STUDY INDICATES PAIN REDUCTION ASSOCIATED WITH VULVAR LICHEN SCLEROSUS
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Vulvar Lichen Sclerosus is an inflammatory condition of the vulva, which manifests in itching and burning, with either thickened or thinned skin. Traditionally treated with ultra high-potency steroid creams, these topical prescriptions are not intended for long-term use due to health risks. NEOGYN Vulvar Soothing Cream, now available, can be used as adjunctive care to steroid treatments and part of a successful, longstanding regimen to minimize recurrence and maintain vulvar comfort. NEOGYN Vulvar Soothing Cream is a non-medicated soothing cream ideal for use in combination with other Lichen Sclerosus therapies. A clinical study recently demonstrated a significant improvement in itching, burning and pain reduction after using NEOGYN Vulvar Soothing Cream twice daily for three months. Conducted by Dr. Andrew Goldstein, a leading authority on Lichen Sclerosus and vulvar diseases, the 30 subject, placebo controlled study suggests that adjunctive care such as NEOGYN provides a new option both with steroids and in-between steroid treatments. NeoGyn Vulvar Soothing Cream is a cosmetic product, not a medication. Dr. Goldstein is the author of numerous medical textbooks on Vulvodnia, as well as When Sex Hurts, a woman’s guide to banishing sexual pain. Dr. Goldstein is also the Director of the Center for Vulvovaginal disorders in Washington D.C. and New York City.
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Similar to STUDY INDICATES PAIN REDUCTION ASSOCIATED WITH VULVAR LICHEN SCLEROSUS
Estudiante- Vanessa María Espinosa Cano
FHL2 is overexpressed in cervical cancer (CC) tissues compared to normal tissues. The study investigated the prognostic significance and effects of FHL2 expression in CC cells. Knockdown of FHL2 using siRNA in CC cells lines led to increased apoptosis and reduced proliferation, possibly through the AKT/mTOR pathway. Overexpression of FHL2 in CC cells increased viability. In a mouse model, tumors grew slower with FHL2 knockdown. Therefore, FHL2 appears to promote CC progression and may be a potential therapeutic target, though more research is needed to fully understand its role in cancer.
Immunological issues in recurrent implant failure
1. Despite growing evidence of the involvement of immunological alterations in recurrent implantation failure (RIF), there are no existing evidence-based guidelines focusing on immunological factors of RIF.
2. Antiphospholipid syndrome is one of the most frequent acquired risk factors for RIF. Antiphospholipid antibodies may induce a procoagulant state at the placenta through several mechanisms, leading to defective placentation and a relevant pathogenic mechanism in RIF.
3. Other immunological factors associated with RIF include the expansion of peripheral natural killer cells, deregulation of uterine natural killer cells, interactions between maternal killer immunoglobulin-like receptors and paternal HLA molecules on trophoblast cells,
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1) The document discusses the potential of using human chorionic gonadotropin (hCG) as a therapy for rheumatoid arthritis (RA) and Sjögren's syndrome (SS). HCG contributes to immune tolerance during pregnancy, which alleviates symptoms of these autoimmune diseases.
2) Animal studies show that hCG treatment mimics the benefits of pregnancy for RA and SS, reducing inflammation and immune responses.
3) HCG's immunosuppressive and anti-inflammatory properties suggest it could provide an alternative to current RA and SS therapies, with fewer side effects. Randomized clinical trials of hCG are recommended.
I Mille volti della Nutrizione - Integrazione alimentare nelle patologie neur...
I Mille Volti della Nutrizione - Università degli Studi di Milano - Bicocca, 18 Settembre 2015.
Intervento del dott. Marco Marchetti, CEO - FB Health.
T-Cell Epitopes
1) There is currently no vaccine that completely prevents or reduces HCV viral load, so research focuses on developing effective HCV vaccines.
2) An ideal HCV vaccine would generate both long-lasting antibody responses against the HCV envelope as well as robust and multispecific CD4+ and CD8+ T cell responses targeting the HCV core, NS3 and NS4 regions.
3) Most people infected with HCV are unaware of their infection due to low testing rates and a lack of information about test results. Campaigns aim to increase public awareness of HCV.
Gonadotropins.pptx
Which gonadotropin is best for ivf stimulation . the answer to this questions is a million dollar one. Trying to get the best evidence for the same
Luteal phase support in ART Cases Dr Sharda Jain
The document discusses luteal phase support in assisted reproductive technology (ART) cycles. It provides 3 key points:
1. Luteal phase deficiency is common in ART cycles due to multiple factors like multifollicular development and aspiration of granulosa cells, leading to premature luteolysis and defective progesterone secretion.
2. Progesterone supplementation is important for luteal phase support as progesterone prepares the endometrium, decreases uterine contractility, and regulates immunity - all of which are important for embryo implantation and maintenance of early pregnancy.
