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EMBL Australia
Bioinformatics Resource
ABACBS Conference 2016
Pip Griffin, Sonika Tyagi, Ira Cooke, Philipp E. Bayer, Dave Edwards,
Dominique Gorse, Saravanan Dayalan, Sylvain Forêt, Jac
Charlesworth, Steven Androulakis, Marc Wilkins, Rob Cook, Malcolm
McConville, Richard Edwards, Madison Flannery, Simon Gladman,
Andrew Lonie, Maria Victoria Schneider
EMBL Australian Bioinformatics Resource
(EMBL-ABR) is a distributed national
research infrastructure providing
bioinformatics support to life science
researchers in Australia.
About
@EMBL_ABR
www.embl-abr.org.au
National level bioinformatics infrastructure?
- fosters excellence in data
science to support
progress in biological
research and health
- bioinformatics
infrastructure
- resources
- expertise
- services
- federating world-class
researchers
- delivering training in
bioinformatics
- provides first-class services
to users in life sciences
research, industry and
medicine
- coordinates bioinformatics
training and education
- coordinates cooperation of
the German bioinformatics
community with
international bioinformatics
network structures
A rapidly evolving international context
EMBL Australian Bioinformatics Resource
(EMBL-ABR) is a distributed national
research infrastructure providing
bioinformatics support to life science
researchers in Australia.
About
2. Contribute to the development and provision of training in data, tools and
platforms to enable Australia’s life science researchers to undertake
research in the age of big data.
3. Showcase Australian research and datasets at an international level.
4. Enable engagement in international programs that create, deploy and
develop best practice approaches to data management, software tools
and methods, computational platforms and bioinformatics services.
Mission
EMBL ABR aims to:
1. Increase Australia’s capacity to collect,
integrate, analyse, exploit, share and
archive the large heterogeneous data sets
now part of modern life science research.
Key Areas
About EMBL-ABR
• EMBL-ABR started in its current
form in March 2016
• hub – nodes network structure
• hub hosted at VLSCI, University
of Melbourne
• 10 nodes at the
institution/organisation level
across Australia
EMBL-ABR node Institution State
VLSCI node Victorian Life Science Computation Initiative Victoria
Monash node Monash University Victoria
MA node Metabolomics Australia Victoria
AGRF node Australian Genome Research Facility Victoria
SBI node Systems Biology Initiative New South Wales
UWA node University of Western Australia Western Australia
UTas node University of Tasmania Tasmania
JCU node James Cook University Queensland
QCIF node Queensland Cyber Infrastructure Foundation Queensland
ANU node Australian National University Australian Capital
Territory
About EMBL-ABR
About EMBL-ABR
Heads of Nodes
About EMBL-ABR
Heads of Nodes
+
Executive
International Science
Advisory Group
• Paul FlicekEMBL-EBI
• Vivien BonazziNIH/BD2K
• Jason WilliamsCyVerse
• Jaap HaringaELIXIR
• Andrew YoungCSIRO
• Rebecca JohnsonAU Animals
• Delphine FleuryAU Plants
• Mark WalkerAU Microbes
• Sean GrimmondAU Medical
• Jenny MartinAU Diversity, Industry
Key Area Coordinators
EMBL-ABR is the vehicle for the Australian
Bioinformatics community to actively
participate in world’s best practice
bioinformatics, positioning our institutions at
the forefront with international partners.
EMBL-ABR Biosharing Collection: A
collection of Australian databases,
standards and policies relevant to Australia
life scientists and medical researchers
ISATools
A framework for managing metadata
in complex life science, environmental
and biomedical experiments
Data Chaperoning Service
EMBL-ABR:QCIF Node
Get advice or assistance in submitting your
data to international repositories
dc@embl-abr.org.au
Event Registry
Registry of
bioinformatics-related
training events
Powered by iAnn
Do your bioinformatics-
related events appear here?
If not, let us know:
contact@embl-abr.org.au
embl-abr.org.au/events
Do your open training materials appear here?
If not, let us know and we will add the source:
contact@embl-abr.org.au
ToolsAU
Catalogue of Australian
bioinformatics tools
Harvested from ELIXIR bio.tools
Do your tools appear here?
