The document details the experiences of a father, Ed Nemeth, whose daughter Rebecca suffers from severe disabilities, and their journey with hyperbaric oxygen therapy (HBOT) for brain injuries. It discusses the therapeutic benefits of HBOT, including significant medical improvements, safety data, and legislative support for its reimbursement under specific conditions in California. Additionally, it highlights research findings on HBOT's effectiveness in treating chronic traumatic brain injury and other debilitating conditions.

1. NFL Brain Injuries, Treatments & Medical RightsEd NemethRebecca’s DadIndep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen Therapies

2. Who am I?The loving and faithfulfather of Rebecca, a severely disabled child! Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen Therapies

3. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesWho am I?Rebecca’s Dad!Trained as a scientist - objectiveResearched nerve regeneration / plasticity Department of Neurobiology, University of Vermont Medical School Businessman / Entrepreneur - pragmatic

4. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesOur Journey Birth, Death & Resuscitation

5. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesOur JourneyComa

6. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesOur Journey~~ The Journey! ~~

7. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesOur Journey~~ The Journey! ~~

8. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesOur JourneyHypberbaric Oxygen! Dismissed HBOT in 1998 Struggled to get help for RebeccaMouth-to-mouth rescusitation 9 times1-hour long static gran mal seizures monthlyBronchitis & pneumonia 6 times a yearWeak, myriad challenging problemsThen…. Surgical Neurology, vol 10 Oct. 78Ischemic Penumbra reversed @ 7 years post injuryHBOT “had to” work!

9. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesWhat we did!Went to Dr Neubauer’s HBOT Clinic in FloridaFor Hyperbaric Oxygen Therapies - HBOT40 Sessions in 2 months July-August, 2000Great immediate responsesHorrible SPECT scans2nd SPECT’s showed great response!

10. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesFantastic Changes!Went seizure and drug FREE for 6 years!Could maintain own body temp. at night!Pneumonias and bronchitis STOPPED!Feeding time dropped from:1 hour 10 minutes to 20 minutes!Gained coordination (had NONE!)!Gained endurance and strength (had NONE!)!

11. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesSPECT Scans Single Photon Emission Computed TomographyUses Ceretec radio-isotope

12. Crosses blood brain barrier (BBB)

13. Binds to active neurons

14. Objective

15. View function, not structure

16. Compares CNS metabolism before & after HBOT

17. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesSPECT ScansSingle Photon Emission Computed TomographyUses Ceretec radio-isotope

18. Crosses blood brain barrier (BBB)

19. Binds to active neurons

20. Objective

21. View function, not structure

22. Compares CNS metabolism before & after HBOT

23. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesClear Benefits - SPECT ScansPre HBOTPost 36 HBOT

24. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesClear Benefits - SPECT ScansPost 36 HBOTPost 4 Month Rest

25. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesClear Benefits - SPECT ScansPost 4 Month RestPost 32 HBOT (add’l)

26. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesClear Benefits - SPECT ScansPre HBOTPost 72 HBOT

27. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesHBO Effect on Blood O2 Contentat 2.4 ATA HBOT delivers O2 = HbO2 desaturationHBOT creates high O2 gradient & O2 activity

28. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesDepthApplication0 fsw; 1 ATA16.5 fsw; 1.5 ATA33 fsw; 2 ATA49.5 fsw; 2.5 ATA59.4 fsw; 2.8 ATA66 fsw; 3 ATA165 fsw; 6 ATASea levelChronic Brain InjuryBurnsDiabetic Wounds/OsteoCO PoisoningAcute Cyanide PoisoningAcute Decompression Illness

29. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesHBOT MechanismsMultiple mechanismsAngiogenisis Neural re-activation *Normalization of oxygen deficit Re-establish neuronal metabolismNeuronal RegenerationIncrease natural stem cells 800%* Ischemic penumbra is now accepted as the primary cause of deficits

30. How it works - 5,769+* ways* Oxygen-sensitive outcomes and gene expression in acute ischemic stroke. Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen CK, Khanna S. J Cereb Blood Flow Metab. 2010 Feb 10. Up-regulates growth factorsReduces edemaIncreases neuronal ATPEnhances Mitochondrial: ReplicationEnergy Production (ATP)Promotes neural pathway growthStimlates aging neuronsDown-regulates inflammationReduces reperfusion injuryIndep. Football Veterans Conf. March 25, 2011

31. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesHBOT Benefits - SPECT ScansPre HBOTPost 72 HBOT

32. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesHBOT Is Very Safe From a 10 year study of 1,505 patients receiving 52,758 2-hour HBOT sessions at 2.4 ATA once or twice daily. inability to equalize middle ear pressure 0.37% paranasal sinus blocks 0.09% confinement anxiety 0.05% oxygen convulsions 0.009% pulmonary oxygen toxicity 0.00% permanent ocular refractive changes 0.00%

33. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesComparative Drug SafetyUSA Today 1998:

34. 16,500 died from gastrointestinal bleeding taking NSAIDs (1997)

35. …...yet is fully accepted. Different HBOT ChambersMulti-place Chamber

36. Hyperbaric Oxygen Therapies Different HBOT ChambersMono-place Chamber

37. Different HBOT ChambersHome Chamber

38. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesSPECT ScansSingle Photon Emission Computed TomographyUses Ceretec radio-isotope

39. Crosses blood brain barrier (BBB)

40. Binds to active neurons

41. Objective

42. View function, not structure

43. Compares CNS metabolism before & after HBOT

44. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesWar Veteran TBIBefore & After HBOT

45. NFL Player: TBI impact assessmentFibers passing through areasArea of Tissue changeEnlarged Fiber Tract showing fibers from concussive eventNFL football player with concussion Loss of about 2% of the fiber tracts in the region of the corpus callosum. Courtesy Dr. Walter Schneider, U Pittsburgh

46. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesNFL Veteran TBIBefore HBOT

47. Indep. Football Veterans Conf. March 25, 2011Hyperbaric Oxygen TherapiesNFL Veteran TBIAfter HBOT