Domperidone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Domperidone Dosage & Rx Info | Domperidone Uses, Side Effects -: Indications, Side Effects, Warnings, Domperidone - Drug Information - Taj Pharma, Domperidone dose Taj pharmaceuticals Domperidone interactions, Taj Pharmaceutical Domperidone contraindications, Domperidone price, Domperidone Taj Pharma Domperidone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Domperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Topiramate tablets ip 25mg, 50mg, 100mg taj pharma smpcTajPharmaQC
This document provides information on Topiramate Tablets IP 25mg, 50mg, 100mg (Topamet) manufactured by Taj Pharma, including its uses, dosage, administration and warnings. It is used to treat partial seizures, generalized tonic-clonic seizures, seizures associated with Lennox-Gastaut syndrome, and migraine prophylaxis. The recommended starting dose is 25mg daily for epilepsy or 25mg nightly for migraine, titrated up based on response and tolerability to a target daily dose of 100-200mg for epilepsy and 100mg for migraine. Special warnings include risk of fetal harm, need for adequate hydration to reduce kidney stone risk, and possibility of increased seizures from changes in
Thalidomide Capsule USP Taj Pharma SmPCTajPharmaQC
Thalidomide Capsule USP 50mg/100mg/200mg/250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Thalidomide Dosage & Rx Info | Thalidomide Uses, Side Effects Thalidomide: Indications, Side Effects, Warnings, Thalidomide -Drug Information –Taj Pharma, Thalidomide dose Taj pharmaceuticals Thalidomide interactions, Taj Pharmaceutical Thalidomide contraindications, Thalidomide price, Thalidomide Taj Pharma Thalidomide SmPC-Taj Pharma Stay connected to all updated on Thalidomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Metoclopramide Injection USP Taj Pharma SmPCTajPharmaQC
Metoclopramide Injection USP 10mg/2ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects Metoclopramide: Indications, Side Effects, Warnings, Metoclopramide -Drug Information –Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide SmPC-Taj Pharma Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Tramadol 50mg per ml solution for injection or infusion smpc taj pharmaceuti...Taj Pharma
Tramadol - Drug Information - Taj Pharma, Tramadol dose Taj pharmaceuticals Tramadol interactions, Taj Pharmaceutical Tramadol contraindications, Tramadol price, Tramadol Taj Pharma Tramadol 50mg/ml Solution for Injection or Infusion SMPC- Taj Pharma . Stay connected to all updated on Tramadol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Lamotrigine Dispersible Tablets Taj Pharma SmPCTajPharmaQC
Lamotrigine Dispersible Tablets 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lamotrigine Dosage & Rx Info | Lamotrigine Uses, Side Effects Lamotrigine: Indications, Side Effects, Warnings, Lamotrigine-Drug Information –Taj Pharma, Lamotrigine dose Taj pharmaceuticals Lamotrigine interactions, Taj Pharmaceutical Lamotrigine contraindications, Lamotrigine price, Lamotrigine Taj Pharma Lamotrigine SmPC- Taj Pharma Stay connected to all updated on Lamotrigine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Tramdol and paracetamol tablets ip 37.5mg 325mg, 50mg 325mg taj pharma_smpcTajPharmaQC
Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaTaj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaDosage & Rx Info | Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaUses, Side Effects, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaIndications, Side Effects, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma- Drug Information – Taj Pharma, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmadose Taj pharmaceuticals Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmainteractions, Taj Pharmaceutical Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma SmPC
Topiramate tablets ip 25mg, 50mg, 100mg taj pharma smpcTajPharmaQC
This document provides information on Topiramate Tablets IP 25mg, 50mg, 100mg (Topamet) manufactured by Taj Pharma, including its uses, dosage, administration and warnings. It is used to treat partial seizures, generalized tonic-clonic seizures, seizures associated with Lennox-Gastaut syndrome, and migraine prophylaxis. The recommended starting dose is 25mg daily for epilepsy or 25mg nightly for migraine, titrated up based on response and tolerability to a target daily dose of 100-200mg for epilepsy and 100mg for migraine. Special warnings include risk of fetal harm, need for adequate hydration to reduce kidney stone risk, and possibility of increased seizures from changes in
Thalidomide Capsule USP Taj Pharma SmPCTajPharmaQC
Thalidomide Capsule USP 50mg/100mg/200mg/250mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Thalidomide Dosage & Rx Info | Thalidomide Uses, Side Effects Thalidomide: Indications, Side Effects, Warnings, Thalidomide -Drug Information –Taj Pharma, Thalidomide dose Taj pharmaceuticals Thalidomide interactions, Taj Pharmaceutical Thalidomide contraindications, Thalidomide price, Thalidomide Taj Pharma Thalidomide SmPC-Taj Pharma Stay connected to all updated on Thalidomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Metoclopramide Injection USP Taj Pharma SmPCTajPharmaQC
Metoclopramide Injection USP 10mg/2ml Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects Metoclopramide: Indications, Side Effects, Warnings, Metoclopramide -Drug Information –Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide SmPC-Taj Pharma Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Tramadol 50mg per ml solution for injection or infusion smpc taj pharmaceuti...Taj Pharma
Tramadol - Drug Information - Taj Pharma, Tramadol dose Taj pharmaceuticals Tramadol interactions, Taj Pharmaceutical Tramadol contraindications, Tramadol price, Tramadol Taj Pharma Tramadol 50mg/ml Solution for Injection or Infusion SMPC- Taj Pharma . Stay connected to all updated on Tramadol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Lamotrigine Dispersible Tablets Taj Pharma SmPCTajPharmaQC
Lamotrigine Dispersible Tablets 25mg, 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lamotrigine Dosage & Rx Info | Lamotrigine Uses, Side Effects Lamotrigine: Indications, Side Effects, Warnings, Lamotrigine-Drug Information –Taj Pharma, Lamotrigine dose Taj pharmaceuticals Lamotrigine interactions, Taj Pharmaceutical Lamotrigine contraindications, Lamotrigine price, Lamotrigine Taj Pharma Lamotrigine SmPC- Taj Pharma Stay connected to all updated on Lamotrigine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Tramdol and paracetamol tablets ip 37.5mg 325mg, 50mg 325mg taj pharma_smpcTajPharmaQC
Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaTaj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaDosage & Rx Info | Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaUses, Side Effects, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj PharmaIndications, Side Effects, Warnings, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma- Drug Information – Taj Pharma, Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmadose Taj pharmaceuticals Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharmainteractions, Taj Pharmaceutical Tramadol Hydrochloride and Paracetamol Tablets IP 37.5mg/325mg; 50mg/325mg (Tramataj-A) Taj Pharma SmPC
Olmesartan medoxomil and Amlodipine Tablets Taj Pharma SmPCTajPharmaQC
The document discusses Olmesartan medoxomil and Amlodipine besilate tablets, which are fixed-dose combination antihypertensive medications produced by Taj Pharmaceuticals. It provides information on the composition of the tablets, therapeutic indications for treating hypertension, dosing and administration guidance stratified by factors like renal or hepatic impairment, contraindications, and warnings regarding dual renin-angiotensin system blockade or use in pregnancy. The document also includes sections on clinical pharmacology, interactions, adverse effects, and overdose management.
