Kidney Organ Shortage in America is PreventableWoody Savage
Why do we continually chase solutions to unsolvable problems BUT ignore the problems that have solutions?
Kidney Organ Transplants account for the majority of our organ transplant shortages in America; live organ donation is the obvious solution...we don't need a medical miracle to make it happen--we simply need to educate and motivate the masses to support changing our archaic 30 year-old 1984 law so that we make it affordable for anyone who desires to become a living kidney organ transplant donor. Please share this presentation with others so we can eradicate the kidney organ transplant shortage in America!
Kidney Organ Shortage in America is PreventableWoody Savage
Why do we continually chase solutions to unsolvable problems BUT ignore the problems that have solutions?
Kidney Organ Transplants account for the majority of our organ transplant shortages in America; live organ donation is the obvious solution...we don't need a medical miracle to make it happen--we simply need to educate and motivate the masses to support changing our archaic 30 year-old 1984 law so that we make it affordable for anyone who desires to become a living kidney organ transplant donor. Please share this presentation with others so we can eradicate the kidney organ transplant shortage in America!
El informe analiza cómo evolucionará la legislación fiscal en todo el mundo, el impacto de la nueva regulación en cómo las empresas gestionan sus riesgos y en cómo, ambos factores, están transformando la función fiscal dentro de las compañías.
Kidney Transplant Exploring Living DonationDebra Fette
Hey Everyone, I have kidney failure. I'm trying to get the word out but not having any luck. I created a cool website but no luck so far. Can you do me a huge favor, PLEASE check it out, LIKE & SHARE with all your family, friends, FB friends, twitter, other social media sites & anyone you know. My life depends on finding that caring individual who is willing to donate a kidney. With your help, I know I can find that special person. I welcome all questions, comments, ideas or good wishes. CHECK THIS COOL SITE! Looks more amazing on a laptop or PC over mobile. http://debbie7467.wix.com/kidneykampaign1
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
Alex Tabarrock on Using Incentives to Increase Organ Donation. More at http://www.marginalrevolution.com/marginalrevolution/2010/05/changing-views-on-organ-prohibition.html
Informative Speech Template Outline
I. Introduction (Approximately 30 sec-1min.)
A. Attention Getter
B. Background and Audience Relevance
C. Speaker Credibility
D. Thesis
E. Preview of Main Points
Transition to first main point
II. Body (Approximately 2-3 min)
A. Main Point 1:
1. Sub point 1
2. Sub point 2
Transition (signpost, summary, preview)
B. Main Point 2
1. Sub point 1
2. Sub point 2
Transition and signal closing
III. Conclusion (Approximately 30 seconds-1 minute)
A. Restate Thesis
B. Review Main Points
C. Memorable Closer
Selling Organs for Transplantation
LEWIS BURROWS, M . D .
Abstract
The need for transplant organs has far outstripped the supply of available cadaveric organs. Hundreds
of people on waiting lists, who could be saved by transplantation, die each year. This severe shortage
has justified the extension of transplantation to the use of living donors, but there are still not enough
organs to meet the need. This paper discusses the justification for changing policies in order to encour-
age organ donation. It presents reasons for allowing payments to be made to families that donate
cadaveric organs. It also presents reasons for allowing payments to be made to living donors, and
guidelines for how an ideal policy could be structured.
Key Words: Selling, payment, organs, transplant, financial remuneration, presumed consent, altruism,
ethics.
LIVING DONOR ORGAN TRANSPLANTATION is the
only field of medicine in which two individuals
are intimately involved: the donor and the re-
cipient. It is also the only field of medicine in
which altruistic giving of oneself is the basis of
the medical practice. I have been asked to ad-
dress a very specific aspect of this process, that
is, living organ donation for financial remuner-
ation. No other subject in the transplant experi-
ence is as controversial. Many of those in-
volved in the field—surgeons, physicians, so-
cial scientists, ethicists, and theologians—have
expressed an opinion on this issue.
As a result of impressive gains in this field,
organ recipients now have a significant chance
for both long-term survival and a reasonable
quality of life. These successes have led nearly
80,000 individuals to opt for transplantation as
a form of therapy. Unfortunately, the number of
organs available has lagged far behind the de-
mand. Every year thousands die while waiting
for the gift of life that an organ transplant could
provide.
In the case of cadaveric giving, the family
of the brain-dead person is asked to donate.
