Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis? by Mariana Granito Ponte de Oliveira in Medical & Surgical Ophthalmology Research
Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100% loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but a change in hair texture (i.e, curly or straight) has rarely been reported as a consequence of alopecia areata.
Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100% loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but a change in hair texture (ie, curly or straight) has rarely been reported as a consequence of alopecia areata.
Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100% loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but a change in hair texture (i.e, curly or straight) has rarely been reported as a consequence of alopecia areata.
Alopecia areata is a common cause of hair loss seen in 3.8% of patients in dermatology clinics and in 0.2% to 2.0% of the general US population. The pathology of the disease remains poorly understood. Hair loss in alopecia areata can range from a single patch to 100% loss of body hair. When hair regrowth occurs in alopecia areata, the new hair may demonstrate pigment alterations, but a change in hair texture (ie, curly or straight) has rarely been reported as a consequence of alopecia areata.
Leprosy is a chronic infectious disease caused by
Mycobacterium leprae, discovered by Norwegian physician
in 1873.
The first known written reference to the disease was found
on Egyptian papyrus in about 1550 B.C. The disease was
well recognized in ancient China, Egypt, and India.
According to the WHO research, India continues to
record the highest number of new leprosy cases in
the world.
It currently has about 54% of all the new leprosy
cases in that 48,000 women and 13,610 children are
newly detected with leprosy
The maximum incubation period reported is as
long as 30 years
The average incubation period is between three
and ten years
— Acute Generalized Exanthematous Pustulosis (AGEP) is a rare severe cutaneous adverse reaction mainly caused by drugs. It is characterized by an acute pustular eruption over the body along with fever and leukocytosis. It has been known to resolve spontaneously over a period of 2-3 weeks without long term sequelae. However it is of utmost importance for the physicians to clinically identify this condition as to prevent unwanted extensive management. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAIDs) prescribed over the counter for pain relief. A sixteen year old boy is reported here who developed AGEP after taking mefenamic acid for fever and joint pain. It was diagnosed with the help of history, clinicopathological correlation, AGEP validation score and recovery on withdrawal of the drug. To the best of our knowledge this is the first case report of mefenamic acid causing AGEP in the literature.
Periodontitis and rheumatoid arthritis (RA) are two common chronic inflammatory diseases sharing a similar hostmediated pathogenesis [1].
Periodontitis is characterized by soft and hard tissue destruction around teeth, ultimately leading to tooth loss [2],
while RA is characterized by destruction of cartilage andbone in the joints, mediated by similar boneresorptive cytokines and proteinases [1, 3].
Both diseases lead to significant morbidity, with periodontitis ultimately leading to tooth loss and loss of masticatory function, and RA leading to loss of joint function and loss of mobility
ENDOMETRIOSIS UPDATEFocus on Dienogest Dr Sharda jain dr Jyoti Agarwal Lifecare Centre
ENDOMETRIOSIS UPDATEFocus on Dienogest
AGENDA
Background
What’s New in Endometriosis
Clinical Discussions in Managing Endometriosis
Newer Evidences on Dienogest
“Immunomodulation in Periodontics”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Sri Sai College of Dental Surgery, Vikarabad, India on 24/10/2011.
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus (HPV) infection, and it has a great predilection for the larynx [1]. The most frequently found viral subtypes are HPV 6 and 11, in 90% of cases. Subtypes 16 and 18 are rarer in children with PLR, but if they are present there is a greater potential for malignancy
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the
connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus
(HPV) infection, and it has a great predilection for the larynx [1].
The most frequently found viral subtypes are HPV 6 and 11, in
90% of cases. Subtypes 16 and 18 are rarer in children with PLR,
but if they are present there is a greater potential for malignancy
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the
connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus
(HPV) infection, and it has a great predilection for the larynx [1].
The most frequently found viral subtypes are HPV 6 and 11, in
90% of cases. Subtypes 16 and 18 are rarer in children with PLR,
but if they are present there is a greater potential for malignancy
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus (HPV) infection, and it has a great predilection for the larynx [1]. The most frequently found viral subtypes are HPV 6 and 11, in 90% of cases. Subtypes 16 and 18 are rarer in children with PLR, but if they are present there is a greater potential for malignancy
Right Sided Optic Meningioma in a Young Girl _Crimson PublishersCrimsonpublishersMSOR
ONSMs are rare tumors of anterior visual pathway [1]. ONSMs arise from meningoepithelial cap cells of the arachnoids villi and can develop at any location along the entire course of the optic nerve sheath [2,3]. We received a case of right sided optic tumor completely involving the eyeball requiring exentration surgery and were sent to our department for analysis. On cut opening a firm whicte tumor surface was seen and on microscopy a diagnosis og meningothelial meningioma was made. The diagnosis was confirmed by EMA positivity.
