To share the knowledge from 2015 GI ASCO, Dr. Al Benson, one of FightCRC Medical Advisory Board members, and Andi Dwyer discuss key highlights as they pertain to colorectal cancer from the symposium and what they mean for patients.
Learning about health, family history and what information to collect is important! As we prepare for November as Health History Month, the holidays provide an excellent opportunity for families to share health history. This webinar will help you learn about colorectal cancer and cancer diagnosis, and what this means for you and your family. We’ll give you tools and resources that help you collect this important information.
http://fightcolorectalcancer.org/get-resources/webinar-series/
Tonight’s speakers: Dr. Dan Sargent and Kim Ryan
Disclaimer: “This Report is not an official event of the 2012 Gastrointestinal Cancers Symposium. Not sponsored or endorsed by any of the cosponsoring organizations of the 2012 Gastrointestinal Cancers Symposium.”
At our October webinar we spent time reviewing the importance of family history. In this webinar, we will discuss genetic and familial syndromes that are specific to colorectal cancer. We will discuss what you might look for in your family history and think about implications for prevention and management of the colorectal cancer syndromes based on this information!
About our Speakers:
Lisa Ku, MS, CGC | Certified Genetic Counselor at the University of Colorado.
Lisen Axell, MS, CGC | Certified Genetic Counselor at the University of Colorado.
Take a deeper dive into the topic of Precision Medicine and what this means for colorectal cancer. This webinar is brought to you by Fight CRC’s Research Advocacy Training and Support (RATS) program.
Learning about health, family history and what information to collect is important! As we prepare for November as Health History Month, the holidays provide an excellent opportunity for families to share health history. This webinar will help you learn about colorectal cancer and cancer diagnosis, and what this means for you and your family. We’ll give you tools and resources that help you collect this important information.
http://fightcolorectalcancer.org/get-resources/webinar-series/
Tonight’s speakers: Dr. Dan Sargent and Kim Ryan
Disclaimer: “This Report is not an official event of the 2012 Gastrointestinal Cancers Symposium. Not sponsored or endorsed by any of the cosponsoring organizations of the 2012 Gastrointestinal Cancers Symposium.”
At our October webinar we spent time reviewing the importance of family history. In this webinar, we will discuss genetic and familial syndromes that are specific to colorectal cancer. We will discuss what you might look for in your family history and think about implications for prevention and management of the colorectal cancer syndromes based on this information!
About our Speakers:
Lisa Ku, MS, CGC | Certified Genetic Counselor at the University of Colorado.
Lisen Axell, MS, CGC | Certified Genetic Counselor at the University of Colorado.
Take a deeper dive into the topic of Precision Medicine and what this means for colorectal cancer. This webinar is brought to you by Fight CRC’s Research Advocacy Training and Support (RATS) program.
On September 3, 2015, Ovarian cancer survivors and FDA Patient Representatives Peg Ford, Susan Leighton and Annie Ellis were invited to provide the patient perspective at the recent Ovarian Cancer Endpoints Workshop hosted by the Food and Drug Administration (FDA). This meeting was co-sponsored by the Society of Gynecologic Oncology (SGO), the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO). Many important topics to the ovarian cancer community were discussed, including novel clinical trial designs, biomarkers, and new classes of agents such as immunotherapies.
Breast cancer is the most common cancer among American women (American Cancer Society), but only 5-10 percent of breast cancer cases are hereditary. Of those cases, roughly 20-25 percent are linked to mutations in the BRCA1 and BRCA2 genes (BRCA stands for BReast CAncer susceptibility). View the infographic above for more on the genetics of breast cancer.
For more information on breast cancer, visit the website for Dana-Farber’s Susan F. Smith Center for Women’s Cancers Breast Oncology Program: http://www.dana-farber.org/Adult-Care/Treatment-and-Support/Breast-Cancer.aspx
Genetic counselor, Heather Herrmann, will dive in to the topic of Lynch Syndrome & CRC. Heather has enjoyed working in both pediatric genetics and cancer genetics throughout her career. She has focused the last eight years in the area of hereditary cancer syndromes and hereditary cancer risk assessment.