Address all correspondence to Lewis Burrows, M.D., 201 East
17th Street, Apt. 27H, New York, NY 10003; email: Rock-
[email protected]
Adapted from a presentation at the Issues in Medical Ethics
2001 Conference on "Medicine, Money, and Morals" at the
Mount Sinai School of Medicine, New York, NY on November 2,
2001, and updated as of Eebruary 2004.
There is a serious shortfall in cadaveric organ
donations, with only 40-60% of U.S. families
consenting to organ recov.
El informe analiza cómo evolucionará la legislación fiscal en todo el mundo, el impacto de la nueva regulación en cómo las empresas gestionan sus riesgos y en cómo, ambos factores, están transformando la función fiscal dentro de las compañías.
Kidney Transplant Exploring Living DonationDebra Fette
Hey Everyone, I have kidney failure. I'm trying to get the word out but not having any luck. I created a cool website but no luck so far. Can you do me a huge favor, PLEASE check it out, LIKE & SHARE with all your family, friends, FB friends, twitter, other social media sites & anyone you know. My life depends on finding that caring individual who is willing to donate a kidney. With your help, I know I can find that special person. I welcome all questions, comments, ideas or good wishes. CHECK THIS COOL SITE! Looks more amazing on a laptop or PC over mobile. http://debbie7467.wix.com/kidneykampaign1
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. WPW is caused by the presence of an abnormal accessory electrical conduction pathway between the atria and the ventricles. Electrical signals traveling down this abnormal pathway (known as the bundle of Kent) may stimulate the ventricles to contract prematurely, resulting in a unique type of supra-ventricular tachycardia referred to as an atrio-ventricular reciprocating tachycardia.
Alex Tabarrock on Using Incentives to Increase Organ Donation. More at http://www.marginalrevolution.com/marginalrevolution/2010/05/changing-views-on-organ-prohibition.html
Informative Speech Template Outline
I. Introduction (Approximately 30 sec-1min.)
A. Attention Getter
B. Background and Audience Relevance
C. Speaker Credibility
D. Thesis
E. Preview of Main Points
Transition to first main point
II. Body (Approximately 2-3 min)
A. Main Point 1:
1. Sub point 1
2. Sub point 2
Transition (signpost, summary, preview)
B. Main Point 2
1. Sub point 1
2. Sub point 2
Transition and signal closing
III. Conclusion (Approximately 30 seconds-1 minute)
A. Restate Thesis
B. Review Main Points
C. Memorable Closer
Selling Organs for Transplantation
LEWIS BURROWS, M . D .
Abstract
The need for transplant organs has far outstripped the supply of available cadaveric organs. Hundreds
of people on waiting lists, who could be saved by transplantation, die each year. This severe shortage
has justified the extension of transplantation to the use of living donors, but there are still not enough
organs to meet the need. This paper discusses the justification for changing policies in order to encour-
age organ donation. It presents reasons for allowing payments to be made to families that donate
cadaveric organs. It also presents reasons for allowing payments to be made to living donors, and
guidelines for how an ideal policy could be structured.
Key Words: Selling, payment, organs, transplant, financial remuneration, presumed consent, altruism,
ethics.
LIVING DONOR ORGAN TRANSPLANTATION is the
only field of medicine in which two individuals
are intimately involved: the donor and the re-
cipient. It is also the only field of medicine in
which altruistic giving of oneself is the basis of
the medical practice. I have been asked to ad-
dress a very specific aspect of this process, that
is, living organ donation for financial remuner-
ation. No other subject in the transplant experi-
ence is as controversial. Many of those in-
volved in the field—surgeons, physicians, so-
cial scientists, ethicists, and theologians—have
expressed an opinion on this issue.
As a result of impressive gains in this field,
organ recipients now have a significant chance
for both long-term survival and a reasonable
quality of life. These successes have led nearly
80,000 individuals to opt for transplantation as
a form of therapy. Unfortunately, the number of
organs available has lagged far behind the de-
mand. Every year thousands die while waiting
for the gift of life that an organ transplant could
provide.
In the case of cadaveric giving, the family
of the brain-dead person is asked to donate.
Address all correspondence to Lewis Burrows, M.D., 201 East
17th Street, Apt. 27H, New York, NY 10003; email: Rock-
[email protected]
Adapted from a presentation at the Issues in Medical Ethics
2001 Conference on "Medicine, Money, and Morals" at the
Mount Sinai School of Medicine, New York, NY on November 2,
2001, and updated as of Eebruary 2004.