Domperidone Toxicity (pharmacology point of view)Ahmed Khadr
Domperidone was synthesized in 1974 as an antipsychotic drug with strong anti-emetic effects and minimal central nervous system effects. It is used globally to treat nausea and vomiting and increase breast milk production. Domperidone is more effective than metoclopramide for treating gastroparesis with fewer side effects due to not crossing the blood brain barrier. However, in vitro studies show domperidone can inhibit the hERG potassium channel associated with long QT syndrome and increased risk of arrhythmias. A meta-analysis found a significant association between domperidone use and ventricular arrhythmias or cardiac arrest. However, other studies have found no adverse effects. Future studies are needed comparing risks of
Metformin hydrochloride Tablets Taj Pharma SmPCTajPharmaQC
Metformin hydrochloride ER tablets 500mg/750mg/1000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metformin hydrochloride Dosage & Rx Info | Metformin hydrochloride Uses, Side Effects Metformin hydrochloride: Indications, Side Effects, Warnings, Metformin hydrochloride-Drug Information –Taj Pharma, Metformin hydrochloride dose Taj pharmaceuticals Metformin hydrochloride interactions, Taj Pharmaceutical Metformin hydrochloride contraindications, Metformin hydrochloride price, Metformin hydrochloride Taj Pharma Metformin hydrochloride SmPC- Taj Pharma Stay connected to all updated on Metformin hydrochloride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Glimepride And Metformin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Glimepride And Metformin Dosage & Rx Info | Glimepride And Metformin Uses, Side Effects -: Indications, Side Effects, Warnings, Glimepride And Metformin - Drug Information - Taj Pharma, Glimepride And Metformin dose Taj pharmaceuticals Glimepride And Metformin interactions, Taj Pharmaceutical Glimepride And Metformin contraindications, Glimepride And Metformin price, Glimepride And Metformin Taj Pharma Glimepride And Metformin Hydrochloride Tablets SR SMPC- Taj Pharma . Stay connected to all updated on Glimepride And Metformin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cyclophosphamide for Injection USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Amlodipine 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Amlodipine 5mg, 10mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Amlodipine Dosage & Rx Info | Amlodipine Uses, Side Effects - Amlodipine : Indications, Side Effects, Warnings, Amlodipine - Drug Information - Taj Pharma, Amlodipine dose Taj pharmaceuticals Amlodipine interactions, Taj Pharmaceutical Amlodipine contraindications, Amlodipine price, Amlodipine Taj Pharma Amlodipine 5mg, 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Amlodipine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
This document provides information on lacosamide tablets produced by Taj Pharma, including:
- It describes the composition, pharmaceutical form, clinical uses, dosages, and administration details for lacosamide tablets in 50mg, 100mg, 150mg, and 200mg strengths.
- The tablets are indicated as monotherapy or adjunctive therapy for partial-onset seizures. Common side effects include nausea and vomiting. Special populations may require adjusted dosages.
- Detailed posology and dosage adjustment recommendations are provided for various patient populations including children, elderly patients, and those with renal or hepatic impairment.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
This document provides information on Dobutamine Injection USP 250mg/5ml Taj Pharma, including its uses, dosage, administration, contraindications and other details. Dobutamine is indicated for patients who require positive inotropic support to treat cardiac decompensation due to depressed contractility or cardiogenic/septic shock. It lists recommended dosages for adults and pediatric patients. Administration is by continuous intravenous infusion and the document provides tables of infusion rates based on dosage. Contraindications include mechanical obstruction of ventricular filling/outflow and hypersensitivity to the drug.
Metoclopramide hydrochloride 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Glimepiride Tablets USP Taj Pharma SmPCTajPharmaQC
Glimepiride Tablets USP 1mg, 2mg, 3mg, 4mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Glimepiride Dosage & Rx Info | Glimepiride Uses, Side Effects Glimepiride: Indications, Side Effects, Warnings, Glimepiride-Drug Information –Taj Pharma, Glimepiride dose Taj pharmaceuticals Glimepiride interactions, Taj Pharmaceutical Glimepiride contraindications, Glimepiride price, Glimepiride Taj Pharma Glimepiride SmPC- Taj Pharma Stay connected to all updated on Glimepiride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Tramadol is a narcotic-like pain reliever used to treat moderate to severe pain. It works by binding to opioid receptors in the brain and also inhibiting the reuptake of serotonin and norepinephrine. Common side effects include nausea, dizziness, and constipation. Tramadol can interact dangerously with other drugs and should be used carefully, as prescribed, due to risks of addiction, overdose, and adverse effects.
Tramadol 200mg is a leading medicament that is prescribed to treat moderate to severe pain. It comes under the category of centrally acting analgesic. This drug recommended treating both chronic as well as acute pain. It is prescribed in the medical condition of fibromyalgia, motor neuron disease, restless legs syndrome, rheumatoid arthritis and other chronic pain. Generic Tramadol Hydrochloride being the active ingredient of this drug lessens the intensity of the pain by binding it to the µ-opioid
This document provides information on Dobutamine Injection 5mg/ml and 12.5mg/ml from Taj Pharma, including its uses, dosage, administration, and potential side effects. It is indicated for patients requiring positive inotropic support for cardiac decompensation or cardiogenic/septic shock. The dosage varies depending on the patient's condition and response, and must be individually adjusted. Precautions are mentioned regarding patients with severe coronary heart disease or arrhythmia risk.
