FINDING THE EVIDENCE
•A good answerable question will
help us focus on evidence that is
relevant to a patient’s clinical needs,
(or your own knowledge needs).
•They can suggest high yield search
strategies
•They can suggest the forms that
useful answers might take (i.e. what is
best research design to answer our
question)
THE QUESTION - WHY IS IT SO
IMPORTANT?
FRAMEWORK TO
Patient/Problem
Intervention
Comparison
Outcome
In a man with depressive
symptoms…
…Is cognitive behavioural therapy…
…compared with fluoxetine…
…better at improving depressive
symptoms?
CLINICAL QUESTIONS
• Background - “What is it?”
• General information on a condition or
disease
• Foreground – “What do I do for this
patient?”
• Patient
• Intervention/Investigation
• Comparison Intervention/Investigation
• Outcome (Patient-Oriented)
Framework to
Patient/Problem
Intervention
Comparison
Outcome
In a man with depressive
symptoms…
…Is cognitive behavioural therapy…
…compared with fluoxetine…
…better at improving depressive
symptoms?
31/08/2016 27
Langkah2 dalam memproses EBM
Steps in the Evidence-Based Process are:
(Citrome, & Ketter, 2009)
FSU College of Medicine 40
Constructing A Clinical Question
P
patient
I
intervention
C
comparison
O
outcome
Who? What?
Alternative
Intervention?
Outcomes
“How would I
describe a group
of patients
similar to this
particular
patient?”
”Which
treatment, test
or other
intervention?”
“Compared to what
other treatment, test,
or perhaps compared
to doing nothing”
What is the
patient oriented
outcome – better
prognosis?
Higher rate of
cure? Etc.?”
FSU College of Medicine 41
Examples
P I C O
Kids with acute otitis
media -2-4 y/o
Antibiotics
No treatment except
acetaminophen
for pain/fever
No pain after two
days?
Adult with
microhematuria
IVP CT scan
Diagnostic accuracy
(Predictive value or
likelihood ratio)
Adult patients <70 TIA No TIA
Rates of CVA within
90 days
Healthy adolescents
Routine
scoliosis
screen
No screening –
evaluate only if
problems
Pain, disability, need
for intervention
FSU College of Medicine 42
Types of Questions
Best Answered by EBM Resource
• Therapy Question
– In patients with migraine headaches without auras, is Depakote more
effective than Inderal for prophylaxis of headaches?
• Prognosis Question
– In diabetic patients with foot ulcers, is the diagnosis of osteomyelitis
with MRI as predictive of healing as an audible pulse on Doppler
examination?
• Diagnosis Question
– In geriatric patients with suspected carotid stenosis, is duplex
ultrasound as good as magnetic resonance angiography in detecting
significant carotid stenosis?
• Harm Question
– For pregnant patients, does the consumption of large amounts of
coffee, (compared to non-coffee drinkers) increase the rate of
spontaneous abortion?
Hunting Tools
44
Drilling Down for Information
Grandage KK, Slawson DC, Shaughnessy AF. When less is more: a practical approach
to searching for evidence-based answers. J Med Libr Assoc. 2002 Jul;90(3):298-304.
FSU College of Medicine 45
EBM Hunting Tools
A high-quality Hunting tool employs a transparent
process that
• Searches multiple EBM databases (several
foraging tools)
• Organizes results to make them easy to find
• Provides levels of evidence
(Slawson, et al)
FSU College of Medicine 46
EBM Pyramid
5, C
MEDLINE
InfoRetriever
DynaMed
• Biomedical journal literature
PubMed Database
• Published by:
The National Library of
Medicine
• International scope
Accessing PubMed
• Freely available over the Internet
• Also through library’s home page
@ www.pubmed.gov
tool that searches for evidence-based literature
PubMed’s Clinical Queries
Diagnosis Therapy
Etiology (cause)
Prognosis (prediction of probable outcome)
Clinical Queries Searchable by:
Click Clinical Queries
Enter asthma
Search
Click
Results for Therapy and
Broad Scope
Change to Narrow Scope
Click See all (7542)
Click Limits
Click on the article title
you wish to read

FINDING THE EVIDENCE (1).pdf

  • 1.
