Matthew Dovey & Jessica Parland-von Essen present EOSC governance & objectives.
Workshop title: Open Science policy in the context of EOSC governance framework
Workshop overview:
The challenge of EOSC governance is how to construct a framework allowing varied and disparate stakeholders to work together. The EOSCPilot project has established a Governance Development Forum (EGDF) so that all stakeholders can contribute to the development of a governance framework to inform the establishment of EOSC and its governance structure. In this workshop we will discuss how Open Science should manifest in the EOSC governance framework.
When: DAY 2 - PARALLEL SESSION 4
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EOSCpilot's WP3 has published draft policy recommendations and is now developing a final EOSC policy proposition which will be presented at the Stakeholder Forum. It encompasses Open Science, Data Protection, Procurement and Ethics. The policy workshop provides the opportunity for stakeholders to discuss aspects of the policy proposition and provide feedback about it, which will be taken into account in the final policy recommendations deliverable (D3.6).
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Presentation held by Carmela Asero (European Commission) @ SLA-Ready workshop "Are you SLA-Ready? How to understand your cloud Service Level Agreement", on 15 December 2016 in Brussels, Belgium. http://bit.ly/2fVcCG7
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The presentation made by Antonella Di Fazio (Telespazio) on September 15 at the European Commission's 2014 FP7 Space International Conference, held in Rome.
SCUTUM (SeCUring the EU GNSS adopTion in the dangeroUs Material transport) is the European best practice for the operational adoption of commercial services based on EGNOS.
Chris Atherton (GEANT) and Andres Steijaert (OCRE) presentation about the Open Clouds for Research Environments (OCRE) project and GÉANT's National Research and Education Networks and their Infrastructure support for global Cloud Computing at the 4th GEO Data Technology Workshop.
Vienna, Austria
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EOSC Policy Session - EOSC Stakeholders Forum 2018EOSCpilot .eu
EOSCpilot's WP3 has published draft policy recommendations and is now developing a final EOSC policy proposition which will be presented at the Stakeholder Forum. It encompasses Open Science, Data Protection, Procurement and Ethics. The policy workshop provides the opportunity for stakeholders to discuss aspects of the policy proposition and provide feedback about it, which will be taken into account in the final policy recommendations deliverable (D3.6).
European Open Science Cloud (EOSC) From vision to actionSLA-Ready Network
Presentation held by Carmela Asero (European Commission) @ SLA-Ready workshop "Are you SLA-Ready? How to understand your cloud Service Level Agreement", on 15 December 2016 in Brussels, Belgium. http://bit.ly/2fVcCG7
SCUTUM - SeCUring the EU GNSS adopTion in the dangeroUs Material transportFinmeccanica
The presentation made by Antonella Di Fazio (Telespazio) on September 15 at the European Commission's 2014 FP7 Space International Conference, held in Rome.
SCUTUM (SeCUring the EU GNSS adopTion in the dangeroUs Material transport) is the European best practice for the operational adoption of commercial services based on EGNOS.
Chris Atherton (GEANT) and Andres Steijaert (OCRE) presentation about the Open Clouds for Research Environments (OCRE) project and GÉANT's National Research and Education Networks and their Infrastructure support for global Cloud Computing at the 4th GEO Data Technology Workshop.
Vienna, Austria
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SSHOC at EOSC-hub Week - SSHOC Social Sciences and Humanities Open Cloud - Am...SSHOC
Overview on the Social Sciences and Humanities Open Cloud from Amir Spahic (CESSDA) at the EOSC-hub Week, 10 May 2019.
EOSC for Social Sciences and Humanities panel
OCRE launched its first funding call - specifically focused on stimulating the adoption of digital Earth Observation (EO) services by researchers - on Wednesday 14 October 2020 at 14:00 CEST. Two subsequent calls for projects using earth observation services are planned to open in February and July 2021 respectively.
Under this 1st EO funding call, OCRE aims to fund the consumption of EO services by projects which can become clear showcases for the benefits of using Earth Observation Services; projects which;
Are a part of the European research community.
Use earth observation data from the Copernicus programme in their research.
Support the FAIR data principles and intend to share their research data with peers.
