The Space Shuttle Program at John F. Kennedy Space Center in Florida launched 135 times over 30 years, constructing and supplying the International Space Station and deploying, retrieving, and repairing satellites. Near-field deposition from launch clouds impacted a 221 acre area, damaging exposed vegetation for up to 6 months and killing fish in shallow water. Far-field deposition over 57,142 acres increased metal levels in soil and also impacted wildlife, killing various species. To mitigate the ecological impacts, actions were taken to transition to a multi-user spaceport, alter land uses to reduce environmental effects, and establish an ecological program to monitor impacts and support natural resource management.