Genetics Powerpoint
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Scientists discovered 26 genes that are frequently mutated in lung cancer tumors. When mutated, these genes likely promote the development of lung cancer. The researchers examined over 600 genes in tumor samples and found mutations in 26 genes that were not present in healthy tissue from the same patients. Identifying these lung cancer promoting genes provides targets for new therapies and suggests some existing drugs may work for patients with tumors having certain mutations.
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Scientist have found evidence that life with cancer can be extended and certain cancers can be prevented by changing dietary habits. People who are influenced by western society and maintain a western diet are in great danger if nothing is done to limit the intake of meat and consumption of process meats. New dietary guidelines are released every 5 years by the U.S. Department of Agriculture and the department of Health and Human Services. Both organizations are responsible for reviewing clinical evidence and reports from research, and creating new dietary guidelines for consumers to follow. Critics of the new guidelines argue that the USDA has censored the recommendations to eat less red meat in such a way that only the food corporations funding the research receive benefits. Cancer is caused by multiple factors but mainly from exposure to carcinogens and mutations in DNA. Carcinogens either promote cancer growth or initiate cancer growth. Certain risk factors have been associated with the development of cancers. Air pollution, tobacco use, excessive alcohol consumption, occupational hazards, exposure to radiation, and certain aspects of diet are all risk factors liked to be carcinogenic. The carcinogenic links in diet have been attracting a lot of attention in the scientific community. Scientist working with the national cancer institute, under the national institute of health, have been working together to verify the relationship between consuming meat and processed foods, and the development or progression of cancer. The national cancer institute’s division of cancer prevention, conducted a two-year study that divided 200 people into 2 groups that were diagnosed with colorectal cancer within 3 to 6 months of the study. The control group maintained their normal diet that included eating meat and processed foods while the experimental group eliminated meat and processed foods and maintained a strict vegetarian diet for the life of the experiment. The experiments objective was to test the correlation between meat consumption and the effects of colorectal cancer. The funding assisted with the research needed to find subjects for the study and to transport them to and from facilities rented out to perform colonoscopy or CT scan procedures. Graphs were made to measure the rates of reoccurrence or metastasis. 72 of the 200 participants died during the 24-month long experiment. The participants from the control group suffered a loss of 42%, while the experimental group only lost 30% of its participants before the trial was over. Those who maintained a vegetarian diet displayed an additional 25% chance of not developing metastasis and 26% decrease in polyp reoccurrence. Participants in the study who maintained a vegetarian diet developed end stage cancer or metastasis at slower rates. The informatio ...
Genome Yourself Spreads
Jay Cross, a 63-year-old man with a history of heart attacks and other health issues, pays $999 to have his genome sequenced by 23andMe. He is curious about whether his health problems are due to genetics or lifestyle. The results show he has a 20% lower risk of heart attack than average but provide little other useful information. Critics argue direct-to-consumer genetic testing currently offers limited health value given the complexity of gene-disease relationships and lack of expert guidance on interpreting results. As the science progresses, genetic testing may one day provide clearer insights but also raises concerns about overreaction to risk information.
Biology m vanessa (2)
Scientists have discovered seven new DNA regions that are linked to an increased risk of prostate cancer. A study of prostate cancer patients found variants in these DNA regions that are associated with carcinogenesis. This discovery may help explain the 25% risk of familial prostate cancer. Identifying the specific genes influencing prostate cancer risk can lead to new prevention techniques.
Biology molecular vanessa
Scientists have discovered seven new DNA regions that are linked to an increased risk of prostate cancer. A study of prostate cancer patients found variants in these DNA regions that are associated with carcinogenesis. This discovery may help explain the 25% risk of familial prostate cancer. Identifying the specific genes and DNA regions involved in prostate cancer risk could allow for new prevention techniques.
10 oncologic research
This document discusses several topics related to cancer research and treatment. It begins by explaining that cancer arises from errors in cell replication that can be caused by environmental or lifestyle factors. It then discusses several studies, including one finding that daily multivitamin supplements may reduce cancer risk in older men, and another showing that ovarian cancer screenings are not effective in reducing mortality. The document also discusses how cancer stem cells can fuel tumor growth and how targeting these cells may lead to more effective treatments. Overall, it presents the complexity of cancers and explores new strategies for research based on a deeper understanding of the disease at the cellular level.
Plegable pdf
Scientists have made progress in mapping the cancer genome and identifying genetic markers for lupus. A study identified many new genetic markers for lupus by analyzing over 27,000 people of European, African, and Hispanic descent. Separately, scientists evaluated algorithms used to analyze the cancer genome, finding that subgene algorithms provide a high-resolution view of how mutations in the same gene can lead to different health outcomes depending on location. Genetic mapping provides medical utility by aiding the discovery of drug targets and enabling targeted research in populations with high disease risk.
