The Healthy Chicago public health agenda, developed in 2011, serves as a framework for how the Chicago Department of Public Health will improve the health and well-being of Chicagoans. Healthy Chicago’s development was guided by a commitment to health equity and the recognition of the social and environmental influences on population health. During this presentation, the Healthy Chicago public health agenda will be introduced and key activities addressing health equity and the social determinants of health through policy, systems and environmental change, and programming will be discussed.