Ganoderma lucidum, also known as Lingzhi or Reishi mushroom, has been used in Chinese medicine for centuries to improve overall health and immune function. It can benefit the heart, lungs, liver, pancreas and kidneys. Specifically, Ganoderma lucidum may help treat tumors and cancer by boosting immunity, protect the liver from damage, improve cardiovascular health, delay aging by enhancing metabolism and antioxidant activity, treat neurasthenia and insomnia, lower blood pressure, and help manage diabetes.
The current presentation include the pharmacotherapy for rheumatoid arthritis. The definition, classification, mechanism of action of drugs, pharmacokinetics, adverse effects, contraindications and uses.
This is a presentation detailing the development, dosing and precautions for Thalidomide, Lenalidomide and Pomalidomide, citing the key clinical trials an evidence.
The current presentation include the pharmacotherapy for rheumatoid arthritis. The definition, classification, mechanism of action of drugs, pharmacokinetics, adverse effects, contraindications and uses.
This is a presentation detailing the development, dosing and precautions for Thalidomide, Lenalidomide and Pomalidomide, citing the key clinical trials an evidence.
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Ganoderma: magical Mushroom of ImmortalityGergely Takács
A mystic, amazing healing medicinal mushroom: Ganoderma (Reishi, Lingzhi) was chosen to be the King of Herbs in TCM (Traditional Chinese Medicine) after examining more than 200 herbs.
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Nature's Best Gift to Modern Humans
Works directly on the body to treat the "root cause" of diseases, can be taken long-term- has no side effects-
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Ganoderma ,Reshi, Mushroom,Lingzhi, are the same name of edible Fungus..Before 2000 years Chinese Medical text book marks it the king medicinal herb.Its medicinal efficacy is proven by modern medical science.It can be used as preventive & curative illness.
Dr.Shebendra karmakar
Ph.D in Natural Medicine,USA
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red reishi good natural remedy for health, importance of red reishi, reishi pharmacognosy, chemical composition of red reishi, pharmacological uses of red reishi
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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1. Ganoderma Lucidum Key Effects http://www.superganoderma.com/About_Ganoderma/Ganoderma_Luci...
Ganoderma lucidum, also named Lingzhi or Reishi, has been widely used all over the world for centuries. According to Chinese medicine,
Ganoderma lucidum can penetrate into and work on the five key human organs for impairment of the heart, lung, liver, pancreas, and kidney.
Ganoderma lucidum can cure the sickness of various human systems including respiratory, circulatory, digestive, neural, endocrine, locomotory,
etc, involving medical, surgical, gynecological, paediatric, and ENT. All these are because of its fundamental effect of "supporting the vital essence
and securing the basics", thus to improving the immune system. It differs from any other medicines that are used to cure specific disease, or
supplementary nutrients that only address particular body requirements. Ganoderma lucidum helps regulate entire body mechanism and
metabolism to ensure that all organs function properly. Some specific effects of Ganoderma lucidum are as follows:
1. Effect on Tumor
Main cause to the development of tumor is the disorder of or poor performing immune system. Ganoderma lucidum can best regulate and activate
the immune system. It prominently enhances the body immune function and increase self defense capability against tumor. Ganoderma lucidum
enhances the function of monocytic macrophage via activating synthesis of interleukin H. It also enhances blood synthesis capacity, particularly
white blood cells level. Combining with the inhibitory effect on cancer cells provided by certain ingredients in Ganoderma lucidum, it becomes one
of the most effective medicines for anti-tumor, prevent cancer, and supplement to cancer treatment. Ganoderma lucidum possesses hardly any toxic
to human body. This unique feature of enhancing immunity without toxigenicity is the definite advantage of Ganoderma lucidum over any other
immune system intensifier.
2. Liver Protection & Detoxification
Ganoderma lucidum is able to protect the liver from damaged by various physiological and biological factors. Moreover, effect can be obtained
either pre-or post-damage. Ganoderma lucidum speeds up metabolism of both medicine and toxic substances in liver, leading to curing of toxicated
hepatitis. Ganoderma lucidum is also suitable for treating chronic hepatitis, effectively eliminating the related symptoms as dizzy, fatigue, and so on.