Clearly demonstrate how the use of commercial Earth Observation Services can provide agility in terms of research activities; improve research or enable new research outcomes.
Provide significant relevance within their research discipline.
Are not currently using these tools extensively.
Hope to continue usage of Earth Observation Services in their research.
Can begin to use Earth Observation Services in early 2021.
OCRE launched its first funding call - specifically focused on stimulating the adoption of digital Earth Observation (EO) services by researchers - on Wednesday 14 October 2020 at 14:00 CEST. Two subsequent calls for projects using earth observation services are planned to open in February and July 2021 respectively.
Under this 1st EO funding call, OCRE aims to fund the consumption of EO services by projects which can become clear showcases for the benefits of using Earth Observation Services; projects which;
Are a part of the European research community.
Use earth observation data from the Copernicus programme in their research.
Support the FAIR data principles and intend to share their research data with peers.
Clearly demonstrate how the use of commercial Earth Observation Services can provide agility in terms of research activities; improve research or enable new research outcomes.
Provide significant relevance within their research discipline.
Are not currently using these tools extensively.
Hope to continue usage of Earth Observation Services in their research.
Can begin to use Earth Observation Services in early 2021.
Slide from a 3-minute presentation about my research project ResilRoad (Risk-based Resilience indicators for roadway networks), which is part of SMARTI ETN.
This is a short introduction to the city, the venue, and the organisation of the ICAC 2011. More information is avaialble on the conference website: www.autonomic-conference.org.
H2020
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Working towards the realisation of a sustainable and open single European market for multimodal travel services.
A brief introduction to the MERIKA Project by Damian Collins, Project Knowledge Exchange and Innovation Manager, presented at the EIMR conference in Stornoway, Isle of Lewis, Scotland.
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Virtual Campfire – A Mobile Social Software for Cross Media Communities
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EOSC Governance Development Forum 7th WebinarEOSCpilot .eu
This is the 7th installment in a series of thematic, stakeholder targeted workshops which are held to allow EOSC governance framework to be elaborated from the stakeholder perspective. The Webinar was held on 9 November 2017 by Matthew Dovey (Jisc), Saara Kontro and Per Oster (CSC).
You can watch the recorded video of thi webinar at: https://youtu.be/o-a_XPj5y5M
For more information about the EOSCpilot Governance Development Forum visit https://eoscpilot.eu/about/governance-framework
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://www.linkedin.com/in/eoscpiloteu
SSHOC at EOSC-hub Week - SSHOC Social Sciences and Humanities Open Cloud - Am...SSHOC
Overview on the Social Sciences and Humanities Open Cloud from Amir Spahic (CESSDA) at the EOSC-hub Week, 10 May 2019.
EOSC for Social Sciences and Humanities panel
OCRE launched its first funding call - specifically focused on stimulating the adoption of digital Earth Observation (EO) services by researchers - on Wednesday 14 October 2020 at 14:00 CEST. Two subsequent calls for projects using earth observation services are planned to open in February and July 2021 respectively.
Under this 1st EO funding call, OCRE aims to fund the consumption of EO services by projects which can become clear showcases for the benefits of using Earth Observation Services; projects which;
Are a part of the European research community.
Use earth observation data from the Copernicus programme in their research.
Support the FAIR data principles and intend to share their research data with peers.
Clearly demonstrate how the use of commercial Earth Observation Services can provide agility in terms of research activities; improve research or enable new research outcomes.
Provide significant relevance within their research discipline.
Are not currently using these tools extensively.
Hope to continue usage of Earth Observation Services in their research.
Can begin to use Earth Observation Services in early 2021.
OCRE launched its first funding call - specifically focused on stimulating the adoption of digital Earth Observation (EO) services by researchers - on Wednesday 14 October 2020 at 14:00 CEST. Two subsequent calls for projects using earth observation services are planned to open in February and July 2021 respectively.
Under this 1st EO funding call, OCRE aims to fund the consumption of EO services by projects which can become clear showcases for the benefits of using Earth Observation Services; projects which;
Are a part of the European research community.
Use earth observation data from the Copernicus programme in their research.
Support the FAIR data principles and intend to share their research data with peers.
Clearly demonstrate how the use of commercial Earth Observation Services can provide agility in terms of research activities; improve research or enable new research outcomes.
