A prospective randomised trial of the optimal dose of mannitol for intra operative Brain relaxation in patients undergoing craniotomy for supratentorial brain tumour : Hyungseok et al.
Journal club :Neurosurgical conference , KKU.
I should this paper to review how they study of the optimum dosage of mannitol in neurosurgical operation.
Making cardiovascular risk reduction happen in primary care final diabetes ukTony Willis
Slides from opening plenary at Diabetes UK, 14th March 2018, London: "Cardiovascular risk reduction in diabetes: Maximising patient benefits"
This is some of the output over the last few years of the North West London Diabetes Transformation Team, demonstrating that urban deprivation doesn't need to be a barrier to improvements in care (as shown elsewhere including Tower Hamlets).
North West London Diabetes transformation programmeTony Willis
Over last couple of years we've been working to improve diabetes care in North West London. These slides share some of our initial work and impact, but this is just the start. Over the next two years we aim to transform care even further, improve patient experience and outcomes, reduce complications and have a big impact on type 2 diabetes prevention.
A prospective randomised trial of the optimal dose of mannitol for intra operative Brain relaxation in patients undergoing craniotomy for supratentorial brain tumour : Hyungseok et al.
Journal club :Neurosurgical conference , KKU.
I should this paper to review how they study of the optimum dosage of mannitol in neurosurgical operation.
Making cardiovascular risk reduction happen in primary care final diabetes ukTony Willis
Slides from opening plenary at Diabetes UK, 14th March 2018, London: "Cardiovascular risk reduction in diabetes: Maximising patient benefits"
This is some of the output over the last few years of the North West London Diabetes Transformation Team, demonstrating that urban deprivation doesn't need to be a barrier to improvements in care (as shown elsewhere including Tower Hamlets).
North West London Diabetes transformation programmeTony Willis
Over last couple of years we've been working to improve diabetes care in North West London. These slides share some of our initial work and impact, but this is just the start. Over the next two years we aim to transform care even further, improve patient experience and outcomes, reduce complications and have a big impact on type 2 diabetes prevention.
Metropolitan State University's vision to serve underserved populations, particularly working adults and students of color, employ student-centered strategies to recruit, retain and graduate students at highest levels of success in the MNSCU (Minnesota State Colleges and Universities) system.
More-than-than human contact, conspicuous mobility, and the digital frontierMatthew Wilson
This 'lightning-talk' was delivered at the VGI Preconference at the AAG meetings in Seattle, 11 April 2011. Organized by Dan Sui, Michael Goodchild, and Sarah Elwood.
[This keynote lecture was part of the Digital Landscape Architecture conference, delivered 5 June 2015, at the Bauhaus, Dessau, Germany.]
Humans have never been more capable of identifying their individualized location upon the surface of the Earth. A dazzling mesh of wired and wireless infrastructure permeates the planet and reaches far into the atmosphere. These materials are most recent manifestations within a long continuum of retentional techniques for the reproduction of humanity itself. The map stretches the lengths of this continuum, albeit with differing rhythms and volumes of use. Beyond identifying with the land, humanity inscribes upon the land with the broadest and most minute forces and movements -- all resolved through the machinic assembly of our location-aware society. The map is therefore both a guide for and record of these processes of inscription. However, if the map is not simply understood as a window onto spatial phenomena, as over a century of radical engagements with and upon the map have made evident, then what might be the benefit of treating the map instead as an agar, that material of microbiological inquiry -- a substance upon and within which cultures and acculturation is produced? Perhaps the map is more an artifact of the times and spaces of map-use than a clarified vision of reality. Thought in this way, the map becomes an externalization of human culture, memory, and action, and we can register the reverberations of the power geometries that produced such maps and allowed them to persist.
