This document discusses the history and modern practices of blood donation and transfusion. It covers topics such as the discovery of blood groups by Landsteiner, the development of successful blood transfusions, the establishment of modern blood banks and services, mandatory screening tests for diseases, and the processing of donated whole blood into blood components like red blood cells. The document emphasizes that safe transfusion is only possible from safe donors who voluntarily donate blood and pass disease screening tests. New advances discussed include generating red blood cells ex vivo from stem cells as a potential future standardized blood supply.

1. Blood Donation
Transfusion - Safety,
optimization & new
advances
Dr.Biplabendu Talukdar
MBBS,MD(IHBT),M.Phil( RMTS),MBA, PhD scholar
Assistant Professor , Department of IHBT,MCH,Kolkata
State Program Officer, State Blood Cell,WB
Consultant Narayana Hospital,Howrah

2. Pre historical era

4. Willium Harvey

8. Kerl Landstiner

9. Successful transfusion

10. blood donation and modern blood
service

11. Utilization of Blood or Blood products

12. blood utilization

13. PPH may increased maternal mortality

15. ??? safe blood donation

16. Social factor

19. Safety of the Blood
Supply
• Voluntary and non-remunerated donor
• Donor Health Questionnaire
• NACO/NBTC -Mandatory screening tests
– Hep B, Hep C, HIV 1 & 2
– – Syphilis,
– – Malaria,

20. Blood donation

21. Modern Blood Bank

22. Blood safety/ Transfusion
safety
SAFE
TRANSFUSION
PROCESS
SAFE BLOOD
COMPONENT

23. fate of Whole Blood

24. Bloodprocessing– redcells
• Most of the plasma is removed
• Optimal Additive Solution added -
SAGM in UK
• Red Book Specifications
• Vol = 280+ 60ml
• WBC < 5 x 106 /unit
• Hct 0.5 - 0.7
• 35 day shelf life
• For haemoglobinopathy
• Top up <14 days
• exchange (SCD) <7 days
• (washed red cells)

25. Safe transfusion only possible from Safe Donor

26. Apheresis

28. Red cells from stem cells
Harvey G. Klein. Brewing blood
Blood 2011 118, 5069
Standardised
well characterised,
readily available red cells?
Culture systems to generate
erythroid cells in laboratory from
•Somatic stem cells
•Embryonic stem cells
•Induced pluripotent stem cells
Ex vivo production of human red cells, the
Holy Grail of blood transfusion.
illustration by Debra T. Dartez.

29. Thank you