Provide significant relevance within their research discipline.
Are not currently using these tools extensively.
Hope to continue usage of Earth Observation Services in their research.
Can begin to use Earth Observation Services in early 2021.
Slide from a 3-minute presentation about my research project ResilRoad (Risk-based Resilience indicators for roadway networks), which is part of SMARTI ETN.
This is a short introduction to the city, the venue, and the organisation of the ICAC 2011. More information is avaialble on the conference website: www.autonomic-conference.org.
H2020
Optimodal European Travel Ecosystem:
Working towards the realisation of a sustainable and open single European market for multimodal travel services.
A brief introduction to the MERIKA Project by Damian Collins, Project Knowledge Exchange and Innovation Manager, presented at the EIMR conference in Stornoway, Isle of Lewis, Scotland.
Marine Energy Research Innovation and Research Accelerator
Virtual Campfire – A Mobile Social Software for Cross Media CommunitiesRalf Klamma
Virtual Campfire – A Mobile Social Software for Cross Media Communities
Yiwei Cao, Marc Spaniol, Ralf Klamma, Dominik Renzel
Graz, Austria, 5-7 of September, 2007
EOSC Governance Development Forum 7th WebinarEOSCpilot .eu
This is the 7th installment in a series of thematic, stakeholder targeted workshops which are held to allow EOSC governance framework to be elaborated from the stakeholder perspective. The Webinar was held on 9 November 2017 by Matthew Dovey (Jisc), Saara Kontro and Per Oster (CSC).
You can watch the recorded video of thi webinar at: https://youtu.be/o-a_XPj5y5M
For more information about the EOSCpilot Governance Development Forum visit https://eoscpilot.eu/about/governance-framework
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://www.linkedin.com/in/eoscpiloteu
Soap box session - Intermediaries, Research communities & LibrariesEOSCpilot .eu
This presentation was held at the 1st EOSC Stakeholder Forum 28-29/11/2017 in Brussels.
For more information on the 1st EOSC Stakeholder Forum visit: https://eoscpilot.eu/eosc-stakeholder-forum-shaping-future-eosc
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://uk.linkedin.com/in/eoscpiloteu
Governance and Sustainability of EOSC: ambitions, challenges and opportunitiesEOSCpilot .eu
This presentation was held at the 1st EOSC Stakeholder Forum 28-29/11/2017 in Brussels.
For more information on the 1st EOSC Stakeholder Forum visit: https://eoscpilot.eu/eosc-stakeholder-forum-shaping-future-eosc
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://uk.linkedin.com/in/eoscpiloteu
This presentation was held at the 1st EOSC Stakeholder Forum 28-29/11/2017 in Brussels.
For more information on the 1st EOSC Stakeholder Forum visit: https://eoscpilot.eu/eosc-stakeholder-forum-shaping-future-eosc
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://uk.linkedin.com/in/eoscpiloteu
OSFair2017 Workshop | Towards a Policy Framework for the European Open Scienc...Open Science Fair
Workshop title: Towards a Policy Framework for the European Open Science Cloud
Workshop abstract:
The workshop provides a hands on approach in relation both to the understanding of the EU open science policies and their application by related stakeholders. It will seek to explore, propose and test different aspects of policy documents created by and for different types of stakeholders (e.g. RPOs, funders, policy makers etc) in the context of EOSC. Drawing on the work by the EOSC policy work, the workshop invites participants to bring their own policies or work on model policies to develop a simple but comprehensive policy document tailored to their needs and conforming to the EU policy and legal framework.
It is useful to the broader Open Science community as it brings together services, stakeholders and policies and allows for a better understanding of the interaction between different constituencies.
DAY 2 - PARALLEL SESSION 3
The European Open Science Cloud: From vision to implementationEOSCpilot .eu
This presentation was held at the 1st EOSC Stakeholder Forum 28-29/11/2017 in Brussels by Juan Bicarregui STFC and EOSCpilot project coordinator.