International Biobanking: Oportunities and Challenges for Private-Public Coll...
International Biobanking: Oportunities and Challenges for Private-Public Coll...BBMRI Stakeholder's Forum
David R. Cox M.D.,Ph.D.
Senior Vice President and Chief Scientific Officer
Biotherapeutics and Bioinnovation Center
Pfizer Inc 2016 11-11_TSRI News Release
Macrophages, immune cells, may help tumors grow by forming primitive vascular channels. Researchers discovered that macrophages can create vessel-like structures in tumors to deliver oxygen and nutrients, representing a new potential cancer treatment target. The macrophage-formed conduits have a distinct architecture from blood vessels and appear too small for red blood cells, but may transport dissolved oxygen and glucose in oxygen-deprived tumor environments. Targeting macrophage activity in addition to current anti-angiogenesis drugs could provide a new approach to starving tumors.
Vit D Mrip chart-booklet-08-2018
This document provides information from GrassrootsHealth on vitamin D research and dosing recommendations. It includes the following:
- A summary of studies showing reductions in disease incidence as vitamin D levels increase from 25 to over 60 ng/ml. Many diseases such as cancer, diabetes and heart disease showed reductions of over 30% at levels of 40 ng/ml or higher.
- Charts showing the wide range of serum vitamin D levels achieved at different daily supplemental intake amounts, based on data from over 7,000 participants. Intakes of 4000 IU/day resulted in levels from 20-120 ng/ml, demonstrating individual variability.
- Recommendations that total daily vitamin D intake of around 12,000 IU
Biomarker-Vol-8
The document summarizes research from the Institute for Genomic Biology (IGB) at the University of Illinois. It describes several projects that revealed new insights by reexamining familiar topics with improved tools and approaches. Princess Imoukhuede developed new techniques to identify cancer cell subpopulations to enable more personalized cancer treatments. A collaboration found that a small group of bees do most of the work in a hive, challenging assumptions about bee industriousness. James O'Dwyer improved an ecological model inspired by Lewis Carroll's Red Queen to better understand species evolution over long time periods. Hyunjoon Kong created a self-folding hydrogel that can slowly release drugs for tissue regeneration in a controlled manner, mimicking
Renewed-Focus-CHEMOID
Two Marshall University professors, Dr. Pier Paolo Claudio and Dr. Jagan Valluri, have developed a new technology called ChemoID Assay testing that allows doctors to personalize cancer treatment for patients. ChemoID tests tumor and cancer stem cells to determine which chemotherapy drugs will be most effective, reducing unnecessary side effects and costs of treatment. Early clinical trials found ChemoID predicted the best drug combinations for brain tumors with 100% accuracy. Their collaboration began from a chance conversation on campus and exemplifies Marshall University's focus on interdisciplinary research that benefits both the community and advances medical treatment.
Dna structure
The document discusses several studies related to DNA and cancer. A study identified a gene, NFIB, that is overexpressed in mouse and human lung tumors and appears to drive progression of small cell lung cancer. Another study revealed the molecular mechanism that promotes cancer development by characterizing regions of DNA that are more susceptible to breakage in early cancer development. A third study identified the molecular basis for DNA breakage in cancer cells.
The most complete map of oncogenes to date a summary of 568 oncogenes in 66 c...
By analyzing the genomes of 28,076 tumor samples from 66 types of cancer, 568 cancer driver genes were identified. This is the most complete map of cancer driver genes to date. The research data has been updated on the IntOGen platform.
Your MONEY or Your LIFE?
Dr. Cady deconstructs some the medical literature about the use of nutrients - and the evidence of what happens in the presence of their insufficiency. Everything for decreased viral replication to decrease brain shrinkage is covered. The role of antioxidant and carotenoids, measured by the Pharmanex Biophotonic Scanner, is reviewed.
Please note - there is no representation that any nutrient or supplement can treat, prevent, mitigate, or cure any medical condition. It does seem, however, upon reflecting on the medical literature, that there seems to be a lot of evidence for therapeutic effect in the presence of good levels of nutrient, and harm to patients if they have insufficient levels.
Vit D Chart booklet may2016
This document provides information from the GrassrootsHealth organization regarding vitamin D research and recommendations. It includes the following:
- A summary of several studies showing reductions in disease incidence as vitamin D serum levels increase from 25 ng/ml to higher levels such as 40-60 ng/ml. Diseases such as cancer, diabetes, fractures, and multiple sclerosis showed reductions.