3. Oral dydrogesterone is recommended for luteal phase support in ART cycles due to its greater bioavailability allowing the use of lower doses, minimal side effects
Progestogens in miscarriages | Progestogens in Early Pregnancy | Seeds of In...
Seeds of Innocence is the best IVF centre in Delhi. SOI is best ivf hospital with highest IVF success rate using PGS/PGD technology. Call-9810350512
LaneyVaughanPosterPresentation
This study aimed to identify an antibody that could detect placental growth factor (PGF) in ovarian tissue to determine PGF's role in ovulation. Four candidate antibodies were tested on ovarian tissue from macaques administered hCG to mimic the luteinizing hormone surge in humans. Through various trials adjusting antibody concentration and tissue collection time points, none of the antibodies exhibited specific staining of PGF in granulosa cells of the ovarian follicles. While PGF is thought to be involved in ovulatory angiogenesis, further experimentation is still needed to identify an antibody that successfully binds PGF, which is necessary to understand its precise function in ovulation.
Synergy Assessment of Hypoxia and Lipopolysaccharide on Autophagy in Dendriti...
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This study investigated how hypoxia and lipopolysaccharide (LPS) affect autophagy in mouse-derived dendritic cells. The researchers found that hypoxia induced autophagy in the cells, as evidenced by increased autophagosome formation and expression of autophagy-related proteins LC3, Beclin1, and HIF-1α. Administration of LPS under hypoxic conditions further enhanced autophagy flux. Hypoxia upregulates HIF-1α, which plays an important role in activating autophagy. This study provides insight into how hypoxic environments stimulate autophagy in dendritic cells through the HIF-1α pathway and how LPS can augmentGene related to aging, obesity, and myocardial infarction, Fragile X Syndrome...
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Principles and Practices of LH Administration in Controlled Ovarian Stimulation
The document discusses principles of LH supplementation during controlled ovarian stimulation (COS) cycles. It begins by outlining how the author practices LH supplementation in different patient populations during COS using either recombinant human LH (rec-LH) or human menopausal gonadotropin (hMG), which contains LH activity from hCG. It then reviews the principles of LH supplementation, molecular differences between LH and hCG, and clinical outcomes when using preparations containing LH activity.
Undescended Testis Basics and Advanced.pptx
1. An undescended testis is a testis that fails to descend into the scrotum, and can occur at any point along its normal descent path. The most common locations are within the inguinal canal or just outside the external inguinal ring.
2. Complications of undescended testes include impaired fertility, increased risk of testicular cancer, and temperature-related damage to sperm production. Left uncorrected, nearly 40% of undescended testes lose their germ cells by age 2.
3. Diagnosis involves physical examination to locate the testis. Treatment is surgical orchiopexy between 6 months to 1 year of age to bring the testis into the sc
Ovarian Physiology - Clinical Perspective - Dr Dhorepatil Bharati
Focus Points of Discussions
WHO classification
Basic concepts
Monitoring
Drugs
Gonadotrophins
Complications
Take home messege
Nets (NEUTROPHILL EXTEACELLULAR TRAPS) in wound healing mohit
Neutrophil extracellular traps (NETs) play an important role in wound healing. NETs are released by neutrophils as part of the immune response, but high levels of NETs can also impair wound healing. In diabetes, neutrophils are primed to produce excessive NETs through a process called NETosis. This delays wound healing in diabetic patients. DNase enzymes can degrade NETs and have been shown to accelerate wound healing in diabetic mice. Further research is needed to better understand NET regulation and how DNase may help treat impaired wound healing in diabetes.
Challenges of Progesterone usage
Describes tThe precise dosage and duration of progesterone administration for luteal support in IVF are still topics of ongoing research, which could potentially lead to suboptimal outcomes such as miscarriage or preterm birth if not correctly managed.The efficacy of progesterone in reducing miscarriage and preterm birth rates in IVF, creating uncertainty about the best approach to luteal phase support.
Alloimmune factors in recurrent pregnancy loss
This was a presentation at FOGSI workshp on RPL at Chandrapur on alloimmune factors
Dr Rajesh Gajbhiye
Strategies for Improving Success Rates in ART PART
Strategies for Improving Success Rates in ART
Part - 2
Strategies for Improving Success Rates in ART
Tailoring Controlled Ovarian Stimulation
Strategies for Luteal Phase in ART cycles
Endometrial Receptivity Array
Marfia_et_al-2014-Glia
This research article examines the role of sphingosine-1-phosphate (S1P) in regulating the proliferative and stem-like properties of glioblastoma stem cells (GSCs). The results showed that GSCs rapidly consume ceramide and export S1P into the extracellular environment. Extracellular S1P levels reached nanomolar concentrations in response to increased sphingosine. S1P was also found to act as an autocrine factor that promotes GSC proliferation and maintains their stem-like phenotype. This suggests that microenvironmental S1P critically modulates the GSC population by acting as an autocrine signal to support stemness and favor proliferation, survival, and therapeutic resistance of GSCs.
