
$$$$$
By the first half of 2017 over
$3.5B had been invested in
188 digital health companies
- a new record in terms of
number of companies
funded and total amount
invested.
The Food and Drug Administration
(FDA) approves the first ever digital
drug-tracking tool hybrid for the U.S.
market - Otsuka Pharmaceutical Co
Ltd’s Abilify MyCite powered by
Proteus Digital Health. Coined as
opportunity to address $300B in
wasted medical spend.
So what have we achieved and what can we learn?
SOURCE: http://bit.ly/2tG6o3L
SOURCE: http://for.tn/2zFl34u
The one that really caused shockwaves. In October Amazon announced its
potential disruption of the pharmaceutical industry by selling prescription
drugs online.
Following this CVS, the largest pharmacy chain in the U.S., reached a deal
to buy insurance giant Aetna for $69 billion.
Another step towards democratized healthcare? Or just more cash plays?
SOURCE: http://bit.ly/2AD8B3r
11. Core Themes of Digital Health Success Stories
Evidence-Based Advances
With thousands of digital health solutions
on the market, clinical and economic
proof is vital for companies to prove
validity and efficacy.
Purpose-Built Business Models
Innovative business models are going outside
of the norm to penetrate a tightly-regulated
healthcare industry to produce real outcomes
and provide precedent for future disruptors
looking for guidance.
Widespread Adoption
Are we too quick to term a solution being
‘adopted’ a success? There is still only a
small handful of digital health companies
that are making an impact worldwide.
Notable Acquisitions
The increasing pace of mergers and
acquisitions in digital health signal the
growing maturity of the space and the
opportunity for success that lies ahead
given the involvement of key industry
players.
Acquisition
WidespreadAdoption
PurposeBuiltBusiness
Models
Evidence of Efficacy
MARKERS FOR DIGITAL
HEALTH SUCCESS
12. The Rising Success of Evidence-Based Solutions
Why is this a success? The world's
first FDA-cleared EKG with artificial
intelligence for Apple Watch
Research Partnerships:
● Heart Rhythm Society
Clinical Trials:
● iPhone Helping Evaluate Atrial
Fibrillation Rhythm Through
Technology (iHEART)
Publications
● Detection of Recurrent Atrial
Fibrillation Utilizing Novel
Technology
Why is this a success?
Proven clinical outcomes and cost-reduction
through online behaviour change plans.
Partnerships:
● Aetna
● BlueCross BlueShield
● Premera
● Horizon
Publications:
● A Tele-Behavioral Health Intervention to
Reduce Depression, Anxiety, and Stress
and Improve Diabetes Self-Management
● Leveraging remote behavioral health
interventions to improve medical
outcomes and reduce costs
See More Evidence Based HealthXL Verified Companies Here
Why is this a success?
Delivering an outcome-based health program to
prevent the further development of chronic
disease.
Research Partnerships:
● American Medical Association
● Intermountain Health
● Kaiser Permanente
● Blue Cross Blue Shield of Louisiana
Clinical Trials:
● Preventing Diabetes With Digital Health
and Coaching (PREDICTS)
Publications:
● Long-term outcomes of a Web-based
diabetes prevention program: 2-year
results of a single-arm longitudinal study.
13. FOUNDER & CEO
Brenda Schmidt
13
“As a preventive benefits manager, Solera Health works closely with its network of digital
solution providers to increase enrollment and sustainable revenue through Solera’s
health plan and employer contracts. Solera’s business model was purpose-designed to
help digital therapeutics providers gain access to qualified patients, enhance
engagement by matching patients to specific programs, and facilitating payments for
sustained engagement and outcomes. For digital providers, they can access the
appropriate patients for a low acquisition cost without the long lead time to contract with
a payer.
For payers, health plans and employers contract with Solera to access a dynamic national
network of high-performing digital solution providers that offer a variety of options for
diverse populations. Solera’s approach of matching patients with the digital program
provider that meets their unique needs and preferences drives industry leading
sustained engagement and outcomes. Solera monitors and benchmarks satisfaction
and quality metrics and is only paid for performance. Solera’s unique model aligns
incentives between the payer and digital provider and increases the likelihood of success
for the digital providers in their network. We have enrolled tens of thousands of
patients in digital programs that are improving patient health.”