Atypical Presentation of Orbital Natural Killer cell Lymphoma | Crimson Publi...CrimsonpublishersMSOR
Natural killer (NK)/T-cell lymphoma is a rare malignancy accounting for less than 1 percent of all lymphomas in North America and Europe. Ocular manifestations frequently presented as orbital cellulites that does not improve with adequate antibiotics. We report a case of NK/T cell lymphoma with rare ocular manifestation that was initially confused with orbital cellulites and chronic sinusitis due to multiple negative biopsies. 92-year-old female presented with right eye vision loss, and ipsi lateral orbital swelling for four weeks. MRI demonstrated right intra-orbital extension to the orbital apex. Workups for infection and vasculitis were negative. Multiple biopsies with histopathology and flow cytology were unrevealing for malignancy. Patient failed to improve on antibiotics and steroids. Five months after the initial presentation, patient presented with the same complaint; however, the orbital mass had grown in size and involved the maxillary sinus and contra lateral side. Re-biopsy revealed positive CD 56 for NK lymphoma.
More Related Content
Similar to Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis?_Crimson Publishers
Leprosy is a chronic infectious disease caused by
Mycobacterium leprae, discovered by Norwegian physician
in 1873.
The first known written reference to the disease was found
on Egyptian papyrus in about 1550 B.C. The disease was
well recognized in ancient China, Egypt, and India.
According to the WHO research, India continues to
record the highest number of new leprosy cases in
the world.
It currently has about 54% of all the new leprosy
cases in that 48,000 women and 13,610 children are
newly detected with leprosy
The maximum incubation period reported is as
long as 30 years
The average incubation period is between three
and ten years
— Acute Generalized Exanthematous Pustulosis (AGEP) is a rare severe cutaneous adverse reaction mainly caused by drugs. It is characterized by an acute pustular eruption over the body along with fever and leukocytosis. It has been known to resolve spontaneously over a period of 2-3 weeks without long term sequelae. However it is of utmost importance for the physicians to clinically identify this condition as to prevent unwanted extensive management. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAIDs) prescribed over the counter for pain relief. A sixteen year old boy is reported here who developed AGEP after taking mefenamic acid for fever and joint pain. It was diagnosed with the help of history, clinicopathological correlation, AGEP validation score and recovery on withdrawal of the drug. To the best of our knowledge this is the first case report of mefenamic acid causing AGEP in the literature.
Periodontitis and rheumatoid arthritis (RA) are two common chronic inflammatory diseases sharing a similar hostmediated pathogenesis [1].
Periodontitis is characterized by soft and hard tissue destruction around teeth, ultimately leading to tooth loss [2],
while RA is characterized by destruction of cartilage andbone in the joints, mediated by similar boneresorptive cytokines and proteinases [1, 3].
Both diseases lead to significant morbidity, with periodontitis ultimately leading to tooth loss and loss of masticatory function, and RA leading to loss of joint function and loss of mobility
ENDOMETRIOSIS UPDATEFocus on Dienogest Dr Sharda jain dr Jyoti Agarwal Lifecare Centre
ENDOMETRIOSIS UPDATEFocus on Dienogest
AGENDA
Background
What’s New in Endometriosis
Clinical Discussions in Managing Endometriosis
Newer Evidences on Dienogest
“Immunomodulation in Periodontics”- Guest lecture as a part of Dr NTRUHS Zonal CDE programme at Sri Sai College of Dental Surgery, Vikarabad, India on 24/10/2011.
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus (HPV) infection, and it has a great predilection for the larynx [1]. The most frequently found viral subtypes are HPV 6 and 11, in 90% of cases. Subtypes 16 and 18 are rarer in children with PLR, but if they are present there is a greater potential for malignancy
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the
connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus
(HPV) infection, and it has a great predilection for the larynx [1].
The most frequently found viral subtypes are HPV 6 and 11, in
90% of cases. Subtypes 16 and 18 are rarer in children with PLR,
but if they are present there is a greater potential for malignancy
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the
connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus
(HPV) infection, and it has a great predilection for the larynx [1].