For more information on the 1st EOSC Stakeholder Forum visit: https://eoscpilot.eu/eosc-stakeholder-forum-shaping-future-eosc
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://uk.linkedin.com/in/eoscpiloteu
The value of EOSC from a user perspective: Key themes and actions from Day 1EOSCpilot .eu
This presentation was held at the 1st EOSC Stakeholder Forum 28-29/11/2017 in Brussels.
For more information on the 1st EOSC Stakeholder Forum visit: https://eoscpilot.eu/eosc-stakeholder-forum-shaping-future-eosc
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://uk.linkedin.com/in/eoscpiloteu
EOSC Governance Development Forum workshop: Wrap-up & discussionEOSCpilot .eu
This presentation was given by Saara Kontro, CSC, during 2nd EOSCpilot Governance Development Forum workshop, 3 October 2017, Tallin.
https://eoscpilot.eu/events/2nd-egdf-eoscpilot-governance-development-forum
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://www.linkedin.com/in/eoscpiloteu
Science Demonstrator Session: Social and Earth SciencesEOSCpilot .eu
The main focus of Science Demonstrator sessions is to provide feedback to the EOSC community on the first experience of science demonstrators in the practical use of the emerging EOSC ecosystem.
Each panel will consist of a representative of a Science Demonstrator that will provide an overview of their experiences in the use of emerging EOSC services.
These sessions will help members of the scientific communities understanding the current state of maturity of the EOSC ecosystem and what is obtainable in a field of scientific research. It is also valuable to prospective Service Providers who wish to discover what are the challenges and opportunities that user communities might have to deal with, as a result of the adoption of their services.
This session will focus on Social and Earth Sciences.
OSFair2017 Workshop | The European Open Science Cloud Pilot Open Science Fair
Brian Matthews presents the European Open Science Cloud (EOSC) and the EOSCpilot | OSFair2017 Workshop
Workshop title: How FAIR friendly is your data catalogue?
Workshop overview:
This workshop will build upon the work planned by the EOSCpilot data interoperability task and the BlueBridge workshop held on April 3 at the RDA meeting. We will investigate common mechanisms for interoperation of data catalogues that preserve established community standards, norms and resources, while simplifying the process of being/becoming FAIR. Can we have a simple interoperability architecture based on a common set of metadata types? What are the minimum metadata requirements to expose FAIR data to EOSC services and EOSC users?
DAY 3 - PARALLEL SESSION 6 & 7
EOSC Stakeholders Forum: Enabling Interoperability-Experience from EOSCpilotEOSCpilot .eu
The EOSC faces as well technical, social and economic challenges on interoperability. These have to be overcome in order to provide an efficient EOSC architecture. Some solutions are in place in some domains, but these have to be expanded to the cross-disciplinary and/or international level. In this presentation, we summarise what the results of our studies within the EOSCpilot on interoperability
Science Demonstrator Session: Life and Materials SciencesEOSCpilot .eu
The main focus of Science Demonstrator sessions is to provide feedback to the EOSC community on the first experience of science demonstrators in the practical use of the emerging EOSC ecosystem.
Each panel will consist of a representative of a Science Demonstrator that will provide an overview of their experiences in the use of emerging EOSC services.
These sessions will help members of the scientific communities understanding the current state of maturity of the EOSC ecosystem and what is obtainable in a field of scientific research. It is also valuable to prospective Service Providers who wish to discover what are the challenges and opportunities that user communities might have to deal with, as a result of the adoption of their services.
This session will focus on life science and materials science.
Presenting the EOSCpilot Science DemonstratorsEOSCpilot .eu
This presentation was held at the 1st EOSC Stakeholder Forum 28-29/11/2017 in Brussels by Hermann Lederer, Max Planck Gesellschaft.
For more information on the 1st EOSC Stakeholder Forum visit: https://eoscpilot.eu/eosc-stakeholder-forum-shaping-future-eosc
Follow EOSCpilot on Twitter: https://twitter.com/eoscpilot
and LinkedIn: https://uk.linkedin.com/in/eoscpiloteu
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http://opensciencefair.eu/training/parallel-day-2-1/datathons-in-evidence-based-medicine-applying-open-science-principles-to-support-cross-disciplinary-education-and-research
OSFair2017 Training | What is Open Science and why should I care?Open Science Fair
Nancy Pontika talks about opening up science & implementation.
