Genetics
Vocabulary Review
 Allele
 Dominant vs. Recessive
 Heterozygous vs. Homozygous
 Phenotype vs. Genotype
Law of Segregation
 allele pairs separate or segregate during gamete
  formation, and randomly unite at fertilization.
Monohybrid Crosses (Punnett
Squares)

                   Genotype Ratio?
                  1AA:2Aa:1aa

                   Phenotype Ratio?
                    3dominant:1recessive
Punnett Squares
 Things to consider:
   Which trait is dominant and which is recessive?
   Is each parent heterozygous or homozygous (dominant
    or recessive)?
   What allele abbreviation would we use?
   Genotype and Phenotype ratios can be DIFFERENT!!!
Molly and Neil are planning to have
children. Molly has blue eyes and Neil has
brown eyes. What color eyes could their
children have?

  **Neil’s mom had blue
  eyes and his dad was
  homozygous for brown
  eyes**
 Now we know:
    Molly=bb
    Neil=Bb
 Genotype Ratio:
  1Bb:1bb

 Phenotype Ratio:
  1 brown eyes: 1 blue
  eyes
In plants, tall height (T) is dominant to short (t). A homozygous
dominant plant is crossed with a heterozygous plant. What would
be the resulting phenotypic and genotypic ratios in the resulting
generation of plants?
Incomplete Dominance
 form of intermediate inheritance in which one allele for a specific
  trait is not completely dominant over the other allele resulting in a
  third phenotype that is a combination of the dominant and
  recessive phenotypes
 Genotypic Ratio?
   1:2:1
(WW:RW:RR)

 Phenotypic Ratio?
      1:2:1
  (white:pink:red)
Sex-linked Traits (Examples: red-
green color blindness, hemophilia)
 xBxB : normal female
 xBxb: carrier female
 xbxb :affected female
 xBy: normal male
 xby: affected male
Cross a male with hemophilia with a
normal woman whose father had
hemophilia.
             Xh       y
                               Genotypic ratio: 1xHXh
             x HXh    xHy      :1xHy: 1Xh Xh : 1Xhy
        xH
                               Phenotypic ratio: 1 normal
                               female: 1 hemophiliac female:
             X h Xh   Xhy      1 normal male: 1 hemophiliac
        Xh                     male
Review Questions
 A male with hemophilia marries a normal woman whose
  father had hemophilia. What are the chances of their sons
  and daughters having hemophilia? Be sure to give the
  phenotypic and genotypic ratios.
 A normal male marries a woman who is also normal but
  whose father was colorblind. What are the chances of
  their sons and daughters being color blind? Give the
  phenotypic and genotypic ratios.
Blood Type: Multiple Alleles
 Blood types:
  A, B, AB, and O
 Alleles
   Codominance: A & B
    I A and IB (can be homozygous or heterozygous)
   Recessive: O
    i
A female with type AB blood is crossed with a
 man who has type O blood. What are the
 genotypic and phenotypic combinations their
 children could have?
 Parents: I AIB x ii
                                             IA     IB
 Genotypic Ratio: 1 I A i: 1 I B i          IA i   IB i
 Phenotypic ratio: 1 type A: 1 type B   i
                                             IA i   IB i
                                         i
*Look over dihybrid
cross notes*
END PUNNETT
SQUARES
Pedigrees: chart of an individual's ancestors used in
human genetics to analyze Mendelian inheritance of
certain traits, especially of familial diseases.
Pedigrees


  Female               Male
           Offspring
Pedigrees

  Individuals can be shaded to track certain traits.




 Female with specific trait     Male with specific trait
Pedigree Key:

      &         = color blind

     &      = normal vision     xBxb   xby



   What would be the
   genotype of each of
                                xbxb   xBy
   the individuals?
Genetics 137
Genetics 137

Genetics 137

  • 1.
  • 2.
    Vocabulary Review  Allele Dominant vs. Recessive  Heterozygous vs. Homozygous  Phenotype vs. Genotype
  • 3.
    Law of Segregation allele pairs separate or segregate during gamete formation, and randomly unite at fertilization.
  • 4.
    Monohybrid Crosses (Punnett Squares)  Genotype Ratio? 1AA:2Aa:1aa  Phenotype Ratio? 3dominant:1recessive
  • 5.
    Punnett Squares  Thingsto consider:  Which trait is dominant and which is recessive?  Is each parent heterozygous or homozygous (dominant or recessive)?  What allele abbreviation would we use?  Genotype and Phenotype ratios can be DIFFERENT!!!
  • 7.
    Molly and Neilare planning to have children. Molly has blue eyes and Neil has brown eyes. What color eyes could their children have? **Neil’s mom had blue eyes and his dad was homozygous for brown eyes**
  • 8.
     Now weknow:  Molly=bb  Neil=Bb  Genotype Ratio: 1Bb:1bb  Phenotype Ratio: 1 brown eyes: 1 blue eyes
  • 9.
    In plants, tallheight (T) is dominant to short (t). A homozygous dominant plant is crossed with a heterozygous plant. What would be the resulting phenotypic and genotypic ratios in the resulting generation of plants?
  • 10.
    Incomplete Dominance  formof intermediate inheritance in which one allele for a specific trait is not completely dominant over the other allele resulting in a third phenotype that is a combination of the dominant and recessive phenotypes
  • 12.
     Genotypic Ratio? 1:2:1 (WW:RW:RR)  Phenotypic Ratio? 1:2:1 (white:pink:red)
  • 13.
    Sex-linked Traits (Examples:red- green color blindness, hemophilia)  xBxB : normal female  xBxb: carrier female  xbxb :affected female  xBy: normal male  xby: affected male
  • 14.
    Cross a malewith hemophilia with a normal woman whose father had hemophilia. Xh y Genotypic ratio: 1xHXh x HXh xHy :1xHy: 1Xh Xh : 1Xhy xH Phenotypic ratio: 1 normal female: 1 hemophiliac female: X h Xh Xhy 1 normal male: 1 hemophiliac Xh male
  • 15.
    Review Questions  Amale with hemophilia marries a normal woman whose father had hemophilia. What are the chances of their sons and daughters having hemophilia? Be sure to give the phenotypic and genotypic ratios.  A normal male marries a woman who is also normal but whose father was colorblind. What are the chances of their sons and daughters being color blind? Give the phenotypic and genotypic ratios.
  • 16.
    Blood Type: MultipleAlleles  Blood types:  A, B, AB, and O  Alleles  Codominance: A & B  I A and IB (can be homozygous or heterozygous)  Recessive: O  i
  • 17.
    A female withtype AB blood is crossed with a man who has type O blood. What are the genotypic and phenotypic combinations their children could have?  Parents: I AIB x ii IA IB  Genotypic Ratio: 1 I A i: 1 I B i IA i IB i  Phenotypic ratio: 1 type A: 1 type B i IA i IB i i
  • 18.
  • 19.
  • 20.
    Pedigrees: chart ofan individual's ancestors used in human genetics to analyze Mendelian inheritance of certain traits, especially of familial diseases.
  • 21.
    Pedigrees Female Male Offspring
  • 22.
    Pedigrees Individualscan be shaded to track certain traits. Female with specific trait Male with specific trait
  • 23.
    Pedigree Key: & = color blind & = normal vision xBxb xby What would be the genotype of each of xbxb xBy the individuals?