Purpose-Built Business Models
14. Company Acquisitions
Funding
Round
Amount Date Approximate
Investor ROI
Seed $750k Nov 2011 >25x
Series A $7.6m April 2012 >3x
Series B $15.2m Dec 2013 >2x
Series C $40m Dec 2014 >1x
Total
Raised
$63.5 m Acquired Nov
2015
$260m
Funding
Round
Amount Date Approximate
Investor ROI
Angel $450k Jan 2012 >15x
Seed $1m March 2014 >12x
Series A $4.8m March 2015 5x
Total
Raised
$6.2 m Acquired
Jun 2017
$74m
Funding
Round
Amount Date Approximat
e
Investor
ROI
Seed $1m Feb 2015 >65x
Total
Raised
$1m Acquired
Aug 2016
$200m
Notable Company Acquisitions
SOURCE: crunchbase.com
All investments performed whereby the earliest investors got a higher percentage return for their risk, whilst the later investments had a lower percentage
return, but the highest absolute return, with a relatively short period between investment and exit.
15. Fitbit and MyFitnessPal have both respectively
opened up an arena for wearables to be adopted at
mass.
In Q4 2015, Fitbit reported revenue of nearly $700
million, and 8.2 million devices shipped. They have
seen a sharp drop in both earnings and devices
shipped as Q3 2017 earnings are reported at just $400
million with 3.6 million devices shipped.
Under Armour’s acquisition of MapMyFitness,
EndoMondo and MyFitnessPal has made them the
largest digital health and fitness community in the
world. According to Under Armour's CTO Paul Fipps
215 million people have downloaded one of the 3 apps.
These two companies are examples of the new
school and old school healthcare disruptors that set
out to put health information in the laps of
consumers.
With more than 2 million customers, 23andme hold the
largest collection of gene-linked data in the world. After a
recent funding round of $250 million, the company eying
to expand it’s customer base to 10 million people.
Founded in 1996, WebMD has answered health related
questions for consumers and medical professionals
years. In 2016 they attracted more than 70 million
monthly unique users. KKR acquired WebMD in July
2017 for a deal valued at roughly $2.8 billion.
Widespread Adoption
SOURCE:
16. CASESTUDY-BOSTONCHILDREN'S
HOSPITAL:CIRCULATION
16
The Problem
Each year, ~3.6 million patients across the USA miss at least one
medical appointment due to lack of access to transportation. This
trend has been reported for over a decade, as research from the
Transportation Research Board reports similar figures from 2005.
To date, non-emergency medical transportation (NEMT) has been
coordinated through a variety of parties, such as transportation brokers,
managed care benefits, and non-preauthorized contractors.
Each of these systems operate on a state-by-state basis, with non-
preauthorized contractors able to rely on ‘volunteer drivers’ as sufficient
means for non-emergency medical transportation. As a result, NEMT
systems are fragmented and inefficient.
The issues of appointment access, as demonstrated by missed
appointments, and fragmented transportation systems, as demonstrated
by current transportation systems, are addressed by Circulation.
John Brownstein, PhD is a global leader in
HCIT and, in particular, the emerging fields
of informatics and big data analytics. He
runs a 50-person multi-disciplinary team
focused on digital innovations that span
clinicians and consumers. His group is
supported by a multi-million dollar budget
including grants from NIH, USAID, DoD,
IARPA, CDC, Google, Skoll and Gates
Foundation. His work has pioneered
‘digital epidemiology’- utilizing diverse
digital data sources to understand
population health. His work is published in
over 150 peer-reviewed papers, all
focused on new methods and applications
in digital health. This work was recognized
by the White House with the Presidential
Early Career Award for Scientists and
Engineers.
John Brownstein
Chief Innovation Officer
Boston Children’s Hospital
INSIDER CASE
STUDY
17. 17
The Team
The Circulation team is comprised of 20+ individuals from Boston Children’s
Hospital and beyond. The founding team includes:
● John Brownstein, PhD (co-founder)
● Jared Hawkins, PhD (CTO, co-founder)
● Robin Heffernan, PhD (CEO, co-founder)
Collaborations
Circulation collaborates with a variety of partners, including transportation
companies, investors, and health systems.
