OSHA Hazard Communication and Global Harmonization System (GHS)Elena Fracassa
This training explains the recent changes to the OSHA Hazard Communication Standard, including compliance with the Global Harmonization System of hazard identification, container labeling, and Safety Data Sheets.
During the July OFFSHC, we were presented a great overview of the final rule published by OSHA to align the OSHA Hazard Communication Standard (HCS) with the Globally Harmonized System (GHS). Jorge Delucca, OSHA CAS, provided the OSHA GHS Overview (click the link to view). He discussed the implementation dates, GHS Hazard Classifications, Safety Data Sheet changes and GHS labeling. Mr. Delucca also discussed the other standards that will be affected and current litigation related to the ruling. More information is available at http://www.osha.gov/dsg/hazcom/index.html.
Globally Harmonized System of Classification and Labelling of Chemicals - an initiative to improve employee safety by standardizing chemical labels, Safety Data Sheets and pictograms
OSHA Hazard Communication and Global Harmonization System (GHS)Elena Fracassa
This training explains the recent changes to the OSHA Hazard Communication Standard, including compliance with the Global Harmonization System of hazard identification, container labeling, and Safety Data Sheets.
During the July OFFSHC, we were presented a great overview of the final rule published by OSHA to align the OSHA Hazard Communication Standard (HCS) with the Globally Harmonized System (GHS). Jorge Delucca, OSHA CAS, provided the OSHA GHS Overview (click the link to view). He discussed the implementation dates, GHS Hazard Classifications, Safety Data Sheet changes and GHS labeling. Mr. Delucca also discussed the other standards that will be affected and current litigation related to the ruling. More information is available at http://www.osha.gov/dsg/hazcom/index.html.
Globally Harmonized System of Classification and Labelling of Chemicals - an initiative to improve employee safety by standardizing chemical labels, Safety Data Sheets and pictograms
THe deadline to convert GHS labeling and the new SDS requirements is fast approaching: June 1, 2015. It's time to understand GHS. This webinar will cover everything you need to know about GHS ompliance. This include:
Written Program and Plan Updates
Labeling with Hazard Warnings and Pictograms
Employee Training Requirements
How to implement and stay compliant to new GHS aka WHMIS 2015. Learn how to keep your facility or factory to new chemical labeling and management requirements.
The Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
The following presentation discussess the changes to the OSHA HAZCOM standard to comply with the GHS rules. As of 1 Dec 13, all business should have completed the training to inform the workforce of the changes to product labels and containers as well as information provided on Safety Data Sheets. If you need help with your GHS policy, program, or procedures, contact us by telephone in the US at 1+ 7322215687 or by email at windsgroup@aol.com.
What You Need to Know About GHS Labeling SolutionsPeak-Ryzex
Learn about GHS, the new standard for labeling chemicals, and how it affects you. OSHA is requiring that all Manufacturers, Suppliers, and Users of chemicals must comply with the new GHS labeling standards. Find out what OSHA's GHS compliance requires and how you can become compliant today.
Osha and GHS HAZCOM Training - Webinar with marie atheyFarhan Jaffry
Marie Athey, OSHAcampus.com OSHT trainer answers your questions regarding the latest GHS and OSHA Hazard Communication Standards mandated by OSHA which is synched with the Globally Harmonized System for Classification and Labeling of Chemicals.
Understanding the OSHA requirements for hazard communication and global harmonization is important to meet regulatory obligations. The slide show is a brief example of the OSHA training provided by The Windsor Consulting Group, Inc. for our customers. We have over 60 courses to train your workers on a variety of occupational health and safety hazards. Contact us for pricing and availability.
The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) is designed to improve health and safety protection for workers who handle chemicals. Although the deadline for training employees was December 1, 2013, many businesses have not adequately prepared their employees to understand the new labels.
Hazard Communication How-To: Get Compliant with GHS StandardsHNI Risk Services
The game has changed for OSHA's Hazard Communication Standard. Is your organization up to speed on this critical piece of safety compliance? The training deadline for employees has passed, and your business could face penalties for non-compliance if your safety communications have fallen behind.
THe deadline to convert GHS labeling and the new SDS requirements is fast approaching: June 1, 2015. It's time to understand GHS. This webinar will cover everything you need to know about GHS ompliance. This include:
Written Program and Plan Updates
Labeling with Hazard Warnings and Pictograms
Employee Training Requirements
How to implement and stay compliant to new GHS aka WHMIS 2015. Learn how to keep your facility or factory to new chemical labeling and management requirements.
The Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
The following presentation discussess the changes to the OSHA HAZCOM standard to comply with the GHS rules. As of 1 Dec 13, all business should have completed the training to inform the workforce of the changes to product labels and containers as well as information provided on Safety Data Sheets. If you need help with your GHS policy, program, or procedures, contact us by telephone in the US at 1+ 7322215687 or by email at windsgroup@aol.com.
What You Need to Know About GHS Labeling SolutionsPeak-Ryzex
Learn about GHS, the new standard for labeling chemicals, and how it affects you. OSHA is requiring that all Manufacturers, Suppliers, and Users of chemicals must comply with the new GHS labeling standards. Find out what OSHA's GHS compliance requires and how you can become compliant today.
Osha and GHS HAZCOM Training - Webinar with marie atheyFarhan Jaffry
Marie Athey, OSHAcampus.com OSHT trainer answers your questions regarding the latest GHS and OSHA Hazard Communication Standards mandated by OSHA which is synched with the Globally Harmonized System for Classification and Labeling of Chemicals.
Understanding the OSHA requirements for hazard communication and global harmonization is important to meet regulatory obligations. The slide show is a brief example of the OSHA training provided by The Windsor Consulting Group, Inc. for our customers. We have over 60 courses to train your workers on a variety of occupational health and safety hazards. Contact us for pricing and availability.
The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) is designed to improve health and safety protection for workers who handle chemicals. Although the deadline for training employees was December 1, 2013, many businesses have not adequately prepared their employees to understand the new labels.
Hazard Communication How-To: Get Compliant with GHS StandardsHNI Risk Services
The game has changed for OSHA's Hazard Communication Standard. Is your organization up to speed on this critical piece of safety compliance? The training deadline for employees has passed, and your business could face penalties for non-compliance if your safety communications have fallen behind.
Safe Chemical Handling & Initial Spill ResponseDavid Horowitz
This presentation was prepared for the Sixteenth Annual Southeastern Massachusetts Drinking Water Fair held on June 16, 2011 at the Massachusetts Maritime Academy. The event was hosted by the Barnstable County Water Utilities Association and the Plymouth County Water Works Association. Attendees received Training Contact Hours (TCHs).
Shipping of hazardous materials such as explosives, gases, flammable liquids or solids, oxidizers and organic peroxides and corrosives require immense safety and professional guidance. View this presentation to know why you should choose Road King Freight Logistics for transportation.
Compliance with the Globally Harmonized System of Classification and Labeling of Chemicals, or GHS, entails transitioning from using material safety data sheets (MSDS) to safety data sheets (SDS) and will help ensure common safety standards among all producers and users of chemicals worldwide.
HazCom 2012 Changes Introduced by the GHS: Upcoming Changes and Your Responsi...Sarah Sajedi
The June 1, 2015 GHS Compliance deadline introduces some changes to hazard communication sheets (SDSs) and labels. This presentation outlines the changes to hazard communication you should expect as well as your responsibilities.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. Introduction
The federal Hazard Communication
Standard says that you have a
“Right-To-Know” what hazards you
face on the job and how to protect
yourself against those hazards.
That’s your Right-To-Know!
3. What is GHS?
The Globally Harmonized System (GHS) is
an international approach to chemical
labels and safety data sheets (SDS).
OSHA’s Hazard Communication standard
has adopted the GHS to improve safety
and health of workers through more
effective communications on chemical
hazards.
4. What is the GHS?
Target audiences include workers,
consumers, transport workers, and
emergency responders.
Provides the underlying
infrastructure for establishment of
national, comprehensive chemical
safety programs.
5. Purpose
The standard was developed to
make sure that everyone who works
with any hazardous chemical is
aware of the hazards and the
necessary precautions.
6. Why is the GHS needed?
No country has the ability to identify
and specifically regulate every
hazardous chemical product.
For example, in the United States,
there are an estimated 650,000 such
products.
Adoption of requirements for
information to accompany the
product helps address protection
needs.
7. Why? (cont.)
Many different countries have come
to the same conclusion about using
information dissemination as a
regulatory means to address chemical
hazards.
While similar, they are different enough
to require multiple labels and safety
data sheets for the same product in
international trade.
8. Why? (cont.)
Countries with systems have different
requirements for hazard definitions as well
as information to be included on a label
or material safety data sheet.
For example, a product may be
considered flammable or toxic in one
country, but not in another to which it is
being shipped.
9. Why? (cont.)
These differences impact both protection
and trade.
In the area of protection, users in
countries that don’t have specific
requirements may see different label
warnings or data sheet information for the
same chemical.
10. Why? (cont.)
In the area of trade, the need to comply
with multiple regulations regarding hazard
classification and labelling is costly and
time-consuming.
Small to medium enterprises are
effectively precluded from international
trade in chemicals due to the regulatory
burden of compliance.
11. Benefits of Harmonization
Countries, international organizations,
chemical producers and users of
chemicals all benefit.
Enhance protection of humans and
environment.
Facilitate international trade in chemicals.
Reduce need for testing and evaluation.
Assist countries and international
organizations to ensure the sound
management of chemicals.
12. OSHA Compliance Dates
OSHA is requiring training on new label
elements (pictograms and signal words)
and safety data sheet (SDS) format by
December 2013.
Full compliance in the workplace with the
final rule will begin in 2016.
13. The GHS Elements
Classification Criteria
Health and Environmental Hazards
Physical Hazards
Mixtures
Hazard Communication
Labels
Safety Data Sheets
14. Health & Environmental
Hazards
Acute Toxicity
Skin Corrosion/Irritation
Serious Eye Damage/Eye Irritation
Respiratory or Skin Sensitization
Germ Cell Mutagenicity
Carcinogenicity
Reproductive Toxicity
Target Organ Systemic Toxicity – Single and
Repeated Dose
Hazardous to the Aquatic Environment
15. Tiered Approach to Classification
Generally use test data for the mixture, when
available
Use bridging principles, if applicable
For health and environmental hazards, estimate
hazards based on the known ingredient
information
16. Physical Hazards
Definitions, test methods and
classification criteria for transport
were used as a basis for the work
since they were already
harmonized.
18. Comprehensibility
Guiding principles:
Information should be conveyed in more
than one way.
The comprehensibility of the components
of the system should take account of
existing studies and evidence gained
from testing.
The phrases used to indicate the degree
(severity) of hazard should be consistent
across different hazard types.
19. Hazard Statements
A single harmonized hazard statement for
each level of hazard within each hazard
class
Example: Flammable liquids
Category 1: Extremely flammable liquid and
vapour
Category 2: Highly flammable liquid and
vapour
Category 3: Flammable liquid and vapour
Category 4: Combustible liquid
20. Labels
GHS identified about 35 different
types of information that are currently
required on labels by different
systems.
To harmonize, key information
elements needed to be identified.
Additional harmonization may occur
on other elements in time, in particular
for precautionary statements.
21. Precautionary Information
GHS label should include appropriate
precautionary information.
The GHS document includes examples of
precautionary statements which can be
used.
The intent is to harmonize precautionary
statements in the future.
22. Key Label Elements
Product identifier
Supplier identifier
Chemical identity
Hazard pictograms*
Signal words*
Hazard statements*
Precautionary information
*Standardized
24. Pictograms
A symbol plus a red diamond border
intended to convey specific information
about the hazards of a chemical.
4 Health Hazard Pictograms
5 Physical Hazard Pictograms
31. Physical Hazard Pictogram-
Flame Over Circle
Oxidizer –
a substance that is not
necessarily combustible,
but may, generally by
yielding oxygen, cause or
contribute to the
combustion of other
material
37. Safety Data Sheets (SDS)
SDS are multi-page documents that
contain more detailed information about
a chemical than the container label.
The revised HazCom standard requires
that the information on the SDS is
presented using consistent headings in a
specific order.
38. Role of the SDS in the GHS
The SDS should provide comprehensive
information about a chemical substance or
mixture.
Primary Use: The Workplace
Employers and workers use the SDS as a
source of information about hazards and to
obtain advice on safety precautions.
40. 16-Section SDS Format
9. Physical and Chemical Properties
10. Stability and Reactivity
11. Toxicological Information
12. Ecological Information
13. Disposal Considerations
14. Transport Information
15. Regulatory Information
16. Other Information
41. Confidential Business
Information
National authorities should establish
appropriate mechanisms for CBI protection.
CBI will not be harmonized under the GHS.
The provisions for CBI protection should not
compromise the health and safety of users.
CBI claims should be limited to the names of
chemicals and their concentrations in mixtures.
Mechanisms should be established for
disclosure in emergency and non-emergency
situations.
42. Information Sources
OSHA has a web page on the GHS:
http://www.osha.gov/SLTC/
hazardcommunications/global.html
Includes links to the completed GHS
document & international organizations.
43. Conclusion
During the phase-in period, employees will
see the old and new labels on chemical
containers.
All chemical containers in the workplace
have to be in compliance with the new
standard by June 2016.
Editor's Notes
Based on existing TDG requirements, changes were made to address needs of other sectors.
Focal Point: UN Committee of Experts on Transport of Dangerous Goods, in cooperation with the ILO.
