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Karen Kneisley
Argosy University/Sarasota
       Spring 2009
   Happiness
   Surprise
   Disgust
   Fear
   Sadness
   Anger
   Communicate information about
    relationships of the self and the world
   Motivate withdrawal or approach
   Influence learning and memory
   May be universal
   Body-based and phylogenetically old
Emotions




Thought              Behavior
 How much is external or
  universal?
 How much is internal or
  personal?
   Anger- perceived violation, injustice or
    frustration of wish/desire
   Happiness- perception of expectation or gain
   Anxiety/fear- perception of threat or
    danger and with difficulty coping
   Sadness- perception that something of value
    has been or will be lost
   Physiological system adapted to
    threat or danger
   Mobilizes bodily processes
   Down-regulates restorative
    processes
Mental
Stress
         Fight
                  HPA
         or
                  axis cortisol
         Flight
                                  SNS
Real or
perceived                Active
 threat                 Avoidance



            Emotional
            Response
ANS
  norepinephrine

Locus
coeruleus
PTSD-
 Physical & psychological threats

 Activate the HPA axis

 Enhanced memory (McNally, 1999)

Immunological changes-
 Individuals with trait worry

 Fewer NK cells

 Naturalistic stress

 Acute laboratory stress (Segerstrom et al, 1998 & 1999)
Relational theme
    of unfair      Emotional
                               Inflicting Harm
interference or    Response
      harm
   Widely studied psychosocial risk
    factor
   Strongly and independently
    associated
   Effect sizes as large as smoking
    and diet (Kemeny & Shestyuk, 2008)
   Affective trait and mood state
   Cognitive propensity towards cynicism
   Devaluation of the worth or motives of
    others
   Opposition towards others
   Desire to inflict harm or see others
    harmed
1.   No one cares much what happens to you.
2.   I have often met people who were supposed
     to be experts who were no better than I.
3.   Some of my family have habits that annoy
     me very much.
4.   People often disappoint me.
5.   It is often safer to trust nobody.
   Predict cardiovascular outcomes
I.   High blood pressure
II. Atherosclerosis

III. Coronary artery calcification

IV. Mortality (Suinn, 2001)

    Inflammatory processes
1.   Decrements in cellular immunity
2.   Decreased ability of NK cells
                           ( Kiecolt-Glaser et al, 2001)
Uncontrollable                     Negative
                   Behavioral
  physical or                     affect and
                 disengagement
 psychosocial                     depression
                 and withdrawal
    threat
   Insufficient availability of serotonin
    and dopamine (Phan et al, 2004)
   Abnormal activation of cortical areas
    (Phan et al, 2004)
   Functional and phenotype changes in
    the immune system (Kemeny & Shestyuk, 2008)
PICs
 Released by immunological cells to facilitate
  immune response
 Proteins act on brain to produce “sickness”
  behavior
 Sleep disturbances

 Decreases in social, sexual, aggressive,
  exploratory, or other behaviors
 Lack of appetite

 Motor retardation

 Weight loss    (Kemeny & Shestyuk, 2008)
   Depressed mood alters thinking
   Depressed mood alters activity
    levels
   Depressed mood alters social
    contacts
NHANES
 Depression doubles the risk for HTN in
  whites
 Triples the risk for HTN in African
  Americans
 Increases the risk for CHD by 75% after
  controlling for other risk factors
 Social self preservation theory
 Threats to social connection-
   Rejection
   Stigmatization
   Discrimination
   CNS coordinated activation of the
    HPA (Dickerson & Kemeny, 2004)
   SET and cortisol increase ( Lewis &
    Ramsey, 2002)