Workshop title: Fostering the practical implementation of Open Science in Horizon 2020 and beyond
Workshop overview:
This workshop will showcase some of the elements required for the transition to Open Science: services and tools, policies as guidance for good practices, and the roles of the respective actors and their networks.
DAY 2 - PARALLEL SESSION 4 & 5
OSFair2017 Training | OpenAIRE monitoring services, EC FP7 & H2020 & other na...Open Science Fair
Pedro Principe presents OpenAIRE monitoring services.
Workshop title: Fostering the practical implementation of Open Science in Horizon 2020 and beyond
Workshop overview:
This workshop will showcase some of the elements required for the transition to Open Science: services and tools, policies as guidance for good practices, and the roles of the respective actors and their networks.
DAY 2 - PARALLEL SESSION 4 & 5
OSFair2017 Training | Designing & implementing open access, open data & open ...Open Science Fair
Eloy Rodrigues, José Carvalho & Pedro Príncipe talk about designing & implementing Open Access, Open Data & Open Science policies.
Workshop title: Fostering the practical implementation of Open Science in Horizon 2020 and beyond
Workshop overview:
This workshop will showcase some of the elements required for the transition to Open Science: services and tools, policies as guidance for good practices, and the roles of the respective actors and their networks.
DAY 2 - PARALLEL SESSION 4 & 5
OSFair2017 Training | Best practice in Open ScienceOpen Science Fair
Iryna Kuchma talks about best practices in Open Science.
Workshop title: Fostering the practical implementation of Open Science in Horizon 2020 and beyond
Workshop overview:
This workshop will showcase some of the elements required for the transition to Open Science: services and tools, policies as guidance for good practices, and the roles of the respective actors and their networks.
DAY 2 - PARALLEL SESSION 4 & 5
Peter Kraker, Michela Vignoli & Rainer Bachleitner give an overview of an innovative dissemination framework & present the OpenUP Innovative Dissemination Toolbox.
Workshop title: Innovative dissemination practices & Altmetrics
Workshop abstact:
The goal of the workshop is to further the understanding of innovative dissemination practices in open science and their relationship with altmetrics. In the first part of the workshop, OpenUP project researchers will give an overview of an innovative dissemination framework. The framework describes good practices and gives recommendations on how to create a successful research dissemination strategy beyond traditional academic dissemination. A special focus will lie on how to reach target audiences beyond the research community (e.g. business or the general public). Participants will be able to test the framework and a toolbox based on their dissemination needs and to give feedback in a discussion that involves the perspective of all stakeholders of dissemination and assessment (researchers and research organizations, funders, policy makers, journalists, practitioners & businesses etc.). In the second part, we will present a taxonomy linking channels of dissemination and altmetrics indicators. In between, we will present best practice examples of innovative dissemination.
DAY 2 - PARALLEL SESSION 3
http://opensciencefair.eu/workshops/parallel-day-2-1/innovative-dissemination-practices-and-altmetrics
License: CC-BY, unless otherwise noted
OSFair2017 | Barriers to Open Science for junior researchersOpen Science Fair
Jon Tennant talks about barriers to open science for junior researchers
Plenary: Open for all? Diversity & disparity in Open Science.
Presentation Abstract:
What are the barriers to Open Science, and how do they impact upon different demographics? Open Science is supposed to be about inclusivity, equality, and rigour. But is the way it is implemented meeting these ideals, or simply creating a new set of barriers to scholarship? Younger researchers are basically trying to survive within a hyper-competitive academic system. They are beset on all sides by systemic control and inertia, power dynamics, and fear. What they want to do for science is not always what is best for their career. This creates a system of social barriers that cannot be overcome by mandates and policies that do little to address these structural biases.
Paywalls inflict a huge level of disparity on younger researchers. They may feel they cannot afford the exorbitant fees charged by some publishers for Open Access, even if their research funders provide support for it. The way OA is currently implemented has switched the barrier from the reader side to the author side, due in part to political broadsiding from commercial publishers. Unfunded or self-funded grad students, as well as those from emerging economies, are basically doomed when it comes to such high author-facing charges.