Flutamide Taj Pharma is a medication used to treat advanced prostate cancer. It works by blocking the effects of testosterone on prostate cancer cells. Common side effects include nausea, vomiting, diarrhea, breast tenderness and gynecomastia. When used with an LHRH agonist, it can help reduce side effects from the flare reaction that sometimes occurs with LHRH agonist treatment alone. Regular monitoring of liver function is required due to potential for hepatotoxicity. Other potential side effects include cardiovascular effects like fluid retention and increased risk of blood clots.
Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Lenalidomide Capsules 5mg/10mg/15mg/25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lenalidomide Dosage & Rx Info | Lenalidomide Uses, Side Effects Lenalidomide: Indications, Side Effects, Warnings, Lenalidomide -Drug Information –Taj Pharma, Lenalidomide dose Taj pharmaceuticals Lenalidomide interactions, Taj Pharmaceutical Lenalidomide contraindications, Lenalidomide price, Lenalidomide Taj Pharma Lenalidomide SmPC-Taj Pharma Stay connected to all updated on Lenalidomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Mirtazapine 30mg tablets smpc taj pharmaceuticalsTaj Pharma
Mirtazapine 30mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mirtazapine Dosage & Rx Info | Mirtazapine Uses, Side Effects - Mirtazapine: Indications, Side Effects, Warnings, Mirtazapine - Drug Information - Taj Pharma, Mirtazapine dose Taj pharmaceuticals Mirtazapine interactions, Taj Pharmaceutical Mirtazapine contraindications, Mirtazapine price, Mirtazapine Taj Pharma Mirtazapine 30mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Mirtazapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Motilium (Domperidone 10 mg Tablets) is used to treat nausea, vomiting and discomfort caused by a slow moving stomach known as gastroparesis in adult patients.
Motilium M Tablets (Generic Domperidone Maleate Tablets) The Swiss Pharmacy
Motilium M (Generic Domperidone Maleate Tablets) is used to treat nausea and vomiting in adults. It is also used to treat discomfort caused by a slow moving stomach known as gastroparesis. Symptoms include not being able to finish a meal, a feeling of being "too full" or bloated after a meal, a loss of appetite, feeling sick and maybe vomiting, or belching without relief.
Olmesartan medoxomil and Amlodipine Tablets Taj Pharma SmPCTajPharmaQC
The document discusses Olmesartan medoxomil and Amlodipine besilate tablets, which are fixed-dose combination antihypertensive medications produced by Taj Pharmaceuticals. It provides information on the composition of the tablets, therapeutic indications for treating hypertension, dosing and administration guidance stratified by factors like renal or hepatic impairment, contraindications, and warnings regarding dual renin-angiotensin system blockade or use in pregnancy. The document also includes sections on clinical pharmacology, interactions, adverse effects, and overdose management.
Domperidone Toxicity (pharmacology point of view)Ahmed Khadr
Domperidone was synthesized in 1974 as an antipsychotic drug with strong anti-emetic effects and minimal central nervous system effects. It is used globally to treat nausea and vomiting and increase breast milk production. Domperidone is more effective than metoclopramide for treating gastroparesis with fewer side effects due to not crossing the blood brain barrier. However, in vitro studies show domperidone can inhibit the hERG potassium channel associated with long QT syndrome and increased risk of arrhythmias. A meta-analysis found a significant association between domperidone use and ventricular arrhythmias or cardiac arrest. However, other studies have found no adverse effects. Future studies are needed comparing risks of
Metformin hydrochloride Tablets Taj Pharma SmPCTajPharmaQC
Metformin hydrochloride ER tablets 500mg/750mg/1000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Metformin hydrochloride Dosage & Rx Info | Metformin hydrochloride Uses, Side Effects Metformin hydrochloride: Indications, Side Effects, Warnings, Metformin hydrochloride-Drug Information –Taj Pharma, Metformin hydrochloride dose Taj pharmaceuticals Metformin hydrochloride interactions, Taj Pharmaceutical Metformin hydrochloride contraindications, Metformin hydrochloride price, Metformin hydrochloride Taj Pharma Metformin hydrochloride SmPC- Taj Pharma Stay connected to all updated on Metformin hydrochloride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Glimepride And Metformin Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Glimepride And Metformin Dosage & Rx Info | Glimepride And Metformin Uses, Side Effects -: Indications, Side Effects, Warnings, Glimepride And Metformin - Drug Information - Taj Pharma, Glimepride And Metformin dose Taj pharmaceuticals Glimepride And Metformin interactions, Taj Pharmaceutical Glimepride And Metformin contraindications, Glimepride And Metformin price, Glimepride And Metformin Taj Pharma Glimepride And Metformin Hydrochloride Tablets SR SMPC- Taj Pharma . Stay connected to all updated on Glimepride And Metformin Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Cyclophosphamide for Injection USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Amlodipine 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Amlodipine 5mg, 10mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Amlodipine Dosage & Rx Info | Amlodipine Uses, Side Effects - Amlodipine : Indications, Side Effects, Warnings, Amlodipine - Drug Information - Taj Pharma, Amlodipine dose Taj pharmaceuticals Amlodipine interactions, Taj Pharmaceutical Amlodipine contraindications, Amlodipine price, Amlodipine Taj Pharma Amlodipine 5mg, 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Amlodipine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
This document provides information on lacosamide tablets produced by Taj Pharma, including:
- It describes the composition, pharmaceutical form, clinical uses, dosages, and administration details for lacosamide tablets in 50mg, 100mg, 150mg, and 200mg strengths.
- The tablets are indicated as monotherapy or adjunctive therapy for partial-onset seizures. Common side effects include nausea and vomiting. Special populations may require adjusted dosages.
- Detailed posology and dosage adjustment recommendations are provided for various patient populations including children, elderly patients, and those with renal or hepatic impairment.
Dobutamine Injection USP Taj Pharma SmPCTajPharmaQC
This document provides information on Dobutamine Injection USP 250mg/5ml Taj Pharma, including its uses, dosage, administration, contraindications and other details. Dobutamine is indicated for patients who require positive inotropic support to treat cardiac decompensation due to depressed contractility or cardiogenic/septic shock. It lists recommended dosages for adults and pediatric patients. Administration is by continuous intravenous infusion and the document provides tables of infusion rates based on dosage. Contraindications include mechanical obstruction of ventricular filling/outflow and hypersensitivity to the drug.