DCIS Topic-Driven Round Table: Decision-Making and Treatment Choicesbkling
Facilitator Deb Hackenberry is joined by Cecilia Hammond, Senior Medical Science Liaison at Genomic Health, to discuss better decision-making and your treatment choices with DCIS.
Deborah Collyar, President, Patient Advocates In Research, discusses what new research is telling us about DCIS, both here and abroad. What is low risk DCIS? Is it okay to monitor your DCIS? Is Endocrine Therapy absolutely necessary? What does the future look like? Deborah addresses this and so much more.
Understand the concept of Colorectal Cancer clinical trials and the differences across the phases. Presented by Dr. Sam J. Lubner MD, FACP University of Wisconsin Carbone Cancer Center
Living with Advanced Breast Cancer: Challenges and Opportunitiesbkling
Musa Mayer -- breast cancer survivor, advocate, and author -- presents at SHARE in November 2011. To view a video about the First International Consensus on Metastatic Breast Cancer, visit www.sharecancersupport.org/mayer.
Communities of Color and Participation in Breast Cancer Researchbkling
40 percent of Americans belong to a minority racial or ethnic group, yet only 2 percent of cancer clinical trials have studied enough minorities to provide useful information to these populations. In this webinar Dr. Susan Love, from the Dr. Susan Love Research Foundation, presents on the importance of including communities of color in breast cancer research, the barriers to diversifying research, and what can be done to address them.
Beyond BRCA Mutations: What's New in the World of Genetic Testing?bkling
Dr. Mark Robson, Clinic Director of the Clinical Genetics Service at Memorial Sloan Kettering Cancer Center, presents a medical update regarding the latest developments in genetic testing as it relates to breast and ovarian cancer. Topics include non-BRCA mutations, including both high-penetrance and so-called moderate penetrance mutations, and a framework for management of these.
Presented in collaboration with FORCE.
On September 3, 2015, Ovarian cancer survivors and FDA Patient Representatives Peg Ford, Susan Leighton and Annie Ellis were invited to provide the patient perspective at the recent Ovarian Cancer Endpoints Workshop hosted by the Food and Drug Administration (FDA). This meeting was co-sponsored by the Society of Gynecologic Oncology (SGO), the American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO). Many important topics to the ovarian cancer community were discussed, including novel clinical trial designs, biomarkers, and new classes of agents such as immunotherapies.
Breast cancer is the most common cancer among American women (American Cancer Society), but only 5-10 percent of breast cancer cases are hereditary. Of those cases, roughly 20-25 percent are linked to mutations in the BRCA1 and BRCA2 genes (BRCA stands for BReast CAncer susceptibility). View the infographic above for more on the genetics of breast cancer.
For more information on breast cancer, visit the website for Dana-Farber’s Susan F. Smith Center for Women’s Cancers Breast Oncology Program: http://www.dana-farber.org/Adult-Care/Treatment-and-Support/Breast-Cancer.aspx
Genetic counselor, Heather Herrmann, will dive in to the topic of Lynch Syndrome & CRC. Heather has enjoyed working in both pediatric genetics and cancer genetics throughout her career. She has focused the last eight years in the area of hereditary cancer syndromes and hereditary cancer risk assessment.
DCIS Topic-Driven Round Table: Decision-Making and Treatment Choicesbkling
Facilitator Deb Hackenberry is joined by Cecilia Hammond, Senior Medical Science Liaison at Genomic Health, to discuss better decision-making and your treatment choices with DCIS.
Deborah Collyar, President, Patient Advocates In Research, discusses what new research is telling us about DCIS, both here and abroad. What is low risk DCIS? Is it okay to monitor your DCIS? Is Endocrine Therapy absolutely necessary? What does the future look like? Deborah addresses this and so much more.
