This randomized, double-blind, split-face study investigated the efficacy and safety of intradermal botulinum toxin (BTX) injections for reducing facial erythema in patients with rosacea. Twenty-four participants received intradermal injections of BTX in one cheek and a placebo in the other cheek. Outcomes including erythema, skin properties, and safety were assessed at regular intervals. The results showed that the BTX-treated side had significantly reduced erythema and improved skin elasticity and hydration compared to the placebo side. No significant safety issues were reported. The study demonstrates that intradermal BTX injections can effectively reduce facial erythema and rejuvenate skin in rosace
laser fracionado 1340 em Acne cistica artigo Jauru Freitas
This document describes a study that evaluated the use of fractional laser therapy with a 1,340nm Nd:YAP laser for the treatment of nodular cystic acne resistant to isotretinoin treatment. Nine patients with resistant nodular cystic acne received between two to six laser treatment sessions. Results found an average 65% reduction in inflammatory lesions, with patients receiving more sessions seeing greater reduction. All patients reported satisfaction with the treatment. Evaluation by independent dermatologists found significant or moderate improvement in all patients. No major adverse effects were reported. The study concluded fractional Nd:YAP laser is an effective treatment for inflammatory acne, including resistant cases.
Personalized Medicine: A New Normal for Therapeutic SuccessSarvan Mani
This document discusses the principles of personalized and precision medicine. It begins by providing historical context, noting that the approach to medicine has shifted from a "one size fits all" model to one that tailors treatment to individual patient characteristics based on genetics, biomarkers, and other factors. The document then outlines some key milestones in the development of personalized medicine since the 1990s, enabled by advances like the Human Genome Project. It discusses the use of biomarkers to predict disease risk, outcomes, and treatment response on an individual level. The goal of personalized medicine is to provide the optimal treatment for each patient. Precision medicine aims to do this by leveraging a detailed understanding of disease mechanisms at a molecular level. The challenges of implementing personalized and precision
A Study on Pattern of Using Prophylactic Antibiotics in Caesarean Sectioniosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
This study evaluated a rutin-allicin gel (RAG) for treating diabetic foot ulcers and compared it to tetrachlorodecaoxide (TCDO). 60 patients were divided into two groups, with one group treated with TCDO and the other with RAG. RAG treated wounds started epithelializing by day 6 and fully healed by day 21, significantly faster than the TCDO group. RAG dressing was also significantly cheaper than TCDO. Both treatments showed bactericidal effects with no infections. The authors concluded RAG had a quicker and more effective wound healing response due to the synergistic antioxidant effects of rutin and allicin.
Halometasone monohydrate 0.05% was assessed for efficacy and safety in treating occupational contact dermatitis. 150 patients with occupational contact dermatitis were enrolled and treated with halometasone twice daily for 4 weeks. Assessment scales showed statistically significant improvements in eczema severity, symptoms, and quality of life. Treatment was successful in resolving or improving eczema in 87.8% of patients. Halometasone was well-tolerated with no reported adverse effects, demonstrating it is an effective and safe topical treatment for occupational contact dermatitis.
This study evaluated the efficacy and safety of tabalumab in treating relapsing-remitting multiple sclerosis (RRMS). 210 patients with RRMS were randomized to receive either tabalumab (4, 12, 40, or 120 mg every 4 weeks or 4 or 120 mg every 12 weeks) or a placebo. The primary outcome was the number of new or enlarging MRI lesions over 24 weeks. Treatment with tabalumab did not significantly reduce MRI lesions compared to placebo. Adverse events were more common with tabalumab but were generally mild. The study found that tabalumab was not effective for reducing disease activity in RRMS.
laser fracionado 1340 em Acne cistica artigo Jauru Freitas
This document describes a study that evaluated the use of fractional laser therapy with a 1,340nm Nd:YAP laser for the treatment of nodular cystic acne resistant to isotretinoin treatment. Nine patients with resistant nodular cystic acne received between two to six laser treatment sessions. Results found an average 65% reduction in inflammatory lesions, with patients receiving more sessions seeing greater reduction. All patients reported satisfaction with the treatment. Evaluation by independent dermatologists found significant or moderate improvement in all patients. No major adverse effects were reported. The study concluded fractional Nd:YAP laser is an effective treatment for inflammatory acne, including resistant cases.
Personalized Medicine: A New Normal for Therapeutic SuccessSarvan Mani
This document discusses the principles of personalized and precision medicine. It begins by providing historical context, noting that the approach to medicine has shifted from a "one size fits all" model to one that tailors treatment to individual patient characteristics based on genetics, biomarkers, and other factors. The document then outlines some key milestones in the development of personalized medicine since the 1990s, enabled by advances like the Human Genome Project. It discusses the use of biomarkers to predict disease risk, outcomes, and treatment response on an individual level. The goal of personalized medicine is to provide the optimal treatment for each patient. Precision medicine aims to do this by leveraging a detailed understanding of disease mechanisms at a molecular level. The challenges of implementing personalized and precision
A Study on Pattern of Using Prophylactic Antibiotics in Caesarean Sectioniosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
This study evaluated a rutin-allicin gel (RAG) for treating diabetic foot ulcers and compared it to tetrachlorodecaoxide (TCDO). 60 patients were divided into two groups, with one group treated with TCDO and the other with RAG. RAG treated wounds started epithelializing by day 6 and fully healed by day 21, significantly faster than the TCDO group. RAG dressing was also significantly cheaper than TCDO. Both treatments showed bactericidal effects with no infections. The authors concluded RAG had a quicker and more effective wound healing response due to the synergistic antioxidant effects of rutin and allicin.
Halometasone monohydrate 0.05% was assessed for efficacy and safety in treating occupational contact dermatitis. 150 patients with occupational contact dermatitis were enrolled and treated with halometasone twice daily for 4 weeks. Assessment scales showed statistically significant improvements in eczema severity, symptoms, and quality of life. Treatment was successful in resolving or improving eczema in 87.8% of patients. Halometasone was well-tolerated with no reported adverse effects, demonstrating it is an effective and safe topical treatment for occupational contact dermatitis.