Metoclopramide hydrochloride 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Glimepiride Tablets USP Taj Pharma SmPCTajPharmaQC
Glimepiride Tablets USP 1mg, 2mg, 3mg, 4mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Glimepiride Dosage & Rx Info | Glimepiride Uses, Side Effects Glimepiride: Indications, Side Effects, Warnings, Glimepiride-Drug Information –Taj Pharma, Glimepiride dose Taj pharmaceuticals Glimepiride interactions, Taj Pharmaceutical Glimepiride contraindications, Glimepiride price, Glimepiride Taj Pharma Glimepiride SmPC- Taj Pharma Stay connected to all updated on Glimepiride Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Tramadol is a narcotic-like pain reliever used to treat moderate to severe pain. It works by binding to opioid receptors in the brain and also inhibiting the reuptake of serotonin and norepinephrine. Common side effects include nausea, dizziness, and constipation. Tramadol can interact dangerously with other drugs and should be used carefully, as prescribed, due to risks of addiction, overdose, and adverse effects.
Tramadol 200mg is a leading medicament that is prescribed to treat moderate to severe pain. It comes under the category of centrally acting analgesic. This drug recommended treating both chronic as well as acute pain. It is prescribed in the medical condition of fibromyalgia, motor neuron disease, restless legs syndrome, rheumatoid arthritis and other chronic pain. Generic Tramadol Hydrochloride being the active ingredient of this drug lessens the intensity of the pain by binding it to the µ-opioid
This document provides information on Dobutamine Injection 5mg/ml and 12.5mg/ml from Taj Pharma, including its uses, dosage, administration, and potential side effects. It is indicated for patients requiring positive inotropic support for cardiac decompensation or cardiogenic/septic shock. The dosage varies depending on the patient's condition and response, and must be individually adjusted. Precautions are mentioned regarding patients with severe coronary heart disease or arrhythmia risk.
Flutamide Taj Pharma is a medication used to treat advanced prostate cancer. It works by blocking the effects of testosterone on prostate cancer cells. Common side effects include nausea, vomiting, diarrhea, breast tenderness and gynecomastia. When used with an LHRH agonist, it can help reduce side effects from the flare reaction that sometimes occurs with LHRH agonist treatment alone. Regular monitoring of liver function is required due to potential for hepatotoxicity. Other potential side effects include cardiovascular effects like fluid retention and increased risk of blood clots.
Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Lenalidomide Capsules 5mg/10mg/15mg/25mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Lenalidomide Dosage & Rx Info | Lenalidomide Uses, Side Effects Lenalidomide: Indications, Side Effects, Warnings, Lenalidomide -Drug Information –Taj Pharma, Lenalidomide dose Taj pharmaceuticals Lenalidomide interactions, Taj Pharmaceutical Lenalidomide contraindications, Lenalidomide price, Lenalidomide Taj Pharma Lenalidomide SmPC-Taj Pharma Stay connected to all updated on Lenalidomide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Mirtazapine 30mg tablets smpc taj pharmaceuticalsTaj Pharma
Mirtazapine 30mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mirtazapine Dosage & Rx Info | Mirtazapine Uses, Side Effects - Mirtazapine: Indications, Side Effects, Warnings, Mirtazapine - Drug Information - Taj Pharma, Mirtazapine dose Taj pharmaceuticals Mirtazapine interactions, Taj Pharmaceutical Mirtazapine contraindications, Mirtazapine price, Mirtazapine Taj Pharma Mirtazapine 30mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Mirtazapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Motilium (Domperidone 10 mg Tablets) is used to treat nausea, vomiting and discomfort caused by a slow moving stomach known as gastroparesis in adult patients.
Motilium M Tablets (Generic Domperidone Maleate Tablets) The Swiss Pharmacy
Motilium M (Generic Domperidone Maleate Tablets) is used to treat nausea and vomiting in adults. It is also used to treat discomfort caused by a slow moving stomach known as gastroparesis. Symptoms include not being able to finish a meal, a feeling of being "too full" or bloated after a meal, a loss of appetite, feeling sick and maybe vomiting, or belching without relief.
The document summarizes a drug safety alert issued by the Drugs Regulatory Authority of Pakistan regarding unreasonable serious liver and cardiac problems associated with the drug domperidone. It provides recommendations to update domperidone labels to restrict its use to relieving nausea and vomiting at doses no higher than 10mg three times daily for one week maximum. It also warns against use in patients with liver or heart conditions based on a review by the European Medicines Agency finding increased risks, especially at high doses or long-term use.
Tramadol is a narcotic-like pain reliever used to treat moderate to severe pain. It comes in both immediate and extended release forms, with the extended release form intended for around-the-clock pain treatment rather than as-needed use. Common side effects include nausea, dizziness, constipation, and drowsiness. Tramadol is metabolized in the liver and excreted by the kidneys, so dosage reductions may be needed for those with liver or kidney impairment. Its use during pregnancy and breastfeeding requires caution.
Prednisolone 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Prednisolone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Prednisolone Dosage & Rx Info | Prednisolone Uses, Side Effects -: Indications, Side Effects, Warnings, Prednisolone - Drug Information - Taj Pharma, Prednisolone dose Taj pharmaceuticals Prednisolone interactions, Taj Pharmaceutical Prednisolone contraindications, Prednisolone price, Prednisolone Taj Pharma Prednisolone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Prednisolone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Olmesartan medoxomil/Hydrochlorothiazide Tablets Taj Pharma SmPCTajPharmaQC
This document provides information on olmesartan medoxomil/hydrochlorothiazide combination tablets, including its uses, dosage, side effects and contraindications. It is used for the treatment of hypertension. The dosage varies depending on the severity of hypertension and renal function. Side effects may include dizziness, fatigue and hypokalemia. It should not be used in patients with severe hepatic or renal impairment.
Topiramate tablets are available in 15mg and 100mg strengths from Taj Pharma. Topiramate is indicated as monotherapy for partial seizures in adults and children over 6, and as adjunctive therapy for partial seizures, primary generalized tonic-clonic seizures, and Lennox-Gastaut syndrome in children and adults. It is also indicated for migraine prophylaxis in adults. Common side effects include mood disturbances, depression, and kidney stones. Dosage should be titrated slowly from low starting doses and monitored based on clinical response and tolerability. Special precautions are needed in patients with renal or hepatic impairment.
