gamma GT
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Gama GT is anzyme for the transfer of glumyle group form one peptide to another peptide group. its an specific hapatobilary enzyme which is elevated in biliary obstraction.
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- Discusses factors that influence serum urea levels and the clinical significance of elevated or decreased levels. elevated BUN:creatinine ratio indicates prerenal azotemia while a low ratio suggests renal failure.
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gamma GT
- 2. INTRODUCTION
- 3. TOPIC
- 4. INTRODUCTION •GGT catalyzes the transfer of Gamma glutamyl group from peptides or peptide like compounds to an acceptor peptide molecule •GGT acts on peptide or peptide like compunds containing a terminal glutamate residue joinedto the remained combined through the terminal gamma-carboxy. •Hepatobiliary type enzyme.
- 5. LOCATION • GGT found in many tissues like highest activity of the enzyme is found in kidneys, bile duct, pancreas, gallbladder, spleen, heart, brain, and seminal vesicles. • Some enzyme is present in cytosol,but the larger function is located in cell membrane.
- 6. NORMAL VALUES OF GGT • Normal range of GGT is • for male; 10-50u/l. • for female;7-35u/l.
- 7. FUNCTIONS OF LDH •GGT plays a major role in glutathione metabolism. •Leukotriene synthesis. •Drug •Xenobiotic detoxification. •Resorption of amino acids from glomerular filterate and from the intestinal lumen. •It is involved in the transfer of amino acids across the cell membrane.
- 8. CLINICAL SIGNIFICANCE OF GGT • The enzyme present in serum appears to originate primarily from the hepatobiliary system. • GGT activity is elevated in all forms of liver disease like obstructive jaundice. • cholangitis • cholecystitis • Biliary atresia • Infectious hepatitis
- 9. CONDITIONS IN WHICH IT IS ELEVATED • Obstructive jaundice • myocardial infarction • alcoholic cirrhosis • pancreatitis • Hepatobiliary obstruction • primary and secondary metastatic neoplasms. • Anticonvulsant drugs • GGT is the most sensitive enzyme indicator of the hepatobiliary disease.
- 10. CONDITIONS IN WHICH IT IS ELEVATED • Obstructive jaundice • myocardial infarction • alcoholic cirrhosis • pancreatitis • Hepatobiliary obstruction • primary and secondary metastatic neoplasms. • Anticonvulsant drugs • GGT is the most sensitive enzyme indicator of the hepatobiliary disease.