Ganoderma lucidum can be used to treat chronic toxicosis, the various kinds of chronic hepatitis, and other hepatic diseases.
3. Effect on Cardiovascular
Clinical studies and experiments with animals confirm that Ganoderma lucidum can effectively dilate coronary artery, increase coronary vessel
blood flow, and improve circulation in cardiac muscle capillaries, thus increase the supply of oxygen and energy to cardiac muscle. Therefore
Ganoderma lucidum helps to protect the heart from shortage of blood supply, and it is ideal for both curing and preventing heart diseases like
nausea. Ganoderma lucidum can obviously reduce the level of blood cholesterol, liporotein and triglycerides in hypertensive patienst. It prevents
the formation of arterial atheromatous patches. If patches are already formed, Ganoderma lucidum will reduce cholesterol in arterial wall and soften
the blood vessel to avoid further damage. It also partially improves blood circulation, and inhibits platelet aggregation. All these effects contribute to
preventing various kinds of stroke.
4. Aging Prevention
The polysaccharides and polypeptides found in Ganoderma lucidum can effectively delay aging by the following mechanisms.
1). To enhance and regulate immune function. Such enhancement and regulation can effectively delay aging in adult and aged people. For the
youngster, the immune system will be optimized to ensure healthy growth.
2). To regulate metabolism and enhance synthesis of nucleic acids and proteins. Research works have shown that Ganoderma lucidum enhances
synthesis of nucleic acids and proteins in blood plasma, liver, and bone marrow, hence effectively prevent aging. It is observed that the use of
Ganoderma lucidum to prevent aging benefits not only the aged, but also the young, since growth and development process will ultimately lead to
aging.
3). Effect on Free Radicals. One cause of aging is the reduction of self-originated antioxidant or antioxidant-like material (such as SOD)in the body.
These antioxidants are essential for encountering damage to the body by free radicals. Ganoderma lucidum polysaccharides possess the
properties that are very similar to SOD which can remove the free radicals and prevent its damage to the body by stopping over-oxidation of lipid.
Such action protects the cells and delays their aging.
4). Ganoderma lucidum polysaccharides prominently enhance DNA synthesis in cell nucleus, and increase the number of cell divisions, which
results in delayed aging.
5. Effect on Neurasthenia
In Chinese medication, Ganoderma lucidum has been used to treat neurasthenia and insomnia since it works on the central nervous system.
Extract from Ganoderma lucidum can inhibit and reduce the level of body activity. This inhibitory effect is quantitative and is helpful for resuming the
order of activity level. The fact that Ganoderma lucidum can delay the death as the result of over-dosage of a central stimulant such as caffeine
demonstrates shows that Ganoderma lucidum works on the central nervous system by applying an inhibitory effect.
In ancient Chinese medical publications, Ganoderma lucidum can serve to "stabilize emotion", "increase wisdom", and "enhance memory power".
Recently, it is reported that Ganoderma lucidum has prominent effect on insomnia caused by neurasthenia: Effectiveness is 87.14% to 100%.In
general, effect becomes obvious after a period of 10 to 15 days, when sleep improved, appetite increased, and body weight gained. Related
headache and dizzy will be reduced or stopped. Ganoderma lucidum has a relatively strong effect on the central nervous system that makes
Ganoderma lucidum an effective substance for treatment of neurasthenia and insomnia. Ganoderma lucidum is becoming more and more
indispensable to the sufferers of neurasthenia and insomnia. To date, the effect of Ganoderma lucidum on neurasthenia and insomnia has been
clearly described and stated in the China State pharmacopoeia.