There is a serious shortfall in cadaveric organ
donations, with only 40-60% of U.S. families
consenting to organ recov.
Passport to the World: An Intervention to DepressionHillary Green
Jo Dorhout, President of Virtual Interactive Families, presented at The University of Texas at Arlington Research Institute's Symposium on Biomedical Technologies
The 10th Annual Utah Health Services Research Conference: Assessment of Actual Pediatric Organ Donation Potential: Neurological and Circulatory Determination of Death. By: Erin E. Bennett, M.D., MPH; Jill Sweney, M.D.; Cecile Aguayo, R.N.; Craig Myrick, R.N.; Armand H. Matheny Antommaria, M.D., Ph.D.; Susan L. Bratton, M.D., MPH.
Patient Centered Research Methods Core, University of Utah, CCTS
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tai lieu tong hop, thu vien luan van, luan van tong hop, do an chuyen nganh
A Community Survey of the Willingness, Perceptions and Practice of Blood Dona...Premier Publishers
Blood donation is the major way of acquiring blood in emergency situations, major surgeries and blood related obstetric complications. The disparity between willingness to donate and the real practice of blood donation has implication for the establishment of blood transfusion services in Nigeria. This community survey of the willingness, perceptions and practice of blood donation among adults in Kano metropolis identified factors associated with willingness to donate as well as perceptions and practice of blood donation. This was a descriptive cross-sectional survey of adults from four of the eight local Governments areas within Kano metropolis employing a mixed method of data collection; i.e. comprising a quantitative and qualitative component, using a multi-stage sampling method. Relevant history on the willingness, perceptions and practice of blood donation were obtained using a structured interviewer administered questionnaires and in-depth interviews. Data were entered and analyzed using the Statistical Package for Social Sciences (IBM SPSS) version 20. A total of 215 out of 216 respondents were surveyed, giving a response rate of 99.5%. Their ages ranged from 18years to 65years, with a mean age of 30.5 (± 10.5) years. There were 101 (46.8%) males and 113 (52.3%) females. Respondent’s willingness to donate blood was 94.9%, while practice of blood donation was 25.5%. All respondents had a good perception of blood donation and indicated that it was a way of saving other peoples’ lives. Willingness to donate blood was high in this study; however, this did not translate well to the practice of blood donation. Efforts should be made by government and organizations involved in blood donation to increase awareness and encourage people to donate blood voluntarily through efforts such as signing blood donation card.
The National Kidney and Transplant Institute (NKTI) would like to share the digital copy of the newsletter of our Human Organ Preservation Effort (HOPE):
"Life After Death: Gift of Life Through Organ Donation"
For feedback, you may email hope@nkti.gov.ph or call local 4400.
Alicia, D. (2014). Todd and Tara Storch Increase Organ Donation Aw.docxsimonlbentley59018
Alicia, D. (2014). Todd and Tara Storch Increase Organ Donation Awareness After Tragic Death. Retrieved October 15, 2018, from http://www.people.com/
Annotation: This website is based on a story of a Storch family whereby a youthful daughter has lost control would they have been ski in Denver. The parents accept the organ transplant so that another person gets the opportunity of having a life. these made this decision to change the life of the five strangers who were linked with the family as an indication of gratitude and telling them how Taylor life has changed theirs.
It is evident from this article that those who have received the transplant appreciate the change in their life and how they are impacting on others with regard to these changes. Through this sample work, the author is able to give an explanation regarding a girl who died and her parents are making a decision of donating her organ to help another person so that he can have the opportunity if life. This article is important because it explains the perception and the importance of the organ transplant.
Brazier, Y. (2016, March 10). Organ donation: most are willing to give, so why is there a doctor shortage? Retrieved October 15, 2018, from Medical News Today: https://www.medicalnewstoday,com/articles/307514.php
Annotation: In this article, an example case or a kidney transplant which occurred in 1954 between two twins is given. Organ transplant has become a common thing and there are many cases of organs transplantation procedures which have been performed. The author provides some of the statistics on the organ transplant procedures on kidney, liver, pancreas, heart, lungs, and the intestine which have been carried out. The author of the article is also trying to name and give a discussion on the reasons why individuals who have the ability to donate or undergo organ transplant are not ready to do so. According to the author, there are some personal and the religious beliefs which prevent some individuals from being ready to undergo organ transplant for the purposes of donating to other people. This article is important because it is engaging and more informative with full statistical information.