- Charts analyzing data from over 7,000 participants in the GrassrootsHealth D*action project, showing a wide range of serum levels for any given supplemental vitamin D intake amount. Intakes of 4,000 IU/day resulted in serum levels from 10-150 ng/ml.
- Analysis suggesting supplemental intakes of 9,
Proteins
The document discusses two scientific studies about proteins and their role in Alzheimer's disease and cancer. The first study found that amyloid proteins in the brains of Alzheimer's patients have the ability to self-replicate, and depositing healthy proteins onto the amyloids causes faster replication. The second study showed that the p53 protein can control gene expression by binding to both DNA and RNA, and mutations that prevent p53 from binding DNA are linked to cancer growth. The student observes that these studies provide important insights into developing more effective Alzheimer's and cancer treatments.
The Opposing Viewpoint of Stem CellStem cell research explores t.docx
The Opposing Viewpoint of Stem Cell
Stem cell research explores the nature and growth capabilities of cells essential for ensuring replacement of cells in living organisms (Paddock, 2017). Such cells have an advantage of being manipulated to any type of cells as it is deemed necessary by the scientists based on scarcity or slow rejuvenation process of the natural cells. The general public has largely adopted a reserved approach to stem cell research and therapy despite the positive research and development showcased by leading scientists including;
· Jun Takahashi: he explored the safety and applicability of stem cell therapy in primates in relations to the Parkinson’s disease, recording a major success between the interaction of human cells and animals (Sandoiu). Furthermore, no long-term negative effect was established from the treatment that saw full recovery of the primates.
· Hai Nguyen, Aileen Anderson and colleagues: carried a similar exercise on injured mice to record tremendous success of the donor cells in a period ranging immediately after the induction process to at most one month (Society for Neuroscience. 2017).
· Scientists from the Cedars-Sinai Heart Institute in Los Angeles CA: highlighted the need for stem therapy in replacing aging heart muscles using rats (Paddock, 2017). The induced cells were able to grow and multiply thus repair the heart muscles of the older rats to improve the general body functioning.
Despite the breathtaking discoveries as tested and presented by these scientists, ethical concerns have prevailed to the dismay of an excited global scientists’ fraternity. The general public is cautious in its approach to stem cell therapy from various reasons ranging from the potential to cause cancer to how the media overrates the treatment process that still has critical gaps to full implementation (Begley, 2017). There are two major concerns that arise from the Cedars-Sinai Heart Institute research as reported by Paddock. The first concern as perceived by the layman defined as the general public is the fact the findings are based on animals other than human beings. This experiment was purely run on rodent tissue thus raising a legitimate query as to the consistency if replicated in humans. The second concern arises from Paddocks admission that the scientists proposed the need for further research to determine whether the findings are only valid when the donors are young (2017).
Since the same article admits the fact modern day medicine has seen prolonged life with a possibility of the elderly to exceed the children population, such a dependency on young donors may endanger the human species in the long run.
The excitement surrounding Stem Cell Research is magnified through mainstream media that often cares about moving volumes in sales rather than realistically highlight the caution or reservations pronounced by scientists. However, Sharon Begley is exemplary in her revelation of a high-risk gap in research that li ...
Guideline-Management-Polyarteritis-Nodosa-2021.pdf
This document presents guidelines from the American College of Rheumatology (ACR) and Vasculitis Foundation for the management of polyarteritis nodosa (PAN). It describes the methods used to develop 16 evidence-based recommendations and 1 ungraded statement for diagnosing and treating PAN. Most recommendations received a conditional grade due to the lack of high-quality evidence from randomized controlled trials. Key recommendations include early treatment of severe PAN with cyclophosphamide and glucocorticoids, limiting long-term exposure to these therapies to minimize toxicity, and using imaging and tissue biopsy for disease diagnosis.
Atossa Personalized Medicine Slides
This document describes a breast cancer screening technology called the Mammary Aspirate Specimen Cytology Test (MASCT) developed by Atossa Genetics. The MASCT uses a reusable device to non-invasively collect nipple aspirate fluid, which contains cells that can be analyzed to detect pre-cancerous changes up to 8 years before mammography. The company plans to launch the MASCT product and an accompanying cytology analysis service in breast clinics across the US to tap into the $13 billion annual breast cancer screening market. Management aims to improve the technology and expand the types of molecular biomarkers analyzed over time to further advance breast cancer risk assessment.
Bill Faloon's 2023 RAADfest Presentation Slides
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
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2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
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