This study evaluated the efficacy and safety of tabalumab in treating relapsing-remitting multiple sclerosis (RRMS). 210 patients with RRMS were randomized to receive either tabalumab (4, 12, 40, or 120 mg every 4 weeks or 4 or 120 mg every 12 weeks) or a placebo. The primary outcome was the number of new or enlarging MRI lesions over 24 weeks. Treatment with tabalumab did not significantly reduce MRI lesions compared to placebo. Adverse events were more common with tabalumab but were generally mild. The study found that tabalumab was not effective for reducing disease activity in RRMS.
To study the drug utilization pattern and monitoringGULAM NAVI AZAD
This document summarizes the work done so far on a study analyzing drug utilization patterns and adverse drug reactions (ADRs) in the dermatology outpatient department of ERA Hospital in Lucknow, India. Data has been collected on demographics, prevalent diseases, prescribed medications, and reported ADRs. Most patients were adults and female. Common conditions included eczema and fungal infections. Frequently prescribed drugs were antihistamines and antifungals. Several ADR cases were identified and assessed for causality using the Naranjo scale, with most deemed probable or possible. Further data collection and analysis from inpatient records, literature, and clinical trials is still pending.
- This interim analysis of an ongoing observational study found that topical analgesics may reduce pain severity and interference scores and decrease primary pain complaints and oral pain medication use for patients with neuropathic or musculoskeletal pain.
- Overall patient satisfaction with topical analgesics was high and they were found to be safe and well-tolerated.
- The results were consistent with a previous interim analysis and warrant continuation of the larger OPERA study, though more analysis is still needed.
This study evaluated the effectiveness of a regenerating matrix therapy (RGTA/CACIPLIQ20) for treating chronic wounds. 16 patients with 22 chronic wounds received twice weekly applications of CACIPLIQ20 for up to 4 weeks. Wound size and pain were measured before, during, and after treatment. The results showed that CACIPLIQ20 significantly reduced wound size by 15-18% and pain levels by 60-70% within 4 weeks. Patient and clinician satisfaction with the treatment also remained high. The therapy may help facilitate wound healing and alleviate wound-related pain.
This study evaluated the use of methyl-aminolevulinate (MAL) and red/blue light treatment for severe acne in 39 patients over 14 months. Fluorescence levels significantly increased after MAL application and decreased after cleaning. Acne severity significantly decreased after treatment regardless of location. Most patients were satisfied, reporting average pain of 5/10. The treatment provides an alternative for people who cannot use oral medications or had previous treatment failures or relapses.
The document describes a retrospective analysis of interventions made by a clinical pharmacist (CP) during their participation in the medical intensive care unit (ICU) team of a university hospital over a period of 9 months. The CP reviewed medications for 321 patients and made a total of 307 interventions in 95 patients. The interventions were categorized as: pharmacotherapy adjustments for kidney function (147 interventions), therapeutic drug monitoring (57), administration through a nasogastric tube (30), drug-drug interactions (22), and unspecified (51). The majority of interventions (203) were related to antimicrobial drugs. ICU physicians completely accepted 80.2% of the CP's suggestions. The analysis found that inclusion of a CP contributed to more individualized pharmacological
Detection, reporting and monitoring of ad rs final pptSabeena Choudhary
Adverse drug reactions (ADRs) are important to monitor through pharmacovigilance programs. Spontaneous reporting of ADRs by healthcare professionals and patients allows detection of rare or delayed reactions not seen in clinical trials. Common causes of ADRs include medication errors, non-compliance, and drug interactions. Serious ADRs can lead to death, hospitalization, disability or congenital abnormalities. It is important for doctors, nurses and patients to recognize and report any suspected ADRs to their national pharmacovigilance center to monitor drug safety. Proper causality assessment is needed to determine the likelihood of an ADR being caused by a suspected medication.
This document discusses drug risk assessment and pharmacoepidemiology. It notes that clinical trials prior to drug approval are limited in detecting uncommon or long-term side effects. Observational studies using large patient populations are needed to further evaluate drug safety issues and understand rare or long-term side effects. The document compares different pharmacoepidemiological study designs like cohort studies and case-control studies that can be used to investigate drug safety questions following a drug's approval and entry into widespread use.
The objective of this study was to observe the 1-year and 2-year pressure reduction in an active population of glaucoma patients treated by selective laser trabeculoplasty. We carried out a retrospective study of all patients treated in our department between January 2015 and March 2016. Patients who had already undergone Laser Trabeculoplasty (ALT or SLT) in the past were excluded from the study. Treatment was performed with a Q-Switched, frequency doubled Nd: YAG laser (Solutis - Quantel Medical, France), over 180° or 360° of the trabecular meshwork. The mean decrease in intraocular pressure and the success zrate, defi ned as a decrease in intraocular pressure superior to 20% without increasing the medical treatment, were calculated. The impact of the different clinical and technical characteristics on the decrease in pressure was also studied by multivariate analysis. One hundred and seventeen eyes, in 74 patients, were included. The mean decrease in IOP from baseline was 4.35 mmHg (20.6%) at 1 year and 3.74 mmHg (16.7%) at 2 years. The success rate was 49% at 1 year and 33.3% at 2 years. Selective trabeculoplasty is currently a therapeutic option called-upon at different stages in the progression of glaucoma. The duration of effi cacy of this laser therapy, and the retreatment frequency are yet to be defined.
This document discusses different types of clinical trial designs, including crossover trials, factorial trials, and equivalence trials. Crossover trials involve each patient receiving both the active treatment and control in different sequences, with washout periods in between. Factorial trials assign patients to multiple treatment groups to evaluate the effects of each treatment alone or in combination. Equivalence trials compare an altered treatment to the original to show there is no loss of effectiveness or increased side effects when modifications are made.
The document explores using the Systems-Theoretic Accident Model and Processes (STAMP) to manage risks in drug development. It analyzes the 2006 TGN1412 clinical trial where volunteers suffered severe reactions. STAMP views safety as a control problem rather than failure. The document applies STAMP concepts like safety constraints and control structures to the TGN1412 trial, identifying a lack of coordination between pre-clinical and clinical stages as a systemic vulnerability. It concludes that implementing STAMP methodology could help identify risks and reduce patient casualties by correlating controls with inherent process vulnerabilities in drug development.
The spontaneous reporting system is a passive surveillance system where health professionals voluntarily report adverse drug reactions directly to regulatory authorities or pharmaceutical companies. It involves 3 main processes: 1) data acquisition from reported cases, 2) assessment of individual reports and pooled data, and 3) interpretation of signals based on the available data. Initiatives have been taken to widen reporting bases to include pharmacists and nurses. Special focus has been given to reporting reactions related to HIV drugs, pediatric drugs, and herbal products to improve surveillance in underreported areas.
Extracorporeal shockwave therapy (ESWT) has analgesic and anti-inflammatory effects. With the evolu- tion and comprehension of its biological and physical mechanisms, the application of ESWT on other pathologies has also been studied, especially in musculoskeletal diseases. Recently, studies on animal models have shown its angiogenic capacity and a higher rate of local re-epithelization. These small stud- ies led to few trials using low-energy, radial ESWT to treat problematic chronic skin ulcers. Skin ulcers have diverse etiologies, ranging from pressure ulcers, burns, venous or arterial ulcers, and even diabetic ulcers. Their treatment is usually a challenge, due to the long-term treatment and high costs.
The document outlines the phases of clinical trials. Phase I trials involve small studies with healthy volunteers to determine safety and dosage. Phase II trials enroll more participants and aim to determine efficacy. Phase III trials are large randomized controlled trials to confirm efficacy and monitor adverse effects. Phase IV trials take place after marketing approval to further monitor long-term safety in broad patient populations. The document provides details on objectives, methods, and goals of each phase of clinical trials.
There appears to be a higher cancer control success rate for Brachy over EBRT and Surgery for all groups. Patients are encouraged to look at graphs and determine for themselves
This document discusses pharmacoepidemiology and its objectives, introduction, methods, benefits and applications.
1. Pharmacoepidemiology applies epidemiological methods to study drug use and effects in large populations after approval.
2. It is primarily concerned with post-marketing drug safety surveillance using non-experimental study designs.
3. Key objectives include identifying reasons for adverse drug reactions observed in clinical practice.
This document provides an introduction to pharmacoepidemiology methods. It discusses study designs like cohort studies and case-control studies. It also outlines different data sources that can be used including spontaneous adverse reaction reports, medical billing data, and medical records databases. The document concludes by discussing the future of pharmacoepidemiology, including new scientific developments like applications of epidemiology methods and studies of drug effectiveness, as well as new data sources and the role of genetics.
This document describes a "reverse pharmacology" approach used to develop an anti-malarial herbal medicine in Mali over six years. The key steps were:
1. A retrospective treatment outcome study identified Argemone mexicana as having the best statistical correlation with reported recovery from malaria.
2. In vitro and literature reviews supported Argemone mexicana's safety.
3. A dose-escalating clinical trial was conducted to determine the safest and most effective dose, showing a dose-response effect.
4. A randomized controlled trial then compared the herbal medicine to standard antimalarial treatment.
This process resulted in a new standardized herbal antimal
FACTORS ASSOCIATED WITH UNNECESSARY DRUG THERAPY AND INAPPROPRIATE DOSAGE IN ...Jing Zang
To assess factors associated with unnecessary drug therapy and inappropriate dosage in hospitalized patients. A hospital based cross-sectional study design was employed. The study was conducted in Jimma University Specialized Hospital, Jimma, which is 345 Km from South west of Addis Ababa. All patients who were admitted to medical ward from February 5 – March 21, 2011 were included in the study. Data on socio-demographic variables, past medical history, past medication history, current diagnosis, current medications, vital signs and relevant laboratory data were collected by using bed side patient interview guided semi-structured questionnaire and data abstraction formats for card review. The data were analysed by using SPSS version 16 for windows. Descriptive statistics, cross-tabs, chi-square and logistic regression were done. Out of 257 study participants 140(54.5%) had unnecessary drug therapy or inappropriate dosage. The only independent factors which predicted the unnecessary drug therapy in study population was polypharmacy while not considering organ function test, polypharmacy and clinically significant potential drug-drug interaction were independent factors associated with inappropriate dosage . The prevalence of unnecessary drug therapy or inappropriate dosage is significantly high.
Evaluation of safety and efficacy using venus freeze by dr neil sadickCms Dış Ticaret
This study evaluated the safety and efficacy of the Venus Freeze® system, a radiofrequency device for non-invasive wrinkle treatment. 31 subjects received 10 treatments over 3 months and were evaluated before and after by physicians. Results found significant improvement in wrinkle appearance for 96.7% of subjects with no adverse effects. Statistical analysis showed a significant reduction in wrinkle score from before to after treatment, indicating the Venus Freeze® system is an effective and safe non-surgical option for wrinkle reduction.
Evaluation of safety and efficacy using venus freeze by dr neil sadickCms Dış Ticaret
This study evaluated the safety and efficacy of the Venus Freeze® system, a radiofrequency device for non-invasive wrinkle treatment. 31 subjects received 10 treatments over 3 months and were evaluated before and after by physicians. Results found significant improvement in wrinkle appearance for 96.7% of subjects with no adverse effects. Statistical analysis showed a significant reduction in wrinkle score from before to after treatment, indicating the Venus Freeze® system is an effective and safe option for non-invasive wrinkle therapy.
To study the drug utilization pattern and monitoringGULAM NAVI AZAD
This document summarizes the work done so far on a study analyzing drug utilization patterns and adverse drug reactions (ADRs) in the dermatology outpatient department of ERA Hospital in Lucknow, India. Data has been collected on demographics, prevalent diseases, prescribed medications, and reported ADRs. Most patients were adults and female. Common conditions included eczema and fungal infections. Frequently prescribed drugs were antihistamines and antifungals. Several ADR cases were identified and assessed for causality using the Naranjo scale, with most deemed probable or possible. Further data collection and analysis from inpatient records, literature, and clinical trials is still pending.
- This interim analysis of an ongoing observational study found that topical analgesics may reduce pain severity and interference scores and decrease primary pain complaints and oral pain medication use for patients with neuropathic or musculoskeletal pain.
- Overall patient satisfaction with topical analgesics was high and they were found to be safe and well-tolerated.
- The results were consistent with a previous interim analysis and warrant continuation of the larger OPERA study, though more analysis is still needed.
This study evaluated the effectiveness of a regenerating matrix therapy (RGTA/CACIPLIQ20) for treating chronic wounds. 16 patients with 22 chronic wounds received twice weekly applications of CACIPLIQ20 for up to 4 weeks. Wound size and pain were measured before, during, and after treatment. The results showed that CACIPLIQ20 significantly reduced wound size by 15-18% and pain levels by 60-70% within 4 weeks. Patient and clinician satisfaction with the treatment also remained high. The therapy may help facilitate wound healing and alleviate wound-related pain.
This study evaluated the use of methyl-aminolevulinate (MAL) and red/blue light treatment for severe acne in 39 patients over 14 months. Fluorescence levels significantly increased after MAL application and decreased after cleaning. Acne severity significantly decreased after treatment regardless of location. Most patients were satisfied, reporting average pain of 5/10. The treatment provides an alternative for people who cannot use oral medications or had previous treatment failures or relapses.
The document describes a retrospective analysis of interventions made by a clinical pharmacist (CP) during their participation in the medical intensive care unit (ICU) team of a university hospital over a period of 9 months. The CP reviewed medications for 321 patients and made a total of 307 interventions in 95 patients. The interventions were categorized as: pharmacotherapy adjustments for kidney function (147 interventions), therapeutic drug monitoring (57), administration through a nasogastric tube (30), drug-drug interactions (22), and unspecified (51). The majority of interventions (203) were related to antimicrobial drugs. ICU physicians completely accepted 80.2% of the CP's suggestions. The analysis found that inclusion of a CP contributed to more individualized pharmacological
Detection, reporting and monitoring of ad rs final pptSabeena Choudhary
Adverse drug reactions (ADRs) are important to monitor through pharmacovigilance programs. Spontaneous reporting of ADRs by healthcare professionals and patients allows detection of rare or delayed reactions not seen in clinical trials. Common causes of ADRs include medication errors, non-compliance, and drug interactions. Serious ADRs can lead to death, hospitalization, disability or congenital abnormalities. It is important for doctors, nurses and patients to recognize and report any suspected ADRs to their national pharmacovigilance center to monitor drug safety. Proper causality assessment is needed to determine the likelihood of an ADR being caused by a suspected medication.
This document discusses drug risk assessment and pharmacoepidemiology. It notes that clinical trials prior to drug approval are limited in detecting uncommon or long-term side effects. Observational studies using large patient populations are needed to further evaluate drug safety issues and understand rare or long-term side effects. The document compares different pharmacoepidemiological study designs like cohort studies and case-control studies that can be used to investigate drug safety questions following a drug's approval and entry into widespread use.
The objective of this study was to observe the 1-year and 2-year pressure reduction in an active population of glaucoma patients treated by selective laser trabeculoplasty. We carried out a retrospective study of all patients treated in our department between January 2015 and March 2016. Patients who had already undergone Laser Trabeculoplasty (ALT or SLT) in the past were excluded from the study. Treatment was performed with a Q-Switched, frequency doubled Nd: YAG laser (Solutis - Quantel Medical, France), over 180° or 360° of the trabecular meshwork. The mean decrease in intraocular pressure and the success zrate, defi ned as a decrease in intraocular pressure superior to 20% without increasing the medical treatment, were calculated. The impact of the different clinical and technical characteristics on the decrease in pressure was also studied by multivariate analysis. One hundred and seventeen eyes, in 74 patients, were included. The mean decrease in IOP from baseline was 4.35 mmHg (20.6%) at 1 year and 3.74 mmHg (16.7%) at 2 years. The success rate was 49% at 1 year and 33.3% at 2 years. Selective trabeculoplasty is currently a therapeutic option called-upon at different stages in the progression of glaucoma. The duration of effi cacy of this laser therapy, and the retreatment frequency are yet to be defined.
This document discusses different types of clinical trial designs, including crossover trials, factorial trials, and equivalence trials. Crossover trials involve each patient receiving both the active treatment and control in different sequences, with washout periods in between. Factorial trials assign patients to multiple treatment groups to evaluate the effects of each treatment alone or in combination. Equivalence trials compare an altered treatment to the original to show there is no loss of effectiveness or increased side effects when modifications are made.
The document explores using the Systems-Theoretic Accident Model and Processes (STAMP) to manage risks in drug development. It analyzes the 2006 TGN1412 clinical trial where volunteers suffered severe reactions. STAMP views safety as a control problem rather than failure. The document applies STAMP concepts like safety constraints and control structures to the TGN1412 trial, identifying a lack of coordination between pre-clinical and clinical stages as a systemic vulnerability. It concludes that implementing STAMP methodology could help identify risks and reduce patient casualties by correlating controls with inherent process vulnerabilities in drug development.
The spontaneous reporting system is a passive surveillance system where health professionals voluntarily report adverse drug reactions directly to regulatory authorities or pharmaceutical companies. It involves 3 main processes: 1) data acquisition from reported cases, 2) assessment of individual reports and pooled data, and 3) interpretation of signals based on the available data. Initiatives have been taken to widen reporting bases to include pharmacists and nurses. Special focus has been given to reporting reactions related to HIV drugs, pediatric drugs, and herbal products to improve surveillance in underreported areas.
Extracorporeal shockwave therapy (ESWT) has analgesic and anti-inflammatory effects. With the evolu- tion and comprehension of its biological and physical mechanisms, the application of ESWT on other pathologies has also been studied, especially in musculoskeletal diseases. Recently, studies on animal models have shown its angiogenic capacity and a higher rate of local re-epithelization. These small stud- ies led to few trials using low-energy, radial ESWT to treat problematic chronic skin ulcers. Skin ulcers have diverse etiologies, ranging from pressure ulcers, burns, venous or arterial ulcers, and even diabetic ulcers. Their treatment is usually a challenge, due to the long-term treatment and high costs.
The document outlines the phases of clinical trials. Phase I trials involve small studies with healthy volunteers to determine safety and dosage. Phase II trials enroll more participants and aim to determine efficacy. Phase III trials are large randomized controlled trials to confirm efficacy and monitor adverse effects. Phase IV trials take place after marketing approval to further monitor long-term safety in broad patient populations. The document provides details on objectives, methods, and goals of each phase of clinical trials.
There appears to be a higher cancer control success rate for Brachy over EBRT and Surgery for all groups. Patients are encouraged to look at graphs and determine for themselves
This document discusses pharmacoepidemiology and its objectives, introduction, methods, benefits and applications.
1. Pharmacoepidemiology applies epidemiological methods to study drug use and effects in large populations after approval.
2. It is primarily concerned with post-marketing drug safety surveillance using non-experimental study designs.
3. Key objectives include identifying reasons for adverse drug reactions observed in clinical practice.
This document provides an introduction to pharmacoepidemiology methods. It discusses study designs like cohort studies and case-control studies. It also outlines different data sources that can be used including spontaneous adverse reaction reports, medical billing data, and medical records databases. The document concludes by discussing the future of pharmacoepidemiology, including new scientific developments like applications of epidemiology methods and studies of drug effectiveness, as well as new data sources and the role of genetics.
This document describes a "reverse pharmacology" approach used to develop an anti-malarial herbal medicine in Mali over six years. The key steps were:
1. A retrospective treatment outcome study identified Argemone mexicana as having the best statistical correlation with reported recovery from malaria.
2. In vitro and literature reviews supported Argemone mexicana's safety.
3. A dose-escalating clinical trial was conducted to determine the safest and most effective dose, showing a dose-response effect.
4. A randomized controlled trial then compared the herbal medicine to standard antimalarial treatment.
This process resulted in a new standardized herbal antimal
FACTORS ASSOCIATED WITH UNNECESSARY DRUG THERAPY AND INAPPROPRIATE DOSAGE IN ...Jing Zang
To assess factors associated with unnecessary drug therapy and inappropriate dosage in hospitalized patients. A hospital based cross-sectional study design was employed. The study was conducted in Jimma University Specialized Hospital, Jimma, which is 345 Km from South west of Addis Ababa. All patients who were admitted to medical ward from February 5 – March 21, 2011 were included in the study. Data on socio-demographic variables, past medical history, past medication history, current diagnosis, current medications, vital signs and relevant laboratory data were collected by using bed side patient interview guided semi-structured questionnaire and data abstraction formats for card review. The data were analysed by using SPSS version 16 for windows. Descriptive statistics, cross-tabs, chi-square and logistic regression were done. Out of 257 study participants 140(54.5%) had unnecessary drug therapy or inappropriate dosage. The only independent factors which predicted the unnecessary drug therapy in study population was polypharmacy while not considering organ function test, polypharmacy and clinically significant potential drug-drug interaction were independent factors associated with inappropriate dosage . The prevalence of unnecessary drug therapy or inappropriate dosage is significantly high.
Evaluation of safety and efficacy using venus freeze by dr neil sadickCms Dış Ticaret
This study evaluated the safety and efficacy of the Venus Freeze® system, a radiofrequency device for non-invasive wrinkle treatment. 31 subjects received 10 treatments over 3 months and were evaluated before and after by physicians. Results found significant improvement in wrinkle appearance for 96.7% of subjects with no adverse effects. Statistical analysis showed a significant reduction in wrinkle score from before to after treatment, indicating the Venus Freeze® system is an effective and safe non-surgical option for wrinkle reduction.
Evaluation of safety and efficacy using venus freeze by dr neil sadickCms Dış Ticaret
This study evaluated the safety and efficacy of the Venus Freeze® system, a radiofrequency device for non-invasive wrinkle treatment. 31 subjects received 10 treatments over 3 months and were evaluated before and after by physicians. Results found significant improvement in wrinkle appearance for 96.7% of subjects with no adverse effects. Statistical analysis showed a significant reduction in wrinkle score from before to after treatment, indicating the Venus Freeze® system is an effective and safe option for non-invasive wrinkle therapy.
Evaluation of safety and efficacy using venus freeze by dr neil sadickCms Dış Ticaret
This study evaluated the safety and efficacy of the Venus Freeze® system, a radiofrequency device for non-invasive wrinkle treatment. 31 subjects received 10 treatments over 3 months and were evaluated before and after by physicians. Results found significant improvement in wrinkle appearance for 96.7% of subjects with no adverse effects. Statistical analysis showed a significant reduction in wrinkle score from before to after treatment, indicating the Venus Freeze® system is an effective and safe option for non-invasive wrinkle reduction.
This document provides consensus recommendations from a panel of experts for developing a tailored approach to treating the forehead with botulinum toxin type A injections. The panel developed treatment protocols for men and women that take into account the level of underlying muscle activity as kinetic (regular), hyperkinetic (excessive), or hypertonic (unable to relax). For each category, injection points and doses are defined on a 12-zone map of the forehead to provide natural and individualized results based on a patient's facial anatomy and muscle tone. The goal is to eliminate lines at rest while maintaining some ability for movement and minimal wrinkling with expression.
Does homeopathic Arnica Montana reduce bruising after blepharoplastyBrett Kotlus
Dr. Brett Kotlus and co-authors evaluated the efficacy of homeopathic arnica montana for ecchymosis (bruising) in conjunction with upper eyelid surgery.
This study compared outcomes of patients with MDR/XDR Acinetobactor baumannii pneumonia treated with tigecycline or colistin. 70 patients received either tigecycline (n=30) or colistin (n=40). There were no significant differences in clinical outcomes between the two groups except nephrotoxicity, which only occurred in the colistin group. While the study indicates comparable efficacy, limitations include its small size, retrospective design, and exclusions. Further large randomized studies are still needed to properly evaluate tigecycline and optimal treatment combinations for MDR infections.
In vitro evaluation of transdermal permeation effects of Fu’s cupping therapy...LucyPi1
Abstract In this study, six kinetics models of indomethacin hydrophilic gel patch transdermal in vitro release was established, including zero-level, first-order, Higuchi-level, Ritger-Peppas, Weibull and Hixcon-Crowell dynamic equations. The chemical permeation enhancers, including 3% and 5% Azone, and iontophoresis were used as the control. Transdermal diffusion tests were performed in vitro and indomethacin was quantified by high performance liquid chromatography system. The transdermal parameter of the Higuchi and Weibull dynamic equations, indicated that Fu’s cupping therapy (FCT) could significantly improve Higuchi and Weibull kinetic parameters in vitro transdermal, increased transdermal rate and permeability coefficient, reduced lagging time. Additionally, statistical analysis speculated the skin barrier function could be restored after 46 h treatment. Hence, as a new physical transdermal drug delivery technology, transdermal permeation effects produced by FCT are obvious, which has the characteristics of traditional Chinese medicine and has important clinical application value.
Topical phenytoin effects on palatal wound healing.pptxRutu Dabhi
This study aimed to assess the effects of topical phenytoin (PHT) on healing of experimental palatal wounds. A prospective split-mouth trial was conducted where standardized wounds were created on both sides of participants' palates (n=20). One side received topical PHT treatment and the other received a carrier alone as the control. Wound healing was clinically evaluated on several days post-op using a scoring index. Biopsies were also taken on days 1 or 5 and analyzed histologically. Preliminary results suggested topical PHT application may accelerate palatal wound healing by increasing granulation tissue and stimulating fibroblast proliferation compared to the control wounds. Further analysis is still needed to fully characterize the effects.
Menon, et al. 2020 comparative study of microneedling with tranexamic acid ve...Felix J. Tapia
This study compared the safety and efficacy of microneedling with tranexamic acid (TXA) versus microneedling with vitamin C for the treatment of melasma. Thirty female patients with melasma underwent microneedling with TXA on the left side of their face and microneedling with vitamin C on the right side. Improvement was assessed after 4 and 8 weeks using the Melasma Area Severity Index (MASI) score, physician and patient assessments. At 8 weeks, MASI scores showed greater improvement with TXA (20.5% reduction) compared to vitamin C (12.3% reduction), though the difference was not statistically significant. Both treatments were found to be
2-51-1416911800-5. IJGMP - EFFICIENCY OF SUCTION BLISTER EPIDERMAL GRAFTING I...aerdnaaerdna
This document discusses a study on the efficacy of suction blister epidermal grafting for treating stable vitiligo. 30 patients with stable vitiligo in various body areas underwent the grafting procedure. Results were evaluated after 6 months. Excellent repigmentation of over 75% was seen in 12 patients (40%), and good repigmentation of 51-75% in 10 patients (33%). The main complication observed was hyperpigmentation at the donor and recipient sites. The study concludes that suction blister grafting is an effective and inexpensive alternative for treating stable vitiligo, with good success rates.
is laser treatment is really a good decision for a women????think...Impact of...ShitalSavaliya1
This study examined the impact of oral contraceptive pill (OCP) use on central corneal thickness (CCT) in young women. The study compared CCT, intraocular pressure (IOP), and body mass index (BMI) measurements between 50 women using OCPs and 40 women not using OCPs. The results showed that CCT values were significantly higher in the OCP users compared to non-users, while IOP and BMI did not differ significantly between the groups. The findings suggest that OCP use may impact CCT, and ophthalmologists should be aware of potentially elevated CCT levels when measuring IOP or treating eye conditions in women using OCPs.
This study evaluated the long-term anti-aging effects of regular BroadBand Light (BBL) therapy treatments over 5 to 11 years. Fifteen participants received at least one full-face BBL treatment per year. Before and after photographs were evaluated by 491 blinded evaluators who estimated the participants' ages. While the participants' skin actually aged a median of 9 years, their skin appeared to age by only a median of -2 years. The median estimated post-treatment age was significantly lower than the actual post-treatment age, indicating BBL therapy reduced and delayed signs of skin aging over the long term with regular annual or biannual treatments.
The document discusses strategies for searching and collecting biomedical information and provides several links to articles about post-operative pain treatment, the effect of an antimicrobial paste on healing after tooth extractions in HIV positive patients, a new combination of drugs to prevent post-extraction complications, secondary healing after removal of a large cyst in the mandible using iodoform gauze packing, and the effect of a topical drug combination on early socket healing in monkeys.
A comparative study of intralesional injection of triamcinolone acetonide alo...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Evaluation of topical bioavailability of clotrimazole using dermato pharmaco ...IJSIT Editor
In this single-dose-one arm, open label two way parallel design, pharmacokinetic study of two
marketed formulations of Clotrimazole using 12 healthy Indian male subjects the pharmacokinetic
parameters of two marketed Clotrimazole topical formulations were compared . Marketed Clotrimazole
topical formulations (A & B) were applied on the pre-marked forearms of the subjects as per the dosing
schedule. Treatment sample B was used as a reference sample. Subjects received treatment A & treatment B
on both the arms simultaneously, following open label two way parallel design. Skin Stratum Corneum
samples were collected in sterile glass test tubes during the study period. The samples were collected predose and at 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, & 6.0 hours post-dose application. The Stratum Corneum samples were
analysed for Clotrimazole concentrations only. Pharmacokinetic parameters of Clotrimazole were calculated
as Cmax, tmax, AUC (0-t) and AUC (0-∞) Clotrimazole was estimated in Stratum Corneum using a validated
Spectroscopic method. If the point estimate of the geometric mean ratio and the confidence intervals for the
entire log transformed pharmacokinetic parameters [Cmax, AUC (0-t) and AUC (0-∞)] were entirely included
in the range of 80-125%, then the treatments were claimed to be bio-equivalent.
The document evaluates the efficacy and safety of Takzema tablets and ointment in treating mild to moderate eczema. It describes an 8-week open-label study of the formulation in 50 patients. Results showed reductions in erythema, oozing, induration and pruritus scores from baseline. Adverse effects were minor. Physician and patient global assessments indicated fair to good responses. The study confirms the efficacy and safety of Takzema tablets and ointment for eczema.
This document describes a study that evaluated the safety and efficacy of TriPollar radiofrequency (RF) treatment for acne vulgaris. Twenty patients with active acne lesions received six weekly TriPollar RF treatments. Results found an average 42% reduction in active lesions after treatment, which was sustained at 4-week follow-up. Patients reported good to very good satisfaction with the results. No significant adverse events occurred. The findings confirm TriPollar RF is a safe and effective treatment for acne vulgaris that can provide comparable efficacy to other modalities in a more convenient treatment approach.
The Fabrication of Drug Enfused Microparticles for Drug Delivery PurposesAnurag Ojha
This document describes research into developing biodegradable microparticle implants for long-term delivery of the pain medication celecoxib to manage osteoarthritis pain. Five copolymers of varying compositions were used to fabricate drug-loaded microparticles. In vitro drug release studies found that altering the polymer matrix hydrophobicity affected release patterns, with more hydrophobic matrices releasing drug more slowly over 60 days. The microparticles have the potential to provide over 6 months of therapeutic drug levels for osteoarthritis pain management.
Similar to Assessment of skin physiology change and safety after intradermal injections with botulinum toxin (20)
Evidencia de una ventana de oportunidad en la hidradenitis supurativa tratada...Felix J. Tapia
Este estudio retrospectivo multicéntrico evaluó la respuesta clínica al tratamiento con adalimumab en 389 pacientes con hidradenitis supurativa moderada a grave. Los resultados mostraron que el 44% y el 58% de los pacientes, respectivamente, lograron una respuesta clínica en la semana 16 y 52 según la escala HiSCR. Además, cuanto menor fue el retraso entre el inicio de los síntomas y el tratamiento con adalimumab, mayor fue la probabilidad de respuesta al fármaco. Los efectos adversos fueron en su mayoría
Presentación envejecimiento capilar en diferentes etnias mariaesther vasquezFelix J. Tapia
Este documento discute las diferencias en el envejecimiento del cabello entre diferentes etnias. Explica que aunque el cabello de todas las personas envejece a través de procesos intrínsecos y extrínsecos, las propiedades estructurales varían entre caucásicos, asiáticos, africanos y latinos. Esto significa que el envejecimiento del cabello también es diferente entre grupos étnicos. Aborda factores como el diámetro, la densidad, la pigmentación y la susceptibilidad al daño, y
Historia de la ciencia en venezuela pdf papel literario 2021, marzo 21Felix J. Tapia
Este documento presenta una entrevista con el científico Jaime Requena sobre la historia de la ciencia en Venezuela. Requena discute varios temas, incluyendo las contribuciones de figuras históricas como José María Vargas y Luis Daniel Beauperthuy. También aborda el desarrollo de instituciones científicas como la Universidad de Caracas y el papel de investigadores extranjeros en el avance de la ciencia venezolana. Finalmente, analiza los desafíos que enfrentaron los primeros científicos venez
Este documento resume las últimas actualizaciones sobre las manifestaciones cutáneas y tratamientos asociados con COVID-19. Se describen 5 patrones dermatológicos comunes asociados con COVID-19 y los posibles efectos adversos en la piel de varios medicamentos usados para tratar el virus. También incluye recomendaciones para el manejo de pacientes con comorbilidades dermatológicas que reciben terapias inmunosupresoras durante la pandemia.
Este documento resume las últimas actualizaciones sobre las manifestaciones cutáneas y tratamientos asociados con COVID-19. Se describen 5 patrones dermatológicos comunes asociados con COVID-19 y los posibles efectos adversos en la piel de varios medicamentos usados para tratar el virus. También incluye recomendaciones para el manejo de pacientes con comorbilidades dermatológicas que reciben terapias inmunosupresoras durante la pandemia.
Bilobalide protege a los melanocitos humanos del daño oxidativo inducido por peróxido de hidrógeno al promover la expresión de la enzima antioxidante catalasa y glutation peroxidasa-1, lo que reduce el estrés oxidativo. También inhibe la liberación de proteínas de estrés del retículo endoplásmico inducida por peróxido de hidrógeno, previniendo la apoptosis de los melanocitos.
Adriana de la torre diapos ficha urea y expresión génicaFelix J. Tapia
1) La aplicación tópica de urea aumenta la expresión de genes relacionados con la diferenciación epidérmica, la síntesis de lípidos y los péptidos antimicrobianos en queratinocitos humanos.
2) Los queratinocitos absorben urea a través de los transportadores UT-A1, UT-A2 y las aquaporinas.
3) La absorción de urea regula positivamente la función barrera de la piel y la defensa antimicrobiana a través de la modulación de la expresión génica epidérmica.
Este estudio evaluó el transcriptoma de la piel de pacientes con psoriasis en una gran muestra y lo comparó con estudios previos y modelos in vitro. Se identificaron 1326 genes regulados de manera diferencial entre la piel lesionada y normal, incluyendo 600 nuevos genes como S100A7A, THRSP y ELOVL3. Los genes más sobreexpresados fueron SERPINB4, PI3, DEFB4 y la familia S100, mientras que los más subexpresados fueron WIF1, BTC y CCL27. Las categorías sobreexpresadas se
Este estudio evaluó el transcriptoma de la piel de pacientes con psoriasis en una gran muestra y lo comparó con estudios previos y modelos in vitro. Se identificaron 1326 genes regulados de manera diferencial entre la piel lesionada y normal, incluyendo 600 nuevos. Los genes más sobreexpresados estuvieron relacionados con la respuesta inmune y diferenciación de queratinocitos, mientras que los subexpresados se asociaron con metabolismo lipídico. La comparación con queratinocitos estimulados in vitro mostró poca correspondencia con la expresión
El documento habla sobre las redes sociales y Twitter. Explica las razones para usar Twitter como socializar, aprender, compartir e informar. Da consejos para publicar en Twitter como ser consistente, dejar brillar la personalidad y divertirse. También menciona hashtags populares y cómo hacerse visible en Twitter siguiendo a otros y compartiendo contenido propio de manera regular.
Informe de gestión 2009 Consejo Pleno Dic 2009Felix J. Tapia
Este informe resume las actividades del Consejo de Desarrollo Científico y Humanístico de la Universidad Central de Venezuela entre enero y diciembre de 2009. Detalla la estructura administrativa del Consejo y su función de coordinar la investigación en la universidad. Además, describe las asignaciones y distribución presupuestaria para investigación en 2005-2009, los programas de investigación en 2009 y las medidas implementadas para hacer frente a los recortes presupuestarios, como la limitación de fondos por proyecto y el número de proyectos por investigador.
Stress in the regulation of the immune response in LeishmaniasisFelix J. Tapia
The document summarizes research on the effects of acute stress on the immune response to Leishmania infection in mouse models. The research found that immobilization stress and odorant inhalation stress can alter the numbers and function of Langerhans cells, substances P and CGRP, and skew the Th1/Th2 response in resistant and susceptible mouse strains. This influences the natural course of Leishmania infection depending on the genetic background of the mouse.
Nuevos paradigmas en la investigación dermatológicaFelix J. Tapia
El documento presenta una serie de temas relacionados con la investigación científica actual, incluyendo nuevos paradigmas en investigación dermatológica, la era de los pentabytes y el método científico, la bioinformática, y las posiciones de Stewart Brand sobre temas como el crecimiento poblacional, la urbanización, los organismos genéticamente modificados y la energía nuclear.
Leishmaniasis lo profundo se oculta en la superficieFelix J. Tapia
Este documento discute la leishmaniasis, una enfermedad parasitaria causada por protozoos del género Leishmania. Explora la epidemiología, patogénesis e investigaciones sobre la regulación cutánea en modelos murinos de leishmaniasis cutánea americana. También presenta resultados sobre la interacción entre células dendríticas, macrófagos y el parásito, y el efecto del estrés en la progresión de la infección.
Los Parasitos y su interaccion con el EpitelioFelix J. Tapia
El documento describe las interacciones entre parásitos y el epitelio de la piel. Explica el sistema inmunitario cutáneo y sus células, incluyendo las células de Langerhans. Analiza varias infecciones parasitarias de la piel como la esquistosomiasis, oncocercosis y leishmaniasis, describiendo las respuestas inmunitarias involucradas. Finalmente, presenta algunos de los resultados de investigaciones sobre leishmaniasis cutánea.
El documento describe el sistema inmunitario cutáneo, incluyendo las células dendríticas y su función en la captura y presentación de antígenos. También discute las fases de regulación cutánea como la activación, inmunoestimulación y fase efectora, y presenta modelos de inmunopatología cutánea como la leishmaniasis.
El documento describe el sistema inmunitario de la piel y las células dendríticas. Explica que las células de Langerhans son el prototipo de célula dendrítica epitelial y cumplen las funciones de captura de antígenos en la piel y su migración a los ganglios linfáticos para su presentación. También describe las diferentes vías de presentación de antígenos por parte de las células dendríticas y los receptores que permiten la detección de patrones moleculares asociados a patógenos para activar la resp
Gender and Mental Health - Counselling and Family Therapy Applications and In...PsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Strategies for Effective Upskilling is a presentation by Chinwendu Peace in a Your Skill Boost Masterclass organisation by the Excellence Foundation for South Sudan on 08th and 09th June 2024 from 1 PM to 3 PM on each day.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
-------------------------------------------------------------------------------
Find out more about ISO training and certification services
Training: ISO/IEC 27001 Information Security Management System - EN | PECB
ISO/IEC 42001 Artificial Intelligence Management System - EN | PECB
General Data Protection Regulation (GDPR) - Training Courses - EN | PECB
Webinars: https://pecb.com/webinars
Article: https://pecb.com/article
-------------------------------------------------------------------------------
For more information about PECB:
Website: https://pecb.com/
LinkedIn: https://www.linkedin.com/company/pecb/
Facebook: https://www.facebook.com/PECBInternational/
Slideshare: http://www.slideshare.net/PECBCERTIFICATION
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.
Chapter wise All Notes of First year Basic Civil Engineering.pptxDenish Jangid
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
Communicating effectively and consistently with students can help them feel at ease during their learning experience and provide the instructor with a communication trail to track the course's progress. This workshop will take you through constructing an engaging course container to facilitate effective communication.