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12/16/14 Dr Sagar Sharma 
PARKINSON'S DISEASE 
1 
By 
Dr Sagar Sharma 
SJGAMC, Koppal
CONTENTS 
 Introduction Discussion 
What Is Parkinsonism? Conclusion 
 Prevalence Refrences 
 Etiology 
 Patho-physiology 
 According to Ayurveda 
 Clinical features 
 Investigations 
Management 
Do And Donts 
12/16/14 
2 
Dr Sagar Sharma
INTRODUCTION 
• Modern science through improved sanitation, 
12/vaccination, antibiotics, and medical attention 
16/14 
has eliminated the threat of death from most 
infectious diseases. 
• But the deaths from change in normal lifestyle, 
diseases are in rise. 
• Diseases associated with the way a person or 
group of people lives is called as lifestyle 
disorders like obesity, Diabetes, Hypertension, 
Parkinsonism, Cervical spondolytis etc 
3 
Dr Sagar Sharma
WHAT IS 
PARKINSONISM? 
12/16/14 Dr Sagar Sharma 
4 
Parkinsonism is the 
generic name given to a 
group of conditions that 
feature the main 
characteristics of 
Parkinson’s (Discovered 
by James Parkinson in 
1817): tremor, rigidity of 
muscles, mobility 
problems and 
bradykinesia (slowness of 
movement). In Ayur eda 
it has Similar features as 
“Kampvata”
PREVALENCE 
12/16/14 
5 
Dr Sagar Sharma
ETIOLOGY 
12/16/14 
6 
Dr Sagar Sharma 
1.Positive family history and Race. 
2 Environmental Exposure: Herbicide and 
pesticide exposure, metals( manganese, 
iron) and steel alloy industries. 
3 Exposure to MPTP (1- methyl-4-phenyl- 
1,2,3,6 tetrahydropyridine), a potent 
neurotoxin. 
4 Life experiences (trauma, emotional 
stress).
PATHO-PHYSIOLOGY 
12/16/14 Dr Sagar Sharma 
7
ACCORDING TO 
AYURVEDA 
 The aggravation of Vata is due to many factors 
such as excessive physical activity, lack of 
proper nutrition, severe constipation etc. The 
aggravated vata disturbs the rasa dhatu (tissue) 
which cause the early symptoms of dryness in 
the skin (purva roopam) and then later 
relocated to other dhatus, affecting mansa 
(muscular) and majja (brain tissue) causing the 
muscle stiffness, rigidity, alerted behavior and 
tremors. 
12/16/14 
8 
Dr Sagar Sharma
CLINICAL FEATURES 
The classical syndrome: 
Tremors 
Rigidity 
Bradykinesia 
12/16/14 
9 
Dr Sagar Sharma
12/16/14 
Dr Sagar Sharma 
10
INVESTIGATIONS: 
 Clinical Diagnosis 
 CT or MRI 
12/16/14 
Dr Sagar Sharma 
11
MANAGEMENT 
 Pharmacotherapy 
 Non-Pharmacotherapy 
 Surgery 
12/16/14 
Dr Sagar Sharma 
12
PHARMACOTHERAPY 
 1.Dopaminergic drugs 
Levodopa, Carbidopa 
2. Anticholinergic Drugs 
Anti-cholinergics like Benztropine 
Anti-histamines like Diphenhydramine 
12/16/14 
Dr Sagar Sharma 
13
NON- PHARMACOLOGICAL 
TREATMENT 
Healthy eating 
12/16/14 
Dr Sagar Sharma 
14
SURGERIES 
1 Deep brain stimulation 
2. Pallidotomy 
3 . Thalamotomy 
12/16/14 
Dr Sagar Sharma 
15
TREATMENT IN AYURVEDA 
1. Kappikachhu Seeds -Mucuna pruriens ( Powder 
form) 
2. Swedana (Sudation therapy) – hot steam therapy 
with Nirgundi and Tulsi leaves 
3. Nasya (Medicated nasal drops) – Vacha with 
Ashwagandha oil 
4. Shirodhara – With Ashwagandha oil, Tulsi and 
some essential oils 
12/16/14 
16 
Dr Sagar Sharma
4. Snehana (Medicated oleation therapy) – body 
massage using warm sesame oil blended with herbs 
5. Basti (Medicated enema therapy) – enemas using 
Dashamula tea combined with oil. 
6. Meditation, yoga, Pranayama breathing techniques 
are very beneficial 
12/16/14 
Dr Sagar Sharma 
17
12/16/14 
Dr Sagar Sharma 
18
12/16/14 
Dr Sagar Sharma 
19
 DO’s- Healthy Food 
Exercise 
Meditation 
Yoga 
 DONT’S- Stress 
Sedantary lifestyle 
Unwashed fruit,vegitables 
12/16/14 
Dr Sagar Sharma 
20
DISCUSSION 
 Complete treatment requires proper lifestyle and 
daily regimens Like Dincharya,Rituchatya which 
pacify the patients vikruti (imbalance). 
 All patients should be encouraged to reduce stress 
and practice different exercises, Yoga Techniques 
which bring about peace of mind. 