Cohen, L. E., & Hoffner, C. (2013). Gifts of giving: The role of empathy and perceived benefits to others and self in young adults' decisions to become organ donors. Journal of Health Psychology, 18 (1), 128-138.
Annotation: This was a survey work which was targeted at examining how the perceived benefits of the organ transplantation for other people and the individual's readiness to register as a donor. According to this article, trait empathy and the individual evaluation is exerting a powerful influence on varied prosocial behaviors, nevertheless, there is lack of clarity concerning the role when it comes to the promotion of the organ transplantation.
The authors are trying to address some of the shortages of the organs for transplantation and how it has caused many studies and.
Name 1 Student NameProfessor Morris English 2367 .docxgertrudebellgrove
Name 1
Student Name
Professor Morris
English 2367
14 November 2019
Organ Donation: You Can Make a Difference
The national organ transplant waiting list continues to grow larger and larger, day by day,
and we need to take action to decrease the number of patients dying before they receive a
lifesaving organ. Although the idea of everyone receiving a transplant that will save their life is
desirable, it’s practically impossible to save every single person that is on the waiting list. It may
not be possible to reduce the amount of names added to the waiting list everyday, but it is
certainly possible to reduce the amount of people that die each day while waiting for a lifesaving
transplant. Significant research has been done to explain the reason for the continuous shortage
of organ donors and possible solutions have been proposed to put an end to the issue. Majority of
research on organ donation agrees that proper education about donation processes, improved
procurement processes, and donation after circulatory or cardiac death are all potential solutions
to increase the donor pool. Implementation of these ideas is necessary to decrease the amount of
patients dying and to increase the amount of registered donors.
Many people are opposed to and become uncomfortable when the topic of organ donation
arises in conversation. The primary cause of this opposition and fear are the numerous believable
but certainly untrue misperceptions regarding organ donation after deceased. In his TED Talk,
“Giving the Gift of Life through Organ Donation,” transplant surgeon Chris Barry speaks with a
great deal of emotion and knowledge about organ donation after deceased. Dr. Chris Barry lists a
cmorris71
Highlight
Name 2
few of the formidable myths that surround organ donation which include: belief that a person’s
religion does not accept organ donation, doctors will not work as hard to save your life if they
know that you are a registered organ donor, and finally the belief that one is too old to donate
their organs. He states that, “This kind of thinking is killing people.” It’s important for everyone
to be informed about the facts regarding organ donation and to not fall into the trap of the
countless misperceptions. In fact, Paolo Bruzzone, MD provides the facts of religious beliefs on
organ donation in his article, “Religious Aspects of Organ Transplantation,” he confirms that
“No religion formally forbids donation or receipt of organs or is against transplantation from
living or deceased donors.” These myths are recognized and explained in the majority of
research done on organ donation and transplantation. Specifically, the Health Resources and
Services Administration (HRSA) informs the public about the myths and provides the facts about
the myths eliminating any confusion about organ donation and transplantation. The HRSA states
that, “There’s no age limit to organ donation. To date, .
Name 1 Student NameProfessor Morris English 2367 .docxgertrudebellgrove
Name 1
Student Name
Professor Morris
English 2367
14 November 2019
Organ Donation: You Can Make a Difference
The national organ transplant waiting list continues to grow larger and larger, day by day,
and we need to take action to decrease the number of patients dying before they receive a
lifesaving organ. Although the idea of everyone receiving a transplant that will save their life is
desirable, it’s practically impossible to save every single person that is on the waiting list. It may
not be possible to reduce the amount of names added to the waiting list everyday, but it is
certainly possible to reduce the amount of people that die each day while waiting for a lifesaving
transplant. Significant research has been done to explain the reason for the continuous shortage
of organ donors and possible solutions have been proposed to put an end to the issue. Majority of
research on organ donation agrees that proper education about donation processes, improved
procurement processes, and donation after circulatory or cardiac death are all potential solutions
to increase the donor pool. Implementation of these ideas is necessary to decrease the amount of
patients dying and to increase the amount of registered donors.