More: http://opensciencefair.eu/speakers/jon-tennant
DAY 2 - PLENARY
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
2. EOSC Governance
EC communication on EOSC governance structure (COM(2016) 178 final):
Create a fit-for-purpose pan-European governance structure to federate
scientific data infrastructures and overcome fragmentation. The
institutional setup will oversee long-term funding, sustainability, data
preservation and stewardship. It will build on existing structures to involve
scientific users, research funders and implementers*
* Such as ESFRI, INSPIRE, eIRG, GEANT, PRACE, ELIXIR, the Belmont Forum and
similar federating initiatives
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
2
3. EOSC Declaration – Governance Model
A long-term, sustainable research
infrastructure in Europe requires a strong and
flexible governance model based on trust and
increasing mutuality. As interdisciplinarity is
one of the main objectives of the EOSC, the
governance model should be based on
representativity, proportionality,
accountability, inclusiveness and transparency.
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
3
4. EOSC Governance
Example of basic notion of stakeholder engagement
”Those groups who can affect or are affected by the
achievements of an organization's purpose should be
given the opportunity to comment and input into the
development of decisions that affect them”
(Stakeholder Engagement: A Road Map to Meaningful
Engagement, Doughty Centre, Cranfield School of
Management)
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
4
5. EOSCPilot Objectives
EOSCpilot project will:
establish a governance framework for the EOSC
and contribute to the development of European
open science policy and best practice;
develop a number of pilots that integrate services
and infrastructures to demonstrate interoperability
in a number of scientific domains; and
engage with a broad range of stakeholders,
crossing borders and communities, to build the
trust and skills required for adoption of an open
approach to scientific research
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
5
6. Governance WP Objectives
To design and trial a stakeholder driven governance
framework with the involvement of research
communities, research institutions, research
infrastructures including e-infrastructures, and
research funding bodies, to shape and oversee
future development of the European Open Science
Cloud.
To identify appropriate federated governance
model(s) and decision making structure for the
EOSC
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
6
7. The Governance framework will:
enable and encourage engagement from the key
stakeholder communities:
European e-Infrastructures, Data and Research Initiatives,
Service and cloud providers, Research funders, Research
Communities and Institutions, Research Infrastructures, Policy
makers.
enable interoperability and co-ordination within a
number of different domains:
legal interoperability, interoperability of organisational
processes, technical interoperability, operational
interoperability, data and information interoperability
Governance: Approach
8. EOSC Declaration – Governance Framework
The EOSC governance framework will
be co-designed, stakeholder driven
and composed of three main layers:
1) institutional, including EU Member
States and European Commission
2) operational, including a governance
board and relevant working
committees (e.g. thematic and
functional) and
3) advisory, including a stakeholder
forum.
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
8
Strategic
Executive
Advisory
Current
EOSCPilot
Focus
9. Digital Governance Ecosystem
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
9
https://www.icann.org/news/multimedia/1563
10. EOSC Governance Ecosystem?
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
10
Dataand
ContentLayer
e-Infrastructure
Layer
Key Governance Actors
Key Governance Actors
Research
Community
Layer
Key Governance Actors
Thematic
ServiceLayer
Key Governance Actors
EOSC Stakeholders
European e-
Infrastructures
Data/Research
Initiatives
Cloud providers
Research funders
Cloud community
Research
Communities and
Institutions
Research
Infrastructures (RIs)
Policy makers
Engagement Contexts
LegalPolicy
Organisational
Operational
Technical
DataInformation
Skills
Research
challengesagenda
Financial
Political
Supply Chain Roles
Consumer
IntermediaryAggregator
Provider
Funder
Policy/Regulatory
Engagement
Mechanisms
Expert Group
Forum
Council
Board
Legal Structure
Top down council
e.g. Geant, EGI,
ESFRI
Bottom up forum
e.g. RDA
11. Panel and Discussion
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
11
Athanasios Karalopoulos, EC
Donatella Castelli, OpenAIRE
Penny Labropoulou, clarin:el & OpenMinTeD
Chair
Jessica Parland-von Essen, CSC
12. To participate, register at:
https://eoscpilot.eu/user/register
www.eoscpilot.eu
The European Open Science Cloud for Research pilot project is funded by the
European Commission, DG Research & Innovation under contract no. 739563
12