This document discusses the design and testing of MiCardia's Dynamic Mitral Annuloplasty device. The device aims to address the shortcomings of current treatments for ischemic mitral regurgitation (IMR) by using radiofrequency energy to reshape an implanted annuloplasty ring and reduce recurrent MR. Animal studies and initial human implants demonstrate the device's ability to decrease the mitral annulus diameter and improve leaflet coaptation both during surgery and percutaneously. Future developments discussed include a tricuspid valve version, a transcatheter delivery method, and a magnetic ring that can be adjusted non-invasively.
ComunicaCity è una mobile app per smartphone e tablet che permette agli enti pubblici e alle pubbliche amministrazioni (comuni, provincie, regioni, forze dell’ordine, ministeri, comunità) di inviare al cittadino e alle imprese news, segnalazioni, allerte, aggiornamenti, comunicati, il tutto in tempo reale e in maniera semplice e veloce. All’interno dell’app ci sono inoltre sezioni ad hoc per la raccolta differenziata, per il turismo, info utili, ecc. L’aspetto più innovativo e unico di ComunicaCity è la possibilità, per l’utente, di seguire tutti gli enti che desidera, in una sola app. La ricchezza di funzionalità e informazioni di ComunicaCity la rende veramente appetibile per tutti i cittadini e le imprese.
Il servizio prevede un canone annuale per gli enti variabile in base al numero di abitant, mentre è gratuita per gli utenti finali.
Abbiamo già una partnership con ANCI (Associazione Nazionale dei Comuni Italiani) Lazio e stiamo formalizzando altre partnership con forze di polizia ed enti della pubblica amministrazione centrale, che utilizzeranno il sistema come mezzi di informazione e sensibilizzazione al cittadino.
9 способов повысить эффективность финансовых организаций при помощи FAST SearchMichael Kozloff
Маркетинг, исследования и продуктовые инновации
Исследования рынков и клиентов
Разработка новых продуктов
Поиск в интранет информации и экспертов
Governance, Risk Management, Compliance (GRC)
Соответствие требованиям регуляторов (152ФЗ…)
Ускорение подготовки ответов для разных органов
Объединение разрозненных информационных архивов
Улучшение клиентского обслуживания
Единая версия правды о клиентах (know your client)
Повышение эффективности многоканального обслуживания
Поиск результатов бизнес-анализа
Biography
About Tammy Bality
As an only child growing up on the Colorado farm her family originally homesteaded in
1875, Tammy Bality shared a special connection with animals: The horses, calves, dogs, cats,
and birds were her friends.
Ever since she could hold a crayon, art has been Tammy’s form of expression. Tammy now
creates sculptures that capture animals’ life force and honor their spirits.
Compelled to create
Tammy has always felt a bond with animals and aimed to recreate that feeling in art, but it
wasn’t until the 1988 Loveland Sculpture Show that she felt compelled to try her hand at
sculpting bronze.
Drawing on a variety of life experiences and technical workshops, Tammy developed her
own signature style utilizing different techniques and media to create unique pieces representing
our interconnectedness with animals.
Mixing media and melding heritages
People have always had a spiritual connection to animals through the millennia, whether it’s through Native American folklore
or Celtic mythology, and Tammy aims to honor that through her artwork.
Growing up in Colorado, Tammy loved the tributes to animals incorporating antlers, fur, feather and stone seen in Native
American artwork. These tributes lead the artist to delve into her own heritage, exploring Swedish, Irish and Scottish history
for inspiration and she was thrilled to discover that her Druid and Viking ancestors also had animal totems and tributes.
Tammy combines traditional influences with a variety of media and sculpting techniques to create innovative art that gives
voice to nature’s spirit.
She sculpts horses, dogs, birds of prey, bulls and bears from clay, bronze and crystal, incorporating silver and stone as well.
Tammy enjoys exploring the strengths of each medium – the freedom and spontaneity of ceramic, the strength and precision of
bronze, the luminosity and intrigue of crystal – and complementing their weaknesses with the strengths of the others.
Art on a Grand Scale
In the scope of Tammy’s body of work, you will find delicate Raku horses and Journey Ponies, life-like bronze representational
pieces ranging from miniature to monumental, spiritual Celtic-inspired totems and tributes, and breathtaking birds of
prey.
