Genetically modified cattle treating Ebola

1. 9.1 Manipulating DNA

2. 9.1 Manipulating DNA
• Transgenic animals are used to study diseases and
gene functions.
– transgenic mice used to study development and
disease
– gene knockout mice used to study gene function

3. 9.1 Manipulating DNA
Genetically modified cattle treating Ebola???
• Using cloned, genetically engineered cattle – identical, part
human
• Incubating antibodies against ebola – will be in blood plasma
• Genetically engineered to produce human antibodies
INSTEAD of cattle antibodies
• Vaccinated against deadly disease to make them produce
antibodies which can then be removed and used to treat
humans
• Similar to transfusing patients with survivor serum
• 30-60L of plasma enough = 500-1,000 doses/month/animal
• Currently being used on mice – can protect if only exposed
one day with one dose, beyond that working on everyday
doses
• Next monkeys and then onto humans
• Hantavirus, flu, MERS as well – 50 cattle currently