Understand the concept of Colorectal Cancer clinical trials and the differences across the phases. Presented by Dr. Sam J. Lubner MD, FACP University of Wisconsin Carbone Cancer Center
Living with Advanced Breast Cancer: Challenges and Opportunitiesbkling
Musa Mayer -- breast cancer survivor, advocate, and author -- presents at SHARE in November 2011. To view a video about the First International Consensus on Metastatic Breast Cancer, visit www.sharecancersupport.org/mayer.
Communities of Color and Participation in Breast Cancer Researchbkling
40 percent of Americans belong to a minority racial or ethnic group, yet only 2 percent of cancer clinical trials have studied enough minorities to provide useful information to these populations. In this webinar Dr. Susan Love, from the Dr. Susan Love Research Foundation, presents on the importance of including communities of color in breast cancer research, the barriers to diversifying research, and what can be done to address them.
Beyond BRCA Mutations: What's New in the World of Genetic Testing?bkling
Dr. Mark Robson, Clinic Director of the Clinical Genetics Service at Memorial Sloan Kettering Cancer Center, presents a medical update regarding the latest developments in genetic testing as it relates to breast and ovarian cancer. Topics include non-BRCA mutations, including both high-penetrance and so-called moderate penetrance mutations, and a framework for management of these.
Presented in collaboration with FORCE.
Dr. Dustin Deming led us through a discussion on the latest research and treatments for colorectal cancer patients presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.
A few of the topics covered include research on immunotherapy and trials studying:
– MSI-H (review of the Anti-PD-1 trial)
– HER2 amplification
– BRAF mutations
For more updates on colorectal cancer research, visit our blog: http://fightcolorectalcancer.org/category/research-treatment/
Fight Colorectal Cancer’s Medical Advisory Board Member, Axel Grothey, MD, focused this webinar to stage III colon cancer patients. Dr. Grothey, medical oncologist at Mayo Clinic, will spend the hour discussing current treatment options and exciting new research that pertains to stage III colon cancer patients.
Join Fight CRC and Dr. Scott Kopetz to learn about the latest breaking colorectal cancer research from the American Society of Clinical Oncology 2019 Annual Conference.
2017 ASCO RECAP: The Latest in Colorectal Cancer Research #CRCWebinarFight Colorectal Cancer
Don’t miss our recap webinar from the American Society of Clinical Oncology Annual Conference (ASCO) where we discuss the latest research and treatments for colorectal cancer patients presented during the conference.
Dr. Dustin Deming, a medical oncologist and Fight CRC Medical Advisory Board Member will guide us through his findings. Dr. Deming brings a unique perspective as a researcher, oncologist and colorectal cancer survivor. In this webinar we will dive into the research and explain what it means for those living with colorectal cancer.
RESEARCH & TREATMENT NEWS: Highlights from the 2014 GI Cancer SymposiumFight Colorectal Cancer
Each January, the brightest minds in colorectal cancer research meet at the Gastrointestinal Cancer Symposium.
Fight Colorectal Cancer and The Colon Cancer Alliance are partnering to bring you the big news in colorectal cancer from the symposium. Dr. Allyson Ocean will be presenting.
Get insights about new types of treatments on the horizon, diagnostic tests available, research for upcoming drugs/biomarkers and the way colorectal cancer is treated. We’ll take a look back and a look forward. You’re not going to want to miss it.
Biomarkers and biomarker testing are changing the way some colorectal cancer is treated and knowing your biomarkers can help your doctors identify your best treatment options and help you in making well informed decisions about how your cancer will be treated allowing you to be your own best advocate.
Join in on this informative webinar with guest Dr. Christopher Lieu from the University of Colorado Cancer Center, as he discusses everything you need to know about biomarkers.
In this presentation, Dr. Deborah Schrag, Medical Oncologist from Dana Farber Cancer Institute covers therapy options, surgery options, and radiation options, that are specific to rectal cancer patients. She also touches on the importance of clinical trials for this population, and highlights a few trials in research that she finds most interesting.
