Gamma-glutamyl transferase (GGT) is an enzyme related to glutathione metabolism and is primarily found in the hepatobiliary system, with the highest activity in organs such as the kidneys and pancreas. Normal GGT levels differ by gender, ranging from 10-50 U/L for males and 7-35 U/L for females, and its elevation indicates liver disease and other medical conditions. GGT is considered the most sensitive enzyme indicator for hepatobiliary diseases, including obstructive jaundice and alcoholic cirrhosis.

2. INTRODUCTION

3. TOPIC

4. INTRODUCTION
•GGT catalyzes the transfer of Gamma glutamyl group from
peptides or peptide like compounds to an acceptor peptide
molecule
•GGT acts on peptide or peptide like compunds containing
a terminal glutamate residue joinedto the remained
combined through the terminal gamma-carboxy.
•Hepatobiliary type enzyme.

5. LOCATION
• GGT found in many tissues like highest activity of the
enzyme is found in kidneys, bile duct, pancreas,
gallbladder, spleen, heart, brain, and seminal vesicles.
• Some enzyme is present in cytosol,but the larger function
is located in cell membrane.

6. NORMAL VALUES OF GGT
• Normal range of GGT is
• for male; 10-50u/l.
• for female;7-35u/l.

7. FUNCTIONS OF LDH
•GGT plays a major role in glutathione metabolism.
•Leukotriene synthesis.
•Drug
•Xenobiotic detoxification.
•Resorption of amino acids from glomerular filterate and
from the intestinal lumen.
•It is involved in the transfer of amino acids across the cell
membrane.

8. CLINICAL SIGNIFICANCE OF GGT
• The enzyme present in serum appears to originate
primarily from the hepatobiliary system.
• GGT activity is elevated in all forms of liver disease like
obstructive jaundice.
• cholangitis
• cholecystitis
• Biliary atresia
• Infectious hepatitis

9. CONDITIONS IN WHICH IT IS ELEVATED
• Obstructive jaundice
• myocardial infarction
• alcoholic cirrhosis
• pancreatitis
• Hepatobiliary obstruction
• primary and secondary metastatic neoplasms.
• Anticonvulsant drugs
• GGT is the most sensitive enzyme indicator of the
hepatobiliary disease.

10. CONDITIONS IN WHICH IT IS ELEVATED
• Obstructive jaundice
• myocardial infarction
• alcoholic cirrhosis
• pancreatitis
• Hepatobiliary obstruction
• primary and secondary metastatic neoplasms.
• Anticonvulsant drugs
• GGT is the most sensitive enzyme indicator of the
hepatobiliary disease.