This study evaluated the safety and efficacy of the Venus Freeze® system, a radiofrequency device for non-invasive wrinkle treatment. 31 subjects received 10 treatments over 3 months and were evaluated before and after by physicians. Results found significant improvement in wrinkle appearance for 96.7% of subjects with no adverse effects. Statistical analysis showed a significant reduction in wrinkle score from before to after treatment, indicating the Venus Freeze® system is an effective and safe option for non-invasive wrinkle therapy.
Pregabalin is an effective and safe adjuvant for reducing chronic
post-thoracotomy pain, without significant side effects, in all age
groups and either gender. The pain relief becomes statistically
significant after three weeks of treatment and it continues till six
months. However, larger randomized and placebo-controlled trials
of longer durations are required to further validate these findings.
A single blind RCT to evaluate the effect of intraoperative bupivacaine infilteration fro post operative pain relief was conducted. Observations based on the VAS and mean duration for requirement of 1st analgesic dose post operatively. Results compared with other similar studies and found that the there is significant reduction in the VAS of post operative pain and increase in the duration for requirement for the 1st dose of the analgesic postoperatively
Efficacy of classification-based_cft_in_nsclbpMeziat
Artigo (6) importante para a preparação para o curso de dor lombar crônica. "Eficácia da Terapia Cognitiva Funcional em pacientes com dor lombar crônica inespecífica: ensaio clínico randomizado controlado."
Pregabalin is an effective and safe adjuvant for reducing chronic
post-thoracotomy pain, without significant side effects, in all age
groups and either gender. The pain relief becomes statistically
significant after three weeks of treatment and it continues till six
months. However, larger randomized and placebo-controlled trials
of longer durations are required to further validate these findings.
A single blind RCT to evaluate the effect of intraoperative bupivacaine infilteration fro post operative pain relief was conducted. Observations based on the VAS and mean duration for requirement of 1st analgesic dose post operatively. Results compared with other similar studies and found that the there is significant reduction in the VAS of post operative pain and increase in the duration for requirement for the 1st dose of the analgesic postoperatively
Efficacy of classification-based_cft_in_nsclbpMeziat
Artigo (6) importante para a preparação para o curso de dor lombar crônica. "Eficácia da Terapia Cognitiva Funcional em pacientes com dor lombar crônica inespecífica: ensaio clínico randomizado controlado."
Laura Pietrzak CoolSculpting Treatment Technique - New YorkLaura Pietrzak
Laura Pietrzak has performed more CoolScultping aesthetic treatments than anyone else in the world. This presentation to the American Society of Aesthetic Plastic Surgeons describes her CoolSculpting patient success stories which led to her development of the new Treatment to Transformation protocol for CoolSculpting globally.
The essential use of parecoxib in post operative pain management speaker (1)Setyadi Soeroyo
Presentasi ini tentang obat nyeri yang aman untuk lambung, selain itu obat ini tidak mengganggu pembekuan darah. Parecoxib adalah jenis analgetik cox2. Penggunaan untuk pasien dengan kelainan jantung dan pada penderita kelainan ginjal harus hati-hati.
palmoplantar pustolar Psoriasis induced in a patient treated with infliximab ...Dr. Faramarz Didar
As the use of TNF antagonists has increased, new cutaneous reactions like psoriasis are being seen more in the practice.General practitioners should watch closely any patients who suffer from rheumatoid arthritis, ankylosing spondylitis, psoriasis, Crohn’s disease, and rarely psoriatic arthritis on anti-TNF for any skin presentation like psoriasis . NICE Guidelines and algorithms are very useful and practical in choosing appropriate treatment for different types of psoriasis
Palmoplantar pustolar psoriasis induced with infliximab in treating crohn di...Dr. Faramarz Didar
As the use of TNF(Tumor Necrotic Factor) antagonists has increased, new cutaneous reactions like psoriasis are being seen more in the general practice.it is essential to have a close communication with rheumatologist, oncologist and gastroenterologist in order to manage and treat the dermatological side effect of Anti-TNF treatment in primary care dermatology.
Standard Zone Defenses in Ultimate FrisbeeScott Perlov
Scott Perlov is an accomplished Boulder, Colorado, attorney who has experience in civil litigation and intellectual property law. Earning his bachelor’s degree at Colgate University, Scott Perlov played varsity lacrosse and also captained the chess and ultimate Frisbee clubs. One of the most popular sports on college campuses, ultimate Frisbee includes elements of soccer and football. Despite its reputation as a “pick-up” game, ultimate Frisbee is a highly strategic, competitive team sport.