   Increased production of PICs
    (Kemeny & Shestyuk, 2008)
   Positive emotions are linked to
    approach behaviors
   Psychological and physiological
    foundation for motivation and
    proactive behaviors
   Affective baseline for healthy
    individuals
   Greater frontal left-hemisphere
    asymmetry ( Davidson, 1992)
   Greater activation of the medial
    prefrontal regions (Parkinson, Cardinal, &
    Everett, 2000)
   Greater levels of serotonin
   Greater levels of dopamine and
    norepinephrine (Charney, 2004)
   Associated with changes in the immune
    system (Segerstrom & Miller, 2004)
   Linked to heightened levels of the hormone
    oxytocin (Zak et al, 1994)
   Reduce the duration of cardiovascular
    response induced by a stressor (Fredrickson et al,
    2000)
   Experience less pain and disability related to
    chronic health conditions (Gil et al, 2004)
   Fight off illness and disease more
    successfully (Cohen & Pressman, 2006)
Problem
                                  Focused
Stressor   Primary and            Coping
           Secondary     Stress
           Appraisal
                                   Emotion
                                   Focused
                                   Coping
   Lowering of primary appraisals- upping the level of
    secondary appraisals
   A healthy diet of activities
   Appropriate elicitation of social support
   Regular exercise
   Relaxation/mindfulness
   Developing chronic vs. acute responses
    (both cognitive and behavioral)
Charney, D. S. (2004). Psychobiological mechanisms of resilience and vulnerability:
     Implications for successful adaptation to extreme stress. American Journal of
     Psychiatry, 161, 195-216.
Cox, B. J. & Taylor, S. (1999). Anxiety disorders: Panics and phobias. In T. Millon, P. H.
     Blaney, & R. D. Davis (Eds.) Oxford textbook of psychopathology (pp. 81-113). New
     York: Oxford University Press.
Ekman, P., & Friesen, W. V. (1969). The repertoire of nonverbal behavior:
     Categories, origins, usage, and coding. Semiotica, 1, 49-98
Fredrickson, B. L. & Joiner, T. (2000). Positive emotions trigger upward spirals toward
     emotional well-being. Psychological Science, 13, 172-175
Huckleridge, F., Lambert, S., Clow, A., Warburton, D. M., Evans, P. D. & Sherwood, N.
     (2000). Modulation of seceretory immunoglobulin a in saliva: response to
     manipulation of mood. Biological Psychology, 53, 25-35.
Irwin, M., Daniels, M., Bloom, E. T., & Weiner, H. (1986). Life events, depression, and
     natural killer cell activity. Psychopharmacology Bulletin, 22, 1093-1096.
Kemeny, M. E., & Shestyuk, A. (2008) Emotions, the neuroendocrine and immune
     systems, and health. In M. Lewis, J. M. Havilland-Jones, & L. Feldman Barrett (Eds.)
     Handbook of Emotions (pp. 661-675). New York: Guilford Press.
Kubzansky, L. D., Kawachi, I., Weiss, S. T. & Sparrow, D. (1998). Anxiety and coronary
     heart disease: A synthesis of epidemiological, psychological, and experiential
     evidence. Annals of Behavioral Medicine, 20, 47-58.
Lazarus, R. S. (1991). Emotion and adaptation. London: Oxford University Press.
McNally, R. J. (1999). Posttraumatic stress disorder. In T. Millon, P. H. Blaney, & R. D>
     Davis (Eds.), Oxford textbook of psychopathology. (pp. 144-165). New York: Oxford
     University Press
Sapolsky, R. M. (1993). Endocrinology alfresco: Psychoendocrine studies of wild baboons.
     Recent Progress in Hormone Research, 48, 648-652.
Satterfield, J. Brain, Mind and Behavior: Emotions and Health. Retrieved on Jan. 21,
     2009 from Utube http://www.youtube.com/watch?v=GogLWebO
Segerstrom, S. C. , Glover, D. A., Craske, M. G. & Fahey J. L. (1999). Worry affects the
     immune response to phobic fear. Brain, Behavior and Immunity, 13, 80-92.
Seligman, M. E. P. (2002). Positive psychology, positive prevention, and positive therapy.
     In C. R. Snyder & S. J. Lopez (Eds.), Handbook of positive psychology (pp. 3-9). New
     York: Oxford University Press.
Smith, T. W. (1994). Concepts and methods in the study of anger, hostility, and health .
     In A. W. Siegman & T. W. Smith (Eds.), Anger, hostility and the heart. (pp. 23-42).
     Hillsdale, NJ: Erlbaum.
Stone, A ., Neale, J. M., Cox, D. S., Napoli, A, Valdimarsdottir, H., & Kennedy-Moore, E.
     (1994). Daily events are associated with secretory immune response to oral antigen
     in men. Health Psychology , 13, 440-446.
Taylor, S. E., & Armor, D. A. (1996). Positive illusions and coping with adversity. Journal
     of Personality, 64, 873-898.
Zak,P. J., Kurzban, R. & Matzner, W. T. (2005). Oxtocin is associated with human
     trustworthiness. Hormones and Behavior, 48, 522-527.