More information related to our Webinar Series can be found at http://fightcolorectalcancer.org/about/webinars
In this webinar, Dr. Azad discusses colorectal cancer recurrence. She addresses things to do to help reduce the risk of recurrence, in addition to what steps should be taken if colon or rectal cancer returns.
nside Myriad. At Myriad, our goal is to make a difference in patients' lives and our work has been guided by this mission throughout the Company's history. ... Since 1991, Myriad has invested heavily in educating patients and healthcare professionals about the role genes and proteins play in disease.
Report Back from SGO 2023: What’s New in Cervical Cancer?bkling
Curious about what’s new in cervical cancer research? Join Dr. Evelyn Cantillo, gynecologic oncologist at Weill Cornell Medicine, as she shares the latest updates from the Society of Gynecologic Oncology (SGO) 2023 Annual Meeting on Women’s Cancer. Dr. Cantillo will also highlight what the research presented at the conference means for you and answer your questions about the new developments.
Chair and Presenter, Marianne Davies, DNP, ACNP, AOCNP, FAAN, Matthew A. Gubens, MD, MS, and Elizabeth S. Waxman, BSN, MSN, APN-BC, prepared useful Practice Aids pertaining to NSCLC for this CME/NCPD/ILNA/IPCE activity titled “Nurses at the Forefront of the Continuing Success Story of Immunotherapy in NSCLC: Best Practices for Guiding and Supporting Patients Through Treatment and Survivorship.” For the full presentation, downloadable Practice Aids, and complete CME/NCPD/ILNA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3FvAeOR. CME/NCPD/ILNA/IPCE credit will be available until May 27, 2024.
Hear about the latest breaking colorectal cancer research! Fight CRC will be joined by Dr. Axel Grothey who will spend the hour detailing the research presented at the 2020 Gastrointestinal (GI) Cancers Symposium hosted by the American Society of Clinical Oncology.
Join Fight CRC in a webinar about biomarkers. In this session, Dr. Chris Lieu will focus the discussion on the NTRK biomarker, in addition to ctDNA, and Next-Generation Sequencing.
Downloadable slides highlighting key concepts in colorectal cancer screening and appropriate therapy selection and application in the adjuvant setting and beyond.
Similar to What 2015 Holds for Colorectal Cancer #CRCWebinar (20)
Dr. Murphy presents slides discussing general screening trends in the US, including how the US compares to other countries, different screening modalities, and differences in screening by:
-Age
-Gender
-Geography
-Race/Ethnicity
Looking to kick start your physical activity? Hoping to learn about how body movement can be a huge benefit for CRC patients and survivors? Curious about Climb for a Cure? Join this interactive webinar featuring Karia Coleman, MSK, personal trainer and athletic strength coach, and Fight CRC advocates as they discuss the importance, challenges, and joys of physical activity.
From bowel frequency, pain, and more, many colorectal cancer treatments lead to digestive side effects. Join this webinar with Dr. Cathy Eng to learn all about the digestive system, the side effects that are common due to CRC treatment, and how to manage those side effects.
Maine recently passed major colorectal cancer (CRC) policy at the state level. Join us to listen to their story and learn what worked well for CRC state advocacy!
Indiana just passed major colorectal cancer (CRC) policy this year. Join us to listen to their story and learn what worked well for CRC advocacy in Indiana!
Kentucky was one of the first states in the US to pass major colorectal cancer (CRC) policy. Join us to listen to their story and learn what worked well for CRC state advocacy!
Join us as Eden Stotsky-Himelfarb, BSN, RN from Johns Hopkins Medicine discusses how to manage after a colorectal cancer diagnosis. In this session, she will cover understanding diagnoses, shared decision making, managing mental health, talking to family and colleagues, and more.
Some colorectal cancer treatments lead to side effects of the skin. In this webinar, Dr. Nicole LeBoeuf will discuss these specific side effects. She will talk about why they occur, how to prepare for them, and how to manage them.
Anticipating the end of life and making decisions about medical care at this time can be difficult and distressing for people with cancer and their loved ones. However, it is incredibly important to plan for the transition to end-of-life care.
In this webinar, we will discuss questions to ask when considering an end to curative treatment, what to expect with hospice and end-of-life care, a new medical care team, advance directives and healthcare proxies, options for pain, the role of caregivers and loved ones, and more.
