The document discusses the evolution of health rights from ancient concepts to modern international agreements. It notes that 142 countries have ratified the International Covenant on Economic, Social and Cultural Rights, which recognizes the right to health. National constitutions in 193 countries also recognize some form of right to health. International organizations like the WHO and cooperation between agencies like PAHO and the Inter-American Commission on Human Rights have helped promote and protect health rights.
Universal Health Care: Perceptions, Values, and IssuesRenzo Guinto
From the workshop "Universal Health Care: The First Step to Global Health Equity" held last August 5-9, 2012 in Mumbai, India during the 61st General Assembly March Meeting of the International Federation of Medical Students' Associations (IFMSA). Brought to you by the IFMSA Global Health Equity Initiative (http://www.ifmsa.org/Activities/Initiatives/The-IFMSA-Global-Health-Equity-Initiative).
For more information about the workshop, visit http://www.scribd.com/doc/193822108/Universal-Health-Care-PreGA-Program
An electronic health record (EHR) is a collection of patient’s electronically-stored health information in a digital and systematic format. EHR system can store data accurately.
Understanding the concept of Universal Health Coverage (UHC) and how can we reach it, both globally and also in India. The presentation also includes HLEG report , which is the proposed architecture for India's guide to reach UHC.
What does the right to health entail?
When we talk about the right to health we are not just talking about the physical or mental well-being of a person. The right to health involves many other things without which you cannot enjoy good health. The most authoritative interpretation of the right to health is outlined in Article 12 of the International Covenant on Economic, Social & Cultural Rights (ICESCR) and has been ratified by Namibia and many other countries.
Provided and made available by the Legal Assistance Centre of Namibia
Universal Health Care: Perceptions, Values, and IssuesRenzo Guinto
From the workshop "Universal Health Care: The First Step to Global Health Equity" held last August 5-9, 2012 in Mumbai, India during the 61st General Assembly March Meeting of the International Federation of Medical Students' Associations (IFMSA). Brought to you by the IFMSA Global Health Equity Initiative (http://www.ifmsa.org/Activities/Initiatives/The-IFMSA-Global-Health-Equity-Initiative).
For more information about the workshop, visit http://www.scribd.com/doc/193822108/Universal-Health-Care-PreGA-Program
An electronic health record (EHR) is a collection of patient’s electronically-stored health information in a digital and systematic format. EHR system can store data accurately.
Understanding the concept of Universal Health Coverage (UHC) and how can we reach it, both globally and also in India. The presentation also includes HLEG report , which is the proposed architecture for India's guide to reach UHC.
What does the right to health entail?
When we talk about the right to health we are not just talking about the physical or mental well-being of a person. The right to health involves many other things without which you cannot enjoy good health. The most authoritative interpretation of the right to health is outlined in Article 12 of the International Covenant on Economic, Social & Cultural Rights (ICESCR) and has been ratified by Namibia and many other countries.
Provided and made available by the Legal Assistance Centre of Namibia
Clinical Governance Presentation by Michael Gorton AM - 21 July 2016Russell_Kennedy
Clinical governance in the health sector. This presentation covers the issues of liability, accountability, risk management and compliance that all health organisations must address.
This is the first report on Telehealth in India, and was authored in 2011 by Rajendra Pratap Gupta for Telemedicine Society of India , when he chaired the Organising Committee of the International Telemedicine Congress 2011 at Mumbai
This report gives a detailed overview of where India stands and what is the scope in future
Euthanasia is the painless killing of a patient suffering from an incurable and painful disease or in an irreversible coma. There are different types of Euthanasia voluntary or involuntary.
Governance influences all other health system functions, thereby leading to improved performance of the health system and ultimately to better health outcomes.
The lecture focuses on the evolution of health promotion as well as of the social context of health in postmodern societies. This topic reflects the most commonly used approaches and concepts which are useful for health promotion practice. Finally, the principles and methods of health needs assessment are presented.
DESCRIBE THE CONCEPT OF HEALTH, PUBLIC HEALTH AND PRIMARY HEATH CARE (PHC) ?
WHAT ARE THE COMPONENTS OF HEALTH, PUBLIC HEALTH AND PRIMARY HEALTH CARE (PHC) ?
Clinical Governance Presentation by Michael Gorton AM - 21 July 2016Russell_Kennedy
Clinical governance in the health sector. This presentation covers the issues of liability, accountability, risk management and compliance that all health organisations must address.
This is the first report on Telehealth in India, and was authored in 2011 by Rajendra Pratap Gupta for Telemedicine Society of India , when he chaired the Organising Committee of the International Telemedicine Congress 2011 at Mumbai
This report gives a detailed overview of where India stands and what is the scope in future
Euthanasia is the painless killing of a patient suffering from an incurable and painful disease or in an irreversible coma. There are different types of Euthanasia voluntary or involuntary.
Governance influences all other health system functions, thereby leading to improved performance of the health system and ultimately to better health outcomes.
The lecture focuses on the evolution of health promotion as well as of the social context of health in postmodern societies. This topic reflects the most commonly used approaches and concepts which are useful for health promotion practice. Finally, the principles and methods of health needs assessment are presented.
