The document outlines the history and development of open source GIS technologies. It discusses key developments like the creation of GRASS GIS in 1983, the first web map in 1993, the launch of OpenStreetMap in 2004, and more recent technologies like Earth Engine from 2010. The presentation agenda is also provided, covering topics like PostGIS, gridded data, KML visualization, and OGC services.
Working with Git – a simple introduction for those used to working with a VCS like Subversion. Explains concepts and shows examples. Feel free to steal slides for your own purposes.
Water, hydroinformatics and circular economy - dif dragan savicDragan Savic
An introductory talk for the online session during the Disruptive Innovation Festival 2015. The talk focuses on water, hydroinformatics (including big data analytics) and circular economy, issues and benefits.
Lake Teletskoye is a unique natural reservoir in the south of Western Siberia and is connected to the Biya river. This lake is about 70 km by 3 km and has a maximum depth of about 320m. A special version of Delft3D is used for 3D hydrothermodynamic modelling in combination with 2D ice dynamics modelling.
The water motion in the vertical direction largely depends on the characteristics of turbulence. Turbulent viscosity in such a deep lake is dominated by density stratification. For this reason, Delft3D-FLOW has been extended with an extra formula for the equation of state, namely the TEOS-10 formula. Via the Delft3D open source website the source code is available for other users as well.
During winter lake Teletskoye is usually only partially covered with ice. This reservoir is therefore a suitable case study for the calibration of the Delft3D ice dynamics model. In this presentation the model results will be shown.
Numerical Modelling of Geothermal SystemsPeter Schätzl
This presentation was given as a keynote lecture at the 1st Workshop on Numerical Geothermal Simulation at the Technische Universität München (co-organized by TUM and DHI-WASY) in April 2015.
Working with Git – a simple introduction for those used to working with a VCS like Subversion. Explains concepts and shows examples. Feel free to steal slides for your own purposes.
Water, hydroinformatics and circular economy - dif dragan savicDragan Savic
An introductory talk for the online session during the Disruptive Innovation Festival 2015. The talk focuses on water, hydroinformatics (including big data analytics) and circular economy, issues and benefits.
Lake Teletskoye is a unique natural reservoir in the south of Western Siberia and is connected to the Biya river. This lake is about 70 km by 3 km and has a maximum depth of about 320m. A special version of Delft3D is used for 3D hydrothermodynamic modelling in combination with 2D ice dynamics modelling.
The water motion in the vertical direction largely depends on the characteristics of turbulence. Turbulent viscosity in such a deep lake is dominated by density stratification. For this reason, Delft3D-FLOW has been extended with an extra formula for the equation of state, namely the TEOS-10 formula. Via the Delft3D open source website the source code is available for other users as well.
During winter lake Teletskoye is usually only partially covered with ice. This reservoir is therefore a suitable case study for the calibration of the Delft3D ice dynamics model. In this presentation the model results will be shown.
Numerical Modelling of Geothermal SystemsPeter Schätzl
This presentation was given as a keynote lecture at the 1st Workshop on Numerical Geothermal Simulation at the Technische Universität München (co-organized by TUM and DHI-WASY) in April 2015.
Information is more than ever geolocated, but who decides what we see on maps? who curates that information? Maps have never been neutral, but now they are ubiquitous.
This session will be a hands on workshop to enter the maps world and understand how communities can produce and edit their own maps (with openstreetmap.org) and edit and curate information above them (meipi.org).
The workshop will explore ways to integrate critical maps created in other platforms and websites.
Description
Have you ever wanted to make your own map but you didn't know how? Do you want to use your GPS/smart phone? People usually approach maps as inert things, as invariable objects. Now, it's easy to make your own maps and meanwhile understand that maps are not neutral, that Google Maps is not The Map, but just another map. GPS devices and smart phones, DIY aerial cartography (the Public Laboratory), OpenStreetMap map making, are making easier building maps and sharing them. BYO laptop, smartphone or GPS, but if you don't have one, come anyway. Maps can be drawn with a pencil.
Workshop. at AMC. Friday June 29th 2012
Detroit, Michigan. USA
http://amc.alliedmedia.org/
http://talk.alliedmedia.org/amc2012/sessions/google-maps-not-map
Esta apresentação teve como objetivo mostrar de forma simples como funciona toda arquitetura REST e seu ecossistema.