● Transportation Partners include Uber and Lyft.
● Investors include Flare Capital Partners, Providence Service
Corporation, Echo Health Ventures, Intermountain Healthcare
Innovation Fund, Humana, and NextGen Venture Partners.
● Currently, Circulation services over 1000+ health facilities across the
US, in 44 states, including: Boston Children’s Hospital, Mercy Health
System, and Nemours Children’s Health System.
John Brownstein, PhD is a global leader in
HCIT and, in particular, the emerging fields
of informatics and big data analytics. He
runs a 50-person multi-disciplinary team
focused on digital innovations that span
clinicians and consumers. His group is
supported by a multi-million dollar budget
including grants from NIH, USAID, DoD,
IARPA, CDC, Google, Skoll and Gates
Foundation. His work has pioneered
‘digital epidemiology’- utilizing diverse
digital data sources to understand
population health. His work is published in
over 150 peer-reviewed papers, all
focused on new methods and applications
in digital health. This work was recognized
by the White House with the Presidential
Early Career Award for Scientists and
Engineers.
John Brownstein
Chief Innovation Officer
Boston Children’s Hospital
INSIDER CASE
STUDY
CASESTUDY-BOSTONCHILDREN'S
HOSPITAL:CIRCULATION
18. PATIENT
SATISFACTION
4.9/5
AVERAGE RATING
COST SAVINGS
UP TO 70%
SAVINGS ON RIDE
COSTS
ON-TIME
APPOINTMENTS
95%
INCLUDING WAITING
FOR PATIENTS
NO-SHOW
8%
COMPARED TO
INDUSTRY 20-25%
18
Success Metrics
● Circulation has achieved several key financial metrics. Institutions
participating with Circulation see transportation cost savings of up to
70%.
● Similarly, institutions participating with Circulation report an 8% no-show
rate, compared to an industry average of 20% - 25%.
● Circulation has also achieved several key health outcomes. 95% of
patients arrive to appointments on time to institutions participating with
Circulation.
John Brownstein, PhD is a global leader in
HCIT and, in particular, the emerging fields
of informatics and big data analytics. He
runs a 50-person multi-disciplinary team
focused on digital innovations that span
clinicians and consumers. His group is
supported by a multi-million dollar budget
including grants from NIH, USAID, DoD,
IARPA, CDC, Google, Skoll and Gates
Foundation. His work has pioneered
‘digital epidemiology’- utilizing diverse
digital data sources to understand
population health. His work is published in
over 150 peer-reviewed papers, all
focused on new methods and applications
in digital health. This work was recognized
by the White House with the Presidential
Early Career Award for Scientists and
Engineers.
John Brownstein
Chief Innovation Officer
Boston Children’s Hospital
INSIDER CASE
STUDY
CASESTUDY-BOSTONCHILDREN'S
HOSPITAL:CIRCULATION
19. 19
Transferable Learnings for Future Successes:
Lesson One:
● Consumers want to consume health care. Circulation, which has partnered with
Uber and Lyft, reports an average rating of 4.9 out of 5 from extensive user feedback.
This is, in large part, a result of the convenience and ease that Circulation brings
to healthcare logistics.
“Patients and providers expect the same service that they receive outside healthcare –
namely convenience, quality, and reliability,” says Robin Heffernan, PhD, Circulation CEO
and Co-Founder.
Lesson Two:
● Social barriers can inspire healthcare tech. Iora Health, a Circulation client, is
scaling the Circulation platform to a national level. “A key way to ensure that older
adults can make progress on their health goals is by removing significant social
determinant barriers such as reliable transportation,” says Duncan Reece, Senior Vice
President and General Manager for Iora Health.
● Lesson Three: Create a track record of success. Circulation recently announced Lyft
as a partner. Robin Heffernan, PhD, Circulation CEO and Co-Founder, recognizes Lyft
as a “collaborative partner with a track record demonstrating a strong commitment to
the healthcare space.” Relationships with strong, successful partners have enabled
Circulation to scale rapidly, demonstrated by the 1,000+ healthcare facilities supported
by Circulation and the recent closing of a $10.5 million series A round of funding.