Many people are opposed to and become uncomfortable when the topic of organ donation
arises in conversation. The primary cause of this opposition and fear are the numerous believable
but certainly untrue misperceptions regarding organ donation after deceased. In his TED Talk,
“Giving the Gift of Life through Organ Donation,” transplant surgeon Chris Barry speaks with a
great deal of emotion and knowledge about organ donation after deceased. Dr. Chris Barry lists a
cmorris71
Highlight
Name 2
few of the formidable myths that surround organ donation which include: belief that a person’s
religion does not accept organ donation, doctors will not work as hard to save your life if they
know that you are a registered organ donor, and finally the belief that one is too old to donate
their organs. He states that, “This kind of thinking is killing people.” It’s important for everyone
to be informed about the facts regarding organ donation and to not fall into the trap of the
countless misperceptions. In fact, Paolo Bruzzone, MD provides the facts of religious beliefs on
organ donation in his article, “Religious Aspects of Organ Transplantation,” he confirms that
“No religion formally forbids donation or receipt of organs or is against transplantation from
living or deceased donors.” These myths are recognized and explained in the majority of
research done on organ donation and transplantation. Specifically, the Health Resources and
Services Administration (HRSA) informs the public about the myths and provides the facts about
the myths eliminating any confusion about organ donation and transplantation. The HRSA states
that, “There’s no age limit to organ donation. To date, ...
CLINICAL SCHOLARSHIPSpirituality as a Predictive Factor fo.docxbartholomeocoombs
CLINICAL SCHOLARSHIP
Spirituality as a Predictive Factor for Signing an Organ Donor
Card
Anat Peles Bortz, RN, PhD1, Tamar Ashkenazi, RN, PhD2, & Semyon Melnikov, RN, PhD1
1 Lecturer, Department of Nursing, Tel Aviv University, Tel Aviv, Israel
2 Director, National Organ Donation and Transplantation Center, Ministry of Health, Tel Aviv, Israel
Key words
Spirituality, purpose in life, attitudes toward
organ donation, organ donor card
Correspondence
Dr. Semyon Melnikov, Department of Nursing,
Tel Aviv University, PO Box 39040, Ramat Aviv
69978, Tel Aviv, Israel.
E-mail: [email protected]
Accepted: August 10, 2014
doi: 10.1111/jnu.12107
Abstract
Purpose: To examine differences in spirituality, purpose in life, and attitudes
toward organ donation between people who signed and those who did not
sign an organ donor card.
Design: A descriptive cross-sectional survey conducted in Israel with a sample
of 312 respondents from the general population, of whom 220 (70.5%) signed
an organ donor card. Data were collected during April–June 2013.
Methods: Participants completed a paper questionnaire and a Web-based
questionnaire consisting of four sections: spiritual health, purpose in life, at-
titudes toward organ donation, and social-demographic questions. Descriptive
statistics, t test, chi-square test, and a logistic regression analysis were per-
formed.
Findings: Differences in mean scores between respondents who signed an
organ donor card and those who did not were indicated in transcendental
spirituality (p < .01), purpose in life (p < .05), and attitudes toward organ
donation (p < .01). No statistically significant difference was found between
the groups in the overall spirituality mean score. The spiritual transcendental
dimension, individual’s purpose in life, and attitudes toward organ donation
explained 34.3% of the variance of signing an organ donor card.
Conclusions: Signing an organ donor card was found to be correlated with
high purpose in life, positive attitudes toward organ donation, and low level of
transcendental spirituality.
Clinical Relevance: Nurses should assess the patient’s spiritual needs in or-
der to construct appropriate programs for promoting signing an organ donor
card. Nurses who signed an organ donor card should be encouraged to share
this information with their patients.
Organ donation in the Western world is entirely depen-
dent on the willingness of people to donate organs af-
ter their death. In Israel, organ donation from deceased
donors is made following the determination of donor
brain death, after which the family is required to make
a decision about whether to donate the deceased fam-
ily member’s organs. When family members are aware
of the decedent’s wish to donate organs, they will usu-
ally give consent to donate (Haddow, 2004; Merchant
et al., 2008; Rassin, Lowenthal, & Silner, 2005). When
the family isn’t aware of the decedent’s wishes, they usu-
ally will not donate (Burroughs, Hong, Kappel, & .
This is a research presentation I did with Empire Research. I offer this to anyone who wants to know more about the silent epidemic of kidney disease.