In this webinar, Dr. Angela Nicholas, Dr. Chris Heery, and Wenora Johnson discuss all things clinical trials. Dr. Nicholas, a family practitioner and caregiver to her late husband, John MacCleod will dive into her experience searching for clinical trials along with advice to those currently searching, or planning on searching in the future. Dr. Heery, Chief Medical Officer for Precision Biosciences will spend time dispelling myths around clinical trials and challenges to enrollment, and Wenora Johnson, a stage III colon cancer survivor will describe the process and her point of view curating trials in the Fight CRC trial finder.
In this webinar, Dr. Popp will discuss everything you need to know about palliative care! This is an important webinar for colorectal cancer patients and their loved ones.
eeling worn out and exhausted all the time? You may be experiencing cancer-related fatigue. Tune in to this webinar to learn what cancer-related fatigue is, how to spot it, and how to manage it.
May 2019 – What You Need to Know About Chemotherapy Induced Neuropathy WebinarFight Colorectal Cancer
Neuropathy is a common side effect for colorectal cancer patients. It is a side effect that can be incredibly challenging to manage, and can affect daily living. Join this informative webinar to learn all about neuropathy—why it happens, how to prepare for it, and methods to try and reduce its effects. This is an important webinar for all survivors and patients! Dana will speak from both the medical professional and patient angle, as she is a colon cancer survivor herself!
A cancer diagnosis and cancer treatment can be traumatic. An experience with cancer can lead to serious psychological distress that should be addressed. In this webinar, Schuyler Cunningham, Clinical Social Worker, talks about what trauma is, how to identify it, and what steps to take next.
There are countless questions when it comes to medical cannabis and colorectal cancer: How can it help? How do you get it? Are there drug interactions with chemo? What are the side effects? Is it legal where I live?
There are countless questions when it comes to medical cannabis and colorectal cancer: How can it help? How do you get it? Are there drug interactions with chemo? What are the side effects? Is it legal where I live?
March 2019 - Polyps and Prevention: The Importance of Screening for Colorecta...Fight Colorectal Cancer
Did you know that colon polyps can lead to cancer? Did you know that colorectal cancer can be prevented through regular screening? It is important to stay up to date on CRC screening and guidelines, and it is also important to know about polyps and the role that they play in the development of colorectal cancer.
Are you impacted by someone else’s cancer experience? Maybe it’s a loved one, a friend, or someone you’ve connected with online. If so, you may be familiar with compassion fatigue, which often affects people who are repeatedly exposed to loss, pain, and suffering. Join this important webinar where Teresa Deshields, Ph.D., will explain how to identify compassion fatigue and how to manage it. This is a wonderful webinar for caregivers, loved ones, and patients.
DECODING THE RISKS - ALCOHOL, TOBACCO & DRUGS.pdfDr Rachana Gujar
Introduction: Substance use education is crucial due to its prevalence and societal impact.
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2. • Speaker(s): Dr. Al Benson & Andrea Dwyer
• Archived Webinars: FightColorectalCancer.org/Webinars
• AFTER THE WEBINAR: Expect an email with links to the material & a survey. If you fill it
out, we’ll send you a Blue Star pin.
• Ask a question in the panel on the RIGHT SIDE of your screen
• Follow along via Twitter – use the hashtag #CRCWebinar
Today’s Webinar:
3. Established in 2006, our Lisa Fund
has raised thousands of dollars and
directly funded talented scientists
focused on late-stage (stage III & IV)
colorectal cancer research.
100% of the funds donated go
directly to our research grant.
Learn more or donate:
FightColorectalCancer.org/LisaFu
nd
Funding Science:
5. Disclaimer:
The information and services provided by Fight Colorectal Cancer are for
general informational purposes only. The information and services are not
intended to be substitutes for professional medical advice, diagnoses or
treatment.
If you are ill, or suspect that you are ill, see a doctor immediately. In an
emergency, call 911 or go to the nearest emergency room.
