Innovation Plat Forms are meant to:
1) Identify major development challenges and solutions through community-based approaches that illustrate the value of solutions to communities.
2) Serve as a forum for partnerships between communities, researchers, and the private sector to scale out solutions through learning cycles connected to input and output markets.
3) Be interdisciplinary and inter-sectoral platforms that address all aspects of agriculture and livelihoods through the involvement of extension services, research, information centers, farmers, and the private sector.
Tools for reflexivity and innovation platformsILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
Coordination and facilitation of innovation platformsILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
By Ponniah Anandajayasekeram.
Presented at the ASTI-FARA conference Agricultural R&D: Investing in Africa's Future: Analyzing Trends, Challenges, and Opportunities - Accra, Ghana on December 5-7, 2011. http://www.asti.cgiar.org/2011conf
Kornelia Konrad-La empresa y las políticas de innovación transformadorasFundación Ramón Areces
El 25 de abril de 2017 organizamos en la Fundación Ramón Areces una mesa redonda sobre 'La empresa y las políticas de innovación transformadoras'. En este foro participaron, entre otros, Totti Konnola, CEO de Insight Foresight Institute; Luis Fernando Álvarez-Gascón Pérez, Director General GMV secure eSolutions; y Francisco Marín, Director General del CDTI. Esta actividad se celebró en colaboración con el Grupo de Investigación en Economía y Política de la Innovación de la Universidad Complutense de Madrid (GRINEI-UCM) y el Foro de Empresas Innovadoras (FEI).
Tools for reflexivity and innovation platformsILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
Coordination and facilitation of innovation platformsILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
By Ponniah Anandajayasekeram.
Presented at the ASTI-FARA conference Agricultural R&D: Investing in Africa's Future: Analyzing Trends, Challenges, and Opportunities - Accra, Ghana on December 5-7, 2011. http://www.asti.cgiar.org/2011conf
Kornelia Konrad-La empresa y las políticas de innovación transformadorasFundación Ramón Areces
El 25 de abril de 2017 organizamos en la Fundación Ramón Areces una mesa redonda sobre 'La empresa y las políticas de innovación transformadoras'. En este foro participaron, entre otros, Totti Konnola, CEO de Insight Foresight Institute; Luis Fernando Álvarez-Gascón Pérez, Director General GMV secure eSolutions; y Francisco Marín, Director General del CDTI. Esta actividad se celebró en colaboración con el Grupo de Investigación en Economía y Política de la Innovación de la Universidad Complutense de Madrid (GRINEI-UCM) y el Foro de Empresas Innovadoras (FEI).
Communication for Development: Research Into Practicecccomdev
Andrea Gros of the International Institute of Tropical Agriculture (IITA) presents Communication for Development: Research Into Practice at the Forum on Communication for Development and Community Media for Family Farming (FCCM) held at FAO Headquarters in Rome, Italy
Next Steps for Strengthening Agricultural Innovation Systems: A Roadmap for I...LINKInnovationStudies
Agricultural growth will lead to poverty reduction. The innovation systems concept is a useful way of thinking about how to mobilise knowledge that suits the contemporary agricultural development situation. This requires new forms of capacity development at a systems level, but what is the road map to achieving this?
From technology transfer (TT) to agricultural innovation systems (AIS)ILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
Social Revolutions are new strategies, concepts,ideas and organizations that meet the social needs of different elements which can be from working conditions and education to community development and health ,they extend and strengthen civil society.
Social Revolution includes the social processes of innovation, such as open source methods and techniques and also the innovations which have a social purpose like microcredit or distance learning.
Jim Bennett (consultant for GIZ) made this presentation during the parallel session hosted by the German International
Cooperation (Deutsche gesellschaft für internationale zusammenarbeit) , "Evaluating EITI Impact in Africa"
Not just the adoption of new technology, (agricultural) innovation also involves a new way of organising farmers to do things, of marketing crops and implementing new projects and new policies. Here we discuss the implications for projects and initiatives.
New Regional Cooperation Model by Integrating Cluster InitiativesGerd Meier zu Koecker
New Regional Cooperation Models can be understood as promising approach to better implement regional smart specialization strategies. In such Models cluster initiatives do play an important role, but have to better integrate other SME intermediaries. The presentation describes how such Models look like and what are the necessary policy framework conditions.
Innovation Platforms for increasing impact of research in Mozambique & IndiaFood_Systems_Innovation
Michaela Cosijn (CSIRO) presentation to the 'John Dillon Fellows' Workshop in Canberra in March 2015 & the 'Australian Award Fellowship' in Sydney in May 2015 on how successful collaborations and partnerships using innovation platforms can increase the impact of research.