If not, add them to bio.tools or
email us:
contact@embl-abr.org.au
EMBL-ABR All Hands Meeting
7th December 2016
Hosted by the EMBL-ABR Hub at the University of Melbourne
Talk to us!
www.embl-abr.org.au
@EMBL_ABR
contact@embl-abr.org.au
Key Documents
Mailing List signup
Survey
finding
collecting
integrating
processing
analysing
storing
sharing
publishing
Philippa Griffin (a, b, c), Rudi Appels (d, e), Dieter Bulach (a), Kevin a Pope (a, c), Ute
Roessner (c), Torsten Seemann (a, c), Dan Bolser (g), Jyoti Khadake (h), Suzanna Lewis (i),
Sandra Orchard (g), Sonika Tyagi (j), Andrew Lonie (a, b, c), Maria Victoria Schneider (b, c)
Affiliations:a) EMBL-ABR: VLSCI Node, Victorian Life Science Computation
Initiative, Melbourne, Australia, (b) EMBL-ABR HUB, University of
Melbourne, Melbourne, Australia, (c) University of Melbourne, Australia, (d) AgriBio, Centre for AgriBioscience, Melbourne,
Australia, (e) Murdoch University, Perth, Australia (f) Queensland University of Technology, Brisbane, Australia, (g) European
Bioinformatics Institute, Hinxton, United Kingdom, (h) NIHR BioResource, University of Cambridge, Cambridge, United Kingdom, (i)
Berkeley Bioinformatics Open-source Project, Lawrence Berkeley National Laboratory, Berkeley, USA, (j) EMBL-ABR: AGRF Node,
Australian Genome Research Facility, Melbourne, Australia
Navigating the Research Data Life Cycle
For the public good
- allows others to assess reproducibility
- avoids unnecessary duplication of effort
- combining datasets can increase statistical power
- data collected using public funds should be publicly available
Why
share data?
For your own good
- access to funding
- increased citations and visibility
- good archiving helps you keep track of your own data
Good data areFindable
Accessible
Interoperable
Re-usable
Wilkinson et al. (2016) doi:10.1038/sdata.20
16.18
with a globally unique and persistent identifier
with rich metadata, registered in a searchable resource
retrievable by their identifier
with an open, free, universal retrieval protocol
using a formal, shared language
and format, and FAIR vocabularies
richly, accurately described
to domain-relevant standards
released with a data
usage license
Metadata
is the contextual information that
describes your data. It is the key
to useful and reusable data.
Metadata should be detailed,
accurate and presented using
agreed-upon vocabularies in a
standard format: for example, the
experimental metadata framework
ISATools (isa-tools.org)
As well as collating community standards,
ontologies and controlled vocabularies for
biological metadata, biosharing.org provides a
database of biological databases, searchable by
biological domain or topic and assessed as to
their connectivity and accessibility.
The OBO Foundryobofoundry.org
presents and develops open, collaborative
ontologies for biomedicine and biology
The EBIOntologyLookup Servicewww.ebi.ac.uk/ols
is a user-friendlytool for browsingbiomedical andbiologicalontologies
Data Indexessuch as datamed.org (for
biomedical data) and
www.omicsdi.org (for
multi-omics data) enable
discovery of relevant
datasets across multiple
data repositories.
Good Practicewhen Publishing
Publish detailed methods,
including code. Report persistent
identifiers for data and metadata. Tag
your shared data with the publication
identifier. Consider a full Open Science
approach, including submitting to
open-access journals.
Public DataRepositoriesThe EuropeanBioinformatics Institute (EBI),
National Centre for
Biotechnology Information (NCBI),
Swiss Institute for Bioinformatics (SIB)
and other organisations host and
curate large public data repositories
that do the work of storing and sharing
data for you. Some examples are the
European Nucleotide Archive (ENA),
UniProt, the Database of Genotypes and
Phenotypes (dbGaP) and MetaboLights.
See www.ebi.ac.uk/services and
www.ncbi.nlm.nih.gov/guide/all for
available repositories.
Australian Data Storage
The Australian Code for the Responsible Conduct of
Research states research data should generally be
retained for at least 5 years. In addition to local
institutional data storage infrastructure, the Research
Data Services project (www.rds.edu.au) is a national
network of services that securely store research data. McKiernan et al. (2016) doi:10.7554/eLife.16800
Posters 46, 55, 79

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AB3ACBS 2016: EMBL Australia Bioinformatics Resource

  • 1. EMBL Australia Bioinformatics Resource ABACBS Conference 2016 Pip Griffin, Sonika Tyagi, Ira Cooke, Philipp E. Bayer, Dave Edwards, Dominique Gorse, Saravanan Dayalan, Sylvain Forêt, Jac Charlesworth, Steven Androulakis, Marc Wilkins, Rob Cook, Malcolm McConville, Richard Edwards, Madison Flannery, Simon Gladman, Andrew Lonie, Maria Victoria Schneider
  • 2. EMBL Australian Bioinformatics Resource (EMBL-ABR) is a distributed national research infrastructure providing bioinformatics support to life science researchers in Australia. About @EMBL_ABR www.embl-abr.org.au
  • 4.