Tammy’s work is available in collections nationwide and at Chisholm Gallery in Millbrook, New York.
Преимущества SOTAL Click.AD (адресная реклама и коммуникации с абонентами) дл...Michael Kozloff
Решения на базе технологии SOTAL Сlick.AD позволяет операторам услуг IPTV/OTT повысить доходность и лояльность своей абонентской базы. Сlick.AD дает возможность размещать в сетке вещания целевые рекламные сообщения в контексте того, что происходит на экране телевизора, с возможностью получения обратной связи от зрителя через обычный телевизионный пульт. Кроме того, Click.AD предлагает абонентам услуг IPTV/OTT интерактивный доступ к более чем 20 готовым приложениям: Twitter, Facebook, BКонтакте, Погода, Пробки, «Магазин на диване». Дополнительные приложения доступны по заказу оператора.
ComunicaCity è una mobile app per smartphone e tablet che permette agli enti pubblici e alle pubbliche amministrazioni (comuni, provincie, regioni, forze dell’ordine, ministeri, comunità) di inviare al cittadino e alle imprese news, segnalazioni, allerte, aggiornamenti, comunicati, il tutto in tempo reale e in maniera semplice e veloce. All’interno dell’app ci sono inoltre sezioni ad hoc per la raccolta differenziata, per il turismo, info utili, ecc. L’aspetto più innovativo e unico di ComunicaCity è la possibilità, per l’utente, di seguire tutti gli enti che desidera, in una sola app. La ricchezza di funzionalità e informazioni di ComunicaCity la rende veramente appetibile per tutti i cittadini e le imprese.
Il servizio prevede un canone annuale per gli enti variabile in base al numero di abitant, mentre è gratuita per gli utenti finali.
Abbiamo già una partnership con ANCI (Associazione Nazionale dei Comuni Italiani) Lazio e stiamo formalizzando altre partnership con forze di polizia ed enti della pubblica amministrazione centrale, che utilizzeranno il sistema come mezzi di informazione e sensibilizzazione al cittadino.
9 способов повысить эффективность финансовых организаций при помощи FAST SearchMichael Kozloff
Маркетинг, исследования и продуктовые инновации
Исследования рынков и клиентов
Разработка новых продуктов
Поиск в интранет информации и экспертов
Governance, Risk Management, Compliance (GRC)
Соответствие требованиям регуляторов (152ФЗ…)
Ускорение подготовки ответов для разных органов
Объединение разрозненных информационных архивов
Улучшение клиентского обслуживания
Единая версия правды о клиентах (know your client)
Повышение эффективности многоканального обслуживания
Поиск результатов бизнес-анализа
Biography
About Tammy Bality
As an only child growing up on the Colorado farm her family originally homesteaded in
1875, Tammy Bality shared a special connection with animals: The horses, calves, dogs, cats,
and birds were her friends.
Ever since she could hold a crayon, art has been Tammy’s form of expression. Tammy now
creates sculptures that capture animals’ life force and honor their spirits.
Compelled to create
Tammy has always felt a bond with animals and aimed to recreate that feeling in art, but it
wasn’t until the 1988 Loveland Sculpture Show that she felt compelled to try her hand at
sculpting bronze.
Drawing on a variety of life experiences and technical workshops, Tammy developed her
own signature style utilizing different techniques and media to create unique pieces representing
our interconnectedness with animals.
Mixing media and melding heritages
People have always had a spiritual connection to animals through the millennia, whether it’s through Native American folklore
or Celtic mythology, and Tammy aims to honor that through her artwork.
Growing up in Colorado, Tammy loved the tributes to animals incorporating antlers, fur, feather and stone seen in Native
American artwork. These tributes lead the artist to delve into her own heritage, exploring Swedish, Irish and Scottish history
for inspiration and she was thrilled to discover that her Druid and Viking ancestors also had animal totems and tributes.
Tammy combines traditional influences with a variety of media and sculpting techniques to create innovative art that gives
voice to nature’s spirit.
