This document discusses finding and evaluating evidence to answer clinical questions. It emphasizes that well-constructed clinical questions help focus the search for relevant evidence. The PICO (Patient/Problem, Intervention, Comparison, Outcome) framework is presented as a tool to help formulate answerable clinical questions. Examples of different types of clinical questions that can be answered through evidence-based medicine resources are provided, including questions of therapy, prognosis, diagnosis, and harm. Key hunting tools for searching evidence-based literature are described, including PubMed and its Clinical Queries feature.