Please read and pass on. LV
A guide to understanding charitable giving and charitable bequest giving using neuroimaging with practical examples of applications to planned gift marketing
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Gabriel Danovitch - USA - Monday 28 - Alternatives to increase the number of living donors
1. Promotion of living kidney donation Gabriel M Danovitch: Buenos Aires 2011 … .and the case of the biologically unrelated donor
2. Transplantation: 1954 “ Dr. Merrill and I had an honest and understandable difference of opinion about whether or not…native kidneys should be removed...When (this) exists a compromise is acceptable” - J.E. Murray, M.D.
14. Kidney Transplantation From Unrelated Living Donors: Time to reclaim a discarded opportunity Levey A,Hou S, Bush H N Engl J Med 314;914-916:1986
15. From Cynicism to Skepticism! Skepticism: A doubting or questioning attitude or state of mind Cynicism: An attitude of scornful or jaded negativity especially as a general distrust of the integrity or professional motivations of others
16. “… such donations would not be an act of love, and it is unclear to me what the prospective donor’s motivation would be, if not financial” Letter responding to Levey et al. N Engl J Med 314;713:1986
17. “… such donations would not be an act of love, and it is unclear to me what the prospective donor’s motivation would be, if not financial” Danovitch G . letter responding to Levey et al. N Engl J Med 314;713:1986
18. Epstein M. The declaration of Istanbul on Organ Trafficking and Transplant Tourism: an Important International Achievement with One Disturbing Loophole. BMJ 2008;336:1377 “… Perhaps ‘altruistic unrelated living donation’, as we currently know it, is just a legal fiction that conceals commercial transactions more often than not”.
19.
20. Living Donor Kidney Transplantation Rabin Med Center: Israel Era 1 (2006-2008): Era 2 (2008-2010 ) 0.0001 p,<
21. Graphic explains kidney-selling scheme that Levy Izhak Rosenbaum is accused of arranging. (AP) Brooklyn man's arrest on kidney-selling charges throws a spotlight on organ trafficking By: DAVID PORTER and CARLA K. JOHNSON Associated Press 07/25/09
22.
23. Individual SES characteristics of donors and recipients Related Unrelated p value Overall 41694 (82.4) 8878 (17.6) Recipient characteristics Age (years), Mean ± SD 42.6 ± 16.2 45.7 ± 13.9 <0.001 White race, no. (%) 28,830 (69.1) 6,902 (77.7) <0.001 College educated, no. (%) 7,942 (23.9) 2,341 (32.1) <0.001 Privately insured, no. (%) 25,947 (62.2) 5,870 (66.1 ) <0.001 Preemptive , no. (%) 14,027 (35.6) 3,263 (39.2) <0.001 Donor characteristics Age (years), Mean ± SD 39.9 ± 10.9 40.9 ± 10.4 <0.001 White race, no. (%) 29,112 (69.8) 7,407 (83.4) <0.001 College educated, no. (%) 6,939 (31.8) 2,003 (36.7) <0.001 Transplant center characteristics Laparoscopic donor nephrectomy 25,073 (70.3) 6,381 (76.3) <0.001 High volume ( ≥ 100) , no. (%) 19,624 (47.1) 4,547 (51.2) <0.001
24. Neighborhood characteristics of donors and recipients Recipient Donor Neighborhood characteristic Related Unrelated Related Unrelated Median income ($K) $46.0 ± $17.5 $48.0 ± $17.7 $46.1 ± $17.4 $47.0 ± $16.4 Median housing value ($K) $141 ± $102 $149 ± $109 $142 ± $102 $144 ± $103 Percent receiving int./div./rental income 36.1 ± 13.6 38.3 ± 13.1 36.0 ± 13.5 37.7 ± 12.6 Percent with a high school degree 29.0 ± 9.1 28.5 ± 9.5 28.7 ± 9.1 28.9 ± 9.2 Percent completed college 15.4 ± 8.6 16.7 ± 9.0 15.7 ± 8.7 16.3 ± 8.5 Percent professional 32.8 ± 11.7 34.4 ± 11.9 33.1 ± 11.7 33.8 ± 11.5 Socioeconomic status index -0.11 ± 3.85 0.51 ± 3.74 -0.07 ± 3.88 0.33 ± 3.61
30. Henderson et al. The Living Anonymous Kidney Donor: Lunatic or Saint? AJT 3;203:2003 “ Contrary to our medical community's fears, there are a significant number of psychologically stable, altruistically motivated individuals who want to donate a kidney anonymously to a stranger, and seek no material compensation in return. The evidence is sufficiently compelling to consider developing LAD programs nationally and internationally. This is especially true for Canadian and European programs, which have been more reticent about LADs than their American counterparts”
32. The non-directed live-kidney donor: ethical considerations and practice guidelines: A National Conference Report Adams et al. Transplantation 74;582-589:2002
33. Adams et al.The non-directed live-kidney donor:ethical considerations and practice guidelines:A National Conference Report. Transplantation 74;582:2002
34. Challenges in the Development of Living Donor Exchange Programs Gabriel Danovitch MD David Geffen School of Medicine at UCLA
45. One final thought ! If you plan to get chronic kidney disease ensure you are surrounded by loving and compatible family and friends. … ..probably not a bad idea even if your kidney function is normal!