She sculpts horses, dogs, birds of prey, bulls and bears from clay, bronze and crystal, incorporating silver and stone as well.
Tammy enjoys exploring the strengths of each medium – the freedom and spontaneity of ceramic, the strength and precision of
bronze, the luminosity and intrigue of crystal – and complementing their weaknesses with the strengths of the others.
Art on a Grand Scale
In the scope of Tammy’s body of work, you will find delicate Raku horses and Journey Ponies, life-like bronze representational
pieces ranging from miniature to monumental, spiritual Celtic-inspired totems and tributes, and breathtaking birds of
prey.
Tammy’s work is available in collections nationwide and at Chisholm Gallery in Millbrook, New York.
Преимущества SOTAL Click.AD (адресная реклама и коммуникации с абонентами) дл...Michael Kozloff
Решения на базе технологии SOTAL Сlick.AD позволяет операторам услуг IPTV/OTT повысить доходность и лояльность своей абонентской базы. Сlick.AD дает возможность размещать в сетке вещания целевые рекламные сообщения в контексте того, что происходит на экране телевизора, с возможностью получения обратной связи от зрителя через обычный телевизионный пульт. Кроме того, Click.AD предлагает абонентам услуг IPTV/OTT интерактивный доступ к более чем 20 готовым приложениям: Twitter, Facebook, BКонтакте, Погода, Пробки, «Магазин на диване». Дополнительные приложения доступны по заказу оператора.
Intravascular lithotripsy (ivl) for peripheral arterial diseaseRamachandra Barik
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After receiving his MD from the Mount Sinai School of Medicine, thoracic surgeon Dr. Lawrence J. Markovitz served as chairman of Thoracic and Cardiovascular Surgery at Mayo/Midelfort Clinic in Eau Claire, Wisconsin. Today, Lawrence J. Markovitz, MD, focuses on phlebology and treats vein conditions using techniques like radiofrequency ablation.
Amyotrophic lateral sclerosis Disease- Muscle loose their functionality. Regenerative medicine help to diagnose via cellular therapeutic level. (MSC's used to cure)
Amyotrophic lateral sclerosis Disease Diagnoses via Mesenchymal Stem Cells. Muscles loose their activities or functionality and through the cellular transplantation or implanting MSC's for curing disease. It is Preclinical Phase experiment which is quite affective.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
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Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
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The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Digital Tools and AI for Teaching Learning and Research
Dynamic Mitral Annuloplasty Device Design Concepts, Experimental Insights and First-in-Man
1. MiCardia:
Dynamic Mitral Annuloplasty
Device Design Concepts,
Experimental Insights and
First-in-Man
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
La Jolla, CA
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
2. Why Degradable Stents?
Disclosure
M.Buchbinder – Scientific Advisory,
Board Member
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
3. Ischemic MR
• Ischemic Mitral Regurgitation (IMR) is seen
in up to 20% of patients following acute
myocardial infraction. (Hickey; Circulation 1988;78:151-
159, Lamas; Circulation 1997; 96:827-833)
• Treatment of IMR includes medical therapy
and in severe cases surgical repair with an
undersized annuloplasty ring to reduce the
size of the mitral annulus and improve
leaflet coaptation.
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
4. Ischemic MR
• Following isolated annuloplasty surgery
recurrent (>2+) MR is seen in 10-30% of
patients (McGee; J. Thorac Cardiovasc Surg 2004;128:916-24)
• Recurrent MR appears to be commonly seen
within the first year following surgery and
remains relatively stable thereafter (McGee; J. Thorac
Cardiovasc Surg 2004;128:916-24)
• Unlike in dilated cardiomyopathy IMR is
associated with asymmetric deformation of the
annulus (Kwan; Circulation. 2003;107:1135.)