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Amiodarone 200 mg tablets smpc taj pharmaceuticalsTaj Pharma
Amiodarone 200mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Amiodarone Dosage & Rx Info | Amiodarone Uses, Side Effects - Amiodarone : Indications, Side Effects, Warnings, Amiodarone - Drug Information - Taj Pharma, Amiodarone dose Taj pharmaceuticals Amiodarone interactions, Taj Pharmaceutical Amiodarone contraindications, Amiodarone price, Amiodarone Taj Pharma anti-arrhythmics Amiodarone 200mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Amiodarone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
The document discusses several topics:
1. Baxdrostat, a new drug to treat resistant hypertension by inhibiting aldosterone synthase. It was well tolerated in trials and significantly lowered blood pressure.
2. Finerenone, a mineralocorticoid receptor antagonist approved to reduce kidney disease progression in type 2 diabetes. It has fewer side effects like hyperkalemia than existing drugs.
3. Zavegepant, the first intranasal CGRP receptor antagonist approved for acute migraine treatment. It provided pain relief within 2 hours and was generally well tolerated in trials.
4. New guidelines for gastroparesis diagnosis and management, recommending pharmacologic treatment like metoclopramide
Tramadol hydrochloride 37.5 mg and paracetamol 325 mg film coated tablets smp...Taj Pharma
Tramadol hydrochloride and Paracetamol Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Tramadol hydrochloride and Paracetamol Dosage & Rx Info | Tramadol hydrochloride and Paracetamol Uses, Side Effects -: Indications, Side Effects, Warnings, Tramadol hydrochloride and Paracetamol - Drug Information - Taj Pharma, Tramadol hydrochloride and Paracetamol dose Taj pharmaceuticals Tramadol hydrochloride and Paracetamol interactions, Taj Pharmaceutical Tramadol hydrochloride and Paracetamol contraindications, Tramadol hydrochloride and Paracetamol price, Tramadol hydrochloride and Paracetamol Taj Pharma Tramadol hydrochloride 37.5 mg and Paracetamol 325 mg film-coated tablets SMPC- Taj Pharma . Stay connected to all updated on Tramadol hydrochloride and Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Dexamethasone 4 mg tablets smpc taj pharmaceuticalsTaj Pharma
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Olmesartan 20mg/40mg Tablets USP Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Olmesartan Dosage & Rx Info | Olmesartan Uses, Side Effects Vecuronium bromide: Indications, Side Effects, Warnings, Olmesartan-Drug Information –Taj Pharma, Olmesartan dose Taj pharmaceuticals Olmesartan interactions, Taj Pharmaceutical Olmesartan contraindications, Olmesartan price, Olmesartan Taj Pharma Olmesartan SmPC-Taj Pharma Stay connected to all updated on Olmesartan Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Cyclophosphamide Tablets USP Taj Pharma SmPCTajPharmaQC
Cyclophosphamide Tablets USP 25mg/50mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Deflazacort 6mg tablets smpc taj pharmaceuticalsTaj Pharma
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Diazepam 5mg tablets smpc taj pharmaceuticalsTaj Pharma
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Zolpiderm tartrate 5mg and 10mg tablets pil, taj pharmaceuticals.Taj Pharma
This document is a patient information leaflet for Zolpidem Tartrate 5mg and 10mg tablets produced by Taj Pharmaceuticals. It provides information on:
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- Contraindications and warnings for its use, including not taking it if you have breathing problems or a history of substance abuse.
- How to take zolpidem, including only taking it at bedtime for 2-4 weeks as prescribed by your doctor.
- Possible side effects and drug interactions to be aware of when taking zolpidem with other medications.
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Domperidone 10mg tablets smpc taj pharmaceuticals
1. Domperidone 10mg Tablets SMPC, Taj Pharmaceuticals
Domperidone Taj Pharma : Uses, Side Effect s, Interactions, Pictures, Warnings, Domperidone Dosage & Rx Info | Domperidone Uses, Side Effects -: Indications, Side Effects, Warnings, Domp eridone - Drug Information - Taj Pharma, Domperidone dose Taj pharmaceuticals Domperidone interactions, Taj Pharmaceutical Domperidone contraindications, Domperidone price, Domperidone Taj Pharma Do mperidone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Domperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
RX
DOMPERIDONE
TABLETS
10MG
1.NAME OF THE MEDICINAL PRODUCT
Domperidone 10mg Tablets
2. QUALITATIVE AND QUANTITATIVE
COMPOSITION
Each tablet contains Domperidone maleate
equivalent to 10mg domperidone base.
For a full list of excipients see section 6.1.
3. PHARMACEUTICAL FORM
Tablets
Domperidone 10mg Tablet is presented as a
white round biconvex tablet.
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Domepridone is indicated for the relief of the
symptoms of nausea and vomiting.
4.2 Posology and method of administration
Domeperidone should be used at the lowest
effective dose for the shortest duration necessary
to control nausea and vomiting.
Domperidone 10mg Tablets are for oral
administration.
It is recommended to take oral domperidone
tablets before meals. If taken after meals,
absorption of the drug is somewhat delayed.
Patients should try to take each dose at
scheduled time. If a scheduled dose is missed,
the missed dose should be omitted and the usual
dosing schedule resumed. The dose should not
be doubled to make up for a missed dose.
Usually, the maximum treatment duration
should not exceed one week.
Adults and adolescents (12 years of age and
older and weighing 35 kg or more)
One 10mg tablet up to three times per day with
maximum dose of 30 mg per day.
Neonates, infants, children (less than 12 years of
age) and adolescents weighing less than 35 kg
Due to the need for accurate dosing,
Domperidone tablets are unsuitable for use in
children and adolescents weighing less than 35
kg.
Hepatic Impairment
Domperidone is contraindicated in moderate or
severe hepatic impairment (see section 4.3).
Dose modification in mild hepatic impairment is
however not needed (see section 5.2).
Renal Impairment
Since the elimination half-life of domperidone is
prolonged in severe renal impairment, on
repeated administration, the dosing frequency of
Domperidone tablets should be reduced to once
or twice daily depending on the severity of the
impairment, and the dose may need to be
reduced. Such patients on prolonged therapy
should be reviewed regularly (see sections 4.4
and 5.2)
4.3 Contraindications
Domperidone is contraindicated in the following
situations:
• In patients with moderate or severe hepatic
impairment (see section 5.2).