Prepared for Geographic Representation Now
Harvard Graduate School of Design
11.11.11
Abstract: Critical geographic information systems is an area of research positioned at the intersection of critical geography and geographic information science, drawing together technical capabilities for geographic representation and analysis with the critical capacities of social theory, more-than-human geographies, and the digital humanities. Critical GIS scholarship is particularly influenced by the work of participatory action researchers, the histories of cartography and geographic information technologies, and the inclusion of alternative (radical, local, everyday) knowledges. It inherits a focused attention to the social implications of geospatial technologies from the GIS and Society tradition while being cognizant of the technical debates and intricacies of GIScience. In this presentation, I sketch the present history of critical GIS. That is, I reflect upon specific engagements in Geography that currently situate critical GIS, and outline the more pressing aspects of its research agenda. I then introduce critical mapping efforts at the University of Kentucky, including work around public engagement, the mapping of user-generated content, and open data advocacy in local government.
Metropolitan State University's vision to serve underserved populations, particularly working adults and students of color, employ student-centered strategies to recruit, retain and graduate students at highest levels of success in the MNSCU (Minnesota State Colleges and Universities) system.
More-than-than human contact, conspicuous mobility, and the digital frontierMatthew Wilson
This 'lightning-talk' was delivered at the VGI Preconference at the AAG meetings in Seattle, 11 April 2011. Organized by Dan Sui, Michael Goodchild, and Sarah Elwood.
[This keynote lecture was part of the Digital Landscape Architecture conference, delivered 5 June 2015, at the Bauhaus, Dessau, Germany.]
Humans have never been more capable of identifying their individualized location upon the surface of the Earth. A dazzling mesh of wired and wireless infrastructure permeates the planet and reaches far into the atmosphere. These materials are most recent manifestations within a long continuum of retentional techniques for the reproduction of humanity itself. The map stretches the lengths of this continuum, albeit with differing rhythms and volumes of use. Beyond identifying with the land, humanity inscribes upon the land with the broadest and most minute forces and movements -- all resolved through the machinic assembly of our location-aware society. The map is therefore both a guide for and record of these processes of inscription. However, if the map is not simply understood as a window onto spatial phenomena, as over a century of radical engagements with and upon the map have made evident, then what might be the benefit of treating the map instead as an agar, that material of microbiological inquiry -- a substance upon and within which cultures and acculturation is produced? Perhaps the map is more an artifact of the times and spaces of map-use than a clarified vision of reality. Thought in this way, the map becomes an externalization of human culture, memory, and action, and we can register the reverberations of the power geometries that produced such maps and allowed them to persist.
Prepared for Geographic Representation Now
Harvard Graduate School of Design
11.11.11
Abstract: Critical geographic information systems is an area of research positioned at the intersection of critical geography and geographic information science, drawing together technical capabilities for geographic representation and analysis with the critical capacities of social theory, more-than-human geographies, and the digital humanities. Critical GIS scholarship is particularly influenced by the work of participatory action researchers, the histories of cartography and geographic information technologies, and the inclusion of alternative (radical, local, everyday) knowledges. It inherits a focused attention to the social implications of geospatial technologies from the GIS and Society tradition while being cognizant of the technical debates and intricacies of GIScience. In this presentation, I sketch the present history of critical GIS. That is, I reflect upon specific engagements in Geography that currently situate critical GIS, and outline the more pressing aspects of its research agenda. I then introduce critical mapping efforts at the University of Kentucky, including work around public engagement, the mapping of user-generated content, and open data advocacy in local government.
12 weeks Switch to Vaping: Science of Vaping Fontem Ventures
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Oral Fluid as a Chemical Test for the DRE ProgramNMS Labs
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ATS Symposium: Leukotriene Antagonists As First-line Asthma Controller For St...Zoe Mitchell
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The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Similar to Dr konstantinos farsalinos the royal society 11 13 (20)
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
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Esta publicação só está disponível em inglês até o momento.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Dr konstantinos farsalinos the royal society 11 13
1. Research on safety of
electronic cigarettes
Dr. Konstantinos Farsalinos
Researcher, Onassis Cardiac Surgery Center, Athens, Greece
Researcher, Department of Cardiovascular Diseases, University Hospital
Gathuisberg, Leuven, Belgium
2. E-cigarette facts
• New in the market
• Developed due to inefficiency of currently approved methods for
smoking cessation
• NRTs < 6% success rate (Moore et al., BMJ 2009)
• Oral medications < 20% success rate (Rigotti et al., Circulation
2010)
• Awareness and use growing exponentially
• Used by millions, mostly of young age (40 yo)
• Nicotine delivery, dealing with behavioral addiction
• No tobacco, no combustion
• Any regulation should be based on scientific evidence
5. Chemical studies
• Most commonly performed (mostly on liquids, fewer on
vapor)
• More than 300 analyses in Greece for presence of
TSNAs+PAH
• Provide indirect evidence on safety
• Findings depend on what you search for
• Flavorings used are GRAS for use in food
• We don’t know implications when inhaled
• Example of diacetyl -> bronchiolitis obliterans
9. Chemical studies
Overheating may lead to
production of toxic chemicals
Huge variety of devices, with different battery, liquid capacity and resistance.