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
5. Current technology does not cope with
dynamic ischemic disease
• MITRAL
•Residual post-op Edwards Physio
occurrence of 6-
10%
•6m recurrence of
15%-25% Medtronic Duran
•3 Yr, recurrence of
30% to 50%
• TRICUSPID
•“Upon Discharge”
recurrence of 25% SJM Tailor
to 30%
•Directly contributes
to the onset of HF ATS Simulus
when untreated
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
6. MiCardia Semi-Rigid Dynamic
Annuloplasty “C” Ring (Degenerative)
Baseline Shape (Implanted)
Transparent = Baseline
Red = Post Activation Shape
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
7. MiCardia Rigid Dynamic Annuloplasty
“D” Ring (Ischemic)
Baseline
MiCardia Dynamic Ring
Transparent = Baseline
Red = Activated Shape
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
8. The MiCardia Dynamic Ring
• “C” and “D” shapes available sizes 28mm through 36mm
• Without activation functions as a “standard” ring
• Pre-attached electrodes used for activation make the ring
Dynamic
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
9. Intra-Operative Re-shaping
• Each RF wire is connected
to the propriatary MiCardia
RF generator.
P1 P3
• Following implantation and
pending degree of residual
P2
MR ,Wires are activated as
to re-shape the ring in vivo
• Echocardiography confirms
effectiveness of activation
during and post re-shaping
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
10. Dynamic Ring - Features
• Implants identical to
existing technology
• Semi-rigid metal core
maintains its shape.
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
11. Intra-Operative Reshaping
Early “In-Vivo” experience
• A-P distance
shortening by
0.5-3.0mm
• Inter-Commissural
distance contracted
by 1.0-3.5mm
• No heat damage to
the surrounding Postero-Medial commissure
activation
tissue
Courtesy Dr. Alex Marmureanu
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
12. Degenerative Ring Activation
Pre-Activation Intra-Op Activation
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
13. Ultimate Valve
Repair Modality
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
14. Percutaneous Reshaping
• The implanted ring is
accessed via transeptal
approach.
• Thru a Deflectable guide
catheter system for optimal
positioning
• An Expandable basket with
built in RF electrodes is used
to activate the ring upon
contact in multiple zones.
• On line echocardiography
confirms effectiveness of
activation during and after re-
shaping
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
15. Percutaneous Animal Experience
• A-P distance
shortened by
0.3-2.9mm
• Inter-Commissural
Distance
contracted by
1.2- 3.6mm
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
16. TransQ Device Platform
• Single lead, atrial exit
• No flow interference
• Subcutaneous “pocket“
deployment of lead
• Simple outpatient activation
30 Minute Outpatient
Adjustment • Activate days, weeks or
By Interventional months after the initial
Cardiologist procedure to correct
recurrence
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
22. Transcutaneous Activation
• Lead Exits Left
Atrium
• Completely
encapsulated 40 days
• Connects to
MiCardia RF
Generator
• Allows for Delayed
Activation
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
23. Transcutaneous Activation
• Full activation takes
place within 60
seconds.
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
24. Transcutaneous Activation
• No infection
• No dehiscence
• Full activation 60+
days
• 100% in-growth
• 40 and 60 day testing
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
27. 26 Human Implants completed
(June 09)
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
28. First-in-Man Experience
February 2008
• 4+MR with P2 leaflet prolapse
• Leaflet resection with implantation of a
28mm D+ ring.
• Reduced to trace MR
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
29. First-in-Man Experience
P2 prolapse
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
30. First-in-Man Experience
4+MR with eccentric anterior jet
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
31. First-in-Man Experience
Post repair no MR acute and at discharge
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
32. First-in-Man Experience
Ring shape at discharge
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
33. Future Developments
2004-2008 2009-2010 2009-2011
Mitral
Mitral
Shape Magnetic
Memory
Tricuspid
Percutaneous External
Tricuspid
Intra-Operative Trans‐Q
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
34. Magnetic Ring
• Magnetic drive: no motor
• AP + or AP - models
• Infinitely adjustable
• Can be titrated
• Reversible
• Multiple activations
• Percutaneous activation via
R. Heart Access (16Fr)
• External via TEE access
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine
35. Conclusion
• From this early clinical experience the MiCardia Dynamic
Annuloplasty Ring appears to be a promising device for
treatment of Mitral regurgitation.
• The In-Vivo adjustable feature may be an extremely
valuable tool for optimization of surgical results
• Further percutaneous adjustments in ring geometry in
the healing phase could be a compelling advantage for
its use .
Maurice Buchbinder, MD
Foundation for Cardiovascular Medicine