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Emotions And Health

  • 2.
  • 3. Happiness  Surprise  Disgust  Fear  Sadness  Anger
  • 4. Communicate information about relationships of the self and the world  Motivate withdrawal or approach  Influence learning and memory  May be universal  Body-based and phylogenetically old
  • 5. Emotions Thought Behavior
  • 6.  How much is external or universal?  How much is internal or personal?
  • 7.
  • 8.
  • 9.
  • 10.
  • 11. Anger- perceived violation, injustice or frustration of wish/desire  Happiness- perception of expectation or gain  Anxiety/fear- perception of threat or danger and with difficulty coping  Sadness- perception that something of value has been or will be lost
  • 12.
  • 13. Physiological system adapted to threat or danger  Mobilizes bodily processes  Down-regulates restorative processes
  • 14. Mental Stress Fight HPA or axis cortisol Flight SNS
  • 15. Real or perceived Active threat Avoidance Emotional Response
  • 17. PTSD-  Physical & psychological threats  Activate the HPA axis  Enhanced memory (McNally, 1999) Immunological changes-  Individuals with trait worry  Fewer NK cells  Naturalistic stress  Acute laboratory stress (Segerstrom et al, 1998 & 1999)
  • 18. Relational theme of unfair Emotional Inflicting Harm interference or Response harm
  • 19. Widely studied psychosocial risk factor  Strongly and independently associated  Effect sizes as large as smoking and diet (Kemeny & Shestyuk, 2008)
  • 20. Affective trait and mood state  Cognitive propensity towards cynicism  Devaluation of the worth or motives of others  Opposition towards others  Desire to inflict harm or see others harmed
  • 21. 1. No one cares much what happens to you. 2. I have often met people who were supposed to be experts who were no better than I. 3. Some of my family have habits that annoy me very much. 4. People often disappoint me. 5. It is often safer to trust nobody.
  • 22. Predict cardiovascular outcomes I. High blood pressure II. Atherosclerosis III. Coronary artery calcification IV. Mortality (Suinn, 2001)  Inflammatory processes 1. Decrements in cellular immunity 2. Decreased ability of NK cells ( Kiecolt-Glaser et al, 2001)
  • 23. Uncontrollable Negative Behavioral physical or affect and disengagement psychosocial depression and withdrawal threat
  • 24. Insufficient availability of serotonin and dopamine (Phan et al, 2004)  Abnormal activation of cortical areas (Phan et al, 2004)  Functional and phenotype changes in the immune system (Kemeny & Shestyuk, 2008)
  • 25. PICs  Released by immunological cells to facilitate immune response  Proteins act on brain to produce “sickness” behavior  Sleep disturbances  Decreases in social, sexual, aggressive, exploratory, or other behaviors  Lack of appetite  Motor retardation  Weight loss (Kemeny & Shestyuk, 2008)
  • 26. Depressed mood alters thinking  Depressed mood alters activity levels  Depressed mood alters social contacts
  • 27. NHANES  Depression doubles the risk for HTN in whites  Triples the risk for HTN in African Americans  Increases the risk for CHD by 75% after controlling for other risk factors
  • 28.  Social self preservation theory  Threats to social connection-  Rejection  Stigmatization  Discrimination
  • 29. CNS coordinated activation of the HPA (Dickerson & Kemeny, 2004)  SET and cortisol increase ( Lewis & Ramsey, 2002)  Increased production of PICs (Kemeny & Shestyuk, 2008)
  • 30. Positive emotions are linked to approach behaviors  Psychological and physiological foundation for motivation and proactive behaviors  Affective baseline for healthy individuals
  • 31. Greater frontal left-hemisphere asymmetry ( Davidson, 1992)  Greater activation of the medial prefrontal regions (Parkinson, Cardinal, & Everett, 2000)  Greater levels of serotonin  Greater levels of dopamine and norepinephrine (Charney, 2004)
  • 32. Associated with changes in the immune system (Segerstrom & Miller, 2004)  Linked to heightened levels of the hormone oxytocin (Zak et al, 1994)  Reduce the duration of cardiovascular response induced by a stressor (Fredrickson et al, 2000)  Experience less pain and disability related to chronic health conditions (Gil et al, 2004)  Fight off illness and disease more successfully (Cohen & Pressman, 2006)
  • 33. Problem Focused Stressor Primary and Coping Secondary Stress Appraisal Emotion Focused Coping
  • 34. Lowering of primary appraisals- upping the level of secondary appraisals  A healthy diet of activities  Appropriate elicitation of social support  Regular exercise  Relaxation/mindfulness  Developing chronic vs. acute responses (both cognitive and behavioral)
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Editor's Notes