John Brownstein, PhD is a global leader in
HCIT and, in particular, the emerging fields
of informatics and big data analytics. He
runs a 50-person multi-disciplinary team
focused on digital innovations that span
clinicians and consumers. His group is
supported by a multi-million dollar budget
including grants from NIH, USAID, DoD,
IARPA, CDC, Google, Skoll and Gates
Foundation. His work has pioneered
‘digital epidemiology’- utilizing diverse
digital data sources to understand
population health. His work is published in
over 150 peer-reviewed papers, all
focused on new methods and applications
in digital health. This work was recognized
by the White House with the Presidential
Early Career Award for Scientists and
Engineers.
John Brownstein
Chief Innovation Officer
Boston Children’s Hospital
INSIDER CASE
STUDY
CASESTUDY-BOSTONCHILDREN'S
HOSPITAL:CIRCULATION
21. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
PARTNER
Albion Capital
Christoph Ruedig
Christoph focuses on investments in
healthcare and renewables. He
initially practised as a radiologist,
before spending 3 years at Bain &
Company. In 2006, he joined 3i
working for their Healthcare
Venture Capital after which he
worked for General Electric's
healthcare division, where he was
responsible for mergers and
acquisitions in the medical
technology and healthcare IT
sectors. He holds a degree in
medicine from Ludwig-Maximilians
University, Munich and an MBA
from INSEAD.
21
“I emphatically agree that there is a lot of investment going into the sector but very few
success stories. Our sale of Exco Intouch was one of the very few VC-backed companies to be
sold in the sector in Europe.
At the heart of the problem in my view is that there is a mismatch between:
1. Expectations of quick and fast returns, partly driven by hype around new
technologies incl. AI, partly by investors not familiar with healthcare.
1. The reality of the slow pace of adoption in the healthcare industry.
My prediction is that there will be a correction and that only firms that demonstrably
deliver improved outcomes at lower cost will be able to thrive and attract capital in the long
term.
Success in digital health has to mean improved outcomes and lower cost. This is not the drug
industry where you only need to show improved outcomes – most clinicians are highly
sceptical that tech will deliver improved outcomes, even if a company has demonstrated it, say
in a clinical trial.
Perhaps that scepticism will decline in the future as more and more data is generated and
today's millennials enter medical professions and become the new KOLs. But today, we as
investors always want to see the cost curve being bent. If you achieve both improved
outcomes and cost, than financial returns should follow, all else being equal.”
EXPERT PERSPECTIVE
22. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
22
“There are few successes in Europe of late. Most are in the pharma IT sector (Zinc
being bought by Veeva, Definiens being bought by AstraZeneca, Exco Intouch
being bought by ERT, etc.), far fewer on the provider or patient facing side.
Our strong view is that as far as provider-facing solutions are concerned, just
offering another geeky technology is not going to cut it, for a number of reasons.
You need to be delivering a solution and that most often means providing a
service in addition to the technology if you want to be able to quickly drive
adoption.
A lot of the interesting businesses we see have got a well-run service that they
make more efficient and effective with the use of technology.
The other area where we see strong growth in adoption and businesses scaling
quickly is B2C, i.e. a new software or piece of hardware which consumers pay out
of pocket. This is overlapping with the wellness space but we focus on the ones
which can demonstrate improved clinical outcomes, e.g. by running trials with the
consumer data.
Completely depends on the area. Pharma IT needs an ability to understand the
pharma mindset and a culture sharing the same views, i.e. conservatism, fear of
regulators, etc. B2C needs a culture that is marketing-led.”
PARTNER
Albion Capital
Christoph Ruedig
Christoph focuses on investments in
healthcare and renewables. He
initially practised as a radiologist,
before spending 3 years at Bain &
Company. In 2006, he joined 3i
working for their Healthcare
Venture Capital after which he
worked for General Electric's
healthcare division, where he was
responsible for mergers and
acquisitions in the medical
technology and healthcare IT
sectors. He holds a degree in
medicine from Ludwig-Maximilians
University, Munich and an MBA
from INSEAD.
EXPERT PERSPECTIVE
23. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
23
Would you define digital health success as delivering positive health outcomes and
financial returns?