Laura Pietrzak CoolSculpting Treatment Technique - New YorkLaura Pietrzak
Laura Pietrzak has performed more CoolScultping aesthetic treatments than anyone else in the world. This presentation to the American Society of Aesthetic Plastic Surgeons describes her CoolSculpting patient success stories which led to her development of the new Treatment to Transformation protocol for CoolSculpting globally.
The essential use of parecoxib in post operative pain management speaker (1)Setyadi Soeroyo
Presentasi ini tentang obat nyeri yang aman untuk lambung, selain itu obat ini tidak mengganggu pembekuan darah. Parecoxib adalah jenis analgetik cox2. Penggunaan untuk pasien dengan kelainan jantung dan pada penderita kelainan ginjal harus hati-hati.
palmoplantar pustolar Psoriasis induced in a patient treated with infliximab ...Dr. Faramarz Didar
As the use of TNF antagonists has increased, new cutaneous reactions like psoriasis are being seen more in the practice.General practitioners should watch closely any patients who suffer from rheumatoid arthritis, ankylosing spondylitis, psoriasis, Crohn’s disease, and rarely psoriatic arthritis on anti-TNF for any skin presentation like psoriasis . NICE Guidelines and algorithms are very useful and practical in choosing appropriate treatment for different types of psoriasis
Palmoplantar pustolar psoriasis induced with infliximab in treating crohn di...Dr. Faramarz Didar
As the use of TNF(Tumor Necrotic Factor) antagonists has increased, new cutaneous reactions like psoriasis are being seen more in the general practice.it is essential to have a close communication with rheumatologist, oncologist and gastroenterologist in order to manage and treat the dermatological side effect of Anti-TNF treatment in primary care dermatology.
Standard Zone Defenses in Ultimate FrisbeeScott Perlov
Scott Perlov is an accomplished Boulder, Colorado, attorney who has experience in civil litigation and intellectual property law. Earning his bachelor’s degree at Colgate University, Scott Perlov played varsity lacrosse and also captained the chess and ultimate Frisbee clubs. One of the most popular sports on college campuses, ultimate Frisbee includes elements of soccer and football. Despite its reputation as a “pick-up” game, ultimate Frisbee is a highly strategic, competitive team sport.
Application of Pstim in Clinical Practice MaxiMedRx
The P-Stim and ANSiStim™ miniaturized device is designed to administer auricular point stimulation treatment over several days. The ear provides numerous points for stimulation within a small area. Stimulation is performed by electrical pulses emitted through strategically positioned needles. The ANSiscope device monitors the pain condition of the patient before, during and after the treatment.
The P-Stim and ANSiStim™ point stimulation therapy is mainly used to treat pain. Use of the device is recommended for pre-operative, intra-operative and post-operative pain therapy as well as for the treatment of chronic pain. DyAnsys is researching the possibilities of using this concept for the treatment of depression, addiction and allergy.
P-Stim and ANSiStim™ therapy allows continuous point stimulation over a period of several days while offering the patient a high degree of comfort and mobility. Use of the P-Stim and ANSiStim™ therapy provides advantages over drug therapy by minimizing possible side-effects caused by pain medications (i.e. opioid). In most cases, the patient continues to lead a normal life without side effects or any loss of quality of life.
Abin Abraham Mammen.
Background: Trigger point is a extremely irritable local spot of exquisite tenderness in the nodule
within the tangible taut muscle band. The prevalence studies have shown that the occurrence of myofascial trigger point in the general population.
Objective: The aim of the study was compare the effects of low level laser therapy( LLLT) Vs
ultrasound therapy in the management of active trapezius trigger point.
Methodology: The participants will be allocated into two groups using simple random sampling.
One group has to be given Low level laser therapy (LLLT) and Moist Heat and other group treated
with US and Moist Heat. Both group receive treatment for 3 times a week. Total number of 9
session has to be given in 21 days. The outcome measure has to be taken at the first day and end
of the day.
Conclusion: Based on the above results we conclude that Low Level Laser Therapy can be used as a therapeutic device in the management of Active Trapezius Trigger points.
RecoveryRx® Accelerated healing and better pain reliefMax Poritzky
See why Doctors are switching their patients to RecoveryRx® for reliable, drug-free pain relief and faster healing with no side-effects. Safer, and more effective, see why RecoveryRx is the #1 most innovative pain and healing product and is now available in the US.