Fight Colorectal Cancer never recommends or endorses any specific
physicians, products or treatments for any condition.
6. Speakers:
Dr. Al Benson is the associate director of cooperative groups at
Northwestern University. He has served on a number of American
Society of Clinical Oncology (ASCO) committees, and is currently a
member of the Task Force on Quality of Cancer Care, the Co-Chair
of ASCO’s Colorectal Cancer Guidelines Subcommittee, the Stage II
Colon Cancer Guidelines Panel and the Guidelines Panel for use of
Radiofrequency Ablation for Colorectal Cancer Hepatic Metastases.
Dr. Benson’s research is primarily in the areas of gastrointestinal
cancer clinical trials, cancer clinical trials and biologic therapies.
Andrea (Andi) Dwyer is a public health practitioner from the
University of Colorado Cancer Center and Colorado School of Public
Health. She joined Fight Colorectal Cancer in 2014, bringing nearly
ten years experience in cancer prevention and survivorship, with a
special concentration in colorectal cancer.
8. Vitamin D in CRC
Patients
A large phase 3 trial (CALGB 80405) was conducted to compare
chemo plus bev to chemo plus cetux for patients with newly
diagnosed metastatic CRC, to see if one regimen was better than
the other. They turned out to be basically the same.
As part of this study, the study participants had blood drawn and
their vitamin D levels were tested. Patients filled out
questionnaires that asked them what supplements they were
taking, including vitamin D.
A “normal” vitamin D level is 30.0 to 74.0 nanograms per
milliliter (ng/mL). The median vitamin D level for patients on
the trial was 17.2 ng/mL, which is low.
Low vitamin D associated with:
Older, black, lower dietary and supplemental vitamin D intake,
higher BMI, lower physical activity and blood draws in winter /
spring
Patients with the highest vitamin D levels lived longer than
people with the lowest (32.6 months vs 24.5 months).
Abstract Title:
Vitamin D status and survival of
metastatic colorectal cancer
patients: Results from
CALGB/SWOG 80405 (Alliance).
(Abstract 507)
Presenting Author: Kimmie Ng
9. Vitamin D in CRC Patients: What
does this mean?
Vitamin D levels are important, BUT we don’t know is whether taking a supplement
will help patients live longer.
The patients on the trial who had high vitamin D levels were healthier in general
than the patients with low vitamin D.
What does this mean for patients?
If you want to know your vitamin D levels, talk to your doctor about getting the
test.
Vitamin D levels can be increased naturally. Sunlight and Dietary Sources. Vitamin
D can also be obtained through dietary supplements.
Don’t just start taking a lot of vitamin D pills. Too much vitamin D can be harmful
because it increases calcium levels, which can lead to calcinosis (the deposit of
calcium salts in soft tissues, such as the kidneys, heart, or lungs)
and hypercalcemia (high blood levels of calcium).
http://www.cancer.gov/cancertopics/factsheet/prevention/vitamin-D
10. Rectal Preservation
after Chemo-radiation
For patients with rectal cancer, surgery following pre-surgical
chemo-radiation is the standard of care at many cancer
centers.
At some cancer centers, they don’t always do surgery – if the
chemo-radiation looks like it’s killed all the cancer cells, they
do “non-operative management” or watchful waiting to see if
the tumor starts to re-grow.
They do this to avoid the surgery – allowing rectal
preservation and avoidance of some of the side effects of
surgery (adhesions)
In this study, presented by Jesse Smith from Memorial Sloan
Kettering Cancer Center, they looked back at two groups of
patients:
Patients who had chemo-radiation followed by surgery and didn’t
have cancer cells in their tissue
Patients who didn’t have surgery because it looked like the
chemo-radiation had killed all the cancer cells
These patients were closely monitored; if the tumors appeared
to come back, they had the standard rectal surgery.