As a clinician working in the NHS, my principle focus is patient care so I am heavily weighted
towards looking at positive health outcomes. Having spent time as a commissioner, and also
from previous battles on increasing adoption, those paying for healthcare services look for hard
evidence on clinical outcomes from trial data over pilot experience. Regarding financial returns,
within the NHS this is mostly about reducing net spend.
What examples come to mind when you think of digital health successes and
failures?
What can we learn from these examples?National programme for IT is often cited as a
significant digital health failure, and the lessons learned from this are well known. Out of this,
some successes did arise, such as the NHS Spine and services such as Summary Care Record,
Patient Demographic Service, and eReferrals. The lesson here is that foundation work that
allows people to build on top is an important area to deliver on.
General Practitioner, Digital
Health Consultant and
Founder of VR Doctors
Dr Keith Grimes
Dr Keith Grimes a General
Practitioner and Digital
Healthcare Consultant. With
20 years’ experience of work
within the NHS, he’s led
award winning projects
including MyLittleOne, a
neonatal camera & tablet
system, and Brighton & Hove
Roving GP service and
founded VR Doctoran online
community dedicated to
exploring Virtual &
Augmented Reality in Health
& Social Care.
EXPERT PERSPECTIVE
24. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
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Which segments of digital health do you see as having the greatest potential for
positively impacting health outcomes and delivering financial returns and why?
“There is much interest in Artificial Intelligence as a way of improving outcomes (through better
clinician decision support and early notification of abnormal test results, for example) and
reducing costs (by decreasing the need for costly and scarce clinician human resource). It
remains to be seen whether this can be delivered, but there is reason to be hopeful in areas
such as pathology and radiology. With immersive reality technologies like VR and AR, the hope
is that applications such as pain and anxiety reduction, mental health, and education and
training will lead to improved access to care and greater numbers of doctors and nurses.
Mental health in particular is a difficult area with long waiting lists and growing demand.”
In your perspective, what cultural elements are facilitators/impediments to scaling
digital health success?
“In the UK NHS, the public are not used to paying for any health care services, which is an
impediment to going direct to consumer. The NHS is famously difficult to have innovations
adopted as well, although the National Innovation Accelerator, the Academic Health & Science
Networks, and the tech tariff are beginning to change this. Any products or services that sit on
consumer technology, such as smartphones and popular apps and platforms, are more likely to
succeed by driving the pressure for service change from the patients or frontline staff. A good
example is how whatsapp use between doctors in hospital is growing in the absence of other
options. The NHS needs to be better at accepting this into workflow.”
General Practitioner, Digital
Health Consultant and
Founder of VR Doctors
Dr Keith Grimes
Dr Keith Grimes a General
Practitioner and Digital
Healthcare Consultant. With
20 years’ experience of work
within the NHS, he’s led
award winning projects
including MyLittleOne, a
neonatal camera & tablet
system, and Brighton & Hove
Roving GP service and
founded VR Doctoran online
community dedicated to
exploring Virtual &
Augmented Reality in Health
& Social Care.
EXPERT PERSPECTIVE
25. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
25
“Digital Health definitions range depending on who you ask so it is important to set an agreed
upon definition across the community, granted it may continue to iterate and evolve. The
original definition that was put forth by Paul Sonnier “intersection of digital and genomics”.
If I look at the health & care market, we will continue “hacking our bodies from within” –
meaning while small molecules still here to stay: large molecules, stem cell, RNA, DNA will
continue advancing towards much more personalized experience & medicine.
At the same time, digital health is also broadly used to incorporate efficiency tools and process
improvements, however my personal view is that HealthIT defines that best – leveraging
technology to improve existing cumbersome processes across the health & care ecosystem.
We then get to what I would now define digital health – which is the science of behavior change
leveraging all the hard work the HealthIT community continues doing around data siloes,
combined with huge advancements in artificial intelligence to improve healthcare consumer
experiences.