Foi apresentando um exemplo de como implementar uma api para receber uploads de arquivos.
Foi apresentando API Layers, Gateways, Proxy e SSL, Proxy Reverse, Frameworks...
Frontend Performance: Beginner to Expert to Crazy PersonPhilip Tellis
There’s no such thing as fast enough. You can always make your website faster. This talk will show you how. The very first requirement of a great user experience is actually getting the bytes of that experience to the user before they they get tired and leave.In this talk we’ll start with the basics and get progressively insane. We’ll go over several frontend performance best practices, a few anti-patterns, the reasoning behind the rules, and how they’ve changed over the years. We’ll also look at some great tools to help you.
With a little help from my friends: Handy MongoDB ToolsStennie Steneker
Lightning talk running through my shortlist of handy tools for everyday MongoDB usage: Admin UIs, index & query analysis, log visualizers, shell extensions, and monitoring.
First presented at MongoDB Melbourne user group in July, 2013: http://www.meetup.com/MelbourneMUG/.
Free and Open Source Software for Geospatial (FOSS4G) had a boom after the millennium.
Most applications are available on MS Windows and the majority of the users use these versions.
Nowadays Open Source development became a winning development strategy. The new development
trends of FOSS4G are considered in this presentation by Dr. Zoltán Siki
Angular 1.X Community and API DecissionsDavid Rodenas
A talk presented to AngularCamp 2016 (both January and July editions) explaining how and encourage to participate and contribute inside AngularJS core.
It contains lots of examples and screenshots of github to make the process public, visible and friendly.
Advanced Cartographic Map Rendering in GeoServerGeoSolutions
Various software can style maps and generate a proper SLD document for OGC compliant WMS like GeoServer to use. However, in most occasions, the styling allowed by the graphical tools is pretty limited and not good enough to achieve good looking, readable and efficient cartographic output. For those that like to write their own styles CSS also represents a nice alternatives thanks to its compact-ness and expressiveness.
Several topics will be covered, providing examples in both SLD and CSS for each, including: mastering multi-scale styling, using GeoServer extensions to build common hatch patterns, line styling beyond the basics, such as cased lines, controlling symbols along a line and the way they repeat, leveraging TTF symbol fonts and SVGs to generate good looking point thematic maps, using the full power of GeoServer label lay-outing tools to build pleasant, informative maps on both point, polygon and line layers, including adding road plates around labels, leverage the labelling subsystem conflict resolution engine to avoid overlaps in stand alone point symbology, blending charts into a map, dynamically transform data during rendering to get more explicative maps without the need to pre-process a large amount of views. The presentation aims to provide the attendees with enough information to master SLD/CSS documents and most of GeoServer extensions to generate appealing, informative, readable maps that can be quickly rendered on screen.
DSD-INT 2023 Hydrology User Days - Intro - Day 3 - KroonDeltares
Presentation by Timo Kroon and Nadine Slootjes (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
Presentation by Sabrina Couvin Rodriguez (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
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Similar to DSD-INT 2014 - OpenGIS Workshop - OpenGIS Services, Fedor Baart
Information is more than ever geolocated, but who decides what we see on maps? who curates that information? Maps have never been neutral, but now they are ubiquitous.
This session will be a hands on workshop to enter the maps world and understand how communities can produce and edit their own maps (with openstreetmap.org) and edit and curate information above them (meipi.org).
The workshop will explore ways to integrate critical maps created in other platforms and websites.
Description
Have you ever wanted to make your own map but you didn't know how? Do you want to use your GPS/smart phone? People usually approach maps as inert things, as invariable objects. Now, it's easy to make your own maps and meanwhile understand that maps are not neutral, that Google Maps is not The Map, but just another map. GPS devices and smart phones, DIY aerial cartography (the Public Laboratory), OpenStreetMap map making, are making easier building maps and sharing them. BYO laptop, smartphone or GPS, but if you don't have one, come anyway. Maps can be drawn with a pencil.
Workshop. at AMC. Friday June 29th 2012
Detroit, Michigan. USA
http://amc.alliedmedia.org/
http://talk.alliedmedia.org/amc2012/sessions/google-maps-not-map
Esta apresentação teve como objetivo mostrar de forma simples como funciona toda arquitetura REST e seu ecossistema.
