Dt56a Stimulates Bone Formation
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Femarelle provides a safe and effective solution for the management of menopause. DT56a (Femarelle®/Tofupill) Stimulates Bone Formation in Female Rats
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2. In humans, GH replacement therapy has been shown to improve body composition by increasing lean mass and decreasing fat mass. It also improves lipid profiles and endothelial function. However, some data suggests it may increase cancer risk and insulin resistance. More data is still needed to determine the cardiovascular effects.
3. Overall, the data suggests that reduced signaling through the GH-IGF-1-insulin axis may promote longevity, but the relationship
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Product Overview
Viasil uses 100% natural ingredients for a safe and clinically tested
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Now even better than before thanks to the complementary Viasil -
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Toxicology of genetically modified sheep meat
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This document summarizes strategies for individualizing ovarian stimulation protocols in ART based on patient factors. It discusses how a "one size fits all" approach can lead to poor responses, OHSS, and low patient satisfaction. Biomarkers like AMH, AFC, and genetic profiles can help predict ovarian response and tailor protocols. The document also reviews gonadotropin options including urinary vs recombinant drugs and their differences in purity and dosing precision. Finally, it discusses LH surge prevention with GnRH agonists and antagonists.
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Anabolic-androgenic steroid compounds are one of the most widely abused drugs by athletes and muscle builders with the goal of improving performance/muscle mass. However, increasing concern has been expressed because these compounds not only offer unappreciable benefits to infertile and subfertile males, but also might have deleterious effects on both human and animal physiology including sperm quality. In addition, there is the conflicting outcome of AAS usage in the clinical settings with its attendant reduced spermatogenesis and hypopituitarism in patient management. Hence, we aim to evaluate the effects of mestorolone, an anabolic-androgenic steroid, on the histomorphometry of seminiferous tubules with serum hormonal and seminal analyses in adult male Sprague-Dawley rat. Twenty adult male Sprague dawley rats divided into two groups of 10 each. The treated group received 0.06 mg/g body weight/ day of mesterolone (proviron) by oral gavage for six weeks while the control group received equal volume of 0.9% normal saline per day. SPSS analysis of data generated with P< 0.05 considered statistically significant. The result showed significant (P< 0.05) body weight gain in all the animals. However, both the raw testicular weight and relative testicular weight per 100 g bwt was significantly (P< 0.05) higher in control than treated. The mean sperm count significantly decreased by 28% (P< 0.05) and the motility reduced significantly by 56% (P< 0.05) in the treated compared to control. In addition, both FSH (follicle stimulating hormone) and T (testosterone) of the treated were significantly lowered by 73% (P< 0.05) and 63% (P< 0.05) respectively compared to the control. The use of mesterolone is with caution and short intermittent therapy is desirous for better semen quality and improved overall fertility. Thesis Defense
The document discusses research on using mechanostimulated Wharton's jelly stem cells seeded into human umbilical veins for tendon tissue engineering applications. Previous research found that seeding rat mesenchymal stem cells into human umbilical veins and applying mechanical stimulation improved the constructs' biomechanical properties and cellularity over static controls. The current research seeds human Wharton's jelly stem cells into umbilical veins and applies varying frequencies and durations of mechanical stimulation. Preliminary results found tenomodulin expression increased with stimulation, and collagen I expression increased most with less rigorous stimulation. Lower seeding densities and addition of growth factors may further improve the constructs for tendon tissue engineering.
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1) EZH1 was found to physically interact with UXT, a transcription co-activator.
2) EZH1, along with SUZ12 but not EED, was shown to positively regulate the expression of NF-κB target genes upon TNFα stimulation through its interaction with UXT.
3) EZH1 and UXT were involved in the recruitment of RELA/p65 and RNA polymerase II to NF-κB target genes, but did not affect global or local H3K27 methylation levels.
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Dt56a Stimulates Bone Formation
- 1. Publishes in: Journal of Steroid Biochemistry and Molecular Biology 2007; 104:252-258 "DT56a (Femarelle®): a Natural Selective Estrogen Receptor Modulator (SERM)" Dalia Somjen and Israel Yoles Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel-Aviv, Israel Abstract A selective estrogen receptor modulator (SERM) is defined as a substance with dissimilar effects on ® different tissues: agonist in some and antagonists in others. The natural compound DT56a (Femarelle ) was shown to activate estrogen receptors in human cultured female derived osteoblasts. It was also shown to relieve menopausal symptoms and to increase bone mineral density with no effect on sex steroid hormone levels and on the endometrial thickness. DT56a, similarly to estradiol-17beta (E2), stimulated the specific activity of creatine kinase (CK) in skeletal and vascular tissues of female rats, as a marker of estrogen receptor (ER) activation. However, in the uterus, CK was activated only by E2 but not by DT56a. In order to prove that DT56a is a SERM, we examined the mutual interaction between DT56a and E2, at supra physiological doses, in different tissues in both intact and ovariectomized female rats, as well as in human cultured vascular and bone cells. Administration of DT56a or E2 stimulated CK in all tissues tested, but when given simultaneously, in intact immature female rats, DT56a completely abolished E2 stimulation of CK in all organs except in the diaphyseal bone where the inhibition was partial. In ovariectomized female rats, DT56a abolished E2's stimulation of CK in diaphyseal bone, thymus, uterus and pituitary but caused a partial inhibition in aorta, left ventricle and epiphyseal cartilage. In human bone cells E2 stimulation of CK, of alkaline phosphatase (AP) activity and of DNA synthesis was completely abolished by DT56a in post-menopausal cells and partially inhibited in pre-menopausal cells. In human vascular cells, inhibition of DNA synthesis by E2 was completely abolished by DT56a and E2-induced CK was partially inhibited by DT56a. The results support the finding that DT56a is a SERM; it stimulated different parameters similar to E2, but when given simultaneously, at supra physiological doses, inhibited these E2's effects. Further investigations regarding intra and extra cellular mechanism of action of DT56a are currently performed.