The most frequently found viral subtypes are HPV 6 and 11, in
90% of cases. Subtypes 16 and 18 are rarer in children with PLR,
but if they are present there is a greater potential for malignancy
Intralesional use of Bevacizumab in Adult Recurrent Laryngeal Papillomatosissemualkaira
Recurrent laryngeal papillomatosis (RLP) is a disease characterized by the development of exophytic proliferative lesions of the connective tissue, covered by epithelium, which affects the mucosa of the airways. The responsible agent is human papillomavirus (HPV) infection, and it has a great predilection for the larynx [1]. The most frequently found viral subtypes are HPV 6 and 11, in 90% of cases. Subtypes 16 and 18 are rarer in children with PLR, but if they are present there is a greater potential for malignancy
Similar to Can Blackcurrant (Ribes Nigrum L) Help in Control of Ligneous Conjunctivitis?_Crimson Publishers (20)
Right Sided Optic Meningioma in a Young Girl _Crimson PublishersCrimsonpublishersMSOR
ONSMs are rare tumors of anterior visual pathway [1]. ONSMs arise from meningoepithelial cap cells of the arachnoids villi and can develop at any location along the entire course of the optic nerve sheath [2,3]. We received a case of right sided optic tumor completely involving the eyeball requiring exentration surgery and were sent to our department for analysis. On cut opening a firm whicte tumor surface was seen and on microscopy a diagnosis og meningothelial meningioma was made. The diagnosis was confirmed by EMA positivity.
Atypical Presentation of Orbital Natural Killer cell Lymphoma | Crimson Publi...CrimsonpublishersMSOR
Natural killer (NK)/T-cell lymphoma is a rare malignancy accounting for less than 1 percent of all lymphomas in North America and Europe. Ocular manifestations frequently presented as orbital cellulites that does not improve with adequate antibiotics. We report a case of NK/T cell lymphoma with rare ocular manifestation that was initially confused with orbital cellulites and chronic sinusitis due to multiple negative biopsies. 92-year-old female presented with right eye vision loss, and ipsi lateral orbital swelling for four weeks. MRI demonstrated right intra-orbital extension to the orbital apex. Workups for infection and vasculitis were negative. Multiple biopsies with histopathology and flow cytology were unrevealing for malignancy. Patient failed to improve on antibiotics and steroids. Five months after the initial presentation, patient presented with the same complaint; however, the orbital mass had grown in size and involved the maxillary sinus and contra lateral side. Re-biopsy revealed positive CD 56 for NK lymphoma.
Macular Abnormality after Successful Surgery for Idiopathic Macular Hole Asse...CrimsonpublishersMSOR
Purpose: Macular changes following Internal Limiting Membrane peeling after successful Macular hole closure using optical coherence tomography.
Methods: 5 eyes of 5 patients were included in the study. The inclusion criteria were idiopathic full thickness macular hole and completed at least 6 months follow up. All patients underwent optical coherence tomography assessment before and after surgery until 6 months. Macular thickness and morphology map was analyzed before and after surgery.
Results: There were 3 males and 2 females. The age range from 45 to 59 years. Conspicuous irregular surface of the inner retina on Optical Coherence Tomography surface topography was evident in all eyes at 6 months. This was also associated with downward slope of the temporal macula seen on surface topography. There was trend towards decrease in subfield thickness especially in the T1, S1, I1 and N1 6 months after surgery. The average decrease was -60.4 microns in T1, -20.4 microns in S1, -13.0 microns in I1 and -23.4 microns in N1.
Conclusion: In this small case series brilliant blue assisted ILM peeling after successful macular whole closure showed evidence of decrease in macular thickness in all first subfield quadrant and downward slope of the temporal macula as well as conspicuous irregularity of the inner retina.
Choroidal Neovascular Membrane Association with Tumoral Calcinosis, a Case Re...CrimsonpublishersMSOR
To report a case of Choroidal neovascular membrane in a tumoral calcinosis patient, 2 eyes from 1 patient with choroidal neovascular membrane in one eye, a 40-year-old male with a history of Tumoral calcinosis presented with a choroidal neovascular membrane in his right eye, with his medical work up consisting of elevated levels of phosphorus and normal levels of calcium, with radiological imaging consistent with the diagnosis of tumoral calcinosis. We describe a case of choroidal neovascular membrane in tumoral calcinosis, and its response to Intravitreal anti-VEGF injections.
Case Report of Bilateral Medial Rectii Recessions as a Surgical Modality in C...CrimsonpublishersMSOR
Squint or strabismus is an ocular condition in which an eye deviated from its normal position of parallelism we have different forms of squints 1 con 2 acquires one of the most important things while dealing with a squint is to do the following things
1. Visual assessment
2. Refraction mydriatic
3. Fundus examination
Why funds as in children retinoblastoma and coats disease can present as squint urge we have got various forms of squint
1. Accommodate
2. Non Accommodative
11 paralytic non paralytic 11 concomitant non concomitant squint can be esotopia, exotropia, hypertropia, hypotripia, pseudotropia, hertrotropia, microtropia and cyclotropia.
