This lecture summarizes the key differences between rationalism and empiricism. Rationalism holds that reason is the most reliable source of knowledge, while empiricism believes that sense experience is most reliable. Descartes used rationalism by arguing "I think therefore I am" to prove his own existence despite doubting all his senses. However, empiricists like Locke believed we are born with a blank slate and knowledge comes only through senses, not innate ideas. Berkeley took this further by arguing reality is only perceptions and there is no objective matter. The lecture examines debates between these philosophies around the reliability of senses, nature of reality, and what constitutes true knowledge.