DESCRIBE THE CONCEPT OF HEALTH, PUBLIC HEALTH AND PRIMARY HEATH CARE (PHC) ?
WHAT ARE THE COMPONENTS OF HEALTH, PUBLIC HEALTH AND PRIMARY HEALTH CARE (PHC) ?
Public health concept, i ketut swarjanaswarjana2012
Pemahaman tentang konsep kesehatan masyarakat atau public health concept sangat penting dalam rangka memahami lebih awal dasar dari konsep kesehatan masyarakat itu sendiri, sebelum lebih jauh belajar tentang IKM yang mencakup epidemiologi, manajemen kesehatan, promosi kesehatan dan lain-lain
This Presentation was given to Mr.Wasif Ali Waseer lecturer of Sociology at UMT,Lahore. In the class of Medical Sociology.The presentation covers the history about how Indigenous Health system emerged in the Pakistan. and what types of Indiginous treatments and treaters are available and followed by the people of Pakistan. And How they become victim of them
This paper focuses on various aspects of health care law including the constitutional perspective, obligations, and negligence of medical professionals and remedies available to
consumers of health care.
This is a quick recap of theory of health rights, for healthcare practitioners and policy makers. Includes Information accessibility rights as an important part of health rights.
Remarkable progress is being made on HIV treatment. Ahead of World AIDS Day, UNAIDS has launched a new report showing that access to treatment has risen significantly.
COVID-19 preparedness-and-response WHO certificate of achievementDr Neelesh Bhandari
OpenWHO verifies that the candidate completed the course COVID-19: Operational Planning Guidelines and COVID-19 Partners Platform to support country preparedness and response and passed the necessary exercises and exams to earn a course certificate.
We are a team of experienced medical, paramedical and software professionals, working to bridge the gap between hospitals and their patients. Patients have a little understanding of their disease conditions and treatment plans, even after their discharge. We provide solutions and services that deliver superior patient engagement. We use our proprietary communication platform and engagement protocols with an intimate understanding of people and expertise to become partners in people’s health and wellbeing ; and improve hospital operations and revenue at the same time.
Patient engagement and Hospital Marketing Solutions from Healtho5Dr Neelesh Bhandari
We offer turnkey medical marketing and Patient engagement solutions for single and multi-specialty hospitals in India. Our specialties include Diabetes, Antenatal and postnatal care, Cardiac, Arthritis, Oncology, COPD and related disorders, etc.
Hospitals get a self branded mobile app for their patients and doctors.
Our digital marketing team works closely with our support call center to generate medical leads and enable clinical encounter between genuine patients and hospital.
Post encounter/Discharge, we followup the patients on Hospital's behalf via monthly calls and emails, twice a month SMS, chat-support and updates via app, etc.
Our followup Protocols are built on best evidence backed guidelines and can be customized by hospitals.
Contact info@healtho5.com to know more
An edited version of my presentation at the Mobile Health Workshop for Engineers and PhD scholars at National Institute of Technology Surathkal, Mangalore.
Standard guidelines for management of cardiovascular diseases in IndiaDr Neelesh Bhandari
This brief document will provide a broad outline for selected congenital heart diseases. It needs to
be recognized that there are unlimited possibilities because of the enormous variety of congenital
heart diseases. Therefore only a few common situations will be discussed here. Guidelines have
been recently developed and published through consensus among all leading pediatric cardiologists
in India and these references are listed below. They cover most common situations and provide a
ready reference.
Key Insights and Digital Trends Shaping the Indian Online Space Dr Neelesh Bhandari
The following report examines how the latest
trends in web usage, online video, mobile and
search, social and shopping are currently shaping
the Indian digital marketplace and what that
means for the coming year
How Many Doctors in India Online?
What Indian Doctors Do Online?
Where Do They Need Help?
What are the Communication opportunities for Pharma?
How will e-Doctors evolve down the stream and how can Pharma stay Relevant?
Answers to all these questions and a case study of CiplaMed (a physician only community website started by Cipla Pharmaceuticals in 2008)
Recommendations On Electronic Medical Record Standards In India Dr Neelesh Bhandari
Recommendations of EMR Standards Committee, constituted by an order of Ministry of Health & Family Welfare, Government of India and coordinated by FICCI on its behalf : April 2013
A guide to online professionalism for medical practitioners and medical studentsDr Neelesh Bhandari
One of the best guides to Healthcare Social Media for Doctors:
A joint initiative of the Australian Medical Association Council of Doctors-in-Training, the New Zealand Medical Association
Doctors-in-Training Council, the New Zealand Medical Students’ Association and the Australian Medical Students’ Association
Internet For Doctors: Basics about computer use for PhysiciansDr Neelesh Bhandari
The internet is an extraordinary tool for improving a doctor's quality of service. This presentation is meant to introduce the internet to Physician first timers on computers..