Organ preservation in patients
with rectal cancer with clinical
complete response after
neoadjuvant therapy. (Abstract
509)
Presenting Author: Jesse Joshua
Smith
11. Rectal Preservation after Chemo-radiation
Surgery No surgery
Number of patients 72 73
Regrowth of tumor
at original site in
rectum
0 19
Local regrowth after
surgery 0 0
Metastatic disease 5 9
% patients alive
after 4 years 70 (96%) 69 (91%)
# patients with
rectal
preservation
56 (72%) 0
12. Rectal Preservation after Chemo-
radiation: What does this mean?
Suggests that watchful waiting might be an option for a carefully chosen
group of patients
To really validate this, a trial randomizing patients to watchful waiting vs
surgery needs to be done.
13. Phase III Irinotecan,
Folinic Acid, and FOLFIRI
plus RAM or placebo
Angiogenesis is the formation of new blood vessels.
Tumors need blood vessels to grow and spread.
Angiogenesis inhibitors are designed to prevent the
formation of new blood vessels, thereby stopping or
slowing the growth or spread of tumors.
There are two drugs currently approved for colorectal
cancer that target VEGF – they are bev and ziv-aflib.
At the conference, results of a different vegf targeting
drug were given. This drug is called ramucirumab
Approved for gastric cancer, lung cancer
Design – 2nd line treatment after FOLFOX/bev;
patients randomized to FOLFIRI vs FOLFIRI + RAM
RAISE: A randomized, double-blind,
multicenter phase III study of
irinotecan, folinic acid, and 5-
fluorouracil (FOLFIRI) plus
ramucirumab (RAM) or placebo
(PBO) in patients (pts) with
metastatic colorectal carcinoma
(CRC) progressive during or
following first-line combination
therapy with bevacizumab (bev),
oxaliplatin (ox), and a
fluoropyrimidine (fp). (Abstract
512)
Presenting Author: Josep Tabernero
14. Phase III Irinotecan, Folinic Acid, and
FOLFIRI plus RAM or placebo
FOLFIRI alone FOLFIRI + RAM
# patients 536 536
Median survival 11.7 months 13.3 months
Progression free survival 4.5 months 5.7months
Neutropenia 28.3% 38.45%
High blood pressure 2.8% 11.2%
Diarrhea 9.7% 10.8%
Fatigue 7.8% 11.5%
15. Phase III Irinotecan, Folinic Acid, and FOLFIRI
plus RAM or placebo: What does this mean?
Ramucirumab increased overall survival slightly – about 6 weeks
Side effects are similar to other drugs of this type
If approved by FDA, it will offer a treatment option
What we don’t know:
We can’t predict which patients will respond well to any of these drugs – there are
no genetic tests that can tell us “this person will do well”
If patients receive FOLFIRI/bev in first line, will FOLFIRI/RAM help them in second
line
For more info about angiogenesis drugs, check out
http://www.cancer.gov/cancertopics/factsheet/Therapy/angiogenesis-inhibitors
16. PDL-1 drugs:
Lots of interest in
immunotherapies that target the
Programmed Death Ligand (PDL).
Most research in these drugs in
CRC is in phase 1 or phase 2
trials.
18. PDL-1 drugs:
Very preliminary data were presented from a phase 1b
trial looking at MPDL3280A (an anti-PDL1 drug):
Safety and efficacy of MPDL3280A
(anti-PDL1) in combination with
bevacizumab (bev) and/or
FOLFOX in patients (pts) with
metastatic colorectal cancer
(mCRC).
A pilot study of AMP-224 —a PD-1
inhibitor—in combination with
stereo- tactic body radiation
therapy (SBRT) in patients with
metastatic colorectal cancer.
Presenting Author: Austin G.
Duffy, National Cancer Institute at
the National Institutes of Health,
Bethesda, MD
MPD + bev /
refractory
MPD + bev +
folfox / oxali-
naïve
Number of
patients 14 30
# prior lines of
therapy >= 3 lines 70% had no prior
therapy
Unconfirmed
response rate
(the tumors
shrank)
1 in 13 (8%)
9 in 25 (36%)
8 in 18 (44%) for
naïve patients
19. PDL-1 drugs:
Another trial was presented – this trial opened in November 2014, and
is currently recruiting patients.