  1. Body-based processes are circulatory, respiratory, digestive, nervous, muscle-skeletal, endocrine, reproductive systems and these are tied to emotionsHigher cortical functions are higher level processes are higher levels of functioning for conscious awareness of feelings
  2. In 1972 Paul Ekman took pictures of people from around the world and in different cultures and showed to members of the Fore tribe in Papua, New Guinea. The members of the isolated stone-age tribe could identify expressions of emotions as these six listedTake the 6 primary and blend them into emotional richness
  3. How you relate to others, your sense of self-worth and how you understand yourselfPush you away from things and others or pull you closerThe brain structures that underlie learning and memory are the same structures that regulate emotionsStress reduces brain cells involved in learningEmotions are expressed facially the exact same way all over the worldMore primitive than reason, intellect, or memory. Darwin said that primitiveness of differing human emotions are similar to animals expressions
  4. There is an interrelatedness with emotions, thoughts and behaviorEmotion effect the way you think, what you remember, what you selectively attend to, and the images or songs that come to mindEffect what you do at work, who you talk to, what you do with your free time
  5. Write down the emotions the picture evokes in you
  6. All perception. It doesn’t have to be rational or make sense to others
  7. Amygdala- when this is stimulated electrically animals respond with aggression and when removed animals become indifferent to stimuliHypothalmus- regulates the functioning of the sympathetic nervous system which in turn regulates blood pressure, breathing and arousal response to emotional responsesHippocampus- converts short-term memory to long-term memories. Emotion and memory are closely related
  8. Fight or flight system becomes activated in response to threat or danger with the central goal of self preservationMobilizes threat-relevant physical actions such as fighting or fleeingNot critical to addressing a threat such as reproduction, repair, and growth
  9. Perceived threat, danger, frustration, violation, injustice or difficulty with copingF or F system mobilizes body processes that are relevant to threatsFighting requires energy. Hypothalmus- pituitary- adrenal cortex work to releaseCortisol also exerts an effect on the sympathetic allowing SNS products to activate the cardiovascular systemSNS accelerates the heart rate, constrict blood vessels, and raises the blood pressureCortisol which mobilizes energy resources by converting substrates into glucose, a metabolic fuel
  10. Fear and anxiety share patterns of central and peripheral activation (ANS & SNS) Autonomic regulates the activity of the heart muscle, smooth muscles, and the glandsEmotional response is the sameThe avoidance action is differientated based on action- immediate action for imminent threat (fear) and preparation for action for uncertain and anticipated threats (anxiety)
  11. Repeated norepinephrine activity is linked to greater risk for cardiovascular disease especially with individuals with anxiety disordersNorepinephrine is a hormone or nuerotransmitter for sudden energy in times of stress
  12. Threats are known to elicit fear and anxietyActivate the HPA axis and trigger cortisol releaseHPA activation in these situations is linked to enhanced memory for threatening events and this may play a role in the development and manifestation of symptoms of PTSDTrait worry is crucial to the development and maintenance of anxiety disordersNatural killer cells (NK) constitute a major component of innate immune system. Plays a major in the rejection of tumors and cells infected by virusesNatural stress was an earthquake