• In patients who have known existing
prolongation of cardiac conduction intervals,
particularly QTc, patients with significant
electrolyte disturbances or underlying cardiac
diseases such as congestive heart failure (see
section 4.4)
• Co-administration with QT-prolonging drugs,
at the exception of apomorphine (see section 4.4
and 4.5).
• Co-administration with potent CY3A4
inhibitors (regardless of their QT prolonging
effects) (see section 4.5)
• Known hypersensitivity to domperidone or any
of the excipients.
2. Domperidone 10mg Tablets SMPC, Taj Pharmaceuticals
Domperidone Taj Pharma : Uses, Side Effect s, Interactions, Pictures, Warnings, Domperidone Dosage & Rx Info | Domperidone Uses, Side Effects -: Indications, Side Effects, Warnings, Domp eridone - Drug Information - Taj Pharma, Domperidone dose Taj pharmaceuticals Domperidone interactions, Taj Pharmaceutical Domperidone contraindications, Domperidone price, Domperidone Taj Pharma Do mperidone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Domperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
• Prolactin-releasing pituitary tumour
(prolactinoma.)
• Renal impairment
Domperidone should not be used when
stimulation of gastric motility could be harmful:
gastro-intestinal haemorrhage, mechanical
obstruction or perforation.
4.4 Special Warnings and precautions for use
Precautions for use
Domperidone tablets contain lactose and may be
unsuitable for patients with lactose intolerance,
galactosaemia or glucose/galactose
malabsorption.
Use in infants
Neurological side effects are rare (see
"Undesirable effects" section). Since metabolic
functions and the blood-brain barrier are not
fully developed in the first months of life the
risk of neurological side effects is higher in
young children.
Overdosing may cause extrapyramidal
symptoms in children, but other causes should
be taken into consideration.
Renal Impairment
The elimination half-life of domperidone is
prolonged in severe renal impairment. For
repeated administration, the dosing frequency of
domperidone should be reduced to once or twice
daily depending on the severity of the
impairment. The dose may also need to be
reduced.
Cardiovascular effects
Domperidone has been associated with
prolongation of the QT interval on the
electrocardiogram. During post-marketing
surveillance, there have been very rare cases of
QT prolongation and torsades de pointes in
patients taking domperidone. These reports
included patients with confounding risk factors,
electrolyte abnormalities and concomitant
treatment which may have been contributing
factors (see section 4.8).
Epidemiological studies showed that
domperidone was associated with an increased
risk of serious ventricular arrhythmias or sudden
cardiac death (see section 4.8). A higher risk
was observed in patients older than 60 years,
patients taking daily doses greater than 30 mg,
and patients concurrently taking QT-prolonging
drugs or CYP3A4 inhibitors.
Domperidone should be used at the lowest
effective dose in adults and children.
Domperidone is contraindicated in patients with
known existing prolongation of cardiac
conduction intervals, particularly QTc, in
patients with significant electrolyte disturbances
(hypokalaemia, hyperkalaemia,
hypomagnesaemia), or bradycardia, or in patient
with underlying cardiac diseases such as
congestive heart failure due to increased risk of
ventricular arrhythmia (see section 4.3).
Electrolyte disturbances (hypokalaemia,
hyperkalaemia, hypomagnesaemia) or
bradycardia are known to be conditions
increasing the proarrythmic risk.
Domperidone is contra-indicated with QT
prolonging drugs including apomorphine, unless
the benefit of the co-administration with
apomorphine outweighs the risks, and only if the
recommended precautions for co-administration
mentioned in the apomorphine SmPC are strictly
fulfilled. Please refer to the apomorphine SmPC
Treatment with domperidone should be stopped
if signs or symptoms occur that may be
associated with cardiac arrhythmia, and the
patient should consult their physician.
Patient should be advised to promptly report any
cardiac symptoms.
4.5 Interaction with other medicinal products
and other forms of interaction
The main metabolic pathway of domperidone is
through CYP3A4. In vitro data suggest that the
concomitant use of drugs that significantly
inhibit this enzyme may result in increased
plasma levels of domperidone.
Increased risk of occurrence of QT-interval
prolongation, due to pharmacodynamic and/or
pharmacokinetic interactions.
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Concomitant use of the following substances
is contraindicated
QTc-prolonging medicinal products
• anti-arrhythmics class IA (e.g., disopyramide,
hydroquinidine, quinidine)
• anti-arrhythmics class III (e.g., amiodarone,
dofetilide, dronedarone, ibutilide, sotalol)
• certain antipsychotics (e.g., haloperidol,
pimozide, sertindole)
• certain antidepressants (e.g., citalopram,
escitalopram)
• certain antibiotics (e.g. , erythromycin,
levofloxacin, moxifloxacin, spiramycin)
• certain antifungal agents (e.g., pentamidine)
• certain antimalarial agents (in particular
halofantrine, lumefantrine)
• certain gastro-intestinal medicines (e.g.,
cisapride, dolasetron, prucalopride)
• certain antihistaminics (e.g., mequitazine,
mizolastine)
• certain medicines used in cancer (e.g.,
toremifene, vandetanib, vincamine)
• certain other medicines (e.g., bepridil,
diphemanil, methadone) (see section 4.3).
• apomorphine, unless the benefit of the co-
administration outweighs the risks, and only if
the recommended precautions for co-
administration are strictly fulfilled. Please refer
to the apomorphine SmPC.
Potent CYP3A4 inhibitors (regardless of their
QT prolonging effects), i.e :
• protease inhibitors
• systemic azole antifungals
• some macrolides (erythromycin,
clarithromycin and telithromycin) (see section
4.3).
Concomitant use of the following substances
is not recommended
Moderate CYP3A4 inhibitors i.e. diltiazem,
verapamil and some macrolides.
(see section 4.3)
Concomitant use of the following substances
requires caution in use
Caution with bradycardia and hypokalaemia-
inducing drugs, as well as with the following
macrolides involved in QT-interval
prolongation: azithromycin and roxithromycin
(clarithromycin is contraindicated as it is a
potent CYP3A4 inhibitor).
The above list of substances is representative
and not exhaustive.
Separate in vivo
pharmacokinetic/pharmacodynamic interaction
studies with oral ketoconazole or oral
erythromycin in healthy subjects confirmed a
marked inhibition of domperidone's CYP3A4
mediated first pass metabolism by these drugs.
