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Plk3 deficiency results in enhanced tumorigenesis. A study by Yali Yang et al. found that deficiency of the Polo-like kinase 3 (Plk3) gene enhances cancer formation. Their research published in Cancer Research in 2008 showed that a lack of Plk3 leads to increased tumor growth.
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Cancer
Cancer is caused by abnormal cell growth and can invade other organs, potentially leading to death. Theories of cancer development include mutations in proto-oncogenes, tumor suppressor genes, and DNA repair genes. Most cancers are caused by mutations in somatic cells from external agents or randomly, though some are hereditary. Cancers are classified by their cell of origin and some show genetic tendencies. Incidence and mortality of certain cancers like lung, breast, colorectal, and stomach are provided. Prevention strategies include controlling risk factors like tobacco, diet, and environment as well as screening and early diagnosis.
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MCO 2011 - Slide 20 - R.A. Stahel - Spotlight session - New drugs in oncogeni...
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Full Information: https://bit.ly/3llZgmV
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Contact us :
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
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Bone metastases are a common complication of cancer that can be treated with radiation therapy. According to a 2011 cancer report, 178,000 new cancer cases were diagnosed in Canada that year, with 75,000 cancer deaths, and 48% of patients received radiation therapy. Between 15-70% of cancer patients develop bone metastases.
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Thyroid carcinoma
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F2
- 1. Plk3 deficiency results in enhanced tumorigenesis. Yali Yang et al. Cancer Res 2008;68:4077-4085 ©2008 by American Association for Cancer Research
Editor's Notes
- Plk3 deficiency results in enhanced tumorigenesis. A, tumor incidences of age-matched wild-type and Plk3−/− mice. B, representative liver, lung, uterus, and kidney tumors that developed in aged Plk3−/− mice. Arrowheads, tumors. C, H&E staining of various tumors from Plk3−/− mice. D, sections of representative lung tumors that developed in either wild-type (Plk3+/+) or Plk3−/− mice were stained with the vWF antibody. Arrows, top, some vWF-positive areas/foci; bottom, tumor blood vessel density manifested as vWF-positive areas/foci of six random microscopic fields from representative tumor sections was quantitated. *, significant statistical difference (P < 0.05).