Correlation between Corneal Endothelial Cell Characteristics and Dry Eye Dise...CrimsonpublishersMSOR
In this cross-sectional study, a total of 150 eyes of 75 female students aged 19-25 years who did not have any history of eye injuries or eye disease affecting the corneal endothelium cell density, were recruited from KSU Female Campus. They were divided into groups based on their dry eye disease severity. All subjects undergone full ophthalmic examinations assessing their endothelium cell count using specular microscope and dryness level using Non-invasive Break up Time (NIBUT) using Keratograph.
Selective Laser Trabeculoplasty as a Replacement Therapy in Open Angle Glauco...CrimsonpublishersMSOR
The aim of this study was to investigate the long-term effect of selective laser trabeculoplasty in open angle glaucoma patients as a replacement for medical therapy. 64 eyes of 64 primary open angle glaucoma (POAG) patients under therapy with glaucoma drugs and controlled Intra Ocular Pressure (IOP) were reviewed for 36 months. 360o selective laser therapy (SLT) sessions were performed in two sessions and the medical therapy was stopped. The patients were controlled and evaluated postoperatively 1, 3, 6, 12, 24 and 36 months after surgery for glaucoma progression. In 36 (56.3%) of the 64 patients SLT was successful and there was no need to medical treatment at 36th month. In 28 patients (43.7%) medical treatment was started due to IOP rising. In Logistic regression analysis baseline IOP was found to be significantly effective on success rate of SLT (R2: 0.718, p<0.001).
The Role of Estradiol in Idiopathic Anterior Uveitis during the Eumenorrheic ...CrimsonpublishersMSOR
Women with idiopathic anterior uveitis do not appear to relapse while pregnant. Relapses are reported more frequently and more intensely during premenstrual and menstrual stages. These observations suggest that uveitis may be related to fluctuations of sex steroid hormones.
Histoplasmosis is a systemic mycosis present in an endemic state in many tropical or temperate regions. It is a pathology induced by Histoplasma capsulatum, dimorphic fungus thriving in wetlands and at moderate temperatures. In immunocompetent subjects, 95% of clinical forms are asymptomatic. The preferred sites for this dissemination are pulmonary, medullary, hepatic, splenic and ganglionic. Exceptionally, the fungus can reach the eye.
Epidemiology of Cataract in the Mexican Population, by 2020 | Crimson PublishersCrimsonpublishersMSOR
The objective of this study is to describe, in a retrospective and prospective manner, statistical data on the revalence and incidence of cataract in the Mexican population from data generated by INEGI (Instituto Nacional de Estadísticas Geografica e Informatica - National Institute of Statistics, Geographical and Informatics) and The CONAPO (Consejo Nacional de Poblacion-National Population Council). The OPS (Organizacion Panamericana de Salud) (PAHO (Pan American Health Organization)) has determined 5 priority eye diseases in Latin America, Cases of which CATARATA causes 50% - 60% of reversible blindness. 20% of the population is above 50 years of age and 65% have visual disability.
A Chronic Post Cataract Surgery Endophthalmitis with Suspended Intraocular Le...CrimsonpublishersMSOR
Endophthalmitis is one of the most devastating complications
of intraocular surgeries, leaving patients with permanently
poor vision. Since cataract surgery consists of a large part of
ophthalmic operations, the majority of literature reports about the endophthalmitis is focused on cataract surgery [1]. Chronic post cataract endophthalmitis generally caused by propionibacterium acnes, and this entity is an indolent form of endophthalmitis usually presented 6 weeks or more after cataract surgery [2]. We display a post traumatic cataract endophthalmitic case.
Purtscher’s Retinopathy after Airbag Injury, Six month Progression and Sequel...CrimsonpublishersMSOR
Purtscher’s retinopathy is a microvasculopathy that has been
well documented but poorly understood. The earliest case was
reported by Otmar Purtscher in 1910, which described a man
who suffered cranial trauma after falling out of a tree. The current incidence of Purtscher’s retinopathy is estimated at 0.24 persons per million per year [1]. When identified, Purtscher’s is most commonly seen in young men in the setting of trauma [2]. Seat belt trauma associated with motor vehicle accidents leading to Purtscher’s retinopathy has been reported in several papers. However, only one previous case of Purtscher’s retinopathy associated with traumatic optic neuropathy has been attributed to airbag injury [3-7].
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae