Ergonomics for the sedentary lifestyle
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The spine is made up of 33 bones that keep the body upright and allow for movement. It protects the spinal cord which connects the brain to the rest of the body. Maintaining a healthy spine is important for an active lifestyle. Some ways to protect the spine include proper lifting techniques, low back exercises, adequate nutrition, sleeping 6-8 hours on the side with a pillow between the knees, maintaining good posture, wearing proper shoes, and being mindful of spine protection during all daily activities as the spine only has one.
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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The Electrocardiogram - Physiologic Principles
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
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Top 10 Best Ayurvedic Kidney Stone Syrups in India
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Ketone bodies and metabolism-biochemistry
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Ergonomics for the sedentary lifestyle
- 1. Ergonomics for you PROTECT YOUR SPINE. DR AFUA ADJEI-KWAYISI- SPINE PHYSICIAN
- 2. The spine 33 bones forming a cylindrical unit One of the most important parts of your body. Keeps you upright / even stand up. Your spine gives your body structure and support. It allows you to move and bend.
- 3. The spine also protects your spinal cord. The spinal cord is the column of nerves that connects your brain with the rest of your body, allowing you to control your movements.
- 4. Why do we need to protect it? Movement organs to function. That is why keeping your spine healthy is VITAL if you want to live an active life.
- 5. How do we protect the spine Ergonomics – lifting
- 7. Exercise For low back
- 8. Nutrition – DO NOT over cook. Calcuim – dark green leafy, dairy/milk, salmon, black beans, groundnuts Magnesium – dark green leafy, pear, whole grains Iron- Dark green leafy, poultry, red meat, fish, lentil, beans Vit A- palm, meat, carrots Vit D- morning sunlight, egg yolk, fish oils Vit C- Fruits, green pepper, potatoes Vit K- liver, pork, banana, coconut, dairy Vit B12- liver fish, red meat, eggs, dairy
- 9. Sleep hours – At least 6- 8 hours, on side , not on tummy or back, pillow in between knees
- 10. Sleep right Get a good matteress ~Firm Matteress
- 11. Posture is the window to your spine Keep neutral spine in mind Clothing should be comfortable – Well fitting belts Commuting sit upright Walk right
- 12. Proper shoes Proper handling of bags
- 13. When should we protect it? All the time !!!! Whilst at work, Sleeping, Daily activities
- 14. Protect your back, You have only one Spine.