HOWEVER, all were handled in the same way (2-seconds puff every 10 seconds)
Unrealistic conditions
Goniewicz et al, Tob Control 2013
20. Toxicology studies
Tests on vapor
Relative difference in viability between
cigarette smoke and worst-performing vapor
extract
Romagna, Farsalinos et al, Inhal Toxicol 2013
23. Toxicology studies
Tests on vapor
Myocardial cells
Untreated cells
E-cigarette
vapor treated
cells
Cigarette smoke
treated cells
Farsalinos et al, Int J Environm Res Public Health 2013
24. Toxicology studies
Cinnamon toxicity (?)
Tests on liquid
Irrelevant to e-cig
Approved
cinnamaldehyde dose
up to 4 x 10-2 M
(EPA, 2000)
Behar et al, Toxicol in Vitro 2013
27. Clinical studies
• Few studies performed on safety
• Long-term studies cannot be performed
• May get valuable information from studies on
pathophysiology of smoking-related disease,
immediate effects of use, short-term follow-up
and surveys
28. Clinical studies
Nicotine levels in e-cigarette unlikely to cause
overdose
•
•
•
•
Experienced e-cigarette users
5 minutes-13 puffs
Liquid consumption: 0.052 ± 0.13ml
Nicotine consumption: ≈ 1mg from 18mg/ml
nicotine-containing liquid
• Levels of nicotine absorption lower than
smoking (Dawkins et al, 2013)
Farsalinos et al, Subst Abuse 2013
29. Clinical studies
High nicotine levels
important in complete
substitution of
smoking (111 users)
Farsalinos et al, Subst Abuse 2013
30. Clinical studies
Effects on lung function
•No mention on changes in FEV1/FVC
•Could be due to short-term mechanical irritation and not damage
•Data from surveys report temporary cough as initial symptom
•No comparison with regular cigarettes
Vardavas et al, Chest 2012
41. Clinical studies
More to come…
• Effect on aortic elasticity (EUROECHO 2013)
• Effect on pulsed-wave velocity (measure of
arterial stiffness)
• Always comparison with tobacco cigarettes
42. Clinical studies
What we need to know
• Long-term safety cannot be assessed unless 10-15 years
have passed, because:
Smoking causes disease after many years of use
Current e-cigarette users are of young age (disease
incidence is very low in this population)
E-cigarette is a new product
43. Clinical studies
What we need to know
• Lung function:
Need to compare with tobacco cigarettes
Acute lung dysfunction may be caused by pure mechanical
irritation, which does not predict harm (e.g. cold weather)
Surveys have shown some irritation which is temporary, with
subsequent beneficial effects (subjectively perceived)
• Cardiac function:
Variety of mechanisms by which smoking causes disease
Some of smoking adverse effects take long time to reverse (e.g.
inflammatory markers)
44. Conclusions
• Although there are several chemical studies, few are performed on
vapor
• Need for more toxicology studies
• Need for studies on atomiser materials
• Protocol and device handling are the most crucial factors in getting
results applicable to real use
• Clinical studies are scarce; some already scheduled, need more
• Long-term studies impossible right now
Based on currently available data, it is reasonable to expect a
significant benefit for the health of smokers who switch from
tobacco to e-cigarette use, even in long-term users.
45. Conclusions
Research will help us define the best possible
materials in e-liquids and devices, which should
be done without killing variability and
innovation