 The effectiveness of Ayurvedic treatment goes beyond 
the pharmacological and incorporates the behavioral, 
and ultimately depends upon the internal and subtle 
energies of our being. While these aspects are hard to 
isolate and scrutinize, they can be evaluated as a 
whole, and it is here that genuine Ayurvedic research 
begins. 
12/16/14 
Dr Sagar Sharma 
21
CONCLUSION 
 As it is cleared that in future time lifestyle disorders 
will be a big threat for the humanity. Parkinsonism 
which earlier called old age disorder is now lifestyle 
disorder which has chances of early age incidence too 
 . Allopathy and Ayurveda have different views about 
it and their management is also different, but if one 
adopts integrated way of treatment for this disease 
marked improvement in seen. 
Dr Sagar Sharma 
 If one avoid early life mistake of living sedentary life 
style he/she can avoid this disease and can live life in 
a better way 
12/16/14 
22
REFRENCES 
 The Role of environmental toxins in the etiology 
of Parkinson's disease. Tanner, CM. TINS 1989; 
12:49-54 
 . Langston JW, Ballard P, Tetrud JW, Irvin I. 
Chronic Parkinsonism in humans due to a 
predouce of Meperidine. Analog synthesis. 
Science 1984; 219; 979-980 
 Caraka Samhita Vol. 1-4, Bhagwan Dash and 
R.K. Sharma, Chowkhumba Sanskrit Series, 
Varanasi. 
12/16/14 
Dr Sagar Sharma 
23
 Principles of Internal Medicine: Harrison 10. 
Damodaran M, Ramaswamy R. Isolation of L-dopa 
from the seeds of Mucuna Pruriens. 
Biochemistry 1937;31:2149-51 – 
 Treatment of Parkinsonismin Ayurveda: 
Journal of Royal Society of Medicine; M Gourie- 
Devi, M G Ramu and B S Venkatarum. 
Department of Neurology and Ayurvedic 
Research Unit, National Institute of Medical 
health and Neuroscience's, Bangalore, India. 
1991 Page 491-492 
 Effect of Yoga on motor function in people with 
Parkinsion disease:A randomized control pilot 
study by Neena Sharma and others 
 Role of Matra Basti and Kapikachhu beeja in 
treatment of Kampvata by Hiramath kashavva 
Veerabhasya and Aruna. 
12/16/14 
Dr Sagar Sharma 
24
THANK YOU!!! 
12/16/14 
Dr Sagar Sharma 
25

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Dr sagar sharma

  • 1. 12/16/14 Dr Sagar Sharma PARKINSON'S DISEASE 1 By Dr Sagar Sharma SJGAMC, Koppal
  • 2. CONTENTS  Introduction Discussion What Is Parkinsonism? Conclusion  Prevalence Refrences  Etiology  Patho-physiology  According to Ayurveda  Clinical features  Investigations Management Do And Donts 12/16/14 2 Dr Sagar Sharma
  • 3. INTRODUCTION • Modern science through improved sanitation, 12/vaccination, antibiotics, and medical attention 16/14 has eliminated the threat of death from most infectious diseases. • But the deaths from change in normal lifestyle, diseases are in rise. • Diseases associated with the way a person or group of people lives is called as lifestyle disorders like obesity, Diabetes, Hypertension, Parkinsonism, Cervical spondolytis etc 3 Dr Sagar Sharma
  • 4. WHAT IS PARKINSONISM? 12/16/14 Dr Sagar Sharma 4 Parkinsonism is the generic name given to a group of conditions that feature the main characteristics of Parkinson’s (Discovered by James Parkinson in 1817): tremor, rigidity of muscles, mobility problems and bradykinesia (slowness of movement). In Ayur eda it has Similar features as “Kampvata”
  • 5. PREVALENCE 12/16/14 5 Dr Sagar Sharma
  • 6. ETIOLOGY 12/16/14 6 Dr Sagar Sharma 1.Positive family history and Race. 2 Environmental Exposure: Herbicide and pesticide exposure, metals( manganese, iron) and steel alloy industries. 3 Exposure to MPTP (1- methyl-4-phenyl- 1,2,3,6 tetrahydropyridine), a potent neurotoxin. 4 Life experiences (trauma, emotional stress).