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Health Rights- Discovery and evolution
1. The Discovery and evolution of Health Rights- Current Concepts Dr. Neelesh Bhandari MBBS(AFMC), MD (Path) P.G.P in Human Rights (IIHR, N. Delhi)
2. INTRODUCTION The Discovery and Evolution of Health Rights. The concept of Human rights is part of ages old Indian Culture. The Principles of DHARMA and VASUDEV KUTUMBUM as outlined in the Vedas and The Bhagvad Gita form the foundations of Human rights. Human rights Theory has borrowed heavily from Buddhism, besides Hinduism.
3. The right to the highest attainable standard of health (referred to as the right to health.) was first reflected in the WHO Constitution (1946) and then reiterated in the 1978 Declaration of Alma Ata and in the World Health Declaration adopted by the World Health Assembly in 1998. It has been firmly endorsed in a wide range of international and regional human rights instruments.
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5. The human right to health is recognized in numerous international instruments. Article 25(1) of the UDHR affirms that “ everyone has a right to a standard of living adequate for the health of himself and his family, including food, clothing, housing, and medical care and necessary social services.” The ICESCR provides the most comprehensive article on the right to health in international human rights law. According to article 12(1) of the Covenant, States Parties recognize “the right of everyone to the enjoyment of the highest attainable standard of physical and mental health”, while article 12(2) enumerates, by way of illustration, a number of “ steps to be taken by the States Parties “… to achieve the full realization of this right”.
6. Article 15 of the International Covenant on Economic, Social and Cultural Rights recognizes “the right of everyone to enjoy the benefits of scientific progress and its applications.” This right places obligations on governments to take the steps necessary to conserve, develop and diffuse science and scientific research, as well as ensure freedom of scientific enquiry. The implications of this right for health issues have only recently begun to be explored, for example, with respect to access to drugs for developing countries.
7. Countries that Ratified the ICESCR - 142 Countries that Ratified Regional Treaties with a Right to Health - 83 Countries that Recognize a Right to Health in their National Constitutions - 109 National Recognition of a Right to Health in some form or the other is thus Seen in 193 countries.
8. There has been an increased interest in the role of a human rights framework to mobilize resources for health. The human rights framework provides us with an appropriate understanding of what values should guide a nation’s health policy, A potentially powerful means of moving the health agenda forward.
9. A rights-based approach to health refers to the processes of: . Using human rights as a framework for health development. . Assessing and addressing the human rights implications of any health policy, programme or legislation. . Making human rights an integral dimension of the design, implementation, monitoring and evaluation of health-related policies and programmes in all spheres, including political, economic and social.
10. “ The right to health does not mean the right to be healthy, nor does it mean that poor governments must put in place expensive health services for which they have no resources. But it does require governments and public authorities to put in place policies and action plans which will lead to available and accessible Health care for all in the shortest possible time . To ensure that this happens is the challenge facing both human rights community and public health professionals. “ United Nations High Commissioner for Human Rights, Mary Robinson
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12. In May 2000, The Committee on Economic , Social and Cultural Rights Adopted a general comment on right to Health. The General Comment sets out four criteria by which to evaluate the right to health: (a) Availability . Functioning public health and health-care facilities, goods and services, as well as programmes, have to be available in sufficient quantity. (b) Accessibility . Health facilities, goods and services have to be accessible to everyone without discrimination, within the jurisdiction of the State party. Accessibility has four overlapping dimensions: . Non-discrimination; . Physical accessibility; . Economic accessibility (affordability); . Information accessibility.
13. c) Acceptability . All health facilities, goods and services must be respectful of medical ethics and culturally appropriate, sensitive to gender and life-cycle requirements, as well as being designed to respect confidentiality and improve the health status of those concerned. (d) Quality . Health facilities, goods and services must be scientifically and medically appropriate and of good quality. The Siracusa Principles allow for limiting of health rights if certain criteria are met.
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15. THE INTERNATIONAL SOCIETY FOR HEALTH AND HUMAN RIGHTS adopted in 1993, with amendments adopted in 1998 ARTICLES OF ASSOCIATION, NAME, SEAT AND DURATION Article 1 1. The name of the Association is: International Society for Health and Human Rights. 2. The seat of the Association is in Utrecht. 3. The Association is established for an unlimited period. There are 24 articles which govern the society and annual year corresponds to a calendar year
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18. The collaboration between PAHO/WHO and the Inter-American Commission on Human Rights (IACHR, the body responsible for overseeing the American Convention on Human Rights) concerning the rights of persons with mental disabilities, is an example of the key role specialized agencies can play within international monitoring mechanisms. PAHO/WHO offers technical opinions and assistance on the interpretation of the American Convention on Human Rights and the American Declaration on the Rights and Duties of Man, in light of international standards on mental disability rights. In turn, the IACHR incorporates these standards into final reports of relevant individual cases and in country reports. As a result of this technical assistance, the IACHR has issued the Recommendation for the Promotion and Protection of the Rights of the Mentally ill.
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20. Health is not a blessing to be wished for but a right to be fought for . There are complex linkages between health and human rights: . Violations or lack of attention to human rights can have serious health consequences Health policies and programmes can promote or violate human rights in the ways they are designed or implemented; Vulnerability and the impact of ill health can be reduced by taking steps to respect, protect and fulfill human rights.