Climate change is causing losses and damages that cannot be avoided through mitigation or adaptation. Case studies in several countries found that extreme weather events and slow-onset changes are undermining livelihoods, food security, and culture. While increased mitigation can reduce future impacts, some level of loss and damage is inevitable. Policies are needed at national and global levels to help communities address unavoidable loss and damage through approaches like risk transfer, social safety nets, and managed retreat from vulnerable areas.