Foi apresentando um exemplo de como implementar uma api para receber uploads de arquivos.
Foi apresentando API Layers, Gateways, Proxy e SSL, Proxy Reverse, Frameworks...
Frontend Performance: Beginner to Expert to Crazy PersonPhilip Tellis
There’s no such thing as fast enough. You can always make your website faster. This talk will show you how. The very first requirement of a great user experience is actually getting the bytes of that experience to the user before they they get tired and leave.In this talk we’ll start with the basics and get progressively insane. We’ll go over several frontend performance best practices, a few anti-patterns, the reasoning behind the rules, and how they’ve changed over the years. We’ll also look at some great tools to help you.
With a little help from my friends: Handy MongoDB ToolsStennie Steneker
Lightning talk running through my shortlist of handy tools for everyday MongoDB usage: Admin UIs, index & query analysis, log visualizers, shell extensions, and monitoring.
First presented at MongoDB Melbourne user group in July, 2013: http://www.meetup.com/MelbourneMUG/.
Free and Open Source Software for Geospatial (FOSS4G) had a boom after the millennium.
Most applications are available on MS Windows and the majority of the users use these versions.
Nowadays Open Source development became a winning development strategy. The new development
trends of FOSS4G are considered in this presentation by Dr. Zoltán Siki
Angular 1.X Community and API DecissionsDavid Rodenas
A talk presented to AngularCamp 2016 (both January and July editions) explaining how and encourage to participate and contribute inside AngularJS core.
It contains lots of examples and screenshots of github to make the process public, visible and friendly.
Advanced Cartographic Map Rendering in GeoServerGeoSolutions
Various software can style maps and generate a proper SLD document for OGC compliant WMS like GeoServer to use. However, in most occasions, the styling allowed by the graphical tools is pretty limited and not good enough to achieve good looking, readable and efficient cartographic output. For those that like to write their own styles CSS also represents a nice alternatives thanks to its compact-ness and expressiveness.
Several topics will be covered, providing examples in both SLD and CSS for each, including: mastering multi-scale styling, using GeoServer extensions to build common hatch patterns, line styling beyond the basics, such as cased lines, controlling symbols along a line and the way they repeat, leveraging TTF symbol fonts and SVGs to generate good looking point thematic maps, using the full power of GeoServer label lay-outing tools to build pleasant, informative maps on both point, polygon and line layers, including adding road plates around labels, leverage the labelling subsystem conflict resolution engine to avoid overlaps in stand alone point symbology, blending charts into a map, dynamically transform data during rendering to get more explicative maps without the need to pre-process a large amount of views. The presentation aims to provide the attendees with enough information to master SLD/CSS documents and most of GeoServer extensions to generate appealing, informative, readable maps that can be quickly rendered on screen.
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Presentation by Timo Kroon and Nadine Slootjes (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
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Presentation by Andrew Warren (Deltares, Netherlands) at the Climate Adaptation Symposium 2023, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Wednesday, 29 November 2023, Delft.
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DSD-INT 2023 Modelling implications - IPCC Working Group II - From AR6 to AR7...Deltares
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DSD-INT 2023 Coupling RIBASIM to a MODFLOW groundwater model - BootsmaDeltares
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DSD-INT 2023 Example of unstructured MODFLOW 6 modelling in California - RomeroDeltares
Presentation by Betsy Romero Verástegui (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Challenges and developments in groundwater modeling - BakkerDeltares
Presentation by Mark Bakker (Delft University of Technology, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 Demo new features iMOD Suite - van EngelenDeltares
Presentation by Joeri van Engelen (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
DSD-INT 2023 iMOD and new developments - DavidsDeltares
Presentation by Tess Davids (Deltares, Netherlands) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
Presentation by Christian Langevin (U.S. Geological Survey (USGS), USA) at the Hydrology Suite User Days (Day 3) - Groundwater modelling, during the Delft Software Days - Edition 2023 (DSD-INT 2023). Thursday, 30 November 2023, Delft.
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DSD-INT 2023 Coupling RIBASIM to a MODFLOW groundwater model - BootsmaDeltares
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Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
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In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.