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I Mille volti della Nutrizione - Integrazione alimentare nelle patologie neur...
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Progestogens in miscarriages | Progestogens in Early Pregnancy | Seeds of In...
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Principles and Practices of LH Administration in Controlled Ovarian Stimulation
Principles and Practices of LH Administration in Controlled Ovarian Stimulation
Ovarian Physiology - Clinical Perspective - Dr Dhorepatil Bharati
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Nets (NEUTROPHILL EXTEACELLULAR TRAPS) in wound healing mohit
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Strategies for Improving Success Rates in ART PART
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The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Histololgy of Female Reproductive System.pptx
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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STUDY INDICATES PAIN REDUCTION ASSOCIATED WITH VULVAR LICHEN SCLEROSUS
- 1. Safety and Efficacy of Human Fibroblast Lysate Cream for Vulvar Lichen Sclerosus. Andrew Goldstein, Lara Burrows, Richard Pfau, Matthew Bremmer, LaurileeRoybal, CorrieGoldfinger, & Frank Dreher
- 2. Disclosures: Andrew Goldstein is a consultant and has received research funding for this study from Neogyn, Inc. (Troy, Michigan, USA)
- 5. Circulating autoimmune antibodies > 50%.2
- 6. 30% have autoimmune disease: autoimmune thyroiditis, pernicious anemia, vitiligo, alopecia areata.2
- 7. Circulating autoantibodies to endothelial cell Adhesion molecule (ECAM 1) in 67% and antibodies to BP 180 and BP 230 have been detected in 30% of affected patients.3,41 Lukowsky A, J Invest Dermatol 2000;115:254e9. 2. Ueda K, J Skin Cancer. 2011; 2011: 951250 3 Oyama N, Chan I, Neill SM, et al. Lancet 2003;362:118e23. 4. Howard A, Dean D, Cooper S, et al. Australas J Dermatol 2004;45(1):12e5.
- 9. Human Fibroblast Lysate Cream Cutaneous Lysate Cellular lysate of cultured human fetal fibroblasts (also called Processed Skin Cell Proteins, or PSP®) Origin of Cells Fully tested Cell Bank Lysate Composition Mixture of >100 cytokines - growth factors (EGF, FGFs, VEGF, TGF-b1, TGF-b3, PDGF, …) - anti-inflammatory interleukins (IL-1ra, IL-4, IL-10, …) - interferons (IFN-g, …) In Vitro Activity Promotes proliferation of NHEK Promotes proliferation of NHDF Promotes collagen formation in NHDF Does not promote proliferation of SCC Does not interfere with the normal apoptotic process Clinical Data Post-wound healing Post-cosmetic procedure Skin rejuvenation
- 10. Potential Mechanisms of action of Human Fibroblast Lysate Cream (HFLC) in Lichen Sclerosus Inhibition of pro-inflammatory cytokines that are elevated in lichen sclerosus. Promotion of collagen formation. Additional wound healing properties of HFLC (promotion of growth of keratinocytes and fibroblasts).
- 11. Randomized placebo controlled study of HFCL for vulvar lichen sclerosus 30 subjects (15 cream with lysate [Active], 15 cream w/0 lysate [Placebo]); ; 12 weeks twice daily application Endpoints: Change in inflammation between pre-treatment and post-treatment biopsies as determined by two blinded dermatopathologists Investigator Global Assessment (IGA) Subjective improvement as measured by VAS of pruritus (VAS-PR) and burning/pain (VAS-BP)
- 12. RESULTS All 30 women completed the study without SAE. Significant Improvement in IGA, VAS-PR, and VAS-BP (P < 0.05) in women using HFCL from baseline to the end of the study. However, there was no difference between placebo and HFCL. No significant difference in inflammation between pre and post treatment biopsies. 60% of women using HFCL had an improvement in IGA but only 33% of woman using placebo had an improvement.
- 13. Results of women using HFCL Pre treatment Post treatment
- 14. Results of women using HFCL Pre treatment Post treatment
- 15. Results of women using HFCL Pretreatment Post treatment
- 16. Conclusions HFLC and placebo were well tolerated. There was clinical improvement in 60% the HFCL arm as compared to 33% in the placebo arm. This did not reach statistical significant. High placebo response due to a high quality emollient base. This exploratory study was inadequately powered. HFLC may be an adjunctive therapy, combined with high potency corticosteroids, for lichen sclerosus.
- 17. International Society for the Study of Women’s Sexual Health 2012 (ISSWSH.org) Jerusalem, Israel February 19 – 22, 2012