Friedel-Crafts acylation involves the formation of a new C-C bond between a benzene ring and an acyl group. Specifically, when benzene reacts with an acyl chloride like acetyl chloride in the presence of a Lewis acid catalyst, it forms an acylbenzene product like acetophenone. The reaction mechanism proceeds in three steps: 1) the Lewis acid activates the acyl chloride to form an acylium ion, 2) the acylium ion attacks the aromatic ring, and 3) proton transfer regenerates the aromatic system.

1. Friedel-craft’s Acylaion
Prepared by .-R.M. shelake
Asst. Prof.
Sojar college of pharmacy khandvi

2. Contents
• Introduction
• Reaction
• Mechanism

3. Introduction
• Friedel –Craft acylation involves the formation
Of new C-C bond between a benzene ring & an
acyl group .
• This means that in friedel –craft’s acylation
reaction when benzene reacts with acyl
chloride (acetyl chloride) in the presence of
Lewis acid catalyst, it gives acylbenzene
(acetophenone)

4. Reaction

5. Mechanism
Step 1: Formation of acylium ion

6. Step2: Attack of the alkyl cation on the aromatic
ring

7. Step 3:Proton transfer regenerates the
aromatic ring