Communication for Development: Research Into Practicecccomdev
Andrea Gros of the International Institute of Tropical Agriculture (IITA) presents Communication for Development: Research Into Practice at the Forum on Communication for Development and Community Media for Family Farming (FCCM) held at FAO Headquarters in Rome, Italy
Next Steps for Strengthening Agricultural Innovation Systems: A Roadmap for I...LINKInnovationStudies
Agricultural growth will lead to poverty reduction. The innovation systems concept is a useful way of thinking about how to mobilise knowledge that suits the contemporary agricultural development situation. This requires new forms of capacity development at a systems level, but what is the road map to achieving this?
From technology transfer (TT) to agricultural innovation systems (AIS)ILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
Social Revolutions are new strategies, concepts,ideas and organizations that meet the social needs of different elements which can be from working conditions and education to community development and health ,they extend and strengthen civil society.
Social Revolution includes the social processes of innovation, such as open source methods and techniques and also the innovations which have a social purpose like microcredit or distance learning.
Jim Bennett (consultant for GIZ) made this presentation during the parallel session hosted by the German International
Cooperation (Deutsche gesellschaft für internationale zusammenarbeit) , "Evaluating EITI Impact in Africa"
Not just the adoption of new technology, (agricultural) innovation also involves a new way of organising farmers to do things, of marketing crops and implementing new projects and new policies. Here we discuss the implications for projects and initiatives.
New Regional Cooperation Model by Integrating Cluster InitiativesGerd Meier zu Koecker
New Regional Cooperation Models can be understood as promising approach to better implement regional smart specialization strategies. In such Models cluster initiatives do play an important role, but have to better integrate other SME intermediaries. The presentation describes how such Models look like and what are the necessary policy framework conditions.
Innovation Platforms for increasing impact of research in Mozambique & IndiaFood_Systems_Innovation
Michaela Cosijn (CSIRO) presentation to the 'John Dillon Fellows' Workshop in Canberra in March 2015 & the 'Australian Award Fellowship' in Sydney in May 2015 on how successful collaborations and partnerships using innovation platforms can increase the impact of research.
Presentación realizada por Mar Maestre, del Institute of Development Studies de la Universidad de Sussex en el Máster en Estrategias y Tecnologías para el Desarrollo en mayo de 2017
NETWORK ECONOMY AND THE IMPACT TO BUSINESS MODELRiri Satria
my presentation titled "NETWORK ECONOMY AND THE IMPACT TO BUSINESS MODEL", presented to Indonesian Knowledge Forum 2012 at Ritz Carlton - Jakarta, 29-28 September 2012 ...
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
Composition and initiation of agricultural innovation platformsILRI
Presented by Iddo Dror at the SEARCA Forum-workshop on Platforms, Rural Advisory Services, and Knowledge Management: Towards Inclusive and Sustainable Agricultural and Rural Development, Los Banos, 17-19 May 2016
The short version of the 2012 work plan for MaFI approved by the SEEP Network (MaFI is a working group of the SEEP Network). It’s objectives are (i) to inform MaFI members and other key stakeholders about the intentions of MaFI in 2012 and (ii) to promote collaboration and synergies with the initiatives of other members. Additional to the initiatives included here, MaFI will continue to promote its classic initiatives, such as the MaFI Ambassadors, MaFI-licious, the Top Influencer Award, Facebook and Tweeter for listeners, and synthesis documents! Thanks again to the SEEP Network for its continued support to MaFI.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
2. Definition
• Start with : the identification of major development
challenges and solutions and then identify who can
play part in bringing these solutions (power and
influence mapping)
• We cannot give solutions and expect that people will
accept it, research and development have to use
community-based approaches to work with the
community and illustrate the value of these solutions.
• It is forum for partnership: For scaling out with
learning cycles in connection with inputs/output
market with private sector involvement
3. • IP: is a dynamic process an devolving and self-
learning process
• Other IPs may already be operating, we can learn
from and link with them
• Should take different forms depending on the
enterprise
• It has to be engendered
4. Issues which need to be integrated in
our work?
• Main purpose:
– Mobilizing stakeholders as learning process, to brig about change through
science at scale, and to show tangible economic benefits
• Scale/level:
– Community: mobilizing beneficiaries and linking with other change agents
– Regional, district levels: mobilizing more wider stakeholders who can influence
policy and institutional factors that affect out-scaling research impact
• What level: community, regional, national?
– Example: In FARA: IP is by commodity but in systems research we cannot
organized by commodity because of the complexity of issues involved
It should be part of the integrated system and included crops, markets and
natural resources.
5. IP
• The IP: should be interdisciplinary and inter-
sectoral to address all aspects of
agriculture/livelihoods; include private sector
(input suppliers, traders).
• Example:
– Some extension/advisory, research, information
centers, and farmers and private sector
– Actions should be clear
7. • Next steps:
– Formation of Community-level platforms as a
learning mechanism
– Formation of policy level platforms (at a later
stage)
• Who will drive it:
– identify facilitators (capacity enhancement of
relevant departments)