Editor's Notes
Slight increases in the number of Asian and Hispanic living donors, but negligible change in number of minority living donors
Donor-related 1. Fear of surgery, pain, future kidney failure and need for kidney transplant 2. Lack of awareness of status as a potential donor - studies have shown that many potential donors are open to considering the option of live donation, but are unaware of their status as a potential donor. Candidate-related 1. A number of studies have found that less than half of kidney transplant candidates surveyed felt it was appropriate to request live donation from a family member or were willing to ask a family member to donate. This is often due to candidates’ concerns for the donor - harming their health, causing pain or inconvenience, and disappointing the donor if the kidney were rejected. Also stems from fear of coercing family into donating. Efforts to provide transplant candidates and potential donors with factual information about LDKT have assuaged many candidates’ concerns and increased their willingness to pursue LDKT. 2. Even when candidates have shown a willingness to accept an offer of live donation, many are reluctant to communicate with members of their inner circles about LDKT a. African American transplant candidates are less willing to ask a family member to donate or to discuss LDKT with family than Caucasian candidates b. Rodrigue et al found that white race, college education, fewer concerns about LDKT, and less favorable perceptions of candidates’ own health status predicted willingness to talk about LDKT c. Reese et al revealed that a preference for LDKT and a willingness to ask for help were positively associated with initiating conversations about LDKT Failure to communicate about LDKT has the potential to isolate the patient at a time when family support is crucial. Lack of open communication about LDKT may also delay transplantation and/or severely impair the search for a suitable donor. Indeed, research by Boulware et al. found that patient-physician discussion of LDKT was predicted by patients’ discussion of the topic with their partners. This suggests that family communication about LDKT is an essential component of the transplant process as it significantly improves candidates’ access to LDKT.
Cumulative incidence of live donor transplant access according to SES quartile at initial listing censored at deceased donor transplantation. SES quartiles at transplant were distributed as ≤41, 42 to 45, 46 to 49, and ≥50.
As in most European countries also in the Netherlands the waitlist for deceased donor kidney transplantation increased over the last decennia, from 400 to more than 1200 patients, but it stabilised in the the last years and even slightly decreased to approximately 1000 at the moment. While the total number of transplants remained more or less the same during the 90-ies, we observed a 60% rise in the last 8 years. That resulted from s everal approaches that were undertaken to overcome this discrepancy between demand and supply, especially by the (re)introduction of living kidney donation programs. due to the efforts of the the 7 transplant centers to do more living related transplantations.
Deceased donor kidney transplants did not change much over the last 20 years in the Netherlands, but on this slide you see that the rise in the total number of transplants mainly resulted from the spectacular rise in living donations. Last year in the Netherlands 45% of all kidneys, the blue bars, were derived from living donors. This year 2008 this percentage will be 55%. Till 31 oktober 291 postmortal and 352 living. .
As in most European countries also in the Netherlands the waitlist for deceased donor kidney transplantation increased over the last decennia, from 400 to more than 1200 patients, but it stabilised in the the last years and even slightly decreased to approximately 1000 at the moment. While the total number of transplants remained more or less the same during the 90-ies, we observed a 60% rise in the last 8 years. That resulted from s everal approaches that were undertaken to overcome this discrepancy between demand and supply, especially by the (re)introduction of living kidney donation programs. due to the efforts of the the 7 transplant centers to do more living related transplantations.