Looking to see if AMP-224, another anti-PDL drug, combined with
targeted radiation, can shrink liver mets that chemo hasn’t shrunk.
The clinical trial can be found at
https://clinicaltrials.gov/ct2/show/NCT02298946
20. PDL-1 drugs
What does this mean?
All of the immunotherapy drugs look interesting but we need a lot
more data before we know how to use them and who will benefit.
If you are interested in finding a trial talk with your doctor.
21. BIOMARKERS
Lots of work going on to find biomarkers – changes in the cancer cells
that will predict who will respond to treatment – Personalized
Medicine!
To date, only RAS mutations are really helpful- patients with RAS
mutations do not benefit from treatment with cetuximab or
panitumumab
A very early phase 1 trial was presented with MM-151, a drug that
targets the EGFR receptor for patients who do NOT have a KRAS,
NRAS or BRAF mutation. This trial was for people with CRC (29),
NSCLC (9) and HNSCC (8). Some had prior cetuximab, others didn’t.
Side effects were expected – rash, diarrhea, fatigue. Many people
had an allergic reaction to MM151, which is controlled with pre-
treatment benedryl and steroids.
Initial data suggests that this drug may work best in patients with
unmutated KRAS / NRAS / BRAF, EGFR + colorectal cancer, so the
company is continuing research in this patient population.
These are very early data, and it will take several years of additional
research to see whether these preliminary results can translate to
more patients, and it illustrates the importance of RESEARCH –
funding it, participating in it.
Safety, pharmacology, and
preliminary clinical activity of MM-
151: An oligoclonal anti-EGFR
therapeutic in patients with
cetuximab-resistant CRC and
other refractory solid tumors.
Presenting Author: Christopher
Lieu, MD
22. What to Follow in 2015
TAS-102
http://fightcolorectalcancer.org/research-
treatment/another-treatment-option-coming-pike-tas-102/
Biomarkers
Immunotherapy
23. ANDI DWYER DIRECTOR OF HEALTH
PROMOTION
RESEARCH ADVOCACY TRAINING AND
SUPPORT (RATS) PROGRAM
24. RESEARCH ADVOCACY TRAINING AND
SUPPORT (RATS) PROGRAM
What is a RESEARCH ADVOCATE?
A research advocate brings a patient viewpoint to the
research process and communicates a collective patient
perspective
Fight CRC’s RATS Program:
• In partnership with academic institutions and their partners; pharmaceutical,
governmental agency, and industry sites
• Goal is to improve the ability of research advocates to effectively participate in
the research process.
• Application process open to cancer survivors, caregivers, and champions
• In person meetings, online trainings, and webinars.
• Continued education and ongoing training and support
25. RESEARCH ADVOCACY TRAINING AND
SUPPORT (RATS) PROGRAM
• After graduating RATS advocates have served on
various review panels to include:
The Food and Drug Administration (FDA)
National Cancer Institute (NCI)
Cooperative Groups
Specialized Programs of Research Excellence
(SPOREs)
Local Institutional Review Boards (IRBs) or Data
Safety Monitoring Boards (DSMBs)
• Ongoing connection and training opportunities
26. RESEARCH ADVOCACY TRAINING AND
SUPPORT (RATS) PROGRAM
RATS VALUES
Through the RAT program, Fight Colorectal Cancer is committed to excellence
in research, advocacy, education, and collaboration, upholding the following
values:
1. We value the achievement of advocates at all levels and promotion of their
accomplishments nationally and locally.
2. We value the development of an inclusive learning community.
3. We value the support of creative, critical and reflective thinking and practice.
4. We value ethical conduct by our advocates.
Interested in Learning More?
• Session at our Annual Call-on Congress Event in DC March 16th
• Visit our website
• Accepting applications in June 2015
27. Question & Answer:
SNAP A
#STRONGARMSELFIE
Bayer HealthCare will donate $1 for every
photo posted (up to $25,000).
Flex a “strong arm” & post it to Twitter or
Instagram! (Use the hashtag!)