In addition, the upstream early & preventative diagnostics that enhance the said patient
experiences to much more frequently and with accuracy move towards assisted #selfcare”
Eugene Borukhovich
GLOBAL HEAD OF DIGITAL HEALTH
INNOVATION & INCUBATION
BAYER
Eugene Borukhovich
currently serves as a Global
Head of Digital Health &
Innovation at Bayer. He’s also
an Entrepreneur in
Residence at Personal Health
Solutions (PHS), and a
founder of Health 2.0.
Together with Yoram
Levanon, Chief Scientist
Officer at Startup Beyond
Verbal he will talk about
startups and innovation in
digital health.
EXPERT PERSPECTIVE
26. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
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Which segments of digital health adoption do you see as having the greatest
potential for positively impacting health outcomes and delivering financial returns
and why?
With that definition, laser focus on customer & patient experiences with digital therapeutics at
the core of it is what is already showcasing scientific evidence and even generating revenues.
What examples come to mind when you think of digital health successes and
failures? What can we learn from these examples?
Companies like WellDoc, Omada, Voluntis are great examples of early successes. Of Course
companies like theranos brought some negativity to the overall space. While early stage, our
own G4A recent alum, Oratel Diagnostics that is tackling early diagnostics for woman's fertility
issues via a saliva test..
·In your perspective what cultural elements are facilitators/impediments to scaling
digital health success?
Culture eats strategy for breakfast, lunch and dinner and the short answer is risk-averseness is
the main impediment. Having said that, when one is selling widgets there is not much at risk
unlike in health care when people’s lives are at stake and hence that laser focus on evidence is
key for all the startups and ecosystem partners pushing the envelope in digital health.
Eugene Borukhovich
GLOBAL HEAD OF DIGITAL HEALTH
INNOVATION & INCUBATION
BAYER
EXPERT PERSPECTIVE
Eugene Borukhovich
currently serves as a Global
Head of Digital Health &
Innovation at Bayer. He’s also
an Entrepreneur in
Residence at Personal Health
Solutions (PHS), and a
founder of Health 2.0.
Together with Yoram
Levanon, Chief Scientist
Officer at Startup Beyond
Verbal he will talk about
startups and innovation in
digital health.
27. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
27
Dr Travis Good
MD and CEO at Datica
As CEO, Travis leads Datica’s
vision. His background in
compliance, security, and
cloud infrastructure gives
him technical expertise that,
when paired with his
experiences as an MD, allows
for a unique view on the
challenges of healthcare.
“The success of digital health should align with the quadruple aim of better outcomes, lower costs, and
improved patient and provider experience. Doing that at scale creates massive success.”
What examples come to mind when you think of digital health successes and failures? What can
we learn from these examples?
“My success examples include Omada and Flatiron. The failures are plentiful, many of which I've never
heard about. In my opinion, the biggest failure perhaps is likely Practice Fusion.”
Which segments of digital health do you see as having the greatest potential for positively
impacting health outcomes and delivering financial returns and why?
“I think the hardest nut to crack so to speak, but also the biggest, is going to be the conditions where you
need to activate patients or engage patients that aren't already engaged. This is the source of massive
societal issues and healthcare costs. I'm thinking of things like obesity and diabetes, which then lead to
things like health disease and eventually some sort of cardiovascular episode.
EXPERT PERSPECTIVE
28. INVESTMENTANDOUTCOMEDISPARITIES-ATROUBLINGTREND
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Dr Travis Good
MD and CEO at Datica
As CEO, Travis leads Datica’s
vision. His background in
compliance, security, and
cloud infrastructure gives
him technical expertise that,
when paired with his
experiences as an MD, allows
for a unique view on the
challenges of healthcare.
[Continued] “These conditions, most commonly, result over time from unhealthy
behavior that gets worse and worse in midlife. Finding a way to engage this group
and help them to make even very small, incremental improvements could generate
massive savings.
This is the biggest impact because it affects a large and growing segment of our
society. If I was recommending what segments to target that would be much
easier, I'd say things where patients are already engaged. Things like cancer and
pregnancy. These do have huge impact potential as well.”
In your perspective, what cultural elements are facilitators/impediments to
scaling digital health success?
“The biggest cultural impediments are technology fatigue (EHRs burn out many
clinicians and the boards that paid for them) and the frequent disconnect between
the builders of digital health and the users (patients and providers) of digital
health.”
EXPERT PERSPECTIVE