With the combination of oral domperidone
10mg four times daily and ketoconazole 200mg
twice daily, a mean QTc prolongation of 9.8
msec was seen over the observation period, with
changes at individual time points ranging from
1.2 to 17.5 msec. With the combination of
domperidone 10mg four times daily and oral
erythromycin 500mg three times daily, mean
QTc over the observation period was prolonged
by 9.9 msec, with changes at individual time
points ranging from 1.6 to 14.3 msec. Both the
Cmax and AUC of domperidone at steady state
were increased approximately three-fold in each
of these interaction studies. In these studies
domperidone monotherapy at 10mg given orally
four times daily resulted in increases in mean
QTc of 1.6 msec (ketoconazole study) and 2.5
msec (erythromycin study), while Ketoconazole
monotherapy (200mg twice daily) led to
increases in QTc of 3.8 and 4.9 msec,
respectively, over the observation period.
4.6 Fertility, Pregnancy and lactation
Pregnancy-
There are limited post-marketing data on the use
of domperidone in pregnant women. A study in
rats has shown reproductive toxicity at a high,
maternally toxic dose. The potential risk for
humans is unknown. Therefore, domperidone
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should only be used during pregnancy when
justified by the anticipated therapeutic benefit.
Breast-feeding
Domperidone is excreted in human milk and
breast-fed infants receive less than 0.1% of the
maternal weight-adjusted dose. Occurrence of
adverse effects, in particular cardiac effects
cannot be excluded after exposure via breast
milk. A decision should be made whether to
discontinue breast-feeding or to
discontinue/abstain from domperidone therapy
taking into account the benefit of breast-feeding
for the child and the benefit of therapy for the
women. Caution should be exercised in case of
QTc prolongation risk factor in breast-fed
infants.
4.7 Effects on ability to drive and use
machines
Domperidone has no or negligible influence on
the ability to drive or use machines.
4.8 Undesirable Effects
The following frequencies are used for the
description of the occurrence of adverse
reactions:
Very common (≥1/10); common (≥1/100 to
<1/10); uncommon (≥1/1,000 to <1/100); rare
(≥1/10,000 to <1/1,000); very rare (<1/10,000),
unknown (cannot be estimated from the
available data).
Where frequency cannot be estimated from
clinical trials data, it is recorded as “Not
known”.
System Organ Class Adverse Drug Reaction
Frequency
Common Uncommon
Psychiatric disorders Loss of libido
Anxiety
Nervous system
disorders
Somnolence
Headache
Gastrointestinal
disorders
Dry mouth Diarrhoea
Skin and subcutaneous
tissue disorder
Rash
Pruritus
Reproductive system
and breast disorders
Galactorrhoea
Breast pain
Breast tenderness
General disorders and
administration site
conditions
Asthenia
Postmarketing experience
In addition to the adverse effects reported during
clinical studies and listed above, the following
adverse drug reactions have been reported.
Immune System Disorder:
Not know: anaphylactic reactions including
anaphylactic shock, angioedema, allergic
reaction
Psychiatric System Disorder:
Not known: agitation, nervousness
Nervous system disorders:
Not known; extrapyramidal disorder,
convulsions,
Eye disorders:Not known: Oculogyric crisis
Skin and subcutaneous tissue disorders:
Not known: urticaria, angioedema
Reproductive system and breast disorders:
Not known:, gynaecomastia, amenorrhoea.
Cardiac disorders:
Not known; ventricular arrhythmias, QTc
prolongation, Torsade de pointes, sudden cardiac
death (See sections 4.4).
Investigations:
Not known: liver function test abnormal, blood
prolactin increased
As the hypophysis is outside the blood brain
barrier, domperidone may cause an increase in
prolactin levels. In rare cases this
hyperprolactinaemia may lead to neuro-
endocrinological side effects such as
galactorrhoea, gynaecomastia and amenorrhoea.
Extrapyramidal side effects are very rare in
neonates and infants, and exceptional in adults.
These side effects reverse spontaneously and
completely as soon as the treatment is stopped.
Other central nervous system-related effects of
convulsion, agitation and somnolence also are
very rare and primarily reported in infants and
children.
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Reporting of suspected adverse reactions
Reporting suspected adverse reactions after
authorization of medicinal product is important.
It allows continued monitoring of the
benefit/risk balance of the medicinal product.
4.9 Overdose
Symptoms
Overdose has been reported primarily in infants
and children. Symptoms of overdosage may
include agitation, altered consciousness,
convulsions, disorientation, somnolence and
extrapyramidal reactions.
Treatment
There is no specific antidote to domperidone,
but in the event of overdose, standard
symptomatic treatment should be given
immediately. Gastric lavage as well as the
administration of activated charcoal, may be
useful. ECG monitoring should be undertaken,
because of the possibility of QT interval
prolongation. Close medical supervision and
supportive therapy is recommended.
Anticholinergic, anti-parkinson drugs may be
helpful in controlling the extrapyramidal
reactions.
5. PHARMACOLOGICAL PROPERTIES
5.1 Pharmacodynamic properties
Pharmacotherapeutic Group: Propulsives
Domperidone is a dopamine antagonist with
anti-emetic properties domperidone does not
readily cross the bloodbrain barrier. In
domperidone users, especially in adults,
extrapyramidal side effects are very rare, but
domperidone promotes the release of prolactin
from the pituitary. Its anti-emetic effect may be
due to a combination of peripheral
(gastrokinetic) effects and antagonism of
dopamine receptors in the chemoreceptor trigger
zone, which lies outside the blood-brain barrier
in the area postrema. Animal studies, together
with the low concentrations found in the brain,
indicate a predominantly peripheral effect of
domperidone on dopamine receptors. Studies in
man have shown oral domperidone to increase
lower oesophageal pressure, improve
antroduodenal motility and accelerate gastric
emptying. There is no effect on gastric secretion.
In accordance with ICH-E14 guidelines, a
thorough QT study was performed. This study
included a placebo, an active comparator and a
positive control and was conducted in healthy
subjects with up to 80 mg per day 10 or 20 mg
administered 4 times a day of domperidone. This
study found a maximal difference of QTc
between domperidone and placebo in LS-means
in the change from baseline_of 3.4 msec for 20
mg domperidone administered 4 times a day on
Day 4. The 2-sided 90% CI (1.0 to 5.9 msec) did
not exceed 10 msec. No clinically relevant QTc
effect were observed in this study when
domperidone was administered at up to 80
mg/day (i.e., more than twice the maximum
recommended dosing).