  • 5. - fosters excellence in data science to support progress in biological research and health - bioinformatics infrastructure - resources - expertise - services - federating world-class researchers - delivering training in bioinformatics
  • 6. - provides first-class services to users in life sciences research, industry and medicine - coordinates bioinformatics training and education - coordinates cooperation of the German bioinformatics community with international bioinformatics network structures
  • 7.
  • 8. A rapidly evolving international context
  • 9. EMBL Australian Bioinformatics Resource (EMBL-ABR) is a distributed national research infrastructure providing bioinformatics support to life science researchers in Australia. About
  • 10. 2. Contribute to the development and provision of training in data, tools and platforms to enable Australia’s life science researchers to undertake research in the age of big data. 3. Showcase Australian research and datasets at an international level. 4. Enable engagement in international programs that create, deploy and develop best practice approaches to data management, software tools and methods, computational platforms and bioinformatics services. Mission EMBL ABR aims to: 1. Increase Australia’s capacity to collect, integrate, analyse, exploit, share and archive the large heterogeneous data sets now part of modern life science research.
  • 12. About EMBL-ABR • EMBL-ABR started in its current form in March 2016 • hub – nodes network structure • hub hosted at VLSCI, University of Melbourne • 10 nodes at the institution/organisation level across Australia
  • 13. EMBL-ABR node Institution State VLSCI node Victorian Life Science Computation Initiative Victoria Monash node Monash University Victoria MA node Metabolomics Australia Victoria AGRF node Australian Genome Research Facility Victoria SBI node Systems Biology Initiative New South Wales UWA node University of Western Australia Western Australia UTas node University of Tasmania Tasmania JCU node James Cook University Queensland QCIF node Queensland Cyber Infrastructure Foundation Queensland ANU node Australian National University Australian Capital Territory About EMBL-ABR
  • 15. About EMBL-ABR Heads of Nodes + Executive
  • 16. International Science Advisory Group • Paul FlicekEMBL-EBI • Vivien BonazziNIH/BD2K • Jason WilliamsCyVerse • Jaap HaringaELIXIR • Andrew YoungCSIRO • Rebecca JohnsonAU Animals • Delphine FleuryAU Plants • Mark WalkerAU Microbes • Sean GrimmondAU Medical • Jenny MartinAU Diversity, Industry
  • 18. EMBL-ABR is the vehicle for the Australian Bioinformatics community to actively participate in world’s best practice bioinformatics, positioning our institutions at the forefront with international partners. EMBL-ABR Biosharing Collection: A collection of Australian databases, standards and policies relevant to Australia life scientists and medical researchers ISATools A framework for managing metadata in complex life science, environmental and biomedical experiments Data Chaperoning Service EMBL-ABR:QCIF Node Get advice or assistance in submitting your data to international repositories dc@embl-abr.org.au
  • 19. Event Registry Registry of bioinformatics-related training events Powered by iAnn Do your bioinformatics- related events appear here? If not, let us know: contact@embl-abr.org.au embl-abr.org.au/events
  • 20. Do your open training materials appear here? If not, let us know and we will add the source: contact@embl-abr.org.au
  • 21. ToolsAU Catalogue of Australian bioinformatics tools Harvested from ELIXIR bio.tools Do your tools appear here? If not, add them to bio.tools or email us: contact@embl-abr.org.au
  • 22. EMBL-ABR All Hands Meeting 7th December 2016 Hosted by the EMBL-ABR Hub at the University of Melbourne
  • 23. Talk to us! www.embl-abr.org.au @EMBL_ABR contact@embl-abr.org.au Key Documents Mailing List signup Survey finding collecting integrating processing analysing storing sharing publishing Philippa Griffin (a, b, c), Rudi Appels (d, e), Dieter Bulach (a), Kevin a Pope (a, c), Ute Roessner (c), Torsten Seemann (a, c), Dan Bolser (g), Jyoti Khadake (h), Suzanna Lewis (i), Sandra Orchard (g), Sonika Tyagi (j), Andrew Lonie (a, b, c), Maria Victoria Schneider (b, c) Affiliations:a) EMBL-ABR: VLSCI Node, Victorian Life Science Computation Initiative, Melbourne, Australia, (b) EMBL-ABR HUB, University of Melbourne, Melbourne, Australia, (c) University of Melbourne, Australia, (d) AgriBio, Centre for AgriBioscience, Melbourne, Australia, (e) Murdoch University, Perth, Australia (f) Queensland University of Technology, Brisbane, Australia, (g) European Bioinformatics Institute, Hinxton, United Kingdom, (h) NIHR