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- 1. Plk3 deficiency resultsin enhanced tumorigenesis. Yali Yang et al. Cancer Res 2008;68:4077-4085 ©2008 by American Association for Cancer Research
Editor's Notes
- #2 Plk3 deficiency results in enhanced tumorigenesis. A, tumor incidences of age-matched wild-type and Plk3−/− mice. B, representative liver, lung, uterus, and kidney tumors that developed in aged Plk3−/− mice. Arrowheads, tumors. C, H&E staining of various tumors from Plk3−/− mice. D, sections of representative lung tumors that developed in either wild-type (Plk3+/+) or Plk3−/− mice were stained with the vWF antibody. Arrows, top, some vWF-positive areas/foci; bottom, tumor blood vessel density manifested as vWF-positive areas/foci of six random microscopic fields from representative tumor sections was quantitated. *, significant statistical difference (P < 0.05).