6. Effect on Hypertension
Ganoderma lucidum can effectively reduce blood pressure of an anesthetized rabbit: systolic and diastolic pressure lowered by 15% and 25%
respectively. Related neural activity is also inhibited: inhibition is 20% and 40% respectively. According to a report of a hospital, there had been 18
cases of high blood pressure successfully cured by Ganoderma lucidum extract, effectiveness up to 88.9%. It was stated that the effect of reducing
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2. Ganoderma Lucidum Key Effects http://www.superganoderma.com/About_Ganoderma/Ganoderma_Luci...
cases of high blood pressure successfully cured by Ganoderma lucidum extract, effectiveness up to 88.9%. It was stated that the effect of reducing
blood pressure by Ganoderma lucidum was mainly the result of inhibition to the sympathetic nervous system. From another report, among 30 cases
using Ganoderma lucidum products to cure high blood pressure, effectiveness was 88.3%. Moreover, it was found that Ganoderma lucidum also
extends and stabilizes the effect of reducing blood pressure of other medicine.
7. Treament of Diabetes
The constitutes in Ganoderma lucidum that reduce blood glucose are Ganoderma B and C. The principle is by enhancing utilization of blood
glucose by body tossues. Ganoderma lucidum serves as a substitute to insulin to inhibit release of fatty acids. It thus improves symptoms in high
blood glucose and high urine glucose patients. Blood glucose will be reduced from 173 to 116, cholesterol from 233 to 179, beat-protein from 580 to
465. Water-solubility polysaccharides in Ganoderma lucidum suppresse insulin-independent diabetes. The health food products manufactured by
Japan Numata Kenji, has been widely used for the treatment of diabetes.
8. Effect on Chronic Bronchitis & Bronchus Asthma
Ganoderma lucidum can stop coughing, clear sputum, and suppress asthma. It also relieves the symptoms of the related illnesses. Since
Ganoderma lucidum can activate the immune system, it can prevent from flu, and thus above syndromes. Ganoderma lucidum is particularly
suitable for the treatment of the patients categorized as "cold and wet" by Chinese medicine, while for the "hot and dry" patients would be relatively
less effective. The average effectiveness is 80%.
9. Effect on Hyper Susceptibility
When the body is invaded by an antigen that ellicits an immunological reactions and results the various abnormality and immuno-pathological
symptoms, Ganoderma lucidum can be used to suppress the reactions and resume the body order. The experiment shows that Ganoderma lucidum
can stop the release of hyper susceptible factors and prevent the development of allergic reactions. Therefore, Ganoderma lucidum is relatively
more effective over other current medicines when treating the illnesses caused by abnormal hyper-reactivity or autoimmunity such as allergic
asthma, erythematous lupus vulgaris, rheumatoic arthritis, rheumatoic heart diseases, allergic rhinitis, skin diseases, etc. Ganoderma lucidum can
also help to cure the toxification patients as the result of pro-longed usage of hormones.
10. Effect on Beauty Care
Ganoderma lucidum has been named the "Medicine of Eternal Life". It is mainly contributed to the effect on skin protection, and delaying aging.
Ganoderma lucidum can retain and regulate the water in skin and thus can keep the skin elasticity, hydrated and smooth. It also inhibits the
formation and deposition of melanin in skin. Today, the beauty care products made from Ganoderma lucidum are becoming the new stars in the
industry. Taking Ganoderma lucidum food products will obtain synergistic effect. To add Ganoderma lucidum into the bath will not only keep the
skin smooth and lustrous, but also prevent it from bacterial infection.
In addition to the above effects, Ganoderma lucidum stimulates blood synthesis in bone marrow and increase WBC level, which make it suitable for
the treatment of low WBC symptom caused by over dosage of radiation and blood diseases, etc. By enhancing the body immune system,
Ganoderma lucidum can defend the body from viral infections like AIDS virus. Ganoderma lucidum also promotes tolerance of the body to adverse
environment. It suppresses over contraction of smooth muscle in uterus to remedy the functional uterine bleeding. Ganoderma lucidum is also
effective for the pigment denaturation in retina, the underdeveloped brain, as well as abnormal muscular development. Ganoderma lucidum is also
an effective pain reliever for headache, neural pain, cancer pain, etc.
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