Extracorporeal shockwave therapy (ESWT) has analgesic and anti-inflammatory effects. With the evolu- tion and comprehension of its biological and physical mechanisms, the application of ESWT on other pathologies has also been studied, especially in musculoskeletal diseases. Recently, studies on animal models have shown its angiogenic capacity and a higher rate of local re-epithelization. These small stud- ies led to few trials using low-energy, radial ESWT to treat problematic chronic skin ulcers. Skin ulcers have diverse etiologies, ranging from pressure ulcers, burns, venous or arterial ulcers, and even diabetic ulcers. Their treatment is usually a challenge, due to the long-term treatment and high costs.
Similar to Evaluation of safety and efficacy using venus freeze by dr neil sadick (20)
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Evaluation of safety and efficacy using venus freeze by dr neil sadick
1. Evaluation of Safety and Efficacy of Using Venus Freeze® System for Wrinkles and
Rhytides Treatment - a Post Marketing Study
Neil Sadick, MD Clinical Professor, Dermatology – Weill Cornell Medical College*.
INTRODUCTION PATIENTS AND METHODS
Patient demand for non-surgical, non-invasive, All 31 patients, (1 male, 30 female), ages 36-62
and no-downtime wrinkle treatment procedures years (average 49.23±7.17), were enrolled in
has grown dramatically over the past decade as the study after meeting all inclusion/exclusion
new treatments and technologies have been criteria and providing signed Informed Consent
introduced. Form.
The effects of dermal heating are well
recognized to include immediate effects on The patients’ skin wrinkles were classified
collagen structure with stimulation of according to Fitzpatrick Wrinkle Scale(2). Table 1
neocollagenesis (1). presents the Fitzpatrick Wrinkle Scale. All 31
patients were treated for face wrinkles and
These changes can help reduce the
rhytides.
appearance of fine wrinkles. Radiofrequency
(RF) energy is used in medicine for a few Patients received 10 treatments – the first four
decades. Radiofrequency (RF) energy heats treatments were performed twice weekly, the
tissue through the induction of rotational 5th-10th treatments were performed once a
movement in water molecules. These week. Subjects were scheduled for two follow-
movements produce heat and in turn affect up visits – 1 month and 3 months following last
collagen for wrinkle reduction. treatment.
Multiple Monopolar and Bipolar RF devices are Prior to the RF treatment - the treated areas
FDA cleared for non ablative treatment of were assessed visually as to skin relevant
wrinkles and rhytides and for skin tightening. parameters and photographed in a standardized
method using high-resolution digital
Venus Concept has developed the Venus
photography in order to allow comparison and
Freeze® system for wrinkles and rhytides
assessment of wrinkle appearance
treatment. The Venus Freeze® system
improvement following treatment. Photographs
incorporates a power supply, RF generator, a
were taken prior to each treatment.
computer controller and treatment hand pieces.
The applicator controls the heating of one or
more target tissues (epidermis, dermis and
hypodermis). While treating wrinkles and
rhytides, the treatment creates enough thermal
effect to induce collagen remodeling with no
ablative thermal damage of the epidermis or
dermis. Table 1: Fitzpatrick wrinkle scale.
A post marketing study was conducted in order
to evaluate the efficacy and safety of the Venus The treatment area was cleaned thoroughly with
Freeze® system, an innovative system intended soap and water. The skin surface was dried
for wrinkles treatment. Altogether, 31 subjects prior to the treatment. Treatment parameters
participated in the study. Subjects were treated were determined by the operator and were
for facial wrinkles and followed for 3 months based on patient skin type and area of
following last treatment. In order to evaluate treatment. The following parameters were
treatment efficacy, pre and post treatment chosen:
photos were introduced to two uninvolved
physicians for blinded evaluation. Treatment time (min)
Output Energy (Watt)
The following report describes the cumulative
results of this study.
2. Immediately after the treatment the treated area
was visually assessed for skin responses,
including edema, erythema, hypopigmentation,
hyperpigmentation, and textural changes.
In addition, patients were asked to rate the pain
level which they felt during the treatment by
using analogue pain scale. The study’s efficacy
endpoint was considered by pre-treatment
photographs (baseline) that were assessed and
graded by two physicians blinded to the study
and the patients.
Assessment was conducted by using Fitzpatrick
wrinkle scale. Any wrinkle score improvement
(downgrade score) following treatment,
relatively to pre-treatment wrinkle (baseline)
score, was considered a success.
The safety of the procedure was also evaluated
by monitoring the occurrence of potential
procedure-related side effects.
Patients were asked to evaluate the degree of
pain during treatment. In addition, treated areas
were visually assessed for skin responses,
including edema, erythema, hypopigmentation,
hyperpigmentation, and textural changes
following each treatment.