  13. Unfair is very subjective- all stressors are Irritation, annoyance, fury or rageInflict harm through attacking, destruction or hurtful behaviors
  14. Most studies support this link including a prospective study of initially healthy samples that are controlled for cofounding factorsHostility is strongly & independently associated with CHD
  15. Trait is a relatively stable aspect of the personalityMood state manifests as an interruption of an individual’s emotional state
  16. Answer the questions as true or false
  17. The constructs list high blood pressure as the #1 risk factorAtherosclerosis- damage to the artery wallsCalcification- happens as the result of atherosclerosisIndividuals who behaved in a hostile way toward their spouses-decreased ability of immune cells to proliferate and NK to kill tumor targets
  18. Responses to personal loss Shame and embarrassment occur in response to social threats These emotion and withdrawal behaviors are associated with central and peripheral activation that predicts-Compromised immune functionAbnormal prefrontal functioningHPA dysregulationDiminished serotonin and dopamine
  19. Low concentration of prefrontal dopamine has been linked to loss of motivation, lack of goal oriented behavior, and behavioral withdrawalCauses insufficient regulatory control during negative affect and depression may account for peripheral changes and dysregulation HPA & cortisol release and may prompt withdrawal and disengagementThese changes are similar to those observed in response to major life events and stressors
  20. PICs may be a consequence of major depression but may also contribute to its etiologyPIC is pro-inflammatory cytokine
  21. National Health and Nutrition Examination SurveyHealth statistics agency compiles statistical information to guide actions and policies to improve health for peopleArm of the CDC
  22. Motivated to protect the social self and threats to the social self elicit psychobiology response that supports adaptive behavior of appeasement and behavioral withdrawalThese reflect a lack of social value or status and can result in drops of self-esteem
  23. Release of HPA hormones and peripheral activation account for many of the stress-induced changes discussed earlierSocial evaluative threat – exposure to uncontrollable SET was associated with slower recovery of cortisol baseline levelsPerformance in front of an evaluative audience induces cortisol responseIncreased levels of PIC support behavioral disengagement and support appeasement related behavior
  24. Thought to facilitate exploration pleasure and comfort seeking and affiliationAnticipate more positive than negative events Positive view of selfExhibit preferential processing of and brain activation in response to positive stimuli relative to neutral stimuli
  25. Essential for proper brain function, increases processing capacity, and avoids situations of conflict with brain functionsRegions plays an important role in maintaining representation of behavioral reinforcementAssociated with low arousalAssociated with high arousal and excitement
  26. Increases in subsets of white cells, secretory antibody found in the saliva, elevated levels of antibody in response to specific antigenSexual arousal, bonding, affilative behaviors, empathy increases mediates emotional experiences in relationshipsAbility of positive emotions to lift people out of stressed, narrow states
  27. Primary appraisal- look at the stressor- does it matter? And is it important?Secondary appraisal- capacity to cope, coping resourcesProblem-focused coping- stressor that can be changedEmotion- focused- can’t be changed so call a friend, praying