Glycine's role as a neurotransmitter is highlighted in particular.

1. SPECIAL EMPHASIS ON IMPORTANCE OF NEUROTRANSMITTER LIKE
WITH GLYCINE
• PRESENTED BY :- RIYA KHATUA
• DMBH INSTITU OF MEDICAL SCIENCE
• APPROVED BY PCI & AICTE
• AFFLIATED TO WBSCTVESD & MAKAUT
• COURSE:- B.PHARMA (5 TH SEM)
• SUBJECT :- PHARMACOLOGY
• ROLL NO:- 38201921032
•REGISTRATION NO :- 213820201920014
• SESSION :- 2021 -2024
• DATE :-27.07.22

2. CONTENTS
INTRODUCTION
HISTORY
PROPERTIES
PRODUCTION
PHYSIOLOGICAL FUNCTION
SYNTHESIS
NEUROTRANSMITTER
USES
ADVERSE EFFECT

3. Introduction
• Glycine is an amino acid that amino acid that has a single hydrogen
atom as its side chain .
• It is simplest stable amine acid .
• Chemical Formula : NH2-CH2-COOH(C2H5NO2)
• Other Name:-Amino ethanoic acid , Glycocol

4. HISTORY
 Glycine was discovered in 1820 by French
chemist Henri Braconnot .[1]
 When he hydrolyzed gelatine by boiling it with
H2So4
 He orinally called it “Sugar of gelatin”.

5. -:STRUCTURE:-

6. PROPERTIES
Ǿ It is soluble in pyridine , sparingly soluble in ethanol.
Ǿ It is insoluble in ether.[2]

7. PRODUCTION
• Glycine can be isolated from hydrolyzed protein , this route is not used for industrial product
• It can be manufactured more conveniently by chemical synthesis.
• The two main processes are (1)amination of chloroacetic acid with ammonia , giving glycine
and ammonium chloride ,(2) Strecker amino acid synthesis.

8. PHYSIOLOGICAL FUNCTION
• Glycine is precursor for a variety of important metabolites such as glutathione
,porphyrins ,purines; haem & creation.
• Glycine acts as neurotransmitters in central nervous system.
• It many roles such as antioxidant , anti-inflammatory, cryoprotective &
immunomodulatory in peripheral & nervous tissues.[3]

9. SYNTHESIS
Glycine is synthesized from serine
by the mitochondrial isoform of
serine hydroxy methyltransferase.
Once released from the presynaptic
cell, glycine is rapidly removed from
the synaptic cleft by specific
membrane transporters.

10. GLYCINE ACT AS A NEUROTRANSMITTER
• Glycine is an inhibitory neurotransmitter in the central nervous system,
especially in the spinal cord, brainstem & retina.
• As an inhibitory neurotransmitter, it participates in the processing of motor
& sensory information that permits movement, vision & audition.
• The processing of sensorimotor information & locomotor behavior.

11. -: USES
:-
• Glycine is used for schizophrenia, stroke, memory & thinking skills, insomnia
& many other purpose.
• It helps regulate nerve impulses the CNS.
• FOOD SOURCE OF GLYCINE:- Snacks, pork skins, seeds, Nuts, Almond ,Fish,
Meat, Bison, Beef, Peanuts, Mustard seed, butternuts.

12. ADVERSE EFFECT
• Glycine contributes to cellular growth & health.
• It cause of oxidative stress & damage cells ,proteins,& DNA.
• COMMONLY ADVERSE EFFECT:- Nausea, vomiting, stomach upset & drowsiness,
spinal emphasis on importance of neurotransmitters like with Glycine.

13. REFERENCE
Pharmacology book author of K.D. Tripathi.
https://en.m.wikipedia.org/wiki/Glycine [1][2][3]