![34
Early industry recognition for Micah™
[The fused-ring cyanoacrylates
chemistry] is important and unique
because there is nothing else that
kills the aging phenomenon at the
beginning … this is a long-awaited
breakthrough.
Paolo Giacomoni, Ph.D.,
Biochemist, atomic physicist and
former director of research at both
Estée Lauder and L’Oréal](https://image.slidesharecdn.com/hal17070micahbluelightwebinar170901final-171122033255/85/Change-Your-Suncare-Story-Micah-Blazer-the-Trail-in-Blue-Light-Protection-34-320.jpg)
Uploaded byHallstar
Change Your Suncare Story: Micah Blazer the Trail in Blue Light Protection
This document presents information on blue light protection in sun care products and introduces MicahTM, a new active ingredient from Hallstar. MicahTM is unique in that it stops the formation of free radicals from nearly all light sources, including blue light, before they can cause skin damage. Clinical research shows that MicahTM prevents markers of skin aging and inflammation caused by UVA and visible light. It offers a new category of protection compared to UV filters and antioxidants. MicahTM is easy to formulate at a low use level and supports claims around anti-aging, anti-dark spots, and protection from environmental elements like pollution and blue light from devices.
Change Your Suncare Story: Micah Blazer the Trail in Blue Light Protection
- 1. 1 September2017 Presented by DennisZlotnik Senior Market DevelopmentManager, Beauty & Personal Care Hallstar Change Your Suncare Story: Micah Blazes the Trail in Blue Light Protection TM
- 2. 2 SUNCARE: Highly regulated but ripefor innovation
- 3. 3 Suncare: Highly regulatedbut ripe for innovation Suncare products $24.91 Global growth potential BILLION Source: “Scorching Grow th forSuncare”? happi. May 9, 2017. www.happi.com.
- 4. 4 An industry focusedon UVA and UVB – with minimal differentiation Source: Mintel Brand (SPF) Avobenzone Homosalate Octisalate Octocrylene Octocrylene TiO2 ZNO Aveeno Baby (55) 3 10 5 2.8 6 Walgreens (55) 3 10 5 2.75 6 La Roche (60) 3 15 5 5 6 Coppertone (50) 3 10 5 7 5 CVS (70) 3 15 5 10 6 Clarins (50+) 3 10 5 2.7 6 50+YEARS OF UVB FOCUS 5-10YEARS OF UVA FOCUS Source: Mintel
- 5. 5 A threat –and an opportunity BLUE LIGHT
- 6. 6 Blue light: Achallenge waiting for a solution No product protects against nearly every light form except Micah™ UVB UVA I UVA II VISIBLE BLUE LIGHT
- 7. 7 What exactly isblue light? BLUE LIGHT
- 8. 8 Where does bluelight come from? 30%of sunlight is blue light
- 9. 9 Exposure to bluelight is increasing 10 HOURS 39 MINUTES/DAY SPENT LOOKING AT SCREENS SINCE 2015 HOUR INCREASE +1 88% OF MILLENNIALS USE TWO SCREENS AT ONCESources: “Millennials master the second screen.” Business Wire. January 28, 2016. www.businesswire.com The Total Audience Report: Q1 2016. Nielsen. June 27, 2016. nielsen.com.
- 10. 10 How does bluelight compare with UVA light? Blue light penetrates deeper UVB (280 – 320 nm) UVA-II (320 – 360 nm) UVA-I (360 – 400 nm) VISIBLE BLUE LIGHT (400 – 700 nm)
- 11. 11 Blue light’s effecton skin is comparable to UVA DNA mutations – leads to skin aging and cancer Damage to skin cells Loss of skin elasticity Fine lines and wrinkles Pigment production/ discoloration BLUE LIGHTUV DNA mutations – leads to skin aging and cancer Damage to skin cells Loss of skin elasticity Fine lines and wrinkles Pigment production/ discoloration
- 12. 12 Connecting oxidative stress,free radicals and aging Oxidative Stress Imbalance between the production of reactive oxygen species (ROS) free radicals (FR), and the ability of the body to neutralize these species Solar Light-Induced Oxidative Stress A major cause of ROS/FR generation in human skin Visible Signs of Aging • Damage to extracellular matrix • Loss in skin elasticity • Fine lines and wrinkles
- 13. 13 Visible light producessignificant oxidative stress About 50% of solar-induced oxidative stress is from visible light - not UVA. 50% Source: Zastrow, et al. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pubmed/19319493
- 14. 14 Consumer media iscatching on to blue light Blue light is harmful, because it’s the highest energy wavelength of visible light. – Huffington Post, July 2014 ‘Blue Light’ or high-energy visible (HEV) light emitted from your phones, computers, and tablets penetrates more deeply into layers of skin than the sun's UV rays, thus accelerating aging. – Elle, October 2016 It appears that HEV light could be the ninja of skin aging. – Get the Gloss, August 2016 Though scientists and derms don’t know as much about it as UV light, preliminary research suggests the effects may be similarly damaging. – Women’s Health, March 2016
- 15. 15 Clinical research isproving the dangers of blue light Visible light can cause cell dysfunction through the action of reactive oxygen species on DNA and that this may contribute to cellular aging. – Bernard Godley, et al. Journal of Biological Chemistry, 2005 We determined for the first time the free radical action spectrum covering UV and visible light (280–700 nm). – Leonhard Zastrow, et al. Skin Pharmacology and Physiology, 2009 Visible rays of 400-500 nm length of wave cause an increase of the concentration of oxygen's active form. – A. Tsibadze, et al. Georgian Med News, 2015
- 16. 16 Micah™ the only productthat stops blue light damage before it starts Micah TM Compound: “C4” n-Butyl Ester
- 17. 17 Micah™ : A newcategory in suncare and anti-aging Not an antioxidant Bypasses the limitations of UV filters and antioxidants by stopping free radical formation without stability limitations Not a UV filter A “pre-oxidant” or quenching mechanism
- 18. 18 1 4 How UVAand visible blue light generate free radicals UVA/Vis PS* Photoexcited Chromophore PS e.g. Porphyrins, Flavins, Melanin, Bilirubin 1O2 Singlet Oxygen 3O2 Molecular Oxygen 3 2
- 19. 19 3 2 4 How UVA andvisible blue light generate free radicals PS* Photoexcited Chromophore PS e.g. Porphyrins, Flavins, Melanin, Bilirubin 1O2 Singlet Oxygen 3O2 Molecular Oxygen O2 .- H2O2 •OH VISIBLE SIGNS OF PHOTOAGING MAPK Pathway Oxidation ▲ AP-1 ▼ TGF-b ▲ DNA Damage ▲ Lipid Damage ▲ Protein Damage ▲ Collagen I, III Breakdown & Inflammation ▼Procollagen Production ▲ IL1-a, IL-6, MMP-1 1 UVA/Vis
- 20. 20 How Micah™ works: Stoppingthe formation of free radicals PS* Photoexcited Chromophore PS e.g. Porphyrins, Flavins, Melanin, Bilirubin MicahTM Compound UVA/Vis
- 21. 21 x 1O2 Singlet Oxygen 3O2 Molecular Oxygen How Micah™ works: Stoppingthe formation of free radicals O2 .- H2O2 •OH VISIBLE SIGNS OF PHOTOAGING MAPK Pathway Oxidation ▲ AP-1 ▼ TGF-b ▲ DNA Damage ▲ Lipid Damage ▲ Protein Damage ▲ Collagen I, III Breakdown & Inflammation ▼Procollagen Production ▲ IL1-a, IL-6, MMP-1 UVA/Vis PS* Photoexcited Chromophore PS e.g. Porphyrins, Flavins, Melanin, Bilirubin MicahTM Compound
- 22. 22 Micah™ is not aUV Filter Chemical UV filters • Only absorb up to UVA II or 360 nm • Limited efficacy in longer wavelength UVA (UVA I) • No blue light protection
- 23. 23 Micah™ is not aUV Filter UVB UVA I UVA II VISIBLE BLUE LIGHT MicahTM does not rely on absorbency Stops formation of free radicals from nearly every kind of light
- 24. 24 Micah™ is not anantioxidant Antioxidants like Vitamins A and C “mop up” or quench free radicals after the fact • Limited to a one-time occurrence • Photo, thermal and oxidatively unstable • Formulation challenges – color, texture
- 25. 25 Micah™ is not anantioxidant Micah™ • Proactively stops formation of free radicals – doesn’t work after the fact • Works until metabolized – isomerizes back and forth between its two states • Highly stable structures
- 26. 26 Proof of concept: Micah™ preventsvisible light damage MicahTM prevented 93% of UVA-induced ROS/FR from forming UVA (320 – 400 nm) MicahTM compound effectively prevented visible light- induced ROS/FR in ALA-treated ex vivo porcine skin Visible Light (630 nm)
- 27. 27 Micah™ stopped free radicalsformed by visible red light No fluorescence appears in HaCaT cells exposed to visible light that were treated with MicahTM Visible Light (-) MicahTM (-) Visible Light (+) MicahTM (-) Visible Light (+) MicahTM (+) Cells pre-treated w ith ALA Cells pre-treated w ith ALA Cells pre-treated w ith ALA
- 28. 28 Proof of concept:Micah™ stopped UVA-induced ROS/free radicals Stops UVA damage at use level of .20% * Significantly differentfrom non-irradiated controls # Significantly differentfrom irradiated vehicle Positive Controls
- 29. 29 Proof of concept:Micah™ prevented skin inflammation, redness, irritation from IL-1a * Significantly differentfrom non-irradiated controls # Significantly differentfrom irradiated vehicle Positive Controls
- 30. 30 Proof of concept:Micah™ prevented skin inflammation, redness, irritation from IL-6 * Significantly differentfrom non-irradiated controls # Significantly differentfrom irradiated vehicle Positive Controls
- 31. 31 Proof of concept:Micah™ reduced photoaging caused by other markers from 8-OHdG * Significantly differentfrom non-irradiated controls # Significantly differentfrom irradiated vehicle Positive Controls
- 32. 32 Proof of concept:Ex vivo human skin – MMP-1 * Significantly differentfrom non-irradiated controls # Significantly differentfrom irradiated vehicle
- 33. 33 Micah™ boasts an impressivesafety dossier Micah ™ Safety Tests Safety Test RX-14477 (C3) RX-14478 (C4) RX-14450 (C20) Genotoxicity/Amestest ✓ ✓ ✓ Ocular irritation (HET-CAM) ✓ ✓ ✓ Phototoxicity — in vivo (22 volunteers) ✓ ✓ ✓ Phototoxicity RHE — in vitro NA ✓ NA Phototoxicity MTT — ex vivo NA ✓ NA Sensitization/HRIPT (50 volunteers) ✓ ✓ ✓
- 34. 34 Early industry recognitionfor Micah™ [The fused-ring cyanoacrylates chemistry] is important and unique because there is nothing else that kills the aging phenomenon at the beginning … this is a long-awaited breakthrough. Paolo Giacomoni, Ph.D., Biochemist, atomic physicist and former director of research at both Estée Lauder and L’Oréal
- 35. 35 Early industry recognitionfor Micah™
- 36. 36 Formulating with Micah™ :Easy and flexible • Efficacy-to-cost usage: Just .20% • Odorless and colorless • No effect on aesthetics • Useable in any product type • Solubility easily managed
- 37. 37 A wide arrayof applications and new concepts Micah ™ opens the door to unique new products A few ideas: • More effective sunscreens with extended visible light protection • Standalone blue light protection • Antioxidant enhancers • Pollution-specific antioxidant packages • Unique anti-aging moisturizers or serums • On-the-go or multi-functional products
- 38. 38 Micah™ supports powerful, clinically-backed claims Highperformance supports several product claims: • Prevent skin darkening and dark spots • Blue and red light protection • Anti-aging, anti-wrinkle • Pollution and environmental protection • Cell and DNA protection • Free radical eliminator/quencher
- 39. 39 Micah™ consumer personas: Broader Asianmarket TARGET DEMOGRAPHIC BroaderAsian Market Women,15-50 MICAH’S ROLE Halts UVA-1 and visible light skin damage by eliminating ROS/FR Reduces presenceof IL-1a(skin barrier function), IL-6 (inflammation), lipid peroxidation, 8-OHdG (oxidative stress) PRODUCT CLAIMS • Anti-dark spot • Anti-wrinkle • Skin protectionfrom solar elements • Cell/DNA protection
- 40. 40 Micah™ consumer personas: Skintypes IV – VI TARGET DEMOGRAPHIC Skin Types IV-VI EXPOSURE TO UVA-1 & VISIBLE LIGHT Both UVA-1 and visible light can induce pigmentation in skin types IV-VI, pigmentation induced by visible light was darker and more sustained MICAH’S ROLE Micah’s™ mechanism of action could prevent excess pigmentationfrom occurring in skin type IV-VI populations PRODUCT CLAIMS Prevention from PPD in UVA-1/VisibleLight
- 41. 41 Micah™ consumer personas: Urbanconsumer TARGET DEMOGRAPHIC Urban Consumer BLUE LIGHT INDOOR AND OUTDOOR Blue light from electronic devices and indoor elements can induce oxidative stress, leading to visible signs of aging. MICAH’S ROLE Micah’s™ mechanism of action prevents the formation of oxidative stress induced by blue light PRODUCT CLAIMS • Anti-aging/Anti-wrinkle • Blue light protection
- 42. 42 Consumer personas: Metropolitan TARGETDEMOGRAPHIC Metropolitan EXPOSURE TO UVA-1 & VISIBLE LIGHT Living in stressfulenvironments overwhelms the body’s natural defenses againstFR damage.Ongoing oxidative stress directly relates to an increased rate of aging and eventual illness. PRODUCT CLAIMS • Environmental protection • Smog protection • Smoke protection • Defending against nature’s elements MICAH’S ROLE Eliminates majority of light-induced ROS/FR to free up AOX package to focus on neutralizing non-solar generated FR (ozone, pollutants, sunscreens,alcohol, severe physical and emotional stress,poor nutrition, obesity and toxins.
- 43. 43 Blue light: Quicktakeaways • The suncare market is ripe for innovation • Blue light is gaining traction with consumers • Blue light causes skin photoaging similar to UVA
- 44. 44 Micah™ : Quick takeaways •Micah’s mechanism presents a new category of suncare • Offers the only protection against blue light • Proven through clinical testing • Easy to formulate with and supports multiple claims • Effects match the needs of key demographics
- 45. 45 Start a newchapter in suncare Learn what Micah™ can do for your products. Contact Dennis Zlotnik at dzlotnik@hallstar.com today.