  • 17.
    •A good answerablequestion will help us focus on evidence that is relevant to a patient’s clinical needs, (or your own knowledge needs). •They can suggest high yield search strategies •They can suggest the forms that useful answers might take (i.e. what is best research design to answer our question) THE QUESTION - WHY IS IT SO IMPORTANT?
  • 18.
    FRAMEWORK TO Patient/Problem Intervention Comparison Outcome In aman with depressive symptoms… …Is cognitive behavioural therapy… …compared with fluoxetine… …better at improving depressive symptoms?
  • 19.
    CLINICAL QUESTIONS • Background- “What is it?” • General information on a condition or disease • Foreground – “What do I do for this patient?” • Patient • Intervention/Investigation • Comparison Intervention/Investigation • Outcome (Patient-Oriented)
  • 26.
    Framework to Patient/Problem Intervention Comparison Outcome In aman with depressive symptoms… …Is cognitive behavioural therapy… …compared with fluoxetine… …better at improving depressive symptoms?
  • 27.
  • 38.
  • 39.
    Steps in theEvidence-Based Process are: (Citrome, & Ketter, 2009)
  • 40.
    FSU College ofMedicine 40 Constructing A Clinical Question P patient I intervention C comparison O outcome Who? What? Alternative Intervention? Outcomes “How would I describe a group of patients similar to this particular patient?” ”Which treatment, test or other intervention?” “Compared to what other treatment, test, or perhaps compared to doing nothing” What is the patient oriented outcome – better prognosis? Higher rate of cure? Etc.?”
  • 41.
    FSU College ofMedicine 41 Examples P I C O Kids with acute otitis media -2-4 y/o Antibiotics No treatment except acetaminophen for pain/fever No pain after two days? Adult with microhematuria IVP CT scan Diagnostic accuracy (Predictive value or likelihood ratio) Adult patients <70 TIA No TIA Rates of CVA within 90 days Healthy adolescents Routine scoliosis screen No screening – evaluate only if problems Pain, disability, need for intervention
  • 42.
    FSU College ofMedicine 42 Types of Questions Best Answered by EBM Resource • Therapy Question – In patients with migraine headaches without auras, is Depakote more effective than Inderal for prophylaxis of headaches? • Prognosis Question – In diabetic patients with foot ulcers, is the diagnosis of osteomyelitis with MRI as predictive of healing as an audible pulse on Doppler examination? • Diagnosis Question – In geriatric patients with suspected carotid stenosis, is duplex ultrasound as good as magnetic resonance angiography in detecting significant carotid stenosis? • Harm Question – For pregnant patients, does the consumption of large amounts of coffee, (compared to non-coffee drinkers) increase the rate of spontaneous abortion?
  • 43.
  • 44.
    44 Drilling Down forInformation Grandage KK, Slawson DC, Shaughnessy AF. When less is more: a practical approach to searching for evidence-based answers. J Med Libr Assoc. 2002 Jul;90(3):298-304.
  • 45.
    FSU College ofMedicine 45 EBM Hunting Tools A high-quality Hunting tool employs a transparent process that • Searches multiple EBM databases (several foraging tools) • Organizes results to make them easy to find • Provides levels of evidence (Slawson, et al)
  • 46.
    FSU College ofMedicine 46 EBM Pyramid 5, C MEDLINE InfoRetriever DynaMed
  • 47.
    • Biomedical journalliterature PubMed Database • Published by: The National Library of Medicine • International scope
  • 48.
    Accessing PubMed • Freelyavailable over the Internet • Also through library’s home page @ www.pubmed.gov
  • 49.
    tool that searchesfor evidence-based literature PubMed’s Clinical Queries
  • 50.
    Diagnosis Therapy Etiology (cause) Prognosis(prediction of probable outcome) Clinical Queries Searchable by:
  • 51.
  • 52.
  • 53.
    Results for Therapyand Broad Scope Change to Narrow Scope
  • 54.
  • 55.
  • 56.
    Click on thearticle title you wish to read