BioResource, University of Cambridge, Cambridge, United Kingdom, (i) Berkeley Bioinformatics Open-source Project, Lawrence Berkeley National Laboratory, Berkeley, USA, (j) EMBL-ABR: AGRF Node, Australian Genome Research Facility, Melbourne, Australia Navigating the Research Data Life Cycle For the public good - allows others to assess reproducibility - avoids unnecessary duplication of effort - combining datasets can increase statistical power - data collected using public funds should be publicly available Why share data? For your own good - access to funding - increased citations and visibility - good archiving helps you keep track of your own data Good data areFindable Accessible Interoperable Re-usable Wilkinson et al. (2016) doi:10.1038/sdata.20 16.18 with a globally unique and persistent identifier with rich metadata, registered in a searchable resource retrievable by their identifier with an open, free, universal retrieval protocol using a formal, shared language and format, and FAIR vocabularies richly, accurately described to domain-relevant standards released with a data usage license Metadata is the contextual information that describes your data. It is the key to useful and reusable data. Metadata should be detailed, accurate and presented using agreed-upon vocabularies in a standard format: for example, the experimental metadata framework ISATools (isa-tools.org) As well as collating community standards, ontologies and controlled vocabularies for biological metadata, biosharing.org provides a database of biological databases, searchable by biological domain or topic and assessed as to their connectivity and accessibility. The OBO Foundryobofoundry.org presents and develops open, collaborative ontologies for biomedicine and biology The EBIOntologyLookup Servicewww.ebi.ac.uk/ols is a user-friendlytool for browsingbiomedical andbiologicalontologies Data Indexessuch as datamed.org (for biomedical data) and www.omicsdi.org (for multi-omics data) enable discovery of relevant datasets across multiple data repositories. Good Practicewhen Publishing Publish detailed methods, including code. Report persistent identifiers for data and metadata. Tag your shared data with the publication identifier. Consider a full Open Science approach, including submitting to open-access journals. Public DataRepositoriesThe EuropeanBioinformatics Institute (EBI), National Centre for Biotechnology Information (NCBI), Swiss Institute for Bioinformatics (SIB) and other organisations host and curate large public data repositories that do the work of storing and sharing data for you. Some examples are the European Nucleotide Archive (ENA), UniProt, the Database of Genotypes and Phenotypes (dbGaP) and MetaboLights. See www.ebi.ac.uk/services and www.ncbi.nlm.nih.gov/guide/all for available repositories. Australian Data Storage The Australian Code for the Responsible Conduct of Research states research data should generally be retained for at least 5 years. In addition to local institutional data storage infrastructure, the Research Data Services project (www.rds.edu.au) is a national network of services that securely store research data. McKiernan et al. (2016) doi:10.7554/eLife.16800 Posters 46, 55, 79

Editor's Notes

  1. EMBL Australian Bioinformatics Resource (EMBL-ABR) is a distributed national bioinformatics infrastructure for life science and medical researchers in Australia.
  2. NIH: BD2K and Data Commons NSF: Cyverse - cyberinfrastructure ELIXIR: European research infrastructure for life sciences
  3. EMBL Australian Bioinformatics Resource (EMBL-ABR) is a distributed national bioinformatics infrastructure for life science and medical researchers in Australia.
  4. I removed ‘State Communities’ because I didn’t really understand this… can I add back with more detail? Prioritised groups already involved (due to history, BRAEMBL) Followed approach from similar bioinformatics networks overseas Workign in areas scaleable Like others we are dealing with current uncertainty over longer-term NCRIS funding
  5. Initial phase – wanted to ensure everybody had the chance to be represented Reality of not creating a structure/barriers State nodes could create constraints due to internal politics However we can see the structure evolving and aren’t ruling out the possibility of state nodes in some cases in the future
  6. Omics DI – possibility to adopt this framework for collating multi-omics datasets We can always discuss with the EBI solutions to problems and federating/bringing tools here
  7. If challenged re: ABACBS – mention the international collation, working with ELIXIR
  8. How discoverable are your bioinformatics tools?
  9. Aligning ourselves with existing ELIXIR discussion