  • 8. ACCORDING TO AYURVEDA  The aggravation of Vata is due to many factors such as excessive physical activity, lack of proper nutrition, severe constipation etc. The aggravated vata disturbs the rasa dhatu (tissue) which cause the early symptoms of dryness in the skin (purva roopam) and then later relocated to other dhatus, affecting mansa (muscular) and majja (brain tissue) causing the muscle stiffness, rigidity, alerted behavior and tremors. 12/16/14 8 Dr Sagar Sharma
  • 9. CLINICAL FEATURES The classical syndrome: Tremors Rigidity Bradykinesia 12/16/14 9 Dr Sagar Sharma
  • 10. 12/16/14 Dr Sagar Sharma 10
  • 11. INVESTIGATIONS:  Clinical Diagnosis  CT or MRI 12/16/14 Dr Sagar Sharma 11
  • 12. MANAGEMENT  Pharmacotherapy  Non-Pharmacotherapy  Surgery 12/16/14 Dr Sagar Sharma 12
  • 13. PHARMACOTHERAPY  1.Dopaminergic drugs Levodopa, Carbidopa 2. Anticholinergic Drugs Anti-cholinergics like Benztropine Anti-histamines like Diphenhydramine 12/16/14 Dr Sagar Sharma 13
  • 14. NON- PHARMACOLOGICAL TREATMENT Healthy eating 12/16/14 Dr Sagar Sharma 14
  • 15. SURGERIES 1 Deep brain stimulation 2. Pallidotomy 3 . Thalamotomy 12/16/14 Dr Sagar Sharma 15
  • 16. TREATMENT IN AYURVEDA 1. Kappikachhu Seeds -Mucuna pruriens ( Powder form) 2. Swedana (Sudation therapy) – hot steam therapy with Nirgundi and Tulsi leaves 3. Nasya (Medicated nasal drops) – Vacha with Ashwagandha oil 4. Shirodhara – With Ashwagandha oil, Tulsi and some essential oils 12/16/14 16 Dr Sagar Sharma
  • 17. 4. Snehana (Medicated oleation therapy) – body massage using warm sesame oil blended with herbs 5. Basti (Medicated enema therapy) – enemas using Dashamula tea combined with oil. 6. Meditation, yoga, Pranayama breathing techniques are very beneficial 12/16/14 Dr Sagar Sharma 17
  • 18. 12/16/14 Dr Sagar Sharma 18
  • 19. 12/16/14 Dr Sagar Sharma 19
  • 20.  DO’s- Healthy Food Exercise Meditation Yoga  DONT’S- Stress Sedantary lifestyle Unwashed fruit,vegitables 12/16/14 Dr Sagar Sharma 20
  • 21. DISCUSSION  Complete treatment requires proper lifestyle and daily regimens Like Dincharya,Rituchatya which pacify the patients vikruti (imbalance).  All patients should be encouraged to reduce stress and practice different exercises, Yoga Techniques which bring about peace of mind.  The effectiveness of Ayurvedic treatment goes beyond the pharmacological and incorporates the behavioral, and ultimately depends upon the internal and subtle energies of our being. While these aspects are hard to isolate and scrutinize, they can be evaluated as a whole, and it is here that genuine Ayurvedic research begins. 12/16/14 Dr Sagar Sharma 21
  • 22. CONCLUSION  As it is cleared that in future time lifestyle disorders will be a big threat for the humanity. Parkinsonism which earlier called old age disorder is now lifestyle disorder which has chances of early age incidence too  . Allopathy and Ayurveda have different views about it and their management is also different, but if one adopts integrated way of treatment for this disease marked improvement in seen. Dr Sagar Sharma  If one avoid early life mistake of living sedentary life style he/she can avoid this disease and can live life in a better way 12/16/14 22
  • 23. REFRENCES  The Role of environmental toxins in the etiology of Parkinson's disease. Tanner, CM. TINS 1989; 12:49-54  . Langston JW, Ballard P, Tetrud JW, Irvin I. Chronic Parkinsonism in humans due to a predouce of Meperidine. Analog synthesis. Science 1984; 219; 979-980  Caraka Samhita Vol. 1-4, Bhagwan Dash and R.K. Sharma, Chowkhumba Sanskrit Series, Varanasi. 12/16/14 Dr Sagar Sharma 23
  • 24.  Principles of Internal Medicine: Harrison 10. Damodaran M, Ramaswamy R. Isolation of L-dopa from the seeds of Mucuna Pruriens. Biochemistry 1937;31:2149-51 –  Treatment of Parkinsonismin Ayurveda: Journal of Royal Society of Medicine; M Gourie- Devi, M G Ramu and B S Venkatarum. Department of Neurology and Ayurvedic Research Unit, National Institute of Medical health and Neuroscience's, Bangalore, India. 1991 Page 491-492  Effect of Yoga on motor function in people with Parkinsion disease:A randomized control pilot study by Neena Sharma and others  Role of Matra Basti and Kapikachhu beeja in treatment of Kampvata by Hiramath kashavva Veerabhasya and Aruna. 12/16/14 Dr Sagar Sharma 24
  • 25. THANK YOU!!! 12/16/14 Dr Sagar Sharma 25

Editor's Notes

  1. Slightly more Caucasians and males Like Alzheimer’s disease, the incidence of PD is lower in smokers Death – medical complications 12-15 years or 1-3 years… variable Mutations in Alpha synuclein and Parkin genes May be induced by drugs or toxins (e.g. MPTP), and major tranquillizers cause extrapyramidal side effects, e.g. neuroleptics; manganese and CO produce extrapyramidal effects Exposure to pesticides increased risk for developing PD by 70% (Ascherio et al., 2006). Neuromelanin; oxidation of DA Increased Fe2+ in SN, decreased transferrin = increased oxidation Increased lipid peroxidation