However, two previous drug-drug interaction
studies showed some evidence of QTc
prolongation when domperidone was
administered as monotherapy (10 mg 4 times a
day). The largest time-matched mean difference
of QTcF between domperidone and placebo was
5.4 msec (95 % CI: -1.7 to 12.4) and 7.5msec
(95 % CI: 0.6 to 14.4), respectively.
5.2 Pharmacokinetic properties
Absorption
Domperidone is rapidly absorbed after oral
administration with peak plasma concentrations
occurring at approximately 1 hr after dosing..
The Cmax and AUC values of domperidone
increased proportionally with dose in the 10 mg
to 20 mg dose range. A 2- to 3-fold
accumulation of domperidone AUC was
observed with repeated four times daily (every 5
hr) dosing of domperidone for 4 days.
The low absolute bioavailability of oral
domperidone (approximately 15%) is due to an
extensive first-pass metabolism in the gut wall
and liver. Although domperidone's
bioavailability is enhanced in normal subjects
when taken after a meal, patients with
gastrointestinal complaints should take
domperidone 15-30 minutes before a meal.
Reduced gastric acidity impairs the absorption
of domperidone. Oral bioavailability is
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decreased by prior concomitant administration
of cimetidine and sodium bicarbonate. The time
of peak absorption is slightly delayed and the
AUC somewhat increased when the oral drug is
taken after a meal.
Distribution
Oral domperidone does not appear to
accumulate or induce its own metabolism; a
peak plasma level after 90 minutes of 21ng/ml
after two weeks oral administration of 30 mg per
day was almost the same as that of 18 ng/ml
after the first dose. Domperidone is 91-93%
bound to plasma proteins. Distribution studies
with radiolabelled drug in animals have shown
wide tissue distribution, but low brain
concentration. Small amounts of drug cross the
placenta in rats.
Metabolism
Domperidone undergoes rapid and extensive
hepatic metabolism by hydroxylation and N-
dealkylation. In vitro metabolism experiments
with diagnostic inhibitors revealed that CYP3A4
is a major form of cytochrome P-450 involved in
the N-dealkylation of domperidone, whereas
CYP3A4, CYP1A2 and CYP2E1 are involved in
domperidone aromatic hydroxylation.
Excretion
Urinary and faecal excretions amount to 31 and
66% of the oral dose respectively, The
proportion of the drug excreted unchanged is
small (10% of faecal excretion and
approximately 1% of urinary excretion). The
plasma half life after a single oral dose is 7-9
hours in healthy subjects but is prolonged in
patients with severe renal insufficiency.
Hepatic impairment
In subjects with moderate hepatic impairment
(Pugh score 7 to 9, Child-Pugh rating B), the
AUC and Cmax of domperidone is 2.9- and 1.5-
fold higher, respectively, than in healthy
subjects.
The unbound fraction is increased by 25%, and
the terminal elimination half-life is prolonged
from 15 to 23 hours. Subjects with mild hepatic
impairment have a somewhat lower systemic
exposure than healthy subjects based on Cmax
and AUC, with no change in protein binding or
terminal half-life. Subjects with severe hepatic
impairment were not studied. Domperidone is
contraindicated in patients with moderate or
severe hepatic impairment (see section 4.3).
Renal impairment
In subjects with renal insufficiency (creatinine
clearance<30 ml/min/1.73m2) the elimination
half-life of domperidone was increased from 7.4
to 20.8 hours, but plasma drug levels were lower
than in healthy volunteers.
Since very little unchanged drug (approximately
1%) is excreted via the kidneys, it is unlikely
that the dose of a single administration needs to
be adjusted in patients with renal insufficiency.
However, on repeated administration, the dosing
frequency should be reduced to once or twice
daily depending on severity of the impairment,
and the dose may need to be reduced.
5.3 Preclinical safety data
Electrophysiological in vitro and in vivo studies
indicate an overall moderate risk of
domperidone to prolong the QT interval in
humans. In in vitro experiments on isolated cells
transfected with hERG and on isolated guinea
pig myocytes exposure ratios ranged between 26
– 47-fold, based on IC50 values inhibiting
currents through IKr ion channels in comparison
to the free plasma concentrations in humans
after administration of the maximum daily dose
of 10 mg administered 3 times a day. safety
margins for prolongation of action potential
duration in in vitro experiments on isolated
cardiac tissues exceeded the free plasma
concentrations in humans at maximum daily
dose (10 mg administered 3 times a day) by 45-
fold.
Safety margins in in vitro proarrhythmic models
(isolated Langendorff perfused heart) exceeded
the free plasma concentrations in humans at
maximum daily dose (10 mg administered 3
times a day) by 9- up to 45-fold. In in
vivo models the no effect levels for
QTc prolongation in dogs and induction of
arrhythmias in a rabbit model sensitized for
torsade de pointes exceeded the free plasma
concentrations in humans at maximum daily
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dose (10 mg administered 3 times a day) by
more than 22-fold and 435-fold, respectively. In
the anesthetized guinea pig model following
slow intravenous infusions, there were no effects
on QTc at total plasma concentrations of
45.4ng/ml, which are 3-fold higher than the total
plasma levels in humans at maximum daily dose
(10 mg administered 3 times a day). The
relevance of the latter study for humans
following exposure to rally administered
domperidone is uncertain.
In the presence of inhibition of the metabolism
via CYP3A4 free plasma concentrations of
domperidone can rise up to 3- fold.
At a high, maternally toxic dose (more than 40
times the recommended human dose),
teratogenic effects were seen in the rat. No
teratogenicity was observed in mice and rabbits.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
Microcrystalline cellulose
Lactose monohydrate
Maize starch
Povidone K30
Sodium lauryl sulphate
Silica colloidal, anhydrous
Magnesium stearate
6.2 Incompatibilities
Not Applicable
6.3 Shelf life
24 months.
6.4 Special precautions for storage
Do not store above 25°C. Store in the original
package.
6.5 Nature and contents of container
The tablets are packed in blisters constituted
from a PVC and aluminium foil in packs of 30
and 100.
6.6 Special precautions for disposal and other
handling
None
7. MANUFACTURER:
Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
At:388/34, Changodar Industrial Estate
Changodar- 382 210
Dist- Ahmedabad. Gujarat (India)
MFG. LIC NO: G/25A/4795-A