RESULTS
All 31 patients completed the course of the 10
treatments and 3 months follow-up protocol.
No unexpected adverse side effects were
detected or reported.
In some patients, post treatment edema
(hyperemia) was detected. The edema was
resolved within 10 to 30 minutes.
No patients experienced burns, skin
breakdown, or scarring.
None of the patients has reported pain
during the study.
All patients (100%) were satisfied with
treatment results
The following sets of before and after
photographs (Figure 1, 2, 3 and 4) illustrate the
significant beneficial effect achieved by the
Venus Freeze® System.
3. Photographic analysis of pre-and post treatment DISCUSSION AND CONCLUSIONS
of the digital images was conducted by a board
certified dermatologist and a board certified Thirty one patients were treated for face wrinkle
plastic surgeon. reduction and followed for 3 months following
last treatment. In order to evaluate treatment
Analysis revealed improvement downgrade of at
efficacy, pre and post treatment photos were
list 1 score according to the Fitzpatrick scale in
introduced to two uninvolved physicians for
almost all (96.7%) patients according to both
blinded evaluation.
reviewers. Statistical comparison (using paired
T-Test) was conducted among the pre-
The data reported in this study demonstrate that
treatment Fitzpatrick score (baseline) to
Venus Freeze® device offers a safe and
Fitzpatrick score obtained at the 3 months
follow-up (following 10 treatments) for each effective noninvasive technique to improve the
reviewer. appearance of age-related rhytides and
wrinkles.
Statistical analysis was conducted by SAS (9.1).
Score differences were found to be statistically The clinical results of nonablative RF anti
significant while comparing baseline score to wrinkle effects were first reported in the
the scores obtained at 3 months follow-up periorbital area(3). In this multicenter study,
(p<0.001) for both reviewers, indicating Fitzpatrick and his colleagues demonstrated
treatment efficacy. Table 2 and Figure 4 clinical improvement in periorbital rhytides in
represent averages (± STDV) of Fitzpatrick 80% of subjects. In contrast, in 24 patients who
scores given by the two reviewers at baseline underwent a single RF treatment to improve the
and 3 months follow-up. These results may upper third of the face, only 36% of the patients’
indicate that the treatments have initiated self-assessment reported improvement (4) .
collagen remodeling process that continues
after treatment session has been completed. In this study, statistical analysis has revealed
All 31 patients participating in the study reported improvement (downgrade of at list 1 score
no pain during the treatment. according to the Fitzpatrick scale) in almost all
(96.7%) patients according to both reviewers.
Analysis of study results has revealed statistical
significance while comparing baseline score to
the scores obtained at 3 months follow-up,
following 10 treatments for both reviewers,
indicating treatment efficacy.
In a similar device, it has been reported that the
use of an RF device was associated with
significant pain, and in a small but significant
number of cases subcutaneous fat atrophy
developed (5). No subcutaneous fat atrophy was
noted in this study.
All patients participating in the study have
reported no pain during treatment, although
procedure was performed without using any
anesthetic agents. Furthermore, no patients
considered the procedure intolerable at any
session.
4. The results of this study clearly indicate that this
innovative RF system offers a non-invasive,
effective, safe and virtually painless wrinkle
reduction treatment.
In conclusion, the data reported in this study
support the safety and effectiveness of the
Venus Freeze® System for wrinkle and rhytides
treatment.
REFERENCES
1. Sadick N, Sorhaindo L. The radiofrequency
frontier: a review of radiofrequency and
combined radiofrequency pulsed light
technology in aesthetic medicine. Facial Plast
Surg 2005;21: 131–8.
2. Goldman p & Fitzpatrick E: Cutaneous Laser
Surgery - the art and science of selective
photothermolysis page 377; Mosby 1999.
3. Fitzpatrick R, Geronemus R, Goldberg D, et
al; Multicenter study of noninvasive,
radiofrequency for periorbital tissue tightening.
Lasers Surg Med 2003;33:232–42.
4. Bassichis BA, Dayan S, Thomas JR; Use of
Nonablative radiofrequency device to
rejuvenate the upper one-third of the face.
Otolaryngol Head Neck Surg 2004;130: 397–
406.
5. Biesnman BS. Radiofrequency Devices:
Monopolar vs bipolar vs radiofrequency plus
laser; indications; treatment approaches; novel
applications; results. In: Arndt KA, Dover JS,
Anderson RR, editors. Controversies and
Conversations in Laser and Cosmetic Surgery.
Symposium Proceedings; 2005, Denver, CO.